Obesity in Relation to Ovarian Response in IVF Treatment

作     者：Howaida Hashim Mahmoud Gehad Badawi Khalid Fahad Al Salman Samar Hassan Afaf Felemban Haya Al Fozan M. Al Bugnah 

作者机构：IVF/Reproductive Endocrinology Unit Obstetrics & amp Gynecology Department King Abdul Aziz Medical City Riyadh Saudi Arabia IVF Unit OB/GYN Department Dr. Erfan & amp Bagedo General Hospital Jeddah Saudi Arabia 

出 版 物：《Advances in Reproductive Sciences》 (生殖科学（英文）)

年 卷 期：2018年第6卷第2期

页      面：50-57页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Body Mass Index IVF Pregnancy Rate 

摘      要：Introduction: The effect of Body Mass Index (BMI), which reflects the woman’s obesity, in IVF treatment cycle, remains unclear. In 1997, the World Health Organization (WHO) provided authoritative refinements to the over-weight terminology and BMI cutoffs [1]. Objective: To verify the relationship between BMI and ovarian response in IVF treatment cycle. Design: Retrospective study. Materials & Methods: The study includes 2625 IVF treatment cycles performed in our IVF center in the period of 4 years. Patients were divided into five groups using the WHO criteria according to their BMI [2]. Cancellation rate, mean last E2 before hCG administration, mean endometrial thickness, mean duration of stimulation, number of eggs retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The unpaired t-test was used in statistical analysis. Results: There was statistically significant less mean oestradiol level prior to hCG, less endometrial thickness and less number of simulation days as BMI gets higher. In contrast, there was a positive relationship between cancellation rate and higher BMI except with BMI 39 which was not, possibly due to lower number of patients available. But if we look at the cause of cancellation, it was 100% due to insufficient number of follicles obtained for this group (BMI 39). Also, days of stimulation are significantly lower for the same group of patients in comparison with the other groups. Retrieval, fertilization and pregnancy rates were not significant between all groups. Abortion rate gets significantly higher as BMI increased. Conclusion: Overweight affects ovulation, if we consider the cause of cancellation being insufficient number of follicles reflects the poor response. The fertilization and pregnancy rate were not affected once oocytes retrieved. The reduction of weight is an important part of infertility treatment in obese women with regards to the ovarian response and abortion rate in IVF cycle.