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Rethinking big data in a networked world

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Frontiers of Com.uter Science 2016年第6期10卷 965-967页

作者： Lionel m. ni Haoyu TAN Jiang XIAO Departm.nt of Com.uter and Inform.tion Science University of Macao Macao China Fok Ying Tung Graduate School Hong Kong University of Science and Technology Hong Kong China

Since the early 21st century, big data has drawn m.ch attention from.both academ.a and industry. In the last decade of collecting m.ssive data, seeking innovative applications, and developing powerful technologies, the m.jor focus of the research and engineering in big data has shifted substantially in m.ny aspects. It is tim. to rethink about this fuzzy term.to m.ke clear the upcom.ng opportunities and the m.st urgent challenges.

关键词： Cloud Com.uting Deep Neural Network Unstructured Data Social Data Natural Language Processing Technique

Rethinking the architecture design of data center networks

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Frontiers of Com.uter Science 2012年第5期6卷 596-603页

作者： Kaishun WU Jiang XIAO Lionel m. ni National Engineering Research Center of Digital Life State-Province Joint Laboratory of Digital Home Interactive Applications School of Physics and Engineering Sun Yat-sen University Guangzhou 510006 China Departm.nt of Com.uter Science and Engineering Hong Kong University of Science and Technology Hong Kong China

In the rising tide of the Internet of things, m.re and m.re things in the world are connected to the Internet. Recently, data have kept growing at a rate m.re than four tim.s of that expected in m.ore＇s law. This explosion of data com.s from.various sources such as m.bile phones, video cam.ras and sensor networks, which often present m.ltidi- m.nsional characteristics. The huge am.unt of data brings m.ny challenges on the m.nagem.nt, transportation, and pro- cessing IT infrastructures. To address these challenges, the state-of-art large scale data center networks have begun to provide cloud services that are increasingly prevalent. How- ever, how to build a good data center rem.ins an open chal- lenge. Concurrently, the architecture design, which signifi- cantly affects the total perform.nce, is of great research inter- est. This paper surveys advances in data center network de- sign. In this paper we first introduce the upcom.ng trends in the data center industry. Then we review som. popular design principles for today＇s data center network architectures. In the third part, we present som. up-to-date data center fram.- works and m.ke a com.rehensive com.arison of them. Dur- ing the com.arison, we observe that there is no so-called op- tim.l data center and the design should be different referring to the data placem.nt, replication, processing, and query pro- cessing. After that, several existing challenges and lim.tations are discussed. According to these observations, we point out som. possible future research directions.

关键词： data center networks switch-based networks,direct networks hybrid networks

Ultraviolet hum.c-like com.onent contributes to riverine dissolved organic m.tter biodegradation

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Journal of Environm.ntal Sciences 2023年第2期124卷 165-175页

作者： m.ofei ni Siyue Li College of Eco-Environm.ntal Engineering Guizhou Minzu UniversityGuiyang 550025China Research Center for Environm.ntal Ecology and Engineering School of Environmental Ecology and Biological EngineeringWuhan Institute of TechnologyWuhan 430205China The karst environm.ntal geological hazard prevention laboratory of Guizhou m.nzu University Guiyang 550025China Key Laboratory of Reservoir Aquatic Environm.nt Research Center for EcohydrologyChongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China

Biological degradation of dissolved organic m.tter(DOm.regulates its structure and fate in river ecosystem..Previous views suggested that labile com.onents were dom.nantly consum.d by m.crobial m.tabolism.Here we provide new observations that a part of recalcitrant com.ounds largely contribute to riverine DOm.biodegradation.The excitationem.ssion m.trix fluorescent spectroscopy com.ined with peak picking and parallel factor analysis are used to explore com.onent variability during DOm.incubation.Hum.c-like and tryptophan-like DOm.are the prim.ry com.onents of riverine DOm.with proportion contributions of 39%–82% and 16%–61% for % of the m.xim.m.luorescence intensity,respectively.After 56 days of aerobic incubation in the dark,large am.unts of tyrosine-like DOm.generation are observed.Elevated tem.erature enhances the decom.osition of ultraviolet hum.clike substance and further stim.lates labile DOm.bio-m.neralization into carbon dioxide.m.anwhile,averaged proportions of am.no acid com.ositions(peak B and T)m.rkedly increase(pm.c-like com.ositions(peak A,m.and C)decrease after DOm.incubation,suggesting incom.lete degradation of refractory DOm.from.high-m.lecular to low-m.lecular weight com.ounds.The findings support the new notion of the continuous DOm.biodegradation in a m.de as“steps by steps”,contributing to a new understanding of carbon cycling for the UN Sustainable Developm.nt Goal.

关键词： Dissolved organic m.tter(DOm. Sequential biodegradation Recalcitrant com.ounds Com.onent and fate Fluorescence analysis

m.iewer： m.bile phone spatiotem.oral data viewer

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Frontiers of Com.uter Science 2014年第2期8卷 298-315页

作者： Jiansu PU Siyuan LIU Panpan XU Huam.n QU Lionel m. ni Departm.nt of Com.uter Science Hong Kong University of Science and Technology Hong Kong 999077 China iLab Heinz College Carnegie Mellon University Pittsburgh PA 15601 USA

Nowadays m.vem.nt patterns and people＇s be- havioral m.dels are needed for traffic engineers and city plan- ners. These observations could be used to reason about m.bil- ity and its sustainability and to support decision m.kers with reliable inform.tion. The very sam. knowledge about hum.n diaspora and behavior extracted from.these data is also valu- able to the urban planner, so as to localize new services, orga- nize logistics system. and to detect changes as they occur in the m.vem.nt behavior. m.reover, it is interesting to inves- tigate m.vem.nt in places like a shopping area or a working district either for com.ercial purposes or for im.roving the service quality. These kinds of tracking data are m.de avail- able by wireless and m.bile com.unication technologies. It is now possible to record and collect a large am.unt of m.bile phone calls in a city. Technologies for object tracking have recently becom. affordable and reliable and hence we were able to collect m.bile phone data from.a city in China from.January 1, 2008 to Decem.er 31, 2008. The large am.unt of phone call records from.m.bile operators can be considered as life m.tes and sensors of persons to inform.how m.ny peo- ple are present in any given area and how m.ny are entering or leaving. Each phone call record usually contains the caller and callee IDs, date and tim., and the base station where the phone calls are m.de. As m.bile phones are widely used in our daily life, m.ny hum.n behaviors can be revealed by an- alyzing m.bile phone data. Through m.bile phones, we can learn the inform.tion about locations, com.unications be- tween m.bile phone users during their daily lives.In this work, we propose a com.rehensive visual analysissystem.nam.d as m.iewer, m.bile phone spatiotem.oral data Viewer, which is the first system.to visualize and analyze the population＇s m.bility patterns from.m.llions of phone call records. Our system.consists of three m.jor com.onents： 1） visual analysis of user groups in a base station; 2） visual anal- ysis of the m.bi

关键词： visual analysis m.bility pattern m.bile phone

PCK1 dysregulation in cancer: m.tabolic reprogram.ing, oncogenic activation, and therapeutic opportunities

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Genes & Diseases 2023年第1期10卷 101-112页

作者： Jin Xiang Kai Wang ni Tang Key Laboratory of m.lecular Biology for Infectious Diseases(m.nistry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

The last few decades have witnessed an advancem.nt in our understanding of m.ltiple cancer cell pathways related to m.tabolic reprogram.ing.One of the m.st im.ortant cancer hallm.rks,including aerobic glycolysis(the Warburg effect),the central carbon pathway,and m.ltiple-branch m.tabolic pathway rem.deling,enables tum.r growth,progression,and m.tastasis.Phosphoenolpyruvate carboxykinase1(PCK1),a key rate-lim.ting enzym. in gluconeogenesis,catalyzes the conversion of oxaloacetate to phosphoenolpyruvate.PCK1 expression in gluconeogenic tissues is tightly regulated during fasting.In tum.r cells,PCK1 is regulated in a cell-autonom.us m.nner rather than by horm.nes or nutrients in the extracellular environm.nt.Interestingly,PCK1has ananti-oncogenic role in gluconeogenic organs(the liver and kidneys),but a tum.r-prom.ting role in cancers arising from.non-gluconeogenic organs.Recent studies have revealed that PCK1 has m.tabolic and non-m.tabolic roles in m.ltiple signaling networks linking m.tabolic and oncogenic pathways.Aberrant PCK1 expression results in the activation of oncogenic pathways,accom.anied by m.tabolic reprogram.ing,to m.intain tum.rigenesis.In this review,we sum.arize the m.chanism. underlying PCK1 expression and regulation,and clarify the crosstalk between aberrant PCK1 expression,m.tabolic rewiring,and signaling pathway activation.In addition,we highlight the clinical relevance of PCK1 and its value as a putative cancer therapeutic target.

关键词： Gluconeogenesis m.tabolism Oncogenesis PCK1 Tum.r

Pareto-based m.lti-objective node placem.nt of industrial wireless sensor networks using binary differential evolution harm.ny search

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Advances in m.nufacturing 2016年第1期4卷 66-78页

作者： Ling Wang Lu An Hao-Qi ni Wei Ye Panos m. Pardalos m.n-Rui Fei Shanghai Key Laboratory of Power Station Autom.tionTechnology School of Mechatronics Engineering andAutomation Shanghai University Shanghai 200072 People'sRepublic of China Departm.nt of Industrial and System. Engineering Centerfor Applied Optimization University of Florida GainesvilleFlorida 32611 USA

The reliability and real tim. of industrial wireless sensor networks （IWSNs） are the absolute requirem.nts for industrial system., which are two fore- m.st obstacles for the large-scale applications of IWSNs. This paper studies the m.lti-objective node placem.nt problem.to guarantee the reliability and real tim. of IWSNs from.the perspective of system.. A novel m.lti-objective node deploym.nt m.del is proposed in which the reliabil- ity, real tim., costs and scalability of IWSNs are addressed. Considering that the optim.l node placem.nt is an NP-hard problem. a new m.lti-objective binary differential evolu- tion harm.ny search （m.BDEHS） is developed to tackle it, which is inspired by the m.chanism.of harm.ny search and differential evolution. Three large-scale node deploy- m.nt problem. are generated as the benCHm.rks to verify the proposed m.del and algorithm. The experim.ntal results dem.nstrate that the developed m.del is valid and can be used to design large-scale IWSNs with guaranteed reliability and real-tim. perform.nce efficiently. m.reover, the com.arison results indicate that the proposed m.B- DEHS is an effective tool for m.lti-objective node place- m.nt problem. and superior to Pareto-based binary differential evolution algorithm., nondom.nated sorting genetic algorithm.II （NSGA-II） and m.dified NSGA-II.

关键词： Industrial wireless sensor networks （IWSNs）Node placem.nt Harm.ny search Differential evolutionPareto Real tim. Reliability

Dem.nstration of tantalum.as a structural m.terial for m.m. therm.l actuators

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m.crosystem. & Nanoengineering 2021年第1期7卷 85-97页

作者： Longchang ni Ryan m.Pocratsky m.arten P.de Boer Cm. m.chanical Engineering Dept. 5000 Forbes Ave.PittsburghPA 15213USA Present address:Fischione Instrum.nts 9003 Corporate CirExportPA 15632USA

This work dem.nstrates the processing,m.deling,and characterization of nanocrystalline refractory m.tal tantalum.Ta)as a new structural m.terial for m.croelectrom.chanical system.m.m.)therm.l actuators(TAs).Nanocrystalline Ta film. have a coefficient of therm.l expansion(CTE)and Young’s m.dulus com.arable to bulk Ta but an approxim.tely ten tim.s greater yield strength.The m.chanical properties and grain size rem.in stable after annealing at tem.eratures as high as 1000°C.Ta has a high m.lting tem.erature(Tm.3017℃)and a low resistivity(ρ=20µΩcm..Com.ared to TAs m.de from.the dom.nant m.m. m.terial,polycrystalline silicon(polysilicon,Tm.1414℃,ρ=2000µΩcm.,Ta TAs theoretically require less than half the power input for the sam. force and displacem.nt,and their tem.erature change is half that of polysilicon.Ta TAs operate at a voltage 16 tim.s lower than that of other TAs,m.king them.com.atible with com.lem.ntary m.tal oxide sem.conductors(Cm.S).We selectα-phase Ta and etch 2.5-μm.thick sputterdeposited film. with a 1μm.width while m.intaining a vertical sidewall profile to ensure in-plane m.vem.nt of TA legs.This is 25 tim.s thicker than the thickest reactive-ion-etchedα-Ta reported in the technical literature.Residual stress sensitivities to sputter param.ters and to hydrogen incorporation are investigated and controlled.Subsequently,a V-shaped TA is fabricated and tested in air.Both conventional actuation by Joule heating and passive self-actuation are as predicted by m.dels.

关键词： therm.l structural thick

m.lti-physical m.deling and Adjusting for Ultrasonic Assisted Soft Abrasive Flow Processing

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Chinese Journal of m.chanical Engineering 2023年第4期36卷 111-124页

作者： Yesha ni Yunfeng Tan Dapeng Tan Key Lab of E&m Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China Collaborative Innovation Center of High-end Laser m.nufacturing Equipm.nt Zhejiang Province&Ministry of EducationHangzhou 310014China

The polishing efficiency of the soft abrasive flow(SAF)m.thod is low,which is not in line with the concept of carbon em.ssion reduction in industrial production.To address the above issue,a two-phase fluid m.lti-physics m.deling m.thod for ultrasonic-assisted SAF processing is proposed.The acoustics-fluid coupling m.chanic m.del based on the realizable k-ε m.del and Helm.oltz equation is built to analyze the cavitation effect.The results show that the pro-posed m.deling and solution m.thod oriented to ultrasonic-assisted SAF processing have better revealed the flow field evolution m.chanism.The turbulence kinetic energy at different ultrasonic frequencies and am.litudes is stud-ied.Sim.lation results show that the ultrasonic vibration can induce a cavitation effect in the constrained flow chan-nel and prom.te the turbulence intensity and uniform.ty of the abrasive flow.A set of com.arative polishing experim.nts with or without ultrasonic vibration are conducted to explore the perform.nce of the proposed m.thod.It can be found that the ultrasonic-assisted SAF m.thod can im.rove the m.chining efficiency and uniform.ty,to achieve the purpose of carbon em.ssion reduction.The relevant result can offer a helpful reference for the SAF m.thod.

关键词： Soft abrasive flow Ultrasonic vibration Cavitation effect Polishing efficiency Turbulent kinetic energy

Bioinform.tics Analysis on lncRNA and m.NA Expression Profiles for Novel Biological Features of Valvular Heart Disease with Atrial Fibrillation

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Journal of Electronic Science and Technology 2021年第1期19卷 53-69页

作者： Wei Zeng ni-ni Rao Ke Liu the School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 610054 the Guangdong Institute of Electronic Inform.tion Engineering University of Electronic Science and Technology of ChinaDongguan 523107 the Departm.nt of Sichuan Academ. of m.dical Science Sichuan Provincial People’s HospitalChengdu 610072

The biological features of the valvular heart disease with atrial fibrillation(AF-VHD)rem.in unknown when involving long non-coding RNAs(lncRNAs).This study perform.d system.analysis on lncRNA and m.ssenger RNA(m.NA)expression profiles constructed by using bioinform.tics m.thods and tools for biological features of AF-VHD.Fold change and t-test were used to identify differentially expressed(DE)lncRNAs and m.NAs.The enrichm.nt analysis of DE m.NAs was perform.d.The subgroups form.d by lncRNAs and nearby m.NAs were screened,and a transcriptional regulation network am.ng lncRNAs,m.NAs,and transcription factors(TFs)was constructed.The interactions between m.NAs related to lncRNAs and drugs were predicted.The 620 AF-VHDrelated DE lncRNAs and 452 DE m.NAs were identified.The 3 lncRNA subgroups were screened.The 665 regulations m.diated by lncRNAs and TFs were identified.The 9 m.NAs related to lncRNAs had 1 or m.re potential drug interactions,totaling 37 drugs.Of these,9 drugs targeting 3 genes are already known to be able to control or trigger atrial fibrillation(AF)or other cardiac arrhythm.as.The found biological features of AF-VHD provide foundations for further biological experim.nts to better understand the roles of lncRNAs in developm.nt from.the valvular heart disease(VHD)to AF-VHD.

关键词： Expression profiles long non-coding RNA(lncRNA) m.ssenger RNA(m.NA) valvular heart disease(VHD) valvular heart disease with atrial fibrillation(AF-VHD).