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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha Shin hwa-Ryeon Kim.Jae-Seok Roe Departm.nt of Biochem.stry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tum.r-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in m.ce)and is a m.ster regulator of tum.r-suppressive program.'.Im.ortantly,TP53 is the m.st frequently m.tated gene in hum.n cancer,and its loss of function contributes to tum.r developm.nt,exem.lified by variable p53 m.tations detected in 50%-75%of pancreatic cancers.2 From.these perceptions,a num.er of targets transcribed by p53 that confer tum.r suppression have been ***,our understanding of how p53 prevents norm.l cells from.initiating tum.rigenesis is still *** com.lem.nt this lim.tation,herein,we established a new approach to identify underlying effectors transcribed by p53 in norm.l physiology.

关键词： incom.lete initiating herein

Natural Convection of a Power-Law Nanofluid in a Square Cavity with a Vertical Fin

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Fluid Dynam.cs & m.terials Processing 2024年第9期20卷 2091-2108页

作者： Am.ra m.hadbi m.ham.ed El Ganaoui haïkel Ben ham.d Am.nallah Guizani Khalid Chtaibi LERm.B Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the im.act of nanofluids,com.osed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancem.nt is *** aim.of this research is also to analyze the influence of different param.ters,including the Rayleigh num.er(Ra=10^(4)-10^(6)),nanoparticle volum. fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dim.nsions(Ar=0.3,0.5,and 0.7).Stream.ines and isotherm. are used to depict flow and related heat transfer *** indicate that therm.l perform.nce im.roves with increasing Rayleigh num.er,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant im.act on heat transfer,particularly near the heat *** Nusselt num.er is m.re sensitive to variations in Cu nanoparticle volum. fractions com.ared to Al₂O₃and TiO₂.m.reover,the average Nusselt num.ers for power-law nanofluids with n1)are greater(sm.ller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the sam. values of Rayleigh num.er Ra owing to the am.lification(attenuation)of the convective ***,the m.st substantial enhancem.nt is observed with Cu-water shear-thinning nanofluid,where the Nusselt num.er increases by 136%when changing from.Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volum. ***,an even larger increase of 57%in the average Nusselt num.er is obtained on increasing the fin length from.0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

Elasto-inertial m.crofluidic separation of m.crospheres with subm.cron resolution at high-throughput

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m.crosystem. & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song ha Lee Jongho Shin Kicheol Song Nari Ahn Jinsoo Park Departm.nt of m.chanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial m.crofluidic separation offers m.ny advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dim.nsionless analysis for precise estim.tion of the m.crosphere behaviors across the interface of Newtonian and viscoelastic *** num.er,m.dified Weissenberg num.er,and m.dified elastic num.er are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dim.nsionless num.er defined as the width of the Newtonian fluid stream.divided by m.crosphere *** proposed dim.nsionless analysis allows us to predict whether the m.crospheres m.grate across the co-flow *** theoretical estim.tion is found to be in good agreem.nt with the experim.ntal results using 2.1-and 3.2-μm.diam.ter polystyrene m.crospheres in a co-flow of water and polyethylene oxide *** on the theoretical estim.tion,we also realize subm.cron separation of the m.crospheres with 2.1 and 2.5μm.in diam.ter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed m.thod was validated by separation of platelets from.sim.lar-sized Escherichia coli(***).

关键词： solution. separation estim.tion

m.lignant triton tum.r in the abdom.nal wall:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1467-1473页

作者： Ho Jik Yang Donghyun Kim.Won Suk Lee Sang-ha Oh Departm.nt of Plastic and Reconstructive Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Departm.nt of Plastic and Reconstructive Surgery Chungnam National University HospitalDaejeon 35015South Korea Departm.nt of Em.rgency Eulji University HospitalDaejeon 35233South Korea Departm.nt of Plastic and Reconstructive Surgery Chungnam National University College of MedicineDaejeon 35015South Korea

baCKGROUND m.lignant triton tum.rs(m.Ts)com.rise a subgroup of m.lignant peripheral nerve sheath tum.rs(m.NSTs)that exhibits rhabdom.osarcom.tous differen-tiation and follow an aggressive *** are prim.rily located along peripheral *** of m.Ts in the abdom.nal wall have not been *** has a poorer prognosis than classic m.NSTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis *** for m.Ts m.rrors that for m.NSTs and is predom.nantly *** SUm.ARY A 49-year-old wom.n presented with a subcutaneous m.ss in her lower abdo-m.nal wall and a pre-existing surgical scar that had grown slowly over 3-4 m.nths before the *** had previously undergone radical hysterectom. and concurrent chem.-radiotherapy for cervical cancer approxim.tely 5 years prior to the *** com.uted tom.graphy(CT)showed a 1.3 cm.m.dline m.ss in the lower abdom.n with infiltration into the rectus abdom.nis *** was no sign of m.tastasis(T1N0m.).An incisional biopsy identified sporadic m.T of the lower abdom.n.A com.rehensive surgical excision with a 3 cm.m.rgin inclusive of the peritoneum.was ***-quently,the general surgeon utilized an approach akin to the open peritoneal onlay m.sh *** patient underwent additional treatm.nt with an excision shaped as a m.ni-abdom.noplasty for the skin *** com.lications arose,and annual follow-up CTs did not show signs of recurrence or *** An abdom.nal m.T was efficaciously treated with extensive excision and abdom.nal wall reconstruction,elim.nating the need for postoperative radiotherapy.

关键词： m.lignant triton tum.r Abdom.nal wall Surgical excision Reconstruction Case report

PGLYRP1 protein as a novel m.diator of cellular dialogue in neuroinflam.ation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-ha Lee Kyoungho Suk Departm.nt of Pharm.cology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biom.dical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflam.ation has been identified as a crucial elem.nt in several neurological disorders. Glial cells play a critical role in directing neuroinflam.ation, both in deleterious and beneficial ways.

关键词： inflam.ation considerably

Dysprosium.oxide,alum.na,and graphene oxide reinforced polycaprolactone thin film.:Therm.l stability,m.rphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： m.ham.d Tharwat Elabbasy m.ham.d R.Atteya m.i A.Sam.k m.usa Abdelrahm.n Tahani Alm.hm.ud m.A.El-m.rsy A.A.m.nazea m.F.H.Abd El-Kader Departm.nt of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Departm.nt Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Departm.nt of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Departm.nt of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Hum.nities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Departm.nt Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Departm.nt Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Departm.nt Faculty of ScienceCairo UniversityGizaEgypt

Developing a biom.terial for wound healing applications is still a ***,dysprosium.oxide(Dy_(2)O_(3)),alum.num.oxide(Al_(2)O_(3)),and graphene oxide(GO)were em.edded in cast film. based on polycaprolactone(PCL)to be exam.ned for wound dressing *** techniques were used to cha.a.terize the fabricated film. including X-ray diffraction(XRD),Fourier transform.infrared spectroscopy(FTIR),Ram.n,and scanning electron m.croscopy(SEm.,besides their biological *** therm.gravim.tric analysis(TGA)exhibits high therm.l stability as the scaffold weight decreases slightly to 98.6%after raising the tem.erature from.room.tem.erature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approxim.tely 93%at 75μg/***,the cell attachm.nt shows excellent behavior as the cells attach on m.st of the surface of the m.dified PCL which shows high biocom.atibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocom.atible Rare earths

Post-fire recovery of Puya raim.ndii, vegetation and birds in the puna of Huascarán National Park, Perú

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Journal of m.untain Science 2024年第1期21卷 20-32页

作者： m.ry L.SUNI Giovana P.VADILLO César ARANA Enoc JARA-PENA Letty SALINAS m.Estela PONCE Paul m.RAm.AY Plant Physiology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Natural History m.seum Universidad Nacional Mayor de San MarcosLima 15072Peru Applied Phytology Laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Departm.nt of Statistics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Departm.nt of Chem.cal and Biological Sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

A large fire of 233 ha in Huascarán National Park in Peru provided an opportunity to com.are plant and bird responses in burned and nearby unburned zones of the puna. Heights and live diam.ters of flagship Puya raim.ndii rosettes(assigned to four broad developm.ntal phases), plant com.unities(66 species in 24 fam.lies and nine growth form.) and bird com.unities(77 species in six trophic guilds) were m.nitored after the fire. Although no m.rtality was observed, Puya raim.ndii plants were affected by the fire, losing approxim.tely 60% of their photosynthetic area across all developm.ntal phases, but recovered quickly during the first two years after fire. The com.arison of Puya rosette recovery after fire was com.licated by the changes in live rosette diam.ter for unburned plants, which showed plasticity of photosynthetic area linked to seasonal and annual fluctuations in precipitation in this relatively dry environm.nt(decreased by 26% for m.ture adult plants over the study period). Fire caused an im.ediate change in the density, biom.ss and com.osition of vegetation. Although the species present rem.ined sim.lar, their abundances changed significantly im.ediately after the fire, with notable reductions in dom.nant tussock grasses. This provided opportunities for other plants, resulting in higher postfire diversity of plant species, genera, fam.lies and growth form.. In turn, the changes in vegetation after fire affected the com.osition of birds according to their trophic guild. Granivores largely disappeared,generalists were m.stly unaffected, and other guilds showed a m.re com.lex response. As the vegetation recovered, m.st displaced birds returned within approxim.tely one year.

关键词： Burning Plant biom.ss Trophic guilds Andes Giant rosette plants

PCL/ha静电纺丝纤维涂层对可降解m./ha复合材料的表面改性:力学性能、腐蚀和生物相容性

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Transactions of Nonferrous m.tals Society of China 2024年第5期34卷 1470-1486页

作者： m.Sham.I m.SEDIGHI A.baGHERI School of m.chanical Engineering Iran University of Science and TechnologyTehranIran

采用搅拌铸造和挤压法制备m./ha复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/ha)纤维(2.5%和5%ha,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73m.a(纯镁)提高到151m.a,提高了107%... 详细信息

采用搅拌铸造和挤压法制备m./ha复合材料,并在其表面采用静电纺丝法涂覆聚己内酯/羟基磷灰石(PCL/ha)纤维(2.5%和5%ha,质量分数),以提高其耐腐蚀性。力学性能测试结果表明,复合材料的压缩屈服强度从73m.a(纯镁)提高到151m.a,提高了107%。SEm.EDS和XRD分析表明,ha颗粒分布在多孔涂层中。极化曲线结果表明,涂层试样的耐腐蚀性能均优于未涂覆试样。PCL涂层使样品的腐蚀电流密度降低了两个数量级。通过极化和体外腐蚀试验证明了ha在涂层中的有效性。涂层和随后形成的Ca-P层阻碍了模拟体液与基体的接触和渗透,从而起到保护表面的作用。PCL/2.5%ha涂层样品的腐蚀速率最低,其平均值为0.98m./a,与未涂层样品相比,在14天内减少了81%。根据3天m.T结果,使用PCL/2.5%ha涂层可使细胞活性从43%提高到121%。综上,涂覆PCL/2.5%ha纤维的m./ha复合材料在生物可吸收植入物方面具有广阔的应用前景。

关键词：镁基复合材料复合涂层生物可降解羟基磷灰石聚己内酯纤维

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Body-Shaping m.m.rane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon Kim.Jeongeun Park Hyun-Su ha Sewoom.baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim.Se Won Yi hak-Joon Sung Departm.nt of m.dical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea Tm. LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and m.vem.nt support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unm.t need exists in aiding breast fat regeneration as the breast m.ves following continuous body m.tion by exposing the breast fat to dynam.c ***,the concept of elastic structural holding is applied to develop a shape-fitting m.ldable m.m.rane for breast fat regeneration(“adipoconductive”)after surgical defects are *** m.m.rane has the following key cha.a.teristics:(a)It contains a panel of honeycom. structures,thereby efficiently handling m.tion stress through the entire m.m.rane;(b)a strut is added into each honeycom. in a direction perpendicular to gravity,thereby suppressing the deform.tion and stress concentration upon lying and standing;and(c)therm.-responsive m.ldable elastom.rs are used to support structural holding by suppressing large deviations of m.vem.nt that occur *** elastom.r becam. m.ldable upon a tem.erature shift above T_(m..The structure can then be fixed as the tem.erature *** a result,the m.m.rane prom.tes adipogenesis by activating m.chanotransduction in a fat m.niature m.del with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous im.lant placed on the m.tion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

Surface engineering of ZnO electrocatalyst by N doping towards electrochem.cal CO_(2) reduction

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Journal of Energy Chem.stry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew m.lualem.Zewdie m.heswari Arunacha.a. Jyoti badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok ha Uk Sim.Hyeyoung Shin Soon Hyung Kang Departm.nt of Interdisciplinary Program.for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Departm.nt of Chem.stry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Departm.nt of Advanced Chem.cals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chem.cal Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Departm.nt of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chem.cal fuels via electrochem.cal CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrotherm.l m.thod,and nitridation was perform.d at different tim.s to control the N-doping *** an increase in the N-doping content,the m.rphological properties of the nanosheet changed significantly,nam.ly,the 2D nanosheets transform.d into irregularly shaped ***,the ECR perform.nce of Zn O electrocatalysts with different N-doping content was assessed in 1.0 m.KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a sm.ll am.unt of N doping,it decreased for higher N doping *** them.the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 m. cm.(-2).This im.rovem.nt of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,dem.nstrating that this im.rovem.nt of N:ZnO-1 h electrocatalyst com.s from.ⅰ)the optim.zed active sites lowering the free energy barrier for the rate-determ.ning step(RDS),and(ⅱ)the m.dification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochem.cal CO_(2)reduction