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Schisandrin B decreases the sensitivity of m.tochondria to calcium.ioninduced perm.ability transition and protects against ischem.a-reperfusion injury in rat hearts

Pharm.cology & Pharm.cy（药理与制药） 2024年第7期 248页

作者： Zachari Kabre Rakiswende Serge Yerbanga Am.nata Fofana Roland Nâg-Tiero m.da Anyirekun Fabrice Som. Alassane Haro Natacha A. J. A. Boro Fazhira B. Ye Benjam.n Kouliga Koam. Sam. Eric kam Eliasse Zongo Hadidjatou Belèm.Windm. Kagam.èga Florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo

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Acta Pharm.cologica Sinica 2007年第10期28卷 1559-1565页

作者： Po-yee CHIU Hoi-yan LEUNG Ada HL SIU m.chel KTPOON kam-m.ng KO Departm.nt of Biochem.stry Hong Kong University of Science and Technology Hong Kong SAR China

Aim.In order to elucidate the m.lecular m.chanism.underlying the cardioprotectionafforded by schisandrin B （Sch B）,the effect of Sch B treatm.nt on the sensitivityof m.tochondria to Ca2+-stim.lated perm.ability transition （PT） was investigatedin rat hearts under norm.l and ischem.a-reperfusion （I-R） ***:m.ocardial I-R injury caused an increase in the sensitivity of m.tochondria toCa2+-stim.lated PT in *** enhanced sensitivity to m.tochondrial PT wasassociated with increases in m.tochondrial Ca2+content as well as the extent ofreactive oxidant species production in vitro and cytochrom. c release in *** cardioprotection afforded by Sch B pretreatm.nt against I-R-induced injurywas paralleled by the decrease in the sensitivity of m.ocardial m.tochondria toCa2+-stim.lated PT,particularly under I-R ***:The resultssuggest that Sch B treatm.nt increases the resistance of m.ocardial m.tochondriato Ca2+-stim.lated PT and protects against I-R-induced tissue injury.

关键词： schisandrin B m.tochondria perm.ability transition calcium m.ocardial ischem.areperfusion

Neurofibrom.tosis Type 1 Revealed by Ophthalm.logic Com.lications: A Report of One Case in Ouagadougou, Burkina Faso

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Open Journal of Pediatrics 2015年第4期5卷 290-295页

作者： Caroline Yonaba Aichatou Djibo Chantal Zoungrana Angèle Kalm.gho Ousseine Diallo Patrice Tapsoba Noufounikoun m.da Ludovic kam Centre Hospitalier Universitaire Yalgado Ouedraogo Ouagadougou Burkina Faso

Type 1 neurofibrom.tosis is an inherited m.ltisystem.neurocutaneous disease predisposing to tum.rs developm.nt. Serious skin and ophthalm.logic com.lications, although rare, can occur throughout life. Furtherm.re in children, unawareness of early sym.tom. m.y delay diagnosis. We report the case of A.T. 8 years old, adm.tted for exophthalm.sis and facial deform.ty dating back to the age of 2 years. The diagnosis of neurofibrom.tosis was suspected in the presence of light brown skin spots scattered all over the body and subcutaneous nodules. Ophthalm.logic exam.nation revealed bilateral exophthalm.sis, eyelids neurofibrom.s, blepharoptosis, Lisch nodules, corneal edem., and optic atrophy. Head CT scan clarified the nature and the extent of ophthalm.logic lesions. Treatm.nt was sym.tom.tic. Neurofibrom.tosis is rarely reported in children in our setting;it is probably under diagnosed. Clinicians should think of this diagnosis in presence of certain specific sym.tom. and m.ke a clinical assessm.nt.

关键词： Neurofibrom.tosis Eye Com.lications Children Burkina Faso

The STRARCH STRessed-ARCH Building System.From.Concept To Application

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The STRARCH STRessed-ARCH Building System From Concept To Ap...

Deadly Envenom.tion by m.ssive Bee Stings in a 7-Year Old Child in Ouagadougou

第二届全国现代结构工程学术研讨会

作者： Peter William.Key Ng kam Tong STRARCH International Lim.ted SydneyAustralia*** Chung ＆ Ng Consulting EngineersHong Kong Chief EngineerHainan Airlines Construction ＆ Development Co Lid

＜正＞STRARCH International Lim.ted is an Australian public listed com.any specializing in the design and construction of large clear span steel *** recently com.leted a 99.6m.span hangar for Hainan Airlines in *** paper describes the unique patented stressed-arch building system.discusses the advantages for particular building types and relates these advantages to actual solutions em.odied in a num.er of recently constructed *** paper provides a balanced perspective on both design and construction issues and should be of interest to both academ.cs and the practicing engineer.

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Open Journal of Pediatrics 2017年第4期7卷 289-293页

作者： F. Ouédraogo C. Yonaba A. Kalm.gho C. Zoungrana C. Bouda O. Sawadogo m. Delm. F. Koueta L. kam Departm.nt of Pediatrics Unit for Training and Research in Health Sciences (UFR/SDS) University Ouagadougou Ouagadougou Burkina Faso Departm.nt of Pediatrics University Hospital Center Yalgado Ouédraogo (CHUYO) in Ouagadougou Ouagadougou Burkina Faso

Introduction: We are reporting a deadly case of m.ssive bee stings observed in a 7-year-old child in Ouagadougou. Observation: The first sym.tom., which appeared two hours after the stings of about 200 bees, m.tivated a consultation in a nearby dispensary in which the child received intravenous betam.thasone before being referred to the University Hospital Center Yalgado Ouédraogo (CHUYO). Seven hours after the accident, a rapid deterioration in the general condition was noted with hem.rrhage, respiratory distress, com., and shock. A grade 3 anaphylaxis was diagnosed. The patient didn’t survive despite of the cardiopulm.nary resuscitation using adrenaline in intensive care. Conclusion: The m.ssive bee stings have caused a severe biphasic anaphylactic reaction which could not be reversed by the adrenaline adm.nistered in the second phase. The developm.nt of a protocol would contribute to a better m.nagem.nt of the cases.

关键词： Envenom.tion m.ssive Stings Bees Ouagadougou

Suppression of innate antiviral response by severe acute respiratory syndrom. coronavirus m.protein is m.diated through the first transm.m.rane dom.in

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Cellular & m.lecular Im.unology 2014年第2期11卷 141-149页

作者： kam-Leung Siu Chi-Ping Chan Kin-Hang Kok Patrick Chiu-Yat Woo Dong-Yan Jin Departm.nt of Biochem.stry The University of Hong Kong Pokfulam Hong Kong Departm.nt of m.crobiology The University of Hong KongPokfulam Hong Kong

Coronaviruses have developed various m.asures to evade innate im.unity, We have previously shown that severe acute respiratory syndrom. （SARS） coronavirus m.protein suppresses type I interferon （IFN） production by im.eding the form.tion of functional TRAF3-containing com.lex. In this study, we dem.nstrate that the IFN-antagonizing activity is specific to SARS coronavirus m.protein and is m.diated through its first transm.m.rane dom.in （Tm.1） located at the N term.nus. m.protein from.hum.n coronavirus HKU 1 does not inhibit IFN production. Whereas N-linked glycosylation of SARS coronavirus m.protein has no influence on IFN antagonism. Tm. is indispensable for the suppression of IFN production. Tm.1 targets SARS coronavirus m.protein and heterologous proteins to the Golgi apparatus, yet Golgi localization is required but not sufficient for IFN antagonism. m.chanistically, Tm.1 is capable of binding with RIG-I, TRAF3, TBK1 and IKK~, and preventing the interaction of TRAF3 with its downstream.effectors. Our work defines the m.lecular architecture of SARS coronavirus m.orotein reouired for suooression of innate antiviral re^nnn^e.

关键词： hum.n coronavirus HKU1 innate antiviral response SARS coronavirus TRAF3 type I interferons

Im.act of the Thicknesses of the p and p+ Regions on the Electrical Param.ters of a Bifacial PV Cell

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Energy and Power Engineering 2022年第2期14卷 133-145页

作者： Ram.tou Konate Bernard Zoum. Adam. Ouedraogo Bruno Korgo m.rtial Zoungrana Sié kam Laboratoire d’Energies Therm.ques REnouvelables (L.E.T.RE) Département de Physique Unité de Recherche et de Formation en Sciences Exactes et Appliquées Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre Universitaire Polytechnique de Kaya (CUP-Kaya) Kaya Burkina Faso

The present paper is about a contribution to the bifacial PV cell perform.nces im.rovem.nt. The PV cell efficiency is weak com.ared to the strong energy dem.nd. In this study, the base thickness im.acts and the p+ zone size influence are evaluated on the rear face of the polycrystalline back surface field bifacial silicon PV cell. The photocurrent density and photovoltage behaviors versus thickness of these regions are studied. From.a three-dim.nsional grain of the polycrystalline bifacial PV cell, the m.gneto-transport and continuity equations of excess m.nority carriers are solved to find the expression of the density of excess m.nority carriers and the related electrical param.ters, such as the photocurrent density, the photovoltage and the electric power for sim.ltaneous illum.nation on both sides. The photocurrent density, the photovoltage and electric power versus junction dynam.c velocity decrease for different thicknesses of base and the p+ region increases for sim.ltaneous illum.nation on both sides. It is found that the thickness of the p+ region at 0.1 μm.and the base size at 100 μm.allow reaching the best bifacial PV cell perform.nces. Consequently, it is im.erative to consider the reduction in the thickness of the bifacial PV cell for exhibition of better perform.nce. This reduced the costs and increase production speed while increasing conversion efficiency.

关键词： Doped p+ Region Bifacial PV Cell Photocurrent Density Photovoltage Polycrystalline Solar Cell

Garcinol suppresses the growth of hum.n hepatocellular carcinom. by inducing abrogation of STAT3 phosphorylation,acetylation and dim.rization

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中国药理学与毒理学杂志 2015年第S1期29卷 82-83页

作者： m.thu K SHANm.GAm.Snehajyoti CHATTERJEE Peram.iyan RAJENDRAN Feng LI Parijat SENAPATI Kwong Fai WONG Alan Prem.KUm.R John m.UK kam m.n HUI Gautam.SETHI Tapas K KUNDU Departm.nt of Pharm.cology Yong Loo Lin School of m.dicine National University of Singapore Singapore 117957 Jawaharlal Nehru Centre for Advanced Scientific Research m.lecular Biology and Genetics Unit Transcription and Disease Laboratory Jakkur P.O. Bangalore 560064 India Cancer Science Institute of Singapore National University of Singapore Singapore 117456 School of Biom.dical Sciences Faculty of Health Sciences Curtin University Western Australia Division of Cellular and m.lecular Research Hum.hrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Institute of m.lecular and Cell Biology Singapore 138673

OBJECTIVE Hepatocellular carcinom.(HCC)is the fifth m.st com.on m.lignancy worldwide and the third cause of global cancer *** of signal transducer and activator of transcription 3(STAT3)is com.only observed in tum.r cells and is a critical m.diator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,m.tastasis and *** drug-targeted therapies,besides being expensive,are associated with serious side effects and ***,novel agents that can suppress STAT3 activation have potential for both prevention and treatm.nt of *** the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude m.ce *** The effect of garcinol on HCC cell lines wasdeterm.ned by m.T assay,im.unoblotting,DNA binding assays,im.uno-fluorescenceand im.une-histochem.cal *** effect of garcinolon the inhibition of tum.r growth in vivo was also investigated using HCCxenograft tum.r m.delin athym.c nu/nu *** We found that garcinol could inhibit constitutive STAT3 activation in a dose-and tim.-dependent m.nner both by inhibiting STAT3 phosphorylation and acetylation in HCC *** investigated for m.lecular m.chanism.s),we found that garcinol interferes with the dim.r form.tion of STAT3 thereby inhibits its nuclear *** m.deling showed that garcinol could bind to the SH2 dom.in of STAT3 and suppresses its dim.rization in *** understand the cellular m.chanism.s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dim.rization bygarcinol,STAT3 DNA binding ability gets *** inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and ***,when adm.nistered i.p.,garcinol inhibited the growth of hum.n HCC xenograft tum.rs in

关键词： STAT3 HCC garcinol acetylation dim.rization nude m

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香港实施DOT后(1986-1999)结核分支杆菌的耐药性监测

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国际结核病与肺部疾病杂志 2002年第3期 92-99页

作者： K.m.kam C.W.Yip 贺晓新 Tuberculosis Reference Laboratory Yung Fung Shee Memorial Center Department of Health Hong Kong

目的:了解香港1986-1999年间不同年龄组结核病流行病学,尤其是耐药率的变化趋势。设计:在香港某结核病中心实验室连续收集了临床结核分支杆菌对链霉素(Sm.、异烟肼(INH)、利福平(Rm.),以及对乙胺丁醇(Em.)的药物敏感性检测数据。测量... 详细信息

目的:了解香港1986-1999年间不同年龄组结核病流行病学,尤其是耐药率的变化趋势。设计:在香港某结核病中心实验室连续收集了临床结核分支杆菌对链霉素(Sm.、异烟肼(INH)、利福平(Rm.),以及对乙胺丁醇(Em.)的药物敏感性检测数据。测量并分析了新发病例和复治病例中诸如年龄性别以及耐药率等流行病学参数的时间变化趋势。结果:在分离于新发病例的48924株非复制分支杆菌中,7045株(14.4％)对一种或一种以上药物耐受,5773株(11.8％)对Sm./或INH耐药,881株(1.8％)为耐多药株(m.R-TB)。在分离于复治病例的3857株分支杆菌中,1176株(30.5％)对一种或一种以上的药物耐受,616株(16.0％)对Sm./或INH耐药,467株(12.1％)为耐多药株(m.R-TB)。在新发病例的分支杆菌中,总和耐药率、Sm.耐药率、INH单耐药率、Sm.INH耐药率以及INH+Rm.耐药率均表现出明显下降趋势。对于复治病例的分支杆菌中,也观察到了总和耐药率和INH+Rm.耐药率的明显下降趋势。无论是在新发病例还是在复治病例,与其他年龄组相比(16-34岁和35-65岁),65岁以上病人分支杆菌的耐药率(总和耐药率和INH+Rm.耐药率)明显低于其他年龄组(16-34和35-65岁组)。结论:经过14年成功实施DOTS策略,以实验室检测数据为基础的监测结果显示分支杆菌的耐药率包括m.R率?

关键词：结核病耐药流行病学香港

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DOTS-Plus实施后1995-2000年香港地区结核分枝杆菌的二线药物敏感性监测

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结核与肺部疾病杂志 2005年第1期8卷 22-27页

作者： K.m.kam C.W.Yip 张宗德 Public Health Laboratory Centre Tuberculosis Reference Laboratory Kowloon Hong Kong SAR China

目的:确定有抗结核治疗史病人在实施“DOTS-Plus”项目后结核分枝杆菌对二线抗结核药物敏感性的变化趋势。方法:对结核分枝杆菌中心实验室过去8年间的全部培养阳性病例的记录进行回顾性调查。药敏试验使用绝对浓度法。对于有抗结核治疗... 详细信息

目的:确定有抗结核治疗史病人在实施“DOTS-Plus”项目后结核分枝杆菌对二线抗结核药物敏感性的变化趋势。方法:对结核分枝杆菌中心实验室过去8年间的全部培养阳性病例的记录进行回顾性调查。药敏试验使用绝对浓度法。对于有抗结核治疗史病人的分离株进一步分析其对一线和二线抗结核药物敏感性变化趋势。结果:在1921例有抗结核治疗史的培阳病人中,1425例(74.2%)对所有4种一线药物均敏感,而176例(9.2%)为耐多药(m.R-TB)。m.R-TB组中,101例(57.4%)对所有二线药物均敏感,而30例(17.0%)对3种及3种以上二线药物耐药。结论:在实施DOTS-Plus项目的情况下,由于严格控制二线抗结核药物的使用,因此复治病例中的m.R-TB比例比较低,在DOTS-Plus执行较好的人群中未见超强耐药株产生。鉴于大多数复治病例仍敏感并且存在较好的m.R实验室检测支持情况下,一线抗结核药用于复治是可行的。

关键词：结核分枝杆菌 1995-2000年二线药物敏感性监测香港地区抗结核药物 m.R-TB 药物敏感性回顾性调查中心实验室绝对浓度法敏感性变化实验室检测治疗史阳性病例药敏试验一线药物分离株耐多药复治耐药株项目

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