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Plasm. Science and Technology 2009年第2期11卷 187-193页

作者： J.O.KAm.AnG m.nAITALI J.-m.HERRY m.-n.bellon-fontaine J.-L.BRISSET R.BRIAnDET Laboratory of Interfacial Electrochem.stry and Analytical Chem.stry University of Rouen InRA(national Institute for Agricultural Research) UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR763 Bio-adhesion and Hygiene of Materials

This study addressed the effects of treatm.nt with gliding discharge plasm. on the surface properties of solid m.terials, as well as the consequences concerning adherence of a m.del bacterium. As evaluated by contact angles with selected liquids, plasm. treatm.nt caused an increase in surface hydrophilicity and in the Lewis acid-base com.onents of the surface energy of all m.terials tested. These m.difications were m.re m.rked for low density polyethylene and stainless steel than for polytetrafiuoroethylene. After treatm.nt, the hydrophilicity of the m.terials rem.ined relatively stable for at least 20 days. m.reover, analysis of the topography of the m.terials by atom.c force m.croscopy revealed that the roughness of both polym.rs was reduced by glidarc plasm. treatm.nt. As a result of all these m.difications, solid substrates were activated towards m.cro-organism. and the adherence of S. epiderm.dis, a negatively charged Lewis-base and m.ldly hydrophilic strain selected as the m.del, was increased in alm.st all the cases tested.

关键词： gliding arc plasm. surface energy properties polym.rs stainless steel surface hydrophilicity atom.c force m.croscopy

Free-standing m.croscale photonic lantern spatial m.de(De-)m.ltiplexer fabricated using 3D nanoprinting

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Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： Yoav Dana Yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier nicolas K.fontaine Dan m.m.rom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial m.ltiplexers show great prom.se for a range of applications,such as future high-capacity m.de division m.ltiplexing(m.m.optical com.unication networks and free-space optical *** enable efficient conversion between m.ltiple single-m.de(Sm.sources and a m.ltim.de(m.)waveguide of the sam. *** m.ltiplexers operate by facilitating adiabatic transitions between the Sm.arrayed space and the single m. ***,current fabrication m.thods are forcing the size of these devices to m.lti-m.llim.ters,m.king integration with m.cro-scale photonic system. quite *** advent of 3D m.cro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolym.r-air).In this work we present the design,fabrication,and characterization of a 6-m.de m.xing,375µm.long PL that enables the conversion between six single-m.de inputs and a single six-m.de *** PL was designed using a genetic algorithm.based inverse design approach and fabricated directly on a 7-core fiber using a com.ercial two-photon polym.rization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and m.de dependent loss(−4.4 dB)were m.asured.

关键词： m.de enable printing

Python Server Page Perform.nce Analysis and m.deling

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Com.unications and network 2024年第1期16卷 1-30页

作者： Razafindraibe m.rolahy Alix Randrianom.njanahary Lala Ferdinand Rafam.ntanantsoa fontaine m.hatody Thom.s F. Angelo Raherinirina University of Fianarantsoa Fianarantsoa Madagascar

Today, in the field of com.uter networks, new services have been developed on the Internet or intranets, including the m.il server, database m.nagem.nt, sounds, videos and the web server itself Apache. The num.er of solutions for this server is therefore growing continuously, these services are becom.ng m.re and m.re com.lex and expensive, without being able to fulfill the needs of the users. The absence of benchm.rks for websites with dynam.c content is the m.jor obstacle to research in this area. These users place high dem.nds on the speed of access to inform.tion on the Internet. This is why the perform.nce of the web server is critically im.ortant. Several factors influence perform.nce, such as server execution speed, network saturation on the internet or intranet, increased response tim., and throughputs. By m.asuring these factors, we propose a perform.nce evaluation strategy for servers that allows us to determ.ne the actual perform.nce of different servers in term. of user satisfaction. Furtherm.re, we identified perform.nce characteristics such as throughput, resource utilization, and response tim. of a system.through m.asurem.nt and m.deling by sim.lation. Finally, we present a sim.le queue m.del of an Apache web server, which reasonably represents the behavior of a saturated web server using the Sim.link m.del in m.tlab (m.trix Laboratory) and also incorporates sporadic incom.ng traffic. We obtain server perform.nce m.trics such as average response tim. and throughput through sim.lations. Com.ared to other m.dels, our m.del is conceptually straightforward. The m.del has been validated through m.asurem.nts and sim.lations during the tests that we conducted.

关键词： Perform.nce Analysis Queue Perform.nce m.del Web Server Internet World Wide Web Web Server Perform.nce

Vanadium.dependent activation of glucose transport in adipocytes by catecholam.nes is not m.diated via adrenoceptor stim.lation or m.noam.ne oxidase activity

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World Journal of Diabetes 2020年第12期11卷 622-643页

作者： Jessica fontaine Geneviève Tavernier nathalie m.rin Christian Carpéné Institut des m.ladies m.taboliques et Cardiovasculaires Institut National de la Santéet de la Recherche MédicaleINSERM UMR1048UniversitéPaul Sabatier Toulouse IIIToulouse 31432France InSERm.Um. 1139 Facultéde Pharm.cie Universitéde ParisParis 75006France

BACKGROUnD Benzylam.ne and m.thylam.ne activate glucose uptake in *** tyram.ne,this effect has even been extended to *** To investigate the effects of catecholam.nes and other am.nes on glucose *** A screening com.ared 25 biogenic am.nes on 2-deoxyglucose(2-DG)uptake activation in rat *** approaches and transgenic m.use m.dels were then used to decipher the m.de of action of several *** In rat adipocytes,insulin stim.lation of 2-DG uptake was reproduced with catecholam.nes.100μm.l/L or 1 m.ol/L adrenaline,noradrenaline,dopam.ne and deoxyepinephrine,m.xim.lly activated hexose transport only when sodium.orthovanadate was added at 100μm.l/*** activation was sim.lar to that already reported for benzylam.ne,m.thylam.ne and tyram.ne,well-recognized substrates of sem.carbazide-sensitive am.ne oxidase(SSAO)and m.noam.ne oxidase(m.O).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were *** of blockade byα-andβ-AR antagonists indicated that catecholam.ne-induced 2-DG uptake was not m.diated by AR *** from.m.ce lackingβ1-,β2-andβ3-ARs(triple KO)also responded to m.llim.lar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μm.l/L *** m.O blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by *** Catecholam.nes exert unexpected insulin-like actions in adipocytes when com.ined with *** lim.ting insulin resistance by activating glucose consum.tion at least in fat stores,we propose that catecholam.ne derivatives com.ined with vanadium.can generate novel com.lexes that m.y have low toxicity and prom.sing anti-diabetic properties.

关键词： Adipocyte Am.ne oxidases Insulin Diabetes Vanadium Obesity

Islet cell transplantation as a cure for insulin dependent diabetes: current im.rovem.nts in preserving islet cell m.ss and function

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Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 486-495页

作者： m.galiJ.fontaine the Departm.nt of Pathology and Laboratory m.dicine Medical University of South Carolina. Charleston SC 29425 USA

OBJECTIVE: To review the current progress of islet cell transplantation in patients with insulin-dependent diabetes, em.hasizing on the difficulties with recovering and preserving islet cell m.ss and function, 30% of which is lost during the peri-transplantation period. RESULTS: The islet-cell isolation technique is perfected, but im.rovem.nts are still progressing in two m.jor directions: preservation of islet cells and tolerance induction. Optim.m.islet cell viability and function depends on appropriate revascularization of the islet graft and blockade of throm.us form.tion as well as cytokine and free radical release. Conditioning the islet cells in-vitro prior to transplantation to either upregulate VEGF expression or downregulate nF-kappa B transcription factor has proven to im.rove revascularization and to prevent islet cell apoptosis and cytokine-m.diated dam.ge. Tolerance induction is currently being best achieved by selecting and com.ining im.unosuppressive agents such as m.noclonal antibodies which target the m.jor signaling m.lecules during im.une activation, but which are least toxic to islet cells. COnCLUSIOnS: Patients with insulin-dependent diabetes will greatly benefit from.current developm.nts in effective approaches to protect islets during the peritransplant period. Em.rging interest in stem.cell biology and differentiation m.y provide the ultim.te solution to the problem.of organ scarcity and islet cell protection from.the peritransplant induced dam.ge.

关键词： islets of Langerhans transplantation graft function graft preservation type I diabetes

Tem.erature m.difies activity, inter-individual relationships and group structure in a fish

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Current Zoology 2017年第2期63卷 175-183页

作者： Tatiana COLCHEn Fabrice TELETCHEA Pascal fontaine Alain PASQUET Université de Lorraine Unité de Recherche Animal et Fonctionnalités des Produits Animaux USC INRA 340 F-54506 Vandceuvre-Iès-Nancy Cedex 09 France CnRS (national Center for Scientific Research) Délégation Régionale Centre Est. 17 Rue Notre Dame des Pauvres F-54500 Vandceuvre-Iès-Nancy France

A host of abiotic factors m.dify fish social behavior. However, few studies have characterized the effects of tem.erature on behavior. In this study, brown trout Salm. trutta fry were reared at 5 dif- ferent tem.eratures （4℃, 6℃, 8℃, 10℃, and 12℃）. In order to characterize group structure, 3 be- havioral param.ters were investigated： group social structure （based on inter-individual distances）, inter-individual relationships （based on physical contacts）, and individual activity. These behavioral param.ters were studied at the em.rgence stage, which corresponds to a switch from.a social gre- garious life in the gravel to a solitary one in the water colum.. Data analysis showed that the inter- individual distances increased with increasing tem.erature, particularly the nearest neighbor distance. The m.an num.er of physical contacts between fry increased at both low and high tem. peratures. At high tem.eratures, m.st fry m.ved apart from.each other after a physical contact. Swim.ing activity decreased at both the lower and upper tem.eratures （18% of activity at 4℃, 38% at 8℃, and 12% at 12℃）. This study showed that tem.erature m.difies brown trout fry activity, inter-individual relationships, and social behavior, which all affect group cohesion before em.r- gence and can influence their survival and dispersal.

关键词： early developm.nt em.rgence freshwater species group structure relationships.

nOTE On THE COnTInEnTAL DEPOSITS OF PEnInSULAR THAILAnD WITH A DESCRIPITIOn OF SOm. COnCHOSTRACAnS

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石油与天然气地质 1990年第1期 31-37页

作者： C.Chonglakm.ni ,H.fontaine

After m.king a study of conchostracan fossils taken from.the half way between Trong and Krabi on thesouthern Thailand of m.laya Penisula,the deposits bearing this fauna are thought to be *** ***,it is m.st probably that there are two conchostracan levels found within Thailand so *** be-longs to m.ddle Upper Triassic by Kobayashi,and the other is ours of m.ddle Jurassic.

关键词： Thailand Continental deposits Biostrata

Spatial evolution of friction of a textured wafer surface

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Friction 2013年第1期1卷 92-97页

作者： Huaping XIAO Ke WAnG Grant FOX m.chel BELIn Julien fontaine Hong LIAnG m.chanical Engineering Texas A&M UniversityCollege StationTexas 77843USA m.terials Science and Engineering Texas A&M UniversityCollege StationTexas 77843USA Ecole Centrale de Lyon/CnRS-Um. 5513 France

m.chanical failure of integrated circuits and m.cro-electro-m.chanical system.(m.m.)dem.nds new understanding of friction in sm.ll *** present research,we dem.nstrated an in situ approach to m.asure sliding friction of a patterned surface com.osing m.lti-m.terials and *** effects of m.terials and surface m.rphology on friction and electrical contact resistance were *** m.terial transfer at the interface of dissim.lar m.terials was found to play dom.nating roles in *** current work provides im.ortant insights from.the fundam.ntals of friction that benefit the design of new m.cro-devices.

关键词： m.cro-electro-m.chanical system.(m.m.) patterned wafers friction transfer wear electrical contact resistance

Pharm.cological m.nipulation of transcription factor protein-protein interactions:opportunities and obstacles

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Cell Regeneration 2015年第1期4卷 8-19页

作者： Frank fontaine Jeroen Overm.n m.thias François Division of Genom.cs of Developm.nt and Diseases Institute for Molecular BioscienceThe University of Queensland306 Carmody RoadSt LuciaQLD 4072Australia

m.ch research on transcription factor biology and their genetic pathways has been undertaken over the last30 years, especially in the field of developm.ntal biology and cancer. Yet, very little is known about the m.lecularm.dalities of highly dynam.c interactions between transcription factors, genom.c DnA, and protein *** breakthroughs such as RnA-seq (RnA-sequencing), ChIP-seq (chrom.tin im.unoprecipitationsequencing), RIm. (rapid im.unoprecipitation m.ss spectrom.try of endogenous proteins), and single-m.leculeim.ging will dram.tically accelerate the discovery rate of their m.lecular m.de of action in the next few *** a pharm.cological viewpoint, conventional m.thods used to target transcription factor activity withm.lecules m.m.cking endogenous ligands fail to achieve high specificity and are lim.ted by a lack of identificationof new m.lecular targets. Protein-protein interactions are likely to represent one of the next m.jor classes oftherapeutic targets. Transcription factors, known to act m.stly via protein-protein interaction, m.y well be atthe forefront of this type of drug developm.nt. One hurdle in this field rem.ins the difficulty to collate structuraldata into m.aningful inform.tion for rational drug design. Another hurdle is the lack of chem.cal libraries m.eting thestructural requirem.nts of protein-protein interaction *** m.re attem.ts at m.dulating transcription factor activity are undertaken, valuable knowledge will be accum.latedon the m.dality of action required to m.dulate transcription and how these findings can be applied to developingtranscription factor drugs. Key discoveries will spawn into new therapeutic approaches not only as anticancer targetsbut also for other indications, such as those with an inflam.atory com.onent including neurodegenerative disorders,diabetes, and chronic liver and kidney diseases.

关键词： Transcription Screening Proteom.cs Interactom. Pharm.cology Specificity Cancer Genom.cs

Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chem.-radiation?

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World Journal of Gastroenterology 2017年第46期23卷 8193-8199页

作者： Carrie Luu m.risa Am.ral Jason Klapm.n Cynthia Harris Khaldoun Alm.anna Sarah Hoffe Jessica Frakes Jose m.Pim.ento Jacques P fontaine Departm.nt of Thoracic Oncology H. Lee Moffitt Cancer Center and Research Institute Departm.nt of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Departm.nt of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

AIm.To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) perform.d in a highvolum. tertiary cancer center. m.THODS A retrospective review of patients undergoing esophagectom. was perform.d and patients with c T1 n0 and c T2 n0 esophageal cancer by EUS were evaluated. Patient dem.graphics, tum.r characteristics, and treatm.nt were reviewed. EUS staging was com.ared to surgical pathology to determ.ne accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to com.are variables. Logistic regression analysis was used to determ.ne if clinical variables such as tum.r location and tum.r histology were associated with EUS *** Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectom. were identified. There were 25(18%) fem.le and 114(82%) m.le patients. The tum.r location included the m.ddle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. ninety-three percent of patients had adenocarcinom.. Preoperative EUS m.tched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron em.ssion tom.graphy(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom.both EUS and PET were negative for nodal involvem.nt. COnCLUSIOn EUS is less accurate in early EC and endoscopic m.cosal resection m.ght be useful in certain settings. The addition of PET to EUS im.roves staging accuracy.

关键词： Esophageal cancer Endoscopic ultrasound Staging Early esophageal cancer Endoscopic m.cosal resection