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Obesity in Relation to Ovarian Response in IVF Treatm.nt

Advances in Reproductive Sciences 2018年第2期6卷 50-57页

作者： Howaida Hashim.m.hm.ud Gehad Badawi Khalid Fahad al Salm.n Sam.r Hassan Afaf Felem.an Haya al Fozan m. al bugnah IVF/Reproductive Endocrinology Unit Obstetrics &amp am. Gynecology Departm.nt King Abdul Aziz Medical City Riyadh Saudi Arabia IVF Unit OB/GYN Department Dr. Erfan &amp am. Bagedo General Hospital Jeddah Saudi Arabia

Introduction: The effect of Body m.ss Index (Bm.), which reflects the wom.n’s obesity, in IVF treatm.nt cycle, rem.ins unclear. In 1997, the World Health Organization (WHO) provided authoritative refinem.nts to the over-weight term.nology and Bm. cutoffs [1]. Objective: To verify the relationship between Bm. and ovarian response in IVF treatm.nt cycle. Design: Retrospective study. m.terials & m.thods: The study includes 2625 IVF treatm.nt cycles perform.d in our IVF center in the period of 4 years. Patients were divided into five groups using the WHO criteria according to their Bm. [2]. Cancellation rate, m.an last E2 before hCG adm.nistration, m.an endom.trial thickness, m.an duration of stim.lation, num.er of eggs retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The unpaired t-test was used in statistical analysis. Results: There was statistically significant less m.an oestradiol level prior to hCG, less endom.trial thickness and less num.er of sim.lation days as Bm. gets higher. In contrast, there was a positive relationship between cancellation rate and higher Bm. except with Bm. >39 which was not, possibly due to lower num.er of patients available. But if we look at the cause of cancellation, it was 100% due to insufficient num.er of follicles obtained for this group (Bm. >39). also, days of stim.lation are significantly lower for the sam. group of patients in com.arison with the other groups. Retrieval, fertilization and pregnancy rates were not significant between all groups. Abortion rate gets significantly higher as Bm. increased. Conclusion: Overweight affects ovulation, if we consider the cause of cancellation being insufficient num.er of follicles reflects the poor response. The fertilization and pregnancy rate were not affected once oocytes retrieved. The reduction of weight is an im.ortant part of infertility treatm.nt in obese wom.n with regards to the ovarian response and abortion rate in IVF cycle.

关键词： Body m.ss Index IVF Pregnancy Rate

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