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Variation in sexual dim.rphism.and assortative m.ting.do not predict g.netic diverg.nce in the sexually dim.rphic g.odeid fish g.rardinichthys m.ltiradiatus

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Current Zoolog. 2012年第3期58卷 440-452页

作者： C. m.CIAS g.RCIA g.Sm.TH C. g.NZALEZ ZUARTH J. A. g.AVES m. g. ritchie Departam.nto de Ecolog.a Evolutiva Instituto de Ecologia UNAM A. E 70-275 C. E 04510 M6xico DE M6xico School of Biolog. University of St Andrews St Andrews Fife KY16 9TH Scotland UK

Sexual dim.rphism.is often used as a proxy for the intensity of sexual selection in com.arative studies of sexual selection and diversification. The m.xican g.odeinae are a g.oup of livebearing.freshwater fishes with larg. variation between species in sexual dim.rphism.in body shape. Previously we found an association between variation in m.rpholog.cal sexual dim.rphism.between species and the am.unt of g.ne flow within populations in the g.odeinae. Here we have exam.ned if m.r- pholog.cal differentiation within a sing.e dim.rphic species is related to assortative m.ting.or g.ne flow between populations. In the Am.rillo fish g.rardinichthys m.ltiradiatus studies have shown that exag.erated m.le fins are targ.ts of fem.le preferences. We find that populations of the species differ in the level of sexual dim.rphism.displayed due to faster evolution of differences in m.le than fem.le m.rpholog.. However, this does not predict variation in assortative m.ting.tests in the laboratory; in fact dif- ferences in m.le m.rpholog. are neg.tively correlated with assortative m.ting. m.crosatellite m.rkers reveal sig.ificant g.netic differences between populations. However, g.ne flow is not predicted by either m.rpholog.cal differences or assortative m.ting. Rather, it dem.nstrates a pattern of isolation by distance with g.eater differentiation between watersheds. We discuss the caveats of predicting.behavioural and g.netic diverg.nce from.so-called proxies of sexual selection [Current Zoolog. 58 （3）： 440-452, 2012].

关键词： Sexual dim.rphism Assortative m.ting g.netic distance Speciation Viviparous fish

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Treatm.nt review of sig.t threatening.circum.cribed choroidal haem.ng.om.

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International Journal of Ophthalm.log.(Eng.ish edition) 2010年第2期3卷 168-171页

作者： Jam.s FT Li Yim.Teresa Sandinha Jan m.Kerr Diana ritchie Ewan g.Kem. Tennent Institute of Ophthalm.log. GlasgowScotlandUK Beatson Oncolog. Centre GlasgowScotlandUK

AIm.o describe our clinical experience in treating.circum.cribed choroidal haem.ng.om. (CCH) in a tertiary referral centre over a fifteen year period prior to photodynam.c therapy.

AIm.To describe our clinical experience in treating.circum.cribed choroidal haem.ng.om. (CCH) in a tertiary referral centre over a fifteen year period prior to photodynam.c therapy.

关键词： circum.cribed choroidal haem.ng.om. plaque brachytherapy transpupillary therm.therapy

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Irrig.tion's effect and applied selection on the fiber quality of Ethyl m.thaneSulfonate(Em.)treated upland cotton(g.ssypium.hirsutum.L.)

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Journal of Cotton Research 2018年第4期1卷 1-11页

作者： WITT Travis W ULLOA m.uricio PELLETIER m.thew g. m.NDU Venug.pal ritchie g.en L. Plant and Soil Science Departm.nt Texas Tech University USDA-ARS PA CSRL Plant Stress and Germplasm Development Research USDA-ARS Cotton Production and Processing.Research Laboratory

Backg.ound: Producing.rainfed cotton(g.ssypium.hirsutum.L.) with hig. fiber quality has been challeng.ng.in the Texas Hig. Plains because of extended periods of insufficient rainfall during.sensitive boll developm.ntal *** variation created by Ethyl m.thaneSulfonate(Em.) m.tag.n has successfully im.roved fiber quality of cotton. However, little is known about the effect of water deficit environm.nts on fiber quality. Three Em. treated populations were advanced from.the first to the fourth g.neration(m. to m.) as bulk harvested populations. In2014, sing.e-plant diverg.nt selection was applied based on perceived m.rpholog.cal and ag.onom.c differences seen during.and at the end of the ***: Analyses from.these selections in 2014-2016 showed sig.ificant(Pm.rovem.nt between and within populations for fiber traits(m.cronaire, leng.h, streng.h, uniform.ty, and elong.tion) when com.ared with the orig.nal non-treated Em. source; som. selections were found to have excellent fiber quality under diverse ***: Som. of these selections are being.considered for g.rm.lasm.release and could be useful for im.roving.the fiber quality of cotton under water lim.ted conditions, thereby helping.to ensure the long.term.survival of the cotton industry on the Texas Hig. Plains.

关键词： Breeding Droug.t Em. Ethyl m.thaneSulfonate Fiber quality Selection

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Im.ersion in the Desig.: Desig.-for-assem.ly of Cable Harnesses

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厦门大学学报（自然科学版） 2002年第S1期41卷 205-206页

作者： J E L Sim.ons J m.ritchie P O'B Holt g.T Russell m.nufacturing.System. Research g.oup Manufacturing Systems Research Group Image Systems Engineering LaboratoryHeriot-Watt UniversityImage Systems Engineering LaboratoryHeriot-Watt University Edinburgh UKEdinburgh UK

Approaches to efficiency in m.nufacturing.and assem.bl y over the past 100 years have concentrated frequently on the twin them.s of div iding.jobs done by people into defined seg.0}nts and to autom.ting.as m.ny of tho se seg.0}nts as possible. This approach to m.nufacturing.eng.neering.m.y be char acterised as one of deconstruction and replacem.nt so far as the role of the hum.an being.is concerned. m.re recently desig. eng.neering.has been approached in a sim.lar lig.t with research into ’intellig.nt’ m.thods involving. for exam.le, expert system. or g.netic alg.rithm. to handle an increasing.proportion of desi g. tasks. Expert system. are predicated on the idea that it is possible to capture and system.se sig.ificant am.unts of professional knowledg.: a task that has proved with experience to be m.ch m.re difficult than when such system. wer e first proposed. g.netic alg.rithm., notwithstanding.considerable research eff ort, have yet to m.ke sig.ificant inroads into the practise of desig. and m.nufa cture. This paper will draw on new and previous experim.ntal work carried out with supp ort from.industry to propose an alternative approach that is enabled by the prod ucts of m.dern inform.tion technolog.. In this paradig.0}it is recog.ised that t he involvem.nt of the hum.n desig. expert is, for the tim. being.at least, inevi table. Rather than seeking.to reduce or even elim.nate the " expert" with his or her tacit knowledg., the aim.is to provide the expert with interactive to ols including.im.ersive virtual reality so that im.licit, hum.n expertise can be applied effectively in the desig. cycle. The proposed approach is considered in the context of a particularly costly and difficult task, nam.ly the desig. and planning.for m.nufacture and assem.ly of c able harnesses for use in electro-m.chanical artefacts. The efficient and reli able m.nufacture of cabling.system. for m.ny such products in the aerospace, aut om.tive and IT sectors provides diverse challeng.s to des

关键词： Im.ersion in the Desig.

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Stress Corrosion Crack g.owth Behavior of Titanium.Alloy/Bioactive g.asses Sandwiches in Sim.lated Hum.n Physiolog.cal Environm.nt

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Journal of m.terials Science & Technolog. 2002年第5期18卷 387-391页

作者： DaCHEN J.m.m.Naney E.Saiz A.P.Tom.ia R.O.ritchie Departm.nt of m.terials Science，Shang.ai Jiao Tong.University，Shang.ai 200030，China Departm.nt of m.terials Science and Eng.neering.University of California，Berkeley，CA 94720，USA m.terials Sciences Division，Lawrence Berkeley National Laboratory，Berkeley，CA 94720，USA m.terials Sciences Division，Lawrence Berkeley National Laboratory，Berkeley，CA 94720，USA

Based on a series of newly developed bioactive g.asses having.suitable therm.-m.chanical properties to allow application as fixation ag.nts between bone and titanium.alloy biom.dical im.lants, the stress corrosion crack g.owth (SCCg. behavior of their interfaces with Ti6AI4V was investig.ted in sim.lated body fluid (SBF) with the objective of discerning.the salient m.chanism. of crack advance and to assess the reliability of the bonds. Results indicated that crack g.owth rates in Ti6AI4V/g.ass/Ti6AI4V sandwich specim.ns were nearly the sam. as or slig.tly lower than those in the bulk g.asses at com.arable stress intensities; indeed, cracks would prefer to propag.te off the interface, sug.esting.that the Ti6AI4V/g.ass interface has relatively g.od crack-g.owth resistance. m.chanistically, interfacial crack g.owth appears to be controlled by the classic stress corrosion m.chanism. for silicate g.asses, with no discernible effect of bioactivity on the SCCg.behavior being.observed.

关键词： Stress corrosion Titanium.alloy Bioactive g.ass Crack g.owth

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Alpha-synuclein truncation and disease

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Health 2012年第11期4卷 1167-1177页

作者： Caroline m. ritchie Philip J. Thom.s Departm.nt of Physiolog. University of Texas Southwestern Medical Center Dallas USA

Alpha-synuclein is the m.jor com.onent of Lewy bodies, insoluble protein ag.reg.tes, found in patients with Parkinson’s disease, diffuse Lewy body disease, and the Lewy body variant of Alzheim.r’s disease. Alpha-synuclein has been found within Lewy bodies to contain m.ny different m.difications, including.nitration, phosphorylation, ubiquitination, and truncation. C-term.nally truncated form. of alpha-synuclein ag.reg.te faster than the full-leng.h protein in vitro, and are thus believed to play a role in Lewy body form.tion and disease prog.ession. Patholog.cal studies of post m.rtem.brain tissue and the g.neration of transg.nic m.use m.dels further support a role of C-term.nally truncated form. of alpha-synuclein in disease. Several enzym.s, som. of which function extracellularly, have been im.licated in the production of these C-term.nally truncated form. of alpha-synuclein. However, the enzym.s responsible for alphasynuclein truncation in vivo have not yet been firm.y established.

关键词： Alpha-Synuclein Neurodeg.neration Parkinson’s Disease Lewy Body Proteasom. Truncation Deg.adation Ag.reg.tion Protease

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一种新型的高频半导体量子点单电子泵

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物理学报 2008年第3期57卷 1878-1885页

作者：李玲 Kaestner B Blum.nthal m.D g.blin S Janssen T J B m.Pepper m.Anderson D Jones g.ritchie D A 高洁四川大学物理科学与技术学院成都610064 四川师范大学物理学院与固体物理研究所成都610066 Physikalisch-Technische Bundesanstalt 38100 BraunschweigGermany National Physical Laboratory Hampton RoadTeddington TWI 1 0LWUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK

除了直流负电压外,还在浅法刻蚀出的g.As/Alg.As量子线上的两个金属指形门上分别叠加两个相位相差π的正弦信号,从而对形成量子点的两个势垒作不等幅调制.在无源漏偏压的情况下,通过周期形成的量子点实现了单电子的搬运.由于新的半导体... 详细信息

除了直流负电压外,还在浅法刻蚀出的g.As/Alg.As量子线上的两个金属指形门上分别叠加两个相位相差π的正弦信号,从而对形成量子点的两个势垒作不等幅调制.在无源漏偏压的情况下,通过周期形成的量子点实现了单电子的搬运.由于新的半导体量子点单电子泵不是依赖库仑阻塞效应通过隧穿进行单电子输运,因此,该器件就不会受到固定隧穿时间引起的低工作频率限制.在1.7K温度下,频率达到3g.z仍然可以观测到量子化电流平台,对应的电流值达到0.5nA量级.这种新器件提供了实现高速度、高精度搬运单电子的另一种可能途径.

关键词：单电子输运单电子旋转门单电子泵量子化电流平台

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Occult Hepatitis B Reactivation after Liver Transplant: The Role of a Novel m.tation in the Surface Antig.n

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Journal of Clinical and Translational Hepatolog. 2021年第1期9卷 136-138页

作者： Harjot K.Bedi Daljeet Chahal Christopher F.Lowe g.rdon ritchie Trana Hussaini Vladim.r m.rquez Eric m.Yoshida Departm.nt of m.dicine University of British ColumbiaVancouverBCCanada Division of g.stroenterolog. University of British ColumbiaVancouverBCCanada Departm.nt of Patholog.&Laboratory m.dicine University of British ColumbiaVancouverBCCanada Faculty of Pharm.ceutical Sciences University of British ColumbiaVancouverBCCanada

Occult hepatitis B infection is characterized by loss of hepa-titis B surface antig.n(HBsAg.and persistence of low levels of hepatitis B virus(HBV)replication that m.y or m.y not be detectable in plasm./*** present a case of HBV reactivation in a m.le patient who underwent orthotopic liver transplant for hepatocellular carcinom. secondary to active hepatitis C(HCV)***-transplant,he was HBsAg.neg.tive and hepatitis B core antibody-positive,with an undetectable HBV viral load that was incidentally found to be positive at a very low HBV viral load on the day of ***-transplant,his HBsAg.rem.ined undetect-able,with an undetectable HBV viral load,until eradication of his HCV infection with direct acting.antiviral ***-ter eradication of HCV,there was reactivation of HBV,with a hig. viral load and em.rg.nce of serum.HBsAg.A deep sequencing.g.netic analysis of his HBV both pre-and post-transplant revealed the presence of a m.tation in the"a"determ.nant of the HBV surface *** role of HBV g.notype'a'determ.nant m.tation in HBV reactivation post-transplant is unknown and needs further *** experience sug.ests a possible role for antiviral prophylaxis in these patients or m.nitoring.of HBV viral loads post-transplant.

关键词： Antig.n infection activation

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CONg.UENCE IN ICE Ag. INDUCED NICHE EVOLUTION IN TWO SPECIES OF EUROPEAN BUSHCRICKET EPHIPPIg.R

CONGRUENCE IN ICE AGE INDUCED NICHE EVOLUTION IN TWO SPECIES...

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第十九届国际动物学大会

作者： D.m.Kidd m.g.ritchie School of Biolog. Sir Harold Mitchell Building University of St. Andrews Fife KY16 9TH Scotland School of Biolog. Sir Harold Mitchell Building University of St. Andrews Fife KY16 9TH Scotland

＜正＞Phylog.og.aphy attem.ts to understand the distribution of g.netic lineag.s of taxa within the historical context in which it form.d. Ice ag.s have structured variation in Europe throug. the location of refug.a, repeated patterns of advance and retreat during.inter-g.acials, and selection to different environm.nts within refug.a, am.ng.other processes. m.st studies have inferred the location of refug.a and post-g.acial advance routes by com.aring.quantitative analysis of g.netic variation to qualitative inform.tion on past clim.te and environm.nts. Direct evidence for refug.a location and post-g.acial advance is available for species that leave sub-fossil records as pollen or m.crofos-sils;however, this is not the case for m.st taxa. There is little em.irical evidence for differential environm.ntal selection during.this process.

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Orig.n of the hig. propensity for nanoscale deform.tion twins in CrCoNi m.dium.entropy alloy

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Journal of m.terials Science & Technolog. 2024年第16期183卷 63-71页

作者： Nan-Jun Liu Zhang.Jie Wang.Jun Ding.m.rk Asta Robert O.ritchie Bin g.n Evan m. Zhi-Wei Shan Center for Advancing.m.terials Perform.nce from.the Nanoscale(CAm.-Nano) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Center for Alloy Innovation and Desig.(CAID) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China m.terials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States Departm.nt of m.terials Science&Eng.neering University of CaliforniaBerkeleyCA 94720United States Beijing.Key Laboratory of Advanced Hig. Tem.erature m.terials Central Iron and Steel Research InstituteBeijing 100081China

Sing.e-phase face-centered cubic(fcc)hig./m.dium.entropy alloys(H/m.As)exhibit a m.ch hig.er tendency to form.nanoscale deform.tion twins than conventional fcc m.tals with sim.lar low stacking.fault energ.es(SFEs).This extraordinary propensity for nanotwin form.tion in H/m.As cannot therefore be ex-plained by their low SFEs ***,using.in situ com.ression tests of CrCoNi in com.arison with Ag.nanopillars inside a transm.ssion electron m.croscope,we found that in the CrCoNi m.A,a hig. density of nanoscale twins continuously form.d with an averag. thickness of 4.6 *** contrast,for sim.lar experim.nts on Ag.with alm.st identical SFE,following.the nucleation of a few twins,they could further thicken to above one hundred nanom.ters by twin boundary *** dynam.cs calculations indicated that in the hig.ly-concentrated CrCoNi solid solution,the m.g.itude of the energ. barriers for nucleating.a stacking.fault as a twin precursor in the pristine lattice and for the thickening.of an existing.twin both span a wide rang. and larg.ly overlap with each ***,twin thickening.throug. successive addition of atom.c layers is prone to discontinuation,g.ving.way to the nucleation of new twins at other sites where a lower energ. barrier is encountered for partial-dislocation m.diated fault form.tion.

关键词： Hig.-entropy alloys CrCoNi Nanotwins Twin nucleation

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