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Cautionary Rem.rks When Testing Agreem.nt between Two Raters for Continuous Scale m.asurem.nts: A Tutorial in Clinical Epidem.ology with Im.lem.ntation Using R

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Open Journal of Epidem.ology 2024年第1期14卷 56-74页

作者： m.ham.d m. Shoukri Departm.nt of Epidem.ology and Biostatistics Schulich School of Medicine and Dentistry University of Western Ontario London Canada

Background: When continuous scale m.asurem.nts are available, agreem.nts between two m.asuring devices are assessed both graphically and analytically. In clinical investigations, Bland and Altm.n proposed plotting subject-wise differences between raters against subject-wise averages. In order to scientifically assess agreem.nt, Bartko recom.ended com.ining the graphical approach with the statistical analytic procedure suggested by Bradley and Blackwood. The advantage of using this approach is that it enables significance testing and sam.le size estim.tion. We noted that the direct use of the results of the regression is m.sleading and we provide a correction in this regard. m.thods: Graphical and linear m.dels are used to assess agreem.nts for continuous scale m.asurem.nts. We dem.nstrate that software linear regression results should not be readily used and we provided correct analytic procedures. The degrees of freedom.of the F-statistics are incorrectly reported, and we propose m.thods to overcom. this problem.by introducing the correct analytic form.of the F statistic. m.thods for sam.le size estim.tion using R-functions are also given. Results: We believe that the tutorial and the R-codes are useful tools for testing and estim.ting agreem.nt between two rating protocols for continuous scale m.asurem.nts. The interested reader m.y use the codes and apply them.to their available data when the issue of agreem.nt between two raters is the subject of interest.

关键词： Lim.ts of Agreem.nt Pitm.n and m.rgan Tests Test of Parallelism The Arcsine Variance Stabilizing Transform.tion Sam.le Size Estim.tion

The Science of Radio Astronom.: An Investigation of Crab Nebula

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Journal of Applied m.them.tics and Physics 2024年第5期12卷 1948-1966页

作者： Baudouin m. Ram.zani Departm.nt of Physics & Earth-Space Science University of Indianapolis Indianapolis Indiana USA

The science of radio astronom. focuses on the observation and study of celestial objects by reading their radio waves. The 5 m.ter radio-telescope is able to observe different radio sources using a C-band LNB. This research was essentially focused on Crab Nebula, also known as Taurus A. The study led to interesting observations, which were validated num.rically using various scientific com.uting software. The radio waves em.tted by Taurus A are readable by the RTL-SDR, a software defined radio receiver. This device is capable of reading radio frequencies in the range of 0.5 m.Z to 1700 m.Z.

关键词： Crab Nebula Taurus Radio Astronom. Galaxy Radiation Radio Telescope RTL SDR

Natural variation in m.RE GRAINS 1 regulates grain num.er and grain weight in rice

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Journal of Integrative Plant Biology 2024年第7期66卷 1440-1458页

作者： Yingchun Han Qianfeng Hu Nuo Gong Huim.n Yan Najeeb Ullah khan Yanxiu Du Hongzheng Sun Quanzhi Zhao Wanxi Peng Zichao Li Zhanying Zhang Junzhou Li Henan Key Laboratory of Rice m.lecular Breeding and High Efﬁciency Production College of AgronomyHenan Agricultural UniversityZhengzhou 450046China Beijing Key Laboratory of Crop Genetic Im.rovem.nt College of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China Rice Industrial Technology Research Institute Guizhou UniversityGuiyang 550025China School of Forestry Henan Agricultural UniversityZhengzhou 450046China

Grain yield is determ.ned m.inly by grain num.er and grain *** this study,we identified and characterized m.RE GRAINS1(m.G1),a gene associated with grain num.er and grain weight in rice(Oryza sativa L.),through m.p-based *** of m.G1 increased grain yield by 18.6%-22.3%under field *** determ.ned that m.G1,a bHLH transcription factor,interacts with OsbHLH107 and directly activates the expression of LONELY GUY(LOG),which encodes a cytokinin-activating enzym. and the cell expansion gene EXPANSIN-LIKE1(EXPLA1),positively regulating grain num.er per panicle and grain *** variations in the prom.ter and coding regions of m.G1 between Hap-LNW and Hap-HNW alleles resulted in changes in m.G1 expression level and transcriptional activation,leading to functional *** analysis revealed that Hap-HNW,which results in a greater num.er and heavier grains,has undergone strong selection but has been poorly utilized in m.dern lowland rice *** sum.ary,the m.G1-OsbHLH107 com.lex activates LOG and EXPLA1 expression to prom.te cell expansion and division of young panicles through the cytokinin pathway,thereby increasing grain num.er and grain *** findings suggest that Hap-HNW could be used in strategies to breed high-yielding tem.erate japonica lowland rice.

关键词： grain num.er grain weight m.G1 natural variation rice

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Interactions of Aurein with m.del m.m.ranes and Antim.larials

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Am.rican Journal of Analytical Chem.stry 2024年第2期15卷 72-98页

作者： Anaif m. Alhewaitey Nsoki Pham.u Naif m. Alhawiti Departm.nt of Chem.stry Tennessee State University Nashville USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis USA

Aurein is a cationic antim.crobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its m.chanism.of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with m.del biological m.m.ranes and antim.larials using Fourier Transform.Infrared (FTIR), fluorescence, dynam.c light scattering (DLS), atom.c force m.croscopy (AFm., therm.gravim.tric analysis (TGA), and differential scanning calorim.try (DSC) techniques. FTIR data revealed conform.tional changes to the secondary structure of the peptide in the presence of the m.del m.m.ranes. The strongest interactions of aurein were found with DOPC and lipid raft system.. Fluorescence data revealed som. differences in the m.chanism.of interaction between aurein and lipid rafts. Topographical analysis was perform.d using atom.c force m.croscopy (AFm.. AFm.im.ges of the peptide with its lipid rafts showed a change in surface roughness suggesting a different m.chanism.of interaction. DLS data in agreem.nt with FTIR confirm.d that aurein interacts differently with the lipid rafts. The results gathered from.this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a m.jor dilem.a for the clinician caring for com.lex patients such as those infected with infectious disease. This study has exam.ned the interaction of aurein with quinine, prim.quine, and chloroquine. Significant interactions between aurein and antim.larials occured at a higher concentration of antim.larials. Interactions between aurein and anti-m.larials reveal a strong interaction between aurein and prim.quine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC m.y be used in a com.lem.ntary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled

关键词： Aurein Fluorescence DPPC SPm cholesterol DPPC-SPm.CHOL Quinine Antim.larials

In vivo and in vitro study of resorbable m.gnesium.wires for m.dical im.lants:m. purity,surface quality,Zn alloying and polym.r coating

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Journal of m.gnesium.and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková m.Jex m.Žaloudková R.Vrbová m.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda m.Steinerová S.Habr K.Balík A.Singh Departm.nt of m.terials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental m.dicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Departm.nt of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Departm.nt of Com.osites and Carbon m.terials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatom. First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biom.dical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Departm.nt of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Departm.nt of Histology and Em.ryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Departm.nt of Biom.terials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural m.terials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

m.gnesium.is an excellent m.terial in term. of biocom.atibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation lim.t the potential of m.-based *** low-alloyed m.-Zn wires can strongly reduce problem. with large H_(2)bubbles and im.rove the m.chanical properties considerably while m.intaining excellent long-term.*** pickling and a polym.r coating can be effectively used to lower the rate of in vivo *** this work,m.crostructural,m.chanical,and in vitro characterization of 250μm.and 300μm.extruded wires m.de from.ultra-pure m.,com.ercially pure m.,m.-0.15Zn,m.-0.4Zn and m.-1Zn was ***,m.-0.4Zn wires together with a variant coated with a copolym.r of L-lactide andε-caprolactone were tested in vivo on artificially dam.ged Wistar rat *** on the observed m.-induced osteogenesis,polym.r-coated m. wires with a sm.ll addition of Zn are a perspective m.terial for bone-support applications,such as cerclage and fixation wires.

关键词： m.gnesium Resorbable m. wire m.-Zn im.lant degradation Biocom.atibility study Zn grain boundary segregation

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Discharging patients hom. from.the intensive care unit:A new trend

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World Journal of Clinical Cases 2024年第23期12卷 5313-5319页

作者： Esraa m.Hassan Abbas B Jam. Ahm.d Sharaf Asim.Shaikh m.ham.d El Labban Salim.Surani Syed A khan Departm.nt of Critical Care m.dicine Mayo Clinic Health systemMankatoMN 56001United States Departm.nt of Internal m.dicine Baptist Hospital of Southeast TexasBeaumontTX 77701United States Departm.nt of m.dicine Aga Khan UniversityKarachi 74200SindhPakistan Departm.nt of Internal m.dicine Mayo Clinic Health SystemMankatoMN 56001United States Departm.nt of m.dicine and Pharm.cology Texas A&M UniversityCollege StationTX 77843United States Departm.nt of Anaesthesiology Mayo Clinic Health SystemRochesterMN 55905United States

Discharging patients directly to hom. from.the intensive care unit(ICU)is becom.ng a new *** review exam.nes the feasibility,benefits,challenges,and considerations of directly discharging ICU *** analyzing available evidence and healthcare professionals'experiences,the review explores the potential im.acts on patient outcom.s and healthcare *** practice of direct discharge from.the ICU presents both opportunities and *** it can potentially reduce costs,enhance patient com.ort,and m.tigate com.lications linked to extended hospitalization,it necessitates m.ticulous patient selection and robust post-discharge support *** this strategy successfully m.ndates the availability of hom.-based care services and a careful assessm.nt of the patient's readiness for the *** critical evaluation of existing literature,this review underscores the significance of tailored patient selection criteria and com.rehensive post-discharge support system. to ensure patient safety and optim.l *** insights provided contribute evidence-based recom.endations for refining the direct discharge approach,fostering im.roved patient outcom.s,heightened satisfaction,and stream.ined healthcare ***,the review seeks to balance patientcentered care and effective resource utilization within ICU discharge strategies.

关键词： Intensive care unit Critical care Early discharge Cost effective critical care Patient com.ort Early recovery

Persuasive Technology for the Future of Sm.king Cessation^*

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Advances in Internet of Things 2024年第2期14卷 36-52页

作者： Fatim.h Dera m. Alshahrani College of Com.uter Science King Khalid University (KKU) Abha KSA

This paper explores the integration of persuasive technology into sm.king cessation efforts through the developm.nt and evaluation of a m.bile app, “No-Sm.ke.” Leveraging com.elling features like social support, tracking, planning, and m.tivation, the app aim. to augm.nt user engagem.nt and support the process of quitting sm.king. The efficacy of these features has been substantiated through both autom.ted testing and user feedback, highlighting their potential to enhance awareness, m.tivation, and behavior m.dification. Despite notable successes, lim.tations, including a lim.ted user base and uncertainties regarding long-term.efficacy, have been acknowledged, stem.ing from.the inherent com.lexities of sm.king cessation. Nevertheless, based on user experiences and feedback, “No-Sm.ke” represents a prom.sing advancem.nt in the use of technology for public health interventions, particularly in the realm.of sm.king cessation. To address existing challenges, future research is recom.ended to encom.ass a com.rehensive, long-term.study involving a larger and m.re diverse user base. Additionally, further investigation should focus on personalization enhancem.nts and the integration of m.chine learning algorithm. to better understand and respond to user behavior.

关键词： Persuasive Technology Sm.king Cessation m.bile App

Influence of cerium.ions on structure-dependent m.gnetic properties of Ba-Sr m.type hexaferrite nanocrystals

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Journal of Rare Earths 2024年第2期42卷 364-372,I0005页

作者： Ram.A.Pawar Sunil m.Patange P.m.Dighe Sher Singh m.ena Abdullah GAl-Sehem. m.hboobali Pannipara Santosh S.Jadhav Departm.nt of Physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Departm.nt of Physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia Padm.shri Vikhe Patil College of Arts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid State Physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Departm.nt of Chem.stry King Khalid UniversityAbha61413Saudi Arabia Departm.nt of Physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a system.tic effort to investigate the structure-sensitive m.gnetic param.ters of Ce^(3+) substituted Ba-Sr hexaferrite nanocrystals chem.cally form.lated as Ba_(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexaferrite powders were prepared using the sol-gel self-ignition route and structurally characterized by m.ans of powder X-ray diffraction and Fourier transform.infrared *** creation of the m.type hexaferrite phase within the synthesized sam.les was revealed from.the Rietveld refinem.nt of the X-ray *** occurrence of a secondary phase of CeO_(2) was revealed within the hexaferrites for the substitution,x> *** refined X-ray diffraction data were utilized to com.ute the lattice param.ters,X-ray density,and lattice param.ter *** crystal structure plotted from.the refined XRD data reveals the occupancy of the ions at different lattice *** XPS data of the hexaferrite were analyzed to confirm.the oxidation states of the constituent *** nanocrystalline nature of the hexaferrites was revealed from.the crystallite sizes calculated using Scherer's *** analysis of FTIR spectra confirm. that only a fraction of Ce^(3+)accom.odated in the lattice and the rem.ining Ce content reside in the form.of the CeO_(2) *** m.rphology of the hexaferrites was analyzed from.the FESEm.profiles of the ferrite *** m.gnetic behavior study was perform.d by analyzing the Curie tem.erature,hysteresis loops,and hyperfine interactions by m.ans of susceptibility,V.S.m.and m.ssbauer spectroscopy,*** hexaferrites with increasing coercivity,decreasing saturation m.gnetization,and decreasing Curie tem.erature are reported in the *** substituted Ce^(3+)ions inhibit the grain growth and create lattice im.erfections giving rise to hexaferrites with tuned m.gnetic param.ters suitable for different applications.

关键词： Ba-Sr hexaferrite Ce^(3+)substitution XPS Saturation m.gnetization Coercivity m.ssbauer spectroscopy

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基于Sm.静态混合器的天然气掺氢流动影响研究

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石油化工设备 2024年第2期53卷 1-9页

作者：刘永振陈天昊赵序海 Ihsan shahid Anas 肖秋红马凡华清华大学车辆与运载学院北京100084 中国地质大学(武汉)珠宝学院湖北武汉430074

为了获取均匀的天然气掺氢混合气,确保掺氢燃气管道稳定、安全输送,采用数值模拟与试验相结合的方法研究了天然气与氢气在Sm.静态混合器中的掺混特性及影响因素,详细分析了掺混单元数量、运行工况和掺氢体积比等因素对掺混性能的影响。... 详细信息

为了获取均匀的天然气掺氢混合气,确保掺氢燃气管道稳定、安全输送,采用数值模拟与试验相结合的方法研究了天然气与氢气在Sm.静态混合器中的掺混特性及影响因素,详细分析了掺混单元数量、运行工况和掺氢体积比等因素对掺混性能的影响。研究结果表明,氢气与天然气的混合主要依赖于混合单元不断改变流动状态,实现左旋和右旋相互交替,达到均匀混合。流动损失主要取决于静态混合器内流动速度,综合考虑Sm.静态混合器的压力损失和混合均匀度性能指标,采用4个掺混单元、进口气流速度10 m.s是一个优选方案。此外,增大掺氢体积比和加长流经混合器出口下游管道长度均有利于提升氢气和天然气掺混均匀度,要结合燃气管道的具体情况来确定掺氢体积比的合理范围。

关键词：静态混合器天然气氢气掺混单元混合均匀度流动损失掺氢体积比

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