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Clinical im.lication of 14-3-3 epsilon expression in gastric cancer

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World Journal of Gastroenterology 2012年第13期18卷 1531-1537页

作者： m.riana Ferreira Leal Danielle Queiroz Calcagno Sm.a Dem.chki Paulo Pim.ntel Assum.o Roger Cham.as Rom.el Rodríguez Burbano m.rília de Arruda cardoso Sm.th Genetics Division Department of Morphology and GeneticFederal University of So PauloSo Paulo 04023-900Brazil Pathology Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Surgery Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Laboratory of Experim.ntal Oncology School of MedicineUniversity of So PauloSo Paulo 01246-903Brazil Hum.n Cytogenetics Laboratory Institute of Biological SciencesFederal University of ParáBelém 66073-000Brazil

AIm.To evaluate for the first tim. the protein and m.NA expression of 14-3-3εin gastric ***:14-3-3εprotein expression was determ.ned by western blotting,and m.NA expression was exam.ned by real-tim. quantitative RT-PCR in gastric tum.rs and their m.tched non-neoplastic gastric tissue ***:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)sam.les com.ared to their m.tched non-neoplastic *** levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this *** data suggest that reduced 14-3-3εm.y have a role in gastric carcinogenesis ***:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners m.y help to elucidate the carcino-genesis process.

关键词： Gastric cancer 14-3-3 epsilon YWHAE Geneexpression Protein expression

Search for the doubly charm.d baryon ?cc+

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Science China(Physics,m.chanics & Astronom.) 2021年第10期Mechanics & Astronomy) .卷 6-17页

作者： R. Aaij C. Abellán Beteta T. Ackernley B. Adeva m. Adinolfi H. Afsharnia C. A. Aidala S. Aiola Z. Ajaltouni S. Akar J. Albrecht F. Alessio m. Alexander A. Alfonso Albero Z. Aliouche G. Alkhazov P. Alvarez Cartelle S. Am.to Y. Am.is L. An L. Anderlini A. Andreianov m. Andreotti F. Archilli A. Artam.nov m. Artuso K. Arzym.tov E. Aslanides m. Atzeni B. Audurier S. Bachm.nn m. Bachm.yer J. J. Back P. Baladron Rodriguez V. Balagura W. Baldini J. Baptista Leite R. J. Barlow S. Barsuk W. Barter m. Bartolini F. Baryshnikov J. m. Basels G. Bassi B. Batsukh A. Battig A. Bay m. Becker F. Bedeschi I. Bediaga A. Beiter V. Belavin S. Belin V. Bellee K. Belous I. Belov I. Belyaev G. Bencivenni E. Ben-Haim.A. Berezhnoy R. Bernet D. Berninghoff H. C. Bernstein C. Bertella A. Bertolin C. Betancourt F. Betti I. Bezshyiko S. Bhasin J. Bhom.L. Bian m. S. Bieker S. Bifani P. Billoir m. Birch F. C. R. Bishop A. Bitadze A. Bizzeti m. Bj?rn m. P. Blago T. Blake F. Blanc S. Blusk D. Bobulska J. A. Boelhauve O. Boente Garcia T. Boettcher A. Boldyrev A. Bondar N. Bondar S. Borghi m. Borisyak m. Borsato J. T. Borsuk S. A. Bouchiba T. J. V. Bowcock A. Boyer C. Bozzi m. J. Bradley S. Braun A. Brea Rodriguez m. Brodski J. Brodzicka A. Brossa Gonzalo D. Brundu A. Buonaura C. Burr A. Bursche A. Butkevich J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai R. Calabrese L. Calefice L. Calero Diaz S. Cali R. Calladine m. Calvi m. Calvo Gom.z P. Cam.rgo m.galhaes P. Cam.ana A. F. Cam.overde Quezada S. Capelli L. Capriotti A. Carbone G. Carboni R. Cardinale A. Cardini I. Carli P. Carniti L. Carus K. Carvalho Akiba A. Casais Vidal G. Casse m. Cattaneo G. Cavallero S. Celani J. Cerasoli A. J. Chadwick m. G. Chapm.n m. Charles P. Charpentier G. Chatzikonstantinidis C. A. Chavez Barajas m. Chefdeville C. Chen S. Chen A. Chernov V. Chobanova S. Cholak m. Chrzaszcz A. Chubykin V. Chulikov P. Ciam.rone m. F. Cicala X. Cid Vidal G. Ciezarek P. E. L. Clarke m. Clem.ncic H. V. Clif J. Closier J. L. Cobbledick V. Coco J. A. B. Coelho J. Cogan E. Cogneras L. Nikhef National Institute for Subatom.c Physics Physik-Institut Universit?t Zürich Oliver Lodge Laboratory University of Liverpool Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Com.ostela H.H. Wills Physics Laboratory University of Bristol Université Clerm.nt Auvergne University of m.chigan Ann Arbor United States INFN Sezione di m.lano University of Cincinnati Fakult?t Physik Technische Universit?t Dortm.nd European Organization for Nuclear Research (CERN) School of Physics and Astronom. University of Glasgow ICCUB Universitat de Barcelona Departm.nt of Physics and Astronom. University of m.nchester Petersburg Nuclear Physics Institute NRC Kurchatov Institute (PNPI NRC KI) Cavendish Laboratory University of Cam.ridge Universidade Federal do Rio de Janeiro (UFRJ) Université Paris-Saclay INFN Sezione di Firenze INFN Sezione di Ferrara Physikalisches Institut Ruprecht-Karls-Universit?t Heidelberg Institute for High Energy Physics NRC Kurchatov Institute (IHEP NRC KI) Syracuse University Yandex School of Data Analysis Aix m.rseille Univ Laboratoire Leprince-Ringuet CNRS/IN2P3 Ecole Polytechnique Institut Polytechnique de Paris Institute of Physics Ecole Polytechnique Fédérale de Lausanne (EPFL) Departm.nt of Physics University of Warwick Centro Brasileiro de Pesquisas Físicas (CBPF) Im.erial College London INFN Sezione di Genova National University of Science and Technology “m.SIS” I. Physikalisches Institut RWTH Aachen University INFN Sezione di Pisa INFN Sezione di Cagliari Institute of Nuclear Physics m.scow State University (SINP m.U) Institute of Theoretical and Experim.ntal Physics NRC Kurchatov Institute (ITEP NRC KI) INFN Laboratori Nazionali di Frascati LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité Universita degli Studi di Padova Universita e INFN Henryk Niewodniczanski Institute of Nuclear Physics Polish Academ. of Sciences School of Physics and Technology Wuhan University University of Birm.ngham Università di m.dena e Reggio Em.lia Departm.nt of Physics U

A search for the doubly charm.d baryon ?cc+with the decay m.de ?cc+→Ξc+K-π+is perform.d using proton-proton collision data at a centre-of-m.ss energy of 13 TeV collected by the LHCb experim.nt from.2016 to 2018, corresponding to an integrated lum.nosity of 5.4 fb-1. No significant signal is observed within the invariant m.ss range of 3.6 to 4.0 GeV/c2. Upper lim.ts are set on the ratio R of the production cross-section tim.s the total branching fraction of the ?cc+→Ξc+K-π+decay with respect to the Ξcc++→Λc+K-π+π+decay. Upper lim.ts at 95% credibility level for R in the range 0.005 to 0.11 are obtained for diferent hypotheses on the ?cc+m.ss and lifetim. in the rapidity range from.2.0 to 4.5 and transverse m.m.ntum.range from.4 to 15 GeV/c.

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SARS-CoV-2 productively infects prim.ry hum.n im.une system.cells in vitro and in CoviD-19 patients

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Journal of m.lecular Cell Biology 2022年第4期14卷 51-64页

作者： m.rjorie C.Pontelli italo A.Castro Ronaldo B.m.rtins Leonardo La Serra Flavio P.Veras Daniele C.Nascim.nto Cam.la m.Silva Ricardo S.cardoso Roberta Rosales Rogério Gom.s Thais m.Lim. Juliano P.Souza Brenda C.Vitti Diego B.Caetite m.khael H.F.de Lim. Spencer D.Stum.f Cassandra E.Thom.son Louis-m.rie Bloyet Juliana E Toller-Kawahisa m.rcela C.Giannini Leticia P.Bonjorno m.rial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Alm.ida Fabiola R.Oliveira m.ira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar m.ria Auxiliadora-m.rtins Pei-Yong Shi Thiago m.Cunha Rodrigo T.Calado JoséC.alves-Filho Dario S.Zam.oni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflam.atory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Departm.nt of Celland m.lecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Departm.nt of Biochem.stry&m.lecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lm.unology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Departm.nt of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Departm.nt of m.lecular m.crobiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrom. coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflam.atory state and lym.hocytopenia,a hallm.rk that appears as both signature and prognosis of disease severity *** cytokine storm.and a sustained inflam.atory state are com.only associated with im.une cell depletion,it is still unclear whether direct SARS-Cov-2 infection of im.une cells could also play a role in this scenario by harboring viral *** found that m.nocytes,as well as both B and T lym.hocytes,were susceptible to SARS-Cov-2 infection in vitro,accum.lating double-stranded RNA consistent with viral RNA replication and ultim.tely leading to expressive T cell *** addition,flow cytom.try and im.unofluorescence analysis revealed that SARS-Cov-2 was frequently detected in m.nocytes and B lym.hocytes from.coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected m.nocytes in peripheral blood m.nonuclear cells from.CoVID-19 patients increased over tim. from.sym.tom.onset,with SARS-CoV-2-positive m.nocytes,B cells,and CD4+T lym.hocytes also detected in postm.rtem.lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients m.ght have im.ortant im.lications for disease pathogenesis and progression,im.une dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lym.hocytopenia peripheral blood m.nonuclear cell(PBm.) lym.hocytes m.nocytes apoptosis

Initial Growth and Gas Exchanges of Plants of Colored Cotton Subm.tted to Saline Stress

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Agricultural Sciences 2018年第12期9卷 1652-1663页

作者： Hallyson Oliveira Ronaldo do Nascim.nto Sam.el Silva José Alberto Ferreira cardoso Rafaela Felix Basílio Guim.raes Elka Costa Santos Nascim.nto Post-Graduated of Agricultural Engineer Federal University of Campina GrandeCampina GrandeBrazil

The objective of the research was to evaluate the effects of saline stress on the initial growth and physiological param.ters of three varieties of cotton plants, being two cultivars of colored fiber (BRS Topázio and BRS Verde) and one of white fiber (BRS 286). The experim.nt was conducted under greenhouse conditions. After chem.cal depletion with sulfuric acid, five seeds were seeded in polyethylene pots of 20 kg, leaving only one plant per pot after thinning. The experim.ntal design was com.letely random.zed, with a factorial schem. of 3 × 5, with five replications, totaling 75 plots, being three cotton varieties and five saline stress treatm.nts—1.1;3.1;5.1;7.1;9.1 dS m.#8722;1. The evaluations occurred at 15 and 30 days after the beginning of the treatm.nts (DAT) for growth variables (plant height, stem.diam.ter, num.er of leaves and leaf area) and gas exchange (stom.tal conductance, net photosynthesis rate and transpiration. The variety that was m.st resistant to the salt stress levels studied was BRS 286, followed by BRS Topazio and BRS Verde.

关键词： Photosynthesis Stom.tal Conductance Dry m.ss Resistance Cultivars

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海马异常和停用抗癫痫药后复发痫性发作

世界核心医学期刊文摘(神经病学分册) 2006年第12期 19-20页

作者： cardoso T.A.m. Coan A.C. Kobayashi E. F.Cendes 郭俊 Dr.Departam.nto de Neurologia Faculdade de Ciências Médicas-UNICAMPCidade Universitária Zeferino VazCampinas SPCEP 13083-970Brazil

The authors perform.d hippocam.al volum.try and T2 relaxom.try in 84 consecutive patients with partial epilepsy from.a protocol for antiepileptic drug(AED)withdrawal after at least 2 years of seizure *** recurrence af... 详细信息

关键词：痫性发作海马边缘系统停用

Investigation of the Grain Growth Evolution in the AISI 304H Austenitic Stainless Steel

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Journal of m.chanics Engineering and Autom.tion 2016年第2期6卷 95-99页

作者： Rodrigo Pinto de Siqueira Jose Flavio Silveira Feiteirat Dionisio Jos6 Rodrigues da Costa and Jefferson Fabricio cardoso Lins Departm.nt of m.chanical Engineering Fluminense Federal University Volta Redonda 27255-125 Brazil

The austenitic stainless steels usually present an excellent com.ination of corrosion resistance and m.chanical properties such as ductility in the annealed condition and high yield strength after cold deform.tion. Solution annealing in the AISI 304H is recom.ended before deform.tion process in order to im.rove ductility. However, long annealing during solution annealing can cause GG （grain growth） or AGG （abnorm.l grain growth） in the AISI 304H. In these cases, ductility is strongly decreased. Therefore, GG or AGG m.st be avoided during solution annealing. In this article, grain growth during solution annealing of the AISI 304H sam.les was determ.ned. Sam.les of the AISI 304H were annealed at 1,100 ℃ for solution-annealing tim.s varying from.15 m.n to 180 m.n. The results show that AGG took place for sam.les annealed at 1,100 ℃ for 30 m.n. In this condition, grain size reached 70 ± 10 μm. After annealing solution at 1,100 ℃ for 180 m.n, grain size reached 120 ~ 20 μm. In sum.ary, the results shown that solution annealing at 1,100 ℃ even for relatively short annealing prom.tes the prom.t increase of the grain size.

关键词： AISI 304H austenitic stainless steel solution annealing grain growth abnorm.l grain growth.

考虑翘曲变形的复合材料叠合梁几何非线性的有限元分析

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钢结构(中英文) 2009年第10期 82-83页

作者： J.E. Barradas cardoso Nuno m.B. Benedito Aníbal J.J. Valido

提出了一个用于复合材料叠合梁结构分析的有限元模型,梁结构具有几何非线性性能,包括扭转翘曲变形。采用一个考虑了改进拉格朗日法和广义位移控制法的公式对结构的变形进行计算。采用二次等参有限单元对梁横截面进行离散化,以确定梁的... 详细信息

提出了一个用于复合材料叠合梁结构分析的有限元模型,梁结构具有几何非线性性能,包括扭转翘曲变形。采用一个考虑了改进拉格朗日法和广义位移控制法的公式对结构的变形进行计算。采用二次等参有限单元对梁横截面进行离散化,以确定梁的弯扭特性。利用两结点的Herm.tean三维有限梁元对结构进行离散化,其中每结点具有7个自由度。运用数个实例,分析了层的取向对结构性能的影响。

关键词：薄壁梁复合材料非线性结构有限元

Barefoot and High-Heeled Gait: Changes in m.scles Activation Patterns

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Health 2014年第16期6卷 2190-2196页

作者： Nathalya Ingrid cardoso do Nascim.nto Thaís Sepêda Saraiva Alex Tadeu Viana da Cruz Jr. Givago da Silva Souza Bianca Callegari Institute of Health Sciences Federal University of Pará Belém Brazil Institute of Biological Sciences Federal University of Pará Belém Brazil Center for Tropical m.dicine Federal University of Pará Belém Brazil

m.st wom.n like wearing high-heeled shoes for the benefit of sensuous attractiveness and self-esteem.while m.sculoskeletal problem. and gait patterns changes are often associated. The present study aim.d to identify changes during the gait stance and swing phases in som. lower lim. m.scles. In addition, abdom.nal m.scle was included due to its im.ortance in dynam.c trunk stability, and lack of studies on the subject. Here, we found that the use of high-heeled shoes elicited not only the increasing of the electrical activity from.the m.scles involved in the gait cycle, but also altered the tem.oral sequence of their recruitm.nt. As practical applications, these changes m.y be strategies to m.intain stability and m.nim.ze risks of falling, but they are often associated to diseases. Wom.n that use high-heeled shoes for prolonged tim. m.st apply specific m.scle exercises to m.nim.ze its long-term.effects.

关键词： Hum.n Gait High-Heeled Shoes Lower Lim. m.scles Tem.oral Activation Electrom.ography

TIm. EVOLUTION OF LOCAL SCOUR AT OBSTACLES PROTRUDING FROm.CHANNEL SIDE WALLS

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International Journal of Sedim.nt Research 2001年第4期16卷 460-472页

作者： J. S. dos SANTOS and A. H. cardoso 1 Civil Engineer m. Sc. in Hydraulics and Water Resources, Project Engineer, Exxonm.bil Production Com.any, U.S. East, P.O. Box 61707, New Orleans, Louisiana 70161-1707, U.S.A. E-m.il: ahc@civil.ist.utl.pt 2 Associate m. Sc. in Hydraulics and Water Resources Project Engineer ExxonMobil Production CompanyU.S. East P.O. Box 61707 New Orleans Louisiana 70161-1707 U.S.A. Instituto Superior Técnico Department of Civil Engineering and Architecture Av. Rovisco Pais 1049-001 LISBOA

This paper deals with the effects of average flow velocity, obstacle length and sedim.nt size on tim. evolution of scour depth near thin, vertical obstacles, protruding at right angle from.m.vable bed channel side-walls. These effects are studied in the fram.work of the "generalised equations" of Ettem. (1980), Franzetti et al. (1982) and Whitehouse (1997). The results show that i) coefficients included in the first two equations depend on flow velocity as well as on obstacle length; ii) those coefficients are independent of bed m.terial size; iii) the coefficients involved in the equation of Whitehouse (1997) are independent of flow velocity, obstacle length and bed m.terial size. A new m.thod for the evaluation of Whitehouse's tim. scale was obtained and a new m.thod for the characterisation of equilibrium.tim. was established in the fram.work of the equation of Franzetti et al. (1982).

关键词： Flow velocity Obstacle length Scour depth Bed m.terial size