Bioinformatics Analysis on lncRNA and mRNA Expression Profiles for Novel Biological Features of Valvular Heart Disease with Atrial Fibrillation

作     者：Wei Zeng Ni-Ni Rao Ke Liu Wei Zeng;Ni-Ni Rao;Ke Liu

作者机构：the School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054 the Guangdong Institute of Electronic Information EngineeringUniversity of Electronic Science and Technology of ChinaDongguan 523107 the Department of Sichuan Academy of Medical ScienceSichuan Provincial People’s HospitalChengdu 610072 

出 版 物：《Journal of Electronic Science and Technology》 (电子科技学刊（英文版）)

年 卷 期：2021年第19卷第1期

页      面：53-69页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China under Grants No.61872405 and No.61720106004 the Key Project of Natural Science Foundation of Guangdong Province under Grant No.2016A030311040 

主　　题：Expression profiles long non-coding RNA(lncRNA) messenger RNA(mRNA) valvular heart disease(VHD) valvular heart disease with atrial fibrillation(AF-VHD). 

摘      要：The biological features of the valvular heart disease with atrial fibrillation(AF-VHD)remain unknown when involving long non-coding RNAs(lncRNAs).This study performed system analysis on lncRNA and messenger RNA(mRNA)expression profiles constructed by using bioinformatics methods and tools for biological features of *** change and t-test were used to identify differentially expressed(DE)lncRNAs and *** enrichment analysis of DE mRNAs was *** subgroups formed by lncRNAs and nearby mRNAs were screened,and a transcriptional regulation network among lncRNAs,mRNAs,and transcription factors(TFs)was *** interactions between mRNAs related to lncRNAs and drugs were *** 620 AF-VHDrelated DE lncRNAs and 452 DE mRNAs were *** 3 lncRNA subgroups were *** 665 regulations mediated by lncRNAs and TFs were *** 9 mRNAs related to lncRNAs had 1 or more potential drug interactions,totaling 37 *** these,9 drugs targeting 3 genes are already known to be able to control or trigger atrial fibrillation(AF)or other cardiac *** found biological features of AF-VHD provide foundations for further biological experiments to better understand the roles of lncRNAs in development from the valvular heart disease(VHD)to AF-VHD.