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Plastins regulate ectoplasm.c specialization via its actin bundling activity on m.crofilam.nts in th. rat testis

Asian Journal of Andrology 2016年第5期18卷 716-722页

作者： Nan Li Ch.is KC wong C Yan Ch.ng Th. m.ry m. Woh.ford Laboratory for m.le Contraceptive Research Center for Biomedical Research Population Council 1230 York Avenue New York 10065 USA Departm.nt of Biology Hong Kong Baptist University Hong Kong China

Plastins are a fam.ly of actin binding proteins （ABPs） known to cross-link actin m.crofilam.nts in m.m.alian cells, creating actin m.crofilam.nt bundles necessary to confer cell polarity and cell sh.pe. Plastins also support cell m.vem.nt in response to ch.nges in environm.nt, involved in cell/tissue growth.and developm.nt. Th.y also confer plasticity to cells and tissues in response to infection or oth.r path.logical conditions （e.g., inflam.ation）. In th. testis, th. cell-cell anch.ring junction unique to th. testis th.t is found at th. Sertoli cell-cell interface at th. blood-testis barrier （BTB） and at th. Sertoli-sperm.tid （e.g., 8-19 sperm.tids in th. rat testis） is th. basal and th. apical ectoplasm.c specialization （ES）, respectively. Th. ES is an F-actin-rich.anch.ring junction constituted m.st notably by actin m.crofilam.nt bundles. A recent report using RNAi th.t specifically knocks down plastin 3 h.s yielded som. insigh.ful inform.tion regarding th. m.ch.nism.by wh.ch.plastin 3 regulates th. status of actin m.crofilam.nt bundles at th. ES via its intrinsic actin filam.nt bundling activity. h.rein, we provide a brief review on th. role of plastins in th. testis in ligh. of th.s report, wh.ch.togeth.r with.recent findings in th. field, we propose a likely m.del by wh.ch.plastins regulate ES function during th. epith.lial cycle of sDerm.togenesis via th.ir intrinsic activity on actin m.crofilam.nt organization in th. rat testis.

关键词： actin binding proteins actin bundling proteins cytoskeleton F-actin fim.rins plastins sem.niferous epith.lial cycle sperm.togenesis testis

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m.ssense m.tations of th. fibrillin-1 gene in two Ch.nese patients with.severe m.rfan syndrom.

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Ch.nese m.dical Journal 2001年第5期114卷 25-28页

作者： Ivan F.m. LO, Rosanna m.S. wong, Fanny W.F. LAm. Tony m.F. TONG and Steph.n T.S. LAm Clinical Genetic Service Department of Health 3/F Cheung Sha Wan Jockey Club Clinic 2 Kwong Lee Road Shamshuipo Kowloon Hong Kong Special Administrative Region China. akyblue@***

Objective To describe two Ch.nese patients with.severe form. of m.rfan syndrom. and to report findings of m.tational analysis of th. fibrillin-1 (FBN1) *** Two Ch.nese patients were studied, one suffering from.m.rfan syndrom. of infantile onset and th. oth.r of neonatal onset. Th.ir clinical features were described. m.tational analysis of th. FBN1 gene was perform.d using polym.rase ch.in reaction (PCR) tech.ique and direct sequencing of exons 23 - 32,wh.re th. m.tational h.tspots for severe form. of m.rfan syndrom. are *** Two m.ssense m.tations were successfully identified, a G3037A transition and an A3083T transversion, th. latter being an unreported *** Taking advantage of th. clustering ph.nom.non of m.tations in severe form. of m.rfan syndrom., one can identify FBN1 m.tations in th.se patients by first screening th. m.tational h.tspots,th.s reducing th. effort th.t would oth.rwise be m.ch.greater because of th. size of th. gene.

关键词： m.rfan syndrom. fibrillin-1 m.tation

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室外流行音乐的声控制——以香港中心露天音乐会为例(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 144-149页

作者：黄永豪黄先節沛然環境评估工程顾问有限公司

只要符合噪音管制标准和在指定的时间内结束,在香港一般情况下是允许举办露天音乐会的.由环境保护署对此类活动引起的噪声加以监测和评估.作为六次葛莱美奖得主,被2005时代周刊选为世界100位最具影响的人物,霹雳舞创作人、歌手、歌曲作... 详细信息

只要符合噪音管制标准和在指定的时间内结束,在香港一般情况下是允许举办露天音乐会的.由环境保护署对此类活动引起的噪声加以监测和评估.作为六次葛莱美奖得主,被2005时代周刊选为世界100位最具影响的人物,霹雳舞创作人、歌手、歌曲作者Kanye West于2006年11月28日在香港举办其在亚洲唯一的一场演唱会.该演唱会在维多利亚港中心地带的西九龙全新户外场地h. Outdoor Drive-In举行,名为"轩尼诗V.S.O.P Kanye West"Touch.th. Sky Tour"Live in h.ng Kong",由管弦乐队伴奏并邀请本港h.p h.p界代表陈冠希作开幕演出.位于香港中心区的演唱会场地被多层可俯瞰美丽港湾的豪华住宅环绕.演出要符合严格的噪音管制条例.音乐会期间,在距舞台45m.控制台处连续监测到的声压级达到107dB(A).对此,代替传统上通常采用的依赖于声屏障的降噪技术或采用吸声内衬的方法,利用新的轻质材料和沙包成功地控制了这次音乐会的声溢出.

关键词：露天音乐会噪声控制轻质声屏障可拆卸再生材料

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Superior antibody and m.m.rane protein‑specific T‑cell responses to CoronaVac by intraderm.l versus intram.scular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaim. S.Rosa Duque Sam.el m.S.Ch.ng Carolyn A.Coh.n Daniel Leung Xiwei Wang Xiaofeng m. Yuet Ch.ng Tsun m.ng Lau m.nni Wang Wenyue Zh.ng Yanm.i Zh.ng h.ward h.W.wong Leo C.h.Tsang Sara Ch.oth.i Tsz Ch.n Kwan Joh. K.C.Li Karl C.K.Ch.n Leo L.h.Luk Jenson C.h.h. Wing Yan Li Am.s m.T.Lee Jennifer h.Y.Lam.Sau m.n Ch.n Wilfred h.S.wong Issan Y.S.Tam.m.sash. m.ri Soph.e A.Valkenburg m.lik Peiris Wenwei Tu Yu Lung Lau Departm.nt of Paediatrics and Adolescent m.dicine The University of Hong KongHong KongChina Sch.ol of Public h.alth The University of Hong KongHong KongChina h.U‑Pasteur Research.Pole School of Public HealthThe University of Hong KongHong KongChina Research.Institute for Bioresources and Biotech.ology Ishikawa Prefectural UniversityNonoichiJapan Departm.nt of m.crobiology and Im.unology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Im.unology and Infection C2i Hong KongChina

Background Optim.sing th. im.unogenicity of COVID-19 vaccines to im.rove th.ir protection against disease is *** dosing by intraderm.l(ID)adm.nistration h.s been sh.wn to be equally im.unogenic as intram.scular(Im.adm.nistration for several vaccines,but th. im.unogenicity of ID inactivated wh.le severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)at th. full dose is *** study(NCT04800133)investigated th. superiority of antibody and T-cell responses of full-dose CoronaVac by ID over Im.adm.nistration in *** Participants aged 11–17 years received two doses of Im.or ID vaccine,followed by th. 3rd dose 13–42 days *** and cellular im.unogenicity outcom.s were m.asured post-dose 2(Im.CC versus ID-CC)and post-dose 3(Im.CC versus ID-CCC).Doses 2 and 3 were adm.nistered to 173 and 104 adolescents,*** Spike protein(S)im.unoglobulin G(IgG),S-receptor-binding dom.in(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm.sum.of individual(S),nucleocapsid protein(N),and m.m.rane protein(m.peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNm.specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and m.specific IL-2^(+)CD4^(+)responses fulfilled th. superior and non-inferior criteria for ID-CC com.ared to Im.CC,wh.reas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m.specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estim.ted vaccine efficacies were 49%,52%,66%and 79%for Im.CC,ID-CC,Im.CCC and ID-CCC,*** ID groups reported m.re local,m.ld adverse *** Th.s is th. first study to dem.nstrate superior antibody and m.specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as th. basis for future research.to im.rove th.

关键词： CoronaVac Coronavirus disease 2019 Im.unity Intraderm.l Vaccine

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Lenalidom.de downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses

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Signal Transduction and Targeted Th.rapy 2021年第6期6卷 1664-1667页

作者： Siyuan Su Jianfeng Ch.n Ying Wang Lilly m.wong Zh.ch.an Zh. Guoch.n Jiang Pengda Liu Lineberger Com.reh.nsive Cancer Center The University of North Carolina at Chapel HillChapel HillNCUSA Departm.nt of Bioch.m.stry and Bioph.sics The University of North Carolina at Chapel HillChapel HillNCUSA UNC h.V Cure Center Institute of Global Health and Infectious DiseasesThe University of North Carolina at Chapel HillChapel HillNCUSA

Dear Editor,Th. recent h.alth.em.rgency caused by SARS-CoV-2 created a global *** to oth.r CoVs,SARS-CoV-2 utilizes its Spike(S)protein to specifically recognize th. h.m.n angiotensin converting enzym. 2(ACE2)m.m.rane... 详细信息

关键词： ACE2 infection utilize

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Foreign object ingestion and esoph.geal food im.action:An update and review on endoscopic m.nagem.nt

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World Journal of Gastrointestinal Endoscopy 2019年第3期11卷 174-192页

作者： Brian m.Fung Seth.Sweetser Louis m.wong Kee Song Jam.s h.Tabibian UCLA-Olive View Internal m.dicine Residency Program Division of Gastroenterology and h.patology Mayo Clinic Division of Gastroenterology Olive View-UCLA Medical Center

Foreign body ingestion encom.asses both.foreign object ingestion(FOI) and esoph.geal food im.action(EFI) and represents a com.on and clinically significant scenario am.ng patients of all ages. Th. im.ediate risk to th. patient ranges from.negligible to life-th.eatening, depending on th. ingested substance,its location, patient fitness, and tim. to appropriate th.rapy. Th.s article reviews th. FOI and EFI literature and h.gh.igh.s im.ortant considerations and im.lications for pediatric and adult patients as well as th.ir providers. Wh.re publish.d literature is insufficient to provide evidence-based guidance, expert opinion is included to supplem.nt th. content of th.s com.reh.nsive review.

关键词： Foreign bodies Endoscopy Gastrointestinal em.rgency m.dical m.nagem.nt Dysph.gia

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EXISTENCE AND UNIQUENESS OF NON-TRIVIAL SOLUTION OF PARABOLIC p-LAPLACIAN-LIKE DIFFERENTIAL EQUATION WITh.m.XED BOUNDARIES

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Acta m.th.m.tica Scientia 2016年第6期36卷 1780-1792页

作者：魏利陈蕊 Ravi P.AGARWAL Patricia YJ wong Sch.ol of m.th.m.tics and Statistics Hebei University of Economics and Business Departm.nt of m.th.m.tics Texas A&M University-Kingsville Departm.nt of m.th.m.tics Faculty of ScienceKing Abdulaziz University Sch.ol of Electrical and Electronic Engineering Nanyang Technological University

One parabolic p-Laplacian-like differential equation with.m.xed boundaries is au/at in th. corresponding studies is replaced by a（au/at）, studied in th.s paper, wh.re th. item.au/at wh.ch.m.kes it m.re general. Th. sufficient condition of th. existence and uniqueness of non-trivial solution in L2（O, T; L2 （Ω）） is presented by em.loying th. tech.iques of splitting th. boundary problem. into operator equation. Com.ared to th. corresponding work, th. restrictions im.osed on th. equation are weaken and th. proof tech.ique is sim.lified. It can be regarded as th. extension and com.lem.nt of th. previous work.

关键词： m.xim.l m.notone operator Carath.odory'conditions subdifferential p-Laplacian-tike equation nontrivial solution

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Electrical Tracking,Erosion and Fire Retardancy Perform.nce of Silicone Rubber Insulation Containing Alum.num.Trih.drate,Graph.ne and Glass Fiber Additives

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CSEE Journal of Power and Energy System. 2023年第5期9卷 1918-1925页

作者： m.Tariq Nazir Arslan Kh.lid B.Toan Ph.ng Arup K.Das Peter Ch.eth.m.Ash.sh.Param.ne Sh.keel Akram.Kh.i Loon wong Sch.ol of Engineering RMIT UniversityMelbourneVIC 3000Australia. th. Center for Advanced Power System.(CAPS) Florida State UniversityFL 32310USA th. Flam. Security International Pty Lim.ted Australia th. Sch.ol of Electrical Engineering and Telecom.unications University of New South Wales SydneyNSW 2052Australia Departm.nt of Electrical Engineering National Institute of TechnologySilcharAssam 788010India th. College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjingJiangsu 211816China

Silicone rubber com.osite is a priority electrical insulating m.terial used in h.gh.voltage outdoor insulation *** electrical tracking/erosion and poor flam. resistance perform.nce of silicone rubber once ignited,substantially reduce its working *** paper attem.ts to investigate tracking/erosion perform.nce of room.tem.erature vulcanized(RTV)silicone rubber along with.flam. retardant param.ters using alum.num.trih.drate(ATh.,graph.ne nanosh.ets(GN)and m.lled glass fiber(GF)*** inclined plane test(IPT)was perform.d in line with.criteria defined in IEC 60587 using step-up tracking voltage m.th.d wh.le flam. retardancy is evaluated according to ASTm.E 1354.0 using a cone *** suggest 30% of ATh.assists in im.roving ph.sical tracking/erosion resistance of pristine silicone elastom.r rubber by im.eding developm.nt of leakage current and a great reduction in m.xim.m.average tem.eratures on th. surface of *** im.rovem.nt in perform.nce of RTV2 is ach.eved th.ough.introduction of 1%of GN and 5% of GF as seen in ***,30% of ATh.reduces h.at release rate and sm.ke production rate,and th.s trend is im.roved with.th. introduction of GN/***4 h.s pop up as th. m.st prom.sing silicone rubber com.osite with.excellent electrical tracking,erosion,and flam. resistance perform.nce relative to its counterparts in th.s study.

关键词： Dry band arcing electrical tracking h.at release rate leakage current silicone rubber sm.ke production rate

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Transient elastograph.: Kill two birds with.one stone?

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World Journal of h.patology 2013年第5期5卷 264-274页

作者： Grace Lai-h.ng wong Departm.nt of m.dicine and Th.rapeutics and Institute of Digestive DiseaseThe Chinese University of Hong Kong

Assessm.nt of liver fibrosis and steatosis is crucial in ch.onic liver diseases in order to determ.ne th. prognosis, th. need of treatm.nt, as well as m.nitor disease progression and response to treatm.nt. Liver biopsy is lim.ted by its invasiveness and patient acceptability. Transient elastograph. (TE, Fibroscan ) is a non-invasive tool with.satisfactory accuracy and reproducibility to estim.te liver fibrosis and steatosis. TE h.s been well validated in m.jor liver diseases including ch.onic h.patitis B and C, non-alcoh.lic fatty liver disease, alcoh.lic liver disease, prim.ry biliary cirrh.sis, and prim.ry sclerosing ch.langitis. As alanine am.notransferase (ALT) is one of th. m.jor confounding factors of liver stiffness in ch.onic h.patitis B, an ALT-based algorith.0}h.s been developed and h.gh.r liver stiffness m.asurem.nts (LSm. cutoff values for different stages of liver fibrosis sh.uld be used in patients with.elevated ALT levels up to 5 tim.s of th. upper lim.t of norm.l. Oth.rwise falsely-h.gh.LSm.results up to cirrh.tic range m.y occur during ALT flare. TE is also useful in predicting patient prognosis such.as developm.nt of h.patocellular carcinom. (h.C), portal h.pertension, post-operative com.lications in h.C patients, and also survival. Unfortunately, failed acquisition of TE is com.on in obese patients. Furth.rm.re,obese patients m.y h.ve h.gh.r LSm.results even in th. sam. stage of liver fibrosis. Th. new XL probe, a larger probe with.lower ultrasound frequency and deeper penetration, increases th. success rate of TE in obese patients. Th. m.dian LSm.value with.XL probe was found to be lower th.n th.t by th. conventional m.probe, h.nce cutoff values approxim.tely 1.2 to 1.3 kPa lower th.n th.se of m.probe sh.uld be adopted. Recent studies revealed a novel ultrasonic controlled attenuation param.ter (CAP) of th. m.ch.ne is a useful param.ter to detect even low-grade steatosis noninvasively. CAP m.y also be used to quantify liver steatosis by applying d

关键词： Biopsy Cirrh.sis Fibrosis h.patitis Fatty liver Steatosis of liver

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Design, Synth.sis and Ring-Opening Properties of a New Bipyridine Fused Rh.dam.ne-Like Ch.lating Ligand and th. Related Transition m.tal Com.lexes

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Ch.nese Journal of Ch.m.stry 2021年第6期39卷 1659-1666页

作者： Zh.yuan Qian Yukun Ch.ng Sh.nan Zh.o Keith.m.n-Ch.ng wong Departm.nt of Ch.m.stry Southern University of Science and TechnologyNo.1088Tangchang BoulevardNanshan District，ShenzhenGuangdong 518055China

A new bipyridine fused rh.dam.ne-like ch.lating ligand and th. corresponding transition m.tal com.lexes of platinum.Ⅱ)and iridi-um.Ⅲ)h.ve been designed,synth.sized and structurally ch.racterized by X-ray *** ph.toph.sical properties and acid-or m.tal ion-prom.ted spirocarbon ring-opening properties h.ve been *** platinum.Ⅱ)and iridium.Ⅲ)com.lexes sh.w a drastic color ch.nge in solution with.h.^(2+) ions and em.rgency of an absorption band at around 450-600 nm.assignable to th. absorption band of th. ring-opened rh.dam.ne-like *** platinum.Ⅱ)com.lex was suggested to undergo dissociation with.h.^(2+) ion,based on th. corresponding absorption titration *** titration studies of iridium.Ⅲ)com.lexes were found to suffer from.th. quench.ng process,probably due to th. presence of a lower-lying non-em.ssive excited state from.th. ring-opened form.of ligand.

关键词： Rh.dam.ne Transition m.tals Sensor Lum.nescence Bipyridine

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