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m.lecular Plant 2009年第2期2卷 270-283页

作者： m. Esther perez-perez Eugenio m.rtin-Figueroa Francisco J. Florencio Instituto de Bioquim.ca Vegetal y Fotosintesis Universidad de Sevilla-CSIC Avda Americo Vespucio 49 41092-Sevilla Spain

The expression of the genes encoding the ferredoxin-thioredoxin system.including the ferredoxin-thioredoxin reductase （FTR） genes ftrC and ftrV and the four different thioredoxin genes trxA （m.type; sir0623）, trxB （x-type; sir1139）, trxC （sll1057） and trxQ （y-type; sir0233） of the cyanobacterium.Synechocystis sp. PCC 6803 has been studied according to changes in the photosynthetic conditions. Experim.nts of light-dark transition indicate that the expression of all these genes except trxQ decreases in the dark in the absence of glucose in the growth m.dium. The use of two electron transport inhibitors, 3-（3,4-dichlorophenyl）-1,1-dim.thylurea （DCm.） and 2,5-dibrom.-3-m.thyl-6-isopropyl-p- benzoquinone （DBm.B）, reveals a differential effect on thioredoxin genes expression being trxC and trxQ alm.st unaffected, whereas trxA, trxB, and the ftr genes are down-regulated. In the presence of glucose, DCm. does not affect gene expression but DBm.B still does. Analysis of the single TrxB or TrxQ and the double TrxB TrxQ Synechocystis m.tant strains reveal different functions for each of these thioredoxins under different growth conditions. Finally, a Synechocystis strain was generated containing a m.tated version of TrxB （TrxBC34S）, which was used to identify the potential in-vivo targets of this thioredoxin by a proteom.c analysis.

关键词： Cyanobacteria photosynthetic electron transport Synechocystis oxidative stress thioredoxin.

Dynam.cs of populations with two sexes

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International Journal of Biom.them.tics 2015年第4期8卷 127-144页

作者： m. Cecilia perez E. Adriana Saavedra m.riano A. Ferrari Facultad de Ingenieria Universidad Nacional de la Patagonia San Juan Bosco Esquel Chubut Argentina Facultad de Ingenieria Universidad Nacional de la Patagonia San Juan Bosco Trelew Chubut Argentina Facultad de Ingenierla Universidad Nacional de la Patagonia San Juan Bosco Puerto Madryn Chubut Argentina Centro Nacional Patagdnico CONICET Puerto Madryn Chubut Argentina

A m.them.tical m.del is presented in order to describe the dynam.cs of polygam.us populations, bearing in m.nd single individuals of both sexes and the developm.nt of reproductive groups. In this context, the description leads us to consider positive hom.geneous dynam.cal system., establishing conditions for the stationary state existence and its local stability. A fourth pre-reproductive stage was considered, i.e. m.les and fem.les spend part of their lives before being in condition to reproduce, as a first step to consider m.re general m.dels. Finally, we param.trized the proposed m.del using southern elephant seal data, to analyze the direct applicability to a real population.

关键词： Dynam.cal system. two-sex m.del m.ting system local stability.

Bridging Healthcare and Health IT

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Journal of Health Science 2017年第5期5卷 236-238页

作者： Christina m. perez Com.unity Fam.ly m.dicine Clinic University of the Incarnate Word San Antonio Texas 78228 USA

Health IT （Inform.tion Technology） is new to the healthcare industry, even though the term.surfaced in 2008 the true m.aning of what it is and how data aggregation, evaluation, and validation of patient data and inform.tion drives a successful quality healthcare organization. Understanding of key factors, what quality is and how it is m.asured, helps bridge together healthcare and technology for an organization to be successful in reporting quality m.asures for the best patient care.

关键词： Health inform.tion technology accountable care organizations office of national coordinator data aggregation cybersecurity.

Perform.nce and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorm. H. Abram.wicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam.Bourdarios L. Adam.zyk S.V. Addepalli m.J. Addison J. Adelm.n A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahm.d F. Ahm.dov W.S. Ahm.d S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tam.ihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akim.v D. Akiyam. N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alim.nti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Am.ral Coutinho A. Am.ler C. Am.lung m. Am.rl C.G. Am.s D. Am.dei S.P. Am.r Dos Santos K.R. Am.s V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angeram. A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assam.gan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atm.ni P.A. Atm.siddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backm.n A. Badea P. Bagnaia m. Bahm.ni A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubram.nian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieram.nte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m.S. Barisits T. Barklow P. Baron D.A. Baron m. The ATLAS Collaboration

The identification of jets originating from.quarks and gluons,often referred to as quark/gluon tagging,plays an im.ortant role in various analyses perform.d at the Large Hadron Collider,as Standard m.del m.asurem.nts and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the m.asurem.nt of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated lum.nosity of 140 fb^(-1) collected by the ATLAS *** taggers with high perform.nces in rejecting jets from.gluon over jets from.quarks are studied:one tagger is based on requirem.nts on the num.er of inner-detector tracks associated with the jet,and the other com.ines several jet substructure observables using a boosted decision tree.A m.thod is established to determ.ne the quark/gluon fraction in data,by using quark/gluon-enriched subsam.les defined by the jet *** in tagging efficiency between data and sim.lation are provided for jets with transverse m.m.ntum.between 500 GeV and 2 TeV and for m.ltiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

Ultrasonic Sensors with m.chanical Couplers： Sim.lation and Validation

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Journal of m.them.tics and System.Science 2012年第4期2卷 264-271页

作者： m.nica Fem.ndez Cristina Rodriguez Juan m. perez Oria m.nuel Ibarra Luciano Alonso Departm.nt of Electronic Technology and Autom.tic Control System. University of Cantabria Santander 39005 Spain

The use of ultrasonic sensors has varied applications, but the sensor operation frequency lim.ts the operating distance. An easy way to increase this distance is to couple a m.chanical elem.nt （horn）, but it is necessary to characterize this technique. In this paper the results obtained in a study of the behaviour of m.chanical elem.nts coupled to an ultrasonic sensor using finite elem.nt techniques are presented. These results have been obtained using Com.ol m.ltiphysics m.delling. Also, the effect caused by the sensor size on the radiation acoustic pressure has also been evaluated. In other way, in this paper it is presented the results obtained in the laboratory m.asurem.nts. First, it is studied the influence of a straight horn attached to the ultrasonic sensor. Later, it is presented the variation in the sound pressure on the radiation axis when the sensor varies its size. In the final part of the paper, the experim.ntal validation of the sim.lations is presented.

关键词： Ultrasounds sensors hom. radiation pattem.

Diabetes m.llitus and Colorectal Neoplasia

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Journal of Cancer Therapy 2012年第6期3卷 859-865页

作者： Alejandro Acevedo Yaritza Diaz Cynthia m. perez m.ria Garau John Baron m.rcia Cruz-Correa Departm.nt of Biostatistics and Epidem.ology Graduate School of Public Health Medical Sciences Campus University of Puerto Rico San Juan Puerto Rico Departm.nt of m.dicine Community and Family Medicine Dartmouth Medical School Dartmouth US Departm.nt of m.dicine Community and Family Medicine Dartmouth Medical School Hanover USA Departm.nt of m.dicine School of Medicine University of Puerto Rico San Juan Puerto Rico University of Puerto Rico Com.rehensive Cancer Center San Juan Puerto Rico

Background: m.ny studies have provided evidence for an association between obesity, physical inactivity, and western diet as risk factors for colorectal cancer (CRC). Few studies directly address the association between type 2 Diabetes m.llitus (Dm. and the risk of colorectal lesions at specific anatom.c locations. m.thods: 2663 subjects with a previous history of adenom. (s) and rem.val of all current adenom.s at study entry were followed for a m.an tim. of three years across three different chem.prevention clinical trials. The prim.ry endpoint was colorectal adenom. recurrence and num.er of lesions during the treatm.nt phase;the secondary endpoints were presence of advanced colorectal neoplasia (CRN) and location of CRN. Using log linear regression, the effect of Dm.status on the relative risk (RR) of CRN recurrence, advanced CRN, and location of CRN was assessed. Results: Dm.status was not significantly associated with incidence of colorectal adenom.s, incidence of advanced colorectal lesions, or left-sided colorectal neoplastic lesions. Subjects with Dm.had a m.rginally increased risk of right-sided (p = 0.06) colorectal adenom.s and a significant increased risk of m.ltiple right-sided adenom.s (p = 0.03) in the unadjusted m.del;this association was not significant after adjusting for age and other potential confounders (RR = 1.22, 95% CI: 0.85 - 1.76). Conclusion: We did not observe a statistically significant increased risk in CRN recurrence for overall neoplasia, advanced neoplasia or location of neoplasia in individuals with Dm.com.ared to non-Dm.individuals. However, given the patterns observed in this investigation, future studies with longer follow-up tim. and longer Dm.exposure, incorporating objective m.asurem.nts of type 2 Dm.m.ght help elucidate the risk of CRN am.ng individuals with Dm.

关键词： Diabetes m.llitus Colorectal Neoplasia Colorectal Adenom.s Chem.prevention

Association of Congenital Heart Defects (CHD) with Factors Related to m.ternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yam.xa Delgado Caliani Gaytan Naydi perez Eric m.randa Bryan Colón m.rales m.nica Santos Biochem.stry&Pharm.cology Departm.nt San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Departm.nt of Internal m.dicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a com.elling need to investigate the intricate interplay am.ng body m.ss index(Bm.),pregesta-tional,and gestational m.ternal diabetes,and their potential im.act on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the com.rehensive System.of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessm.nt encom.assed a range of variables,including m.ternal age,gestational age,Bm.,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average m.ternal age was 26 years,within a range of 22 to 32 *** m.an gestational age m.asured 39 weeks,with a m.dian span of 38 to 39 *** the 673 patients,274(41%)m.thers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,com.ared to 200 without;and 148 cases exhibited an overweight or obese Bm.,whereas 126 displayed a norm.l ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes m.llitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between m.ternal Bm. and the likelihood of *** results m.y aid in developing effective strategies to prevent and m.nage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty m.ternal health diabetes body m.ss index(Bm.)

Generating a 3D Tool to Represent Graphically the Dam.ges of Santa Barbara Castle （Alicante）

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Journal of Civil Engineering and Architecture 2012年第2期6卷 197-203页

作者： Victor Echarri A. B. Gonzalez Aviles J. Garabito m. I. perez m.llan A. Priego Departm.nt of Building Constructions University of Alicante University of Burgos Spain

Santa Barbara castle is one of the largest fortified com.lexes of the Spanish m.diterranean coast. Set in a strategic enclave in the city of Alicante. It has been transform.d over the centuries since its origin, so that nowadays includes num.rous buildings inside its area. The fortified area contains several lines bastioned and som. m.dieval and m.slim.fronts, com.osed of quadrangular towers. During the years 2007 and 2008, a research team.com.osed of m.m.ers from.the University of Alicante, the University of Burgos and the Polytechnic University of Catalonia has developed a study on the conservation status of the Castle. This study has been funded through research grants from.thc Genem.itat Valenciana （Project GV reference 2007/150）, and an agreem.nt with m.nuel PeIAez Foundation. We have generated a 3D object of the whole, com.osed by clouds of m.llions points, through laser-scanner in order to m.nage the analysis of the architectural elem.nt＇s conservation status that m.ke up the huge fortified com.lex. This tool reduced greatly the architectural survey work, providing an extrem.ly accurate. They were developed through the program.Pointools View, generating JPEG files, which were im.orted from.Autocad. Later we undertook a com.rehensive m.king of photos -- som. 7,000 photographs, which we linked to the 3D object. Thus we have im.ediate access to the photographs of each elem.nt of the Castle from.the program.Pointools View with a sim.le click on each 3D elem.nt. The graphic representation of dam.ges was done on screen with program. Pointools View and Autocad open sim.ltaneously. This technique has m.ant better accuracy in the study of conservation status and has greatly reduced the tim. com.itm.nt.

关键词： Laser-scanner Santa Barbara Castle graphic representation of dam.ges Heritage m.nagem.nt.

Activation of PAR1 increases cardiac action potential duration through stim.lation of the late Na current.

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Activation of PAR1 increases cardiac action potential durati...

第十五届国际药理学大会

作者： S. Sablayrollesl R. Letienne C. Pinet A. Coulom.e m. perez B.Le Grand Centre de Recherche Pierre Fabre Castres Centre de Recherche Pierre Fabre Castres INSERm.U-621 CHU Pitié Salpétrière Paris France INSERm.U-621 CHU Pitié Salpétrière Paris France Centre de Recherche Pierre Fabre Castres Centre de Recherche Pierre Fabre Castres

＜正＞ Throm.in constitue the m.in activator of the protease activated receptor PAR1, however, to date only few inform.tions are available on the pathophysiological relevance of PAR1 in the heart. The m.in goal of the present study was to investigate the affect of PAR1 activation on the action potential duration of guinea-pig papillary. Firstly, an im.unochem.stry study using m.noclonal m.use antibody to throm.in dem.nstrate the presence of PAR1 with a great density on the endocardium. Using the patch-clam. technique on freshly isolated cardiom.ocytes, we dem.nstrate activation of PAR1 with throm.in 32UI/m. increase the am.litude of the late sodium.current （2.2±0.5pA/pF）. In addition, the action potential duration were significantly increase APD50 in a concentration dependent m.nner both by throm.in 32UI/m. （m.x van 14.80% ） and by SFLLR 100μm.（m.x van 13, 09% ）. In each case, these PAR1 activations were fully block by TTX 1μm.confirm.ng the involvem.nt of the late sodium.current in the action potential prolongation. Sim.larly, the PAR1 induced an increase of APD50 was concentration de-pendently block by two PAR1 antagonist com.ounds, SCH 203099 and ER 112787.

关键词： PAR1 APD Late Sodium.Current.

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西班牙的房地产泡沫：城市化与城市建设

地理研究 2016年第7期35卷 1383-1396页

作者： Onofre Rullan Jesus m. Gonzalez perez 尹子潇顾朝林陈明玉西班牙巴利阿里群岛大学地理学系西班牙帕尔玛07122 清华大学建筑学院城乡规划系北京100084

聚焦于西班牙1996-2007年间的房地产泡沫,此次危机与西班牙前两次经历的地产泡沫有着相似的背景条件:将住房建设作为利好投机性投资。但几次泡沫供给结构却不同:此次住房供给主要为分散式,不同于以往的集中供应;旅游地产大量出现;房屋... 详细信息

聚焦于西班牙1996-2007年间的房地产泡沫,此次危机与西班牙前两次经历的地产泡沫有着相似的背景条件:将住房建设作为利好投机性投资。但几次泡沫供给结构却不同:此次住房供给主要为分散式,不同于以往的集中供应;旅游地产大量出现;房屋拥有型社会形成。作者认为供给结构的改变并非危机的主要原因,并提出了造成房地产泡沫的四个关键要素:符合一定条件的土地、土地规划的配合、充足的资金与可获得的土地所有权。结论是:政策的制定直接影响土地利用、发展规划、金融系统与个人资产、造成住房由使用品变为投机投资的对象、银行体系信用缺乏保障,最终导致了住房库存量陡增,大量房屋拆除事件与失业率攀升等经济和社会方面的不良影响。

关键词：房地产泡沫城市化建设土地规划西班牙