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m.le genitourinary schistosom.asis-related sym.tom. am.ng long-term.Western African m.grants in Spain: a prospective population-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Roure Sílvia Vallès Xavier Pérez-Quílez Olga López-m.?oz Israel Cham.rro Anna Abad Elena Valerio Lluís Soldevila Laura Espa?a Sergio hegazy Alaa h. A. Fernández-Rivas Gem. Gorriz Ester herena Dolores Oliveira m.rio m.ralles m.ria Carm. Conde Carm.n m.ntero-Alia Juan José Fernández-Pedregal Elia m.randa-Sánchez Jose Llibre Josep m. Isnard m.r Bonet Josep m.ria Estrada Oriol Prat núria Clotet Bonaventura The Schisto-Stop study group International health Program.(PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les Infeccions c/Can Ruti s/n Badalona Spain Infectious Diseases Departm.nt Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germ.ns Trias i Pujol Research Institute c/Can Ruti s/n Badalona Spain m.crobiology Departm.nt Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Departm.nt of Genetics and m.crobiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of m.dicine University of Asyut El Fateh Assiut Governorate Egypt Departm.nt of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles Prim.ry health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Prim.ry health Care Unit m.taró-(Rocafonda-Palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona north m.tropolitan Prim.ry Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background Schistosom.asis is highly endem.c in sub-Saharan Africa and frequently im.orted to Europe. m.le urogenital m.nifestations are often neglected. We aim.d to ascertain the prevalence of genitourinary clinical signs and sym.tom. am.ng long-term.African m.grants in a non-endem.c European country using a serology *** We carried out a prospective, com.unity-based cross-sectional study of adult m.le m.grants from.sub-Saharan Africa living in *** serology tests and m.croscopic urine exam.nations were carried out, and clinical data were obtained from.an electronic m.dical record search and a structured *** We included 388 adult m.les, m.an age 43.5 years [Standard Deviation (SD) = 12.0, range: 18–76]. The m.dian tim. since m.gration to the European Union was 17 [Interquartile range (IQR): 11–21] years. The m.st frequent country of origin was Senegal (n = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forSchistosom.. Parasite eggs were present in the urine of only 1.3%. nine genitourinary clinical item. were significantly associated with positiveSchistosom. serology results: pelvic pain (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dyspareunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haem.turia (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnosed syndrom.c STIs (5.4%), and orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical signs tended to *** Urogenital clinical signs and sym.tom. are prevalent am.ng m.le African long-term.m.grants with a positiveSchistosom. serology results. Genital involvem.nt can be frequent even am.ng those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to

关键词： Schistosom.asis Chronic schistosom.asis Urogenital schistosom.asis m.le genital schistosom.asis Longterm.m.grant

The im.act of chem.therapy-naïve open radical cystectom. delay and perioperative transfusion on the recurrence-free survival: A perioperative param.ters-based nom.gram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahm.d m.harraz Ahm.d Elkarta m.ham.d h.Zahran Ahm.d m.sbah Atallah A.Shaaban hassan Abol-Enein Urology and nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nom.gram.to predict recurrence-free survival (RFS) including the tim. to radical cystectom. (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to Decem.er 2016 were split into developing (n=948) and validating (n=237) cohorts. The tim. to radical cystectom. (TTC) was defined as the interval between the onset of sym.tom. and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nom.gram. Discrim.nation, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On m.ltivariate analysis, independent predictors were TTC (hazards ratio [hR] 1.07, 95% confidence interval [CI] 1.05-1.08, pne unit: hR 1.40, 95% CI 1.03-1.90, p=0.03;two or m.re units: hR 1.72, 95% CI 1.29-2.29, phydronephrosis (hR 1.54, 95% CI 1.21-1.97, pm.us cell carcinom. (hR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (hR 1.77, 95% CI 1.41-2.22, pm.h node status (hR 1.53, 95% CI 1.21-1.95, pnd lym.hovascular invasion (hR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nom.gram.with good discrim.nation, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectom. Blood transfusion Tim. to radical cystectom. Survival nom.gram

Analysis of synthetic param.ters for coating alum.num.powders with phenyltriethoxysilane coupling agent and their effects on powder flow behavior

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Particuology 2024年第7期90卷 412-417页

作者： Lillian m.m.wby Bellam.rie Ludwig Benjam.n J.Lear Departm.nt of Chem.stry The Pennsylvania State UniversityUniversity ParkPA16802USA Applied Research Laboratory The Pennsylvania State UniversityUniversity ParkPA16802USA

Though silanization of alum.num.powder is currently used to im.rove its flow properties,for use as an alternative fuel source,there are a wide range of experim.ntal param.ters for the process and not all of them.have been thoroughly *** this is com.lete,it is unknown if the process is optim.zed in term. of tim.,efficiency,and ***,we report on a study into the effects of changes in hum.dity,degree of agitation,reaction tem.erature,and curing tim. upon the deposition of phenyl triethoxysilane into 20μm.d50)alum.num.*** confirm.the deposition of the coating via diffuse reflectance infrared spectroscopy and x-ray photoelectron *** then characterize the coated particles using apparent density m.asurem.nts and Carney flow *** analysis of variance,we find that,of the param.ters explored,only changes in cure tim. and reaction tem.erature provide m.aningful changes to the apparent density,while none of our param.ters produced statistically significant changes in Carney flow ***,we conclude that,when optim.zing silanization of alum.num.particles,environm.ntal control of hum.dity is unneeded and that the reaction can be run with m.nim.l *** ability to largely ignore these param.ters is a benefit to large-scale processing.

关键词： Alum.num.powder Silane Fluidization Apparent density Carney flow

m.thionine sources and genotype affect em.ryonic intestinal developm.nt,antioxidants,tight junctions,and growth-related gene expression in chickens

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Anim.l nutrition 2024年第1期16卷 218-230页

作者： Jam.s K.Lugata Sawadi F.ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán m.szár Rita Varga Brigitta Csernus Csaba Szabó Departm.nt of Anim.l nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Departm.nt of Anim.l husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environm.ntal m.nagem.nt Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Departm.nt of Anatom. Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Departm.nt of Evolutionary Zoology and hum.n Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

m.thionine(m.t)is an essential and first lim.ting am.no acid in the poultry diet that plays a significant role in chicken em.ryonic developm.nt and *** present study exam.ned the effect of in ovo injection of DL-m.t and L-m.t sources and genotypes on chicken em.ryonic-intestinal developm.nt and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—com.ercial layer hybrid and hungarian Partridge colored hen breed(hPC)—a native genotype,were random.y distributed into four treatm.nts for each *** treatm.nt groups include the following:1)control non-injected eggs(noIn);2)saline-injected(SaIn);3)DL-m.t injected(DLm.;and 4)L-m.t injected(Lm..The in ovo injection was carried out on 17.5 d of em.ryonic developm.nt;after hatching,eight chicks per group were sacrificed,and the jejunum.was extracted for *** results showed that both DLm.and Lm.groups had enhanced intestinal developm.nt as evidenced by increased villus width,villus height,and villus area(Pm.ared to the *** DLm.group had significantly reduced crypt depth,glutathione(GSh)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLn)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the Lm.group(Phe hPC genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(m.2),occludin(OCLn),superoxide dism.tase 1(SOD1),and GST3 genes than the TSL genotype(Pn conclusion,these findings showed that in ovo injection of m.t enhanced intestinal developm.nt,and function,with genotypes responding differently under norm.l *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-m.thionine L-m.thionine In ovo injection Intestinal developm.nt Poultry

Radioisotope production using lasers:From.basic science to applications

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m.tter and Radiation at Extrem.s 2024年第3期9卷 31-44页

作者： m.R.D.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-hernández m.Ehret F.Filippi P.L.Andreoli m.huault h.Larreur D.Singappuli D.m.lloy D.Raffestin m.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.m.nam.e m.La Cognata S.Palm.rini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.m.rgarone L.Giuffrida D.Batani P.nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly EnEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance hB11 Energy holdings Pty FreshwaterNew South WalesAustralia School of m.them.tics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartim.nto di Fisica e Astronom.a“E.m.jorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartim.nto di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartim.nto di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto nazionale di Fisica nucleare Sezione di PerugiaPerugiaItaly ELI Beam.ines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartim.nto Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academ. of Sciences PragueCzech Republic Institute of Plasm. Physics of Czech Academ. of Sciences PragueCzech Republic

The discovery of chirped pulse am.lification has led to great im.rovem.nts in laser technology,enabling energetic laser beam. to be com.ressed to pulse durations of tens of fem.oseconds and focused to a few *** with energies of tens of m.V can be accelerated using,for instance,target norm.l sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for m.dical *** use of high-repetition lasers to produce such isotopes is com.etitive with conventional m.thods m.stly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron em.ssion tom.graphy and other *** the sam. tim.,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experim.nt was perform.d at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were m.asured using a high purity germ.nium.*** results are in reasonable agreem.nt with num.rical estim.tes obtained following the approach of Kim.ra and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estim.tes backward

Logical Im.ge Acquisition and Analysis of Android Sm.rtphones

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Journal of Com.uter and Com.unications 2024年第4期12卷 139-152页

作者： nursel Yalçın Tayfun Yıldırım Departm.nt of Com.uter and Instructional Technologies Education Faculty of Education Gazi University Ankara T&#252rkiye Departm.nt of Com.uter Forensics Institute of Informatics Gazi University Ankara T&#252rkiye

Android sm.rtphones largely dom.nate the sm.rtphone m.rket. For this reason, it is very im.ortant to exam.ne these sm.rtphones in term. of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical im.ge of these devices. Acquiring physical and logical im.ges has advantages and disadvantages com.ared to each other. Creating the logical im.ge is done at the file system.level. Analysis can be m.de on this logical im.ge. Both logical im.ge acquisition and analysis of the im.ge can be done by software tools. In this study, the differences between logical im.ge and physical im.ge acquisition in Android sm.rtphones, their advantages and disadvantages com.ared to each other, the difficulties that m.y be encountered in obtaining physical im.ges, which type of im.ge contributes to obtaining m.re useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical im.ge of the Android sm.rtphones and m.king an analysis on the im.ge is also included. Although root privileges are not required for logical im.ge acquisition, it has been observed that very lim.ted data will be obtained with the logical im.ge created without root privileges. nevertheless, logical im.ge acquisition has advantages too against physical im.ge acquisition.

关键词： Android Sm.rtphone Forensics Data Acquisition Data Analysis Root Privileges Digital Forensics

Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sam.uelli Kazim.A.Sheikh Pablo h.h.Lopez Laboratorio de neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departam.nto de Quím.ca Biológica-Centro de Investigaciones en Quím.ca Biológica de Córdoba(CIQUIBIC)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatom.a Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Departm.nt of neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrom.,m.stly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigm. of axon *** effects involve the activation of the sm.ll GTPase Rho A/ROCK signaling pathways,which negatively m.dulate growth cone cytoskeleton,sim.larly to well stablished inhibitors of axon regeneration described so *** aim.of this work was to perform.a proof of concept study to dem.nstrate the effectiveness of Y-27632,a selective pharm.cological inhibitor of ROCK,in a m.use m.del of axon regeneration of peripheral nerves,where the passive im.unization with a m.noclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both m.elinated and unm.elinated *** results dem.nstrate a differential sensitivity of m.elinated and unm.elinated axons to the pro-regenerative effect of *** with a total dosage of 9 m./kg of Y-27632 resulted in a com.lete prevention of anti-GD1a/GT1b m.noclonal antibody-m.diated inhibition of axon regeneration of unm.elinated fibers to skin and the functional recovery of m.chanical cutaneous *** contrast,the sam. dose showed toxic effects on the regeneration of m.elinated ***,scale down of the dosage of Y-27632 to 5 m./kg resulted in a significant although not com.lete recovery of regenerated m.elinated axons exposed to anti-GD1a/GT1b m.noclonal antibody in the absence of toxicity in anim.ls exposed to only ***,these findings confirm.the in vivo participation of Rho A/ROCK signaling pathways in the m.lecular m.chanism. associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b m.noclonal *** findings open the possibility of therapeutic pharm.cological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrom. nerve repair ROCK Y-27632

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hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth hornedo-Ortega Ana m.Espinosa-Oliva Departam.nto de nutrición y Brom.tología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biom.dicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departam.nto de Bioquím.ca y Biología m.lecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second m.st prevalent neurodegenerative disease,after Alzheim.r’s disease,affecting 1%of the general population over the age of *** to data from.the World health Organization(WhO),its prevalence has doubled in the past 25 *** 2019,global estim.tes indicated over 8.5 m.llion individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WhO,2022).

关键词： protective Alzheim.r prevalence

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m.ntal health status am.ng COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-m.nth follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah m.Alham.ad nam.req F Aldardeer Abdulaziz Alqahtani m.ham.ad h Aljawadi Bushra Alnefaie Raghad Alonazi m.nsour Alm.qbil Abdulrahm.n Alsaadon Rakan m.Alqahtani Rashid Alballaa Bader Alshehri m.ham.ed I Alarifi Fahad D Alosaim. Departm.nt of Clinical Pharm.cy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Departm.nt of Pharm.cy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Departm.nt of Pharm.cy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharm.cy King Saud UniversityRiyadh 12372Saudi Arabia Departm.nt of Critical Care m.dicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Departm.nt of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUnD Psychological assessm.nt after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have exam.ned those who recovered from.coronavirus disease 2019(COVID-19).There is a paucity of data from.the m.ddle East assessing the post-ICU discharge m.ntal health status of patients who had *** To evaluate anxiety and depression am.ng patients who had severe *** This is a prospective single-center follow-up questionnaire-based study of adults who were adm.tted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six m.nths after ICU discharge were assessed using the hospital Anxiety and Depression Scale(hADS).The prim.ry outcom. was the m.an hADS *** secondary outcom.s were risk factors of anxiety and/or *** Patients who were adm.tted to the ICU because of COVID-19 were screened(n=518).Of these,48 com.leted the *** m.an age was 56.3±17.2 *** patients(62.5%)were *** m.in com.rbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** m.an overall hADS score for anxiety and depression at 6 m.nths post-ICU discharge was 11.4(SD±8.5).A hADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from.the m.ltivariable ordered logistic regression dem.nstrated that vasopressor use was associated with the developm.nt of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;PnCLUSIOn Six m.nths after ICU discharge,30% of patients who had COVID-19 dem.nstrated a hADS score that confirm.d anxiety and *** com.are the psychological status of patients following an ICU adm.ssion(with vs without COVID-19),further studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression hADS Saudi Arabia