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电子能量损失谱及其在纳米多层膜研究中的应用

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真空科学与技术学报 2007年第6期27卷 540-544页

作者：肖晓玲代明江周克崧刘敏 D.G.mcCulloch P.C.T.Ha D.R.mckenzie m.m.m.bilek 广州有色金属研究院材料表面工程研究所广州510651 Applied Physics School of Applied SciencesRMIT University Applied and Plasma Physics School of Physics(A28)University of Sydney

本文介绍了电子能量损失谱的基本原理、能量过滤成像分析及应用电子能量损失谱计算碳同素异构体的电子密度和sp2键结构的含量。同时应用透射电镜(TEm)和电镜配置的能量过滤成像系统(gatan imaging filter),结合电子能量损失谱研究类金刚... 详细信息

本文介绍了电子能量损失谱的基本原理、能量过滤成像分析及应用电子能量损失谱计算碳同素异构体的电子密度和sp2键结构的含量。同时应用透射电镜(TEm)和电镜配置的能量过滤成像系统(gatan imaging filter),结合电子能量损失谱研究类金刚石(a-C/Ta-C)和Al/AlN两种纳米多层膜的形态、结构和膜中各元素的分布。结果显示透射电镜观察配合电子能量损失谱在纳米多层膜表征中将会扮演一个重要角色。

关键词：电子能量损失谱透射电镜纳米多层膜 a-C/Ta-C Al/AlN

Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 64-72页

作者： miao Zhang Ziyu Wang Anyu Zhang Linyang Liu Suzanne m.mithieux marcela m.m.bilek Anthony S.Weiss Charles Perkins Centre The University of SydneySydneyNSW 2006Australia School of Life and Environmental Sciences The University of SydneySydneyNSW 2006Australia Applied and Plasma Physics Laboratory School of PhysicsThe University of SydneySydneyNSW 2006Australia School of Biomedical Engineering The University of SydneySydneyNSW 2006Australia Sydney Nano Institute The University of SydneySydneyNSW 2006Australia

The highly organized extracellular matrix(ECm)of musculoskeletal tissues,encompassing tendons,ligaments and muscles,is structurally anisotropic,hierarchical and *** features collectively contribute to their unique *** studies have investigated the effect of tissue-engineered scaffold anisotropy on cell morphology and organization for musculoskeletal tissue repair and regeneration,but the hierarchical arrangement of ECm and compartmentalization are not typically ***,we present a method for multi-compartmental scaffold design that allows for physical mimicry of the spatial architecture of musculoskeletal tissue in regenerative *** design is based on an ECm-inspired macromolecule ***(PCL)scaffolds were fabricated with aligned fibers by electrospinning and mechanical stretching,and then surface-functionalized with the cell-supporting ECm protein molecule,tropoelastin(TE).TE was attached using two alternative methods that allowed for either physisorption or covalent attachment,where the latter was achieved by plasma ion immersion implantation(PIII).Aligned fibers stimulated cell elongation and improved cell alignment,in contrast to randomly oriented *** coatings bound by physisorption or covalently following 200 s PIII treatment promoted fibroblast *** represents the first cytocompatibility assessment of novel PIII-treated TE-coated PCL *** demonstrate their versatility,these 2D anisotropic PCL scaffolds were assembled into 3D hierarchical constructs with an internally compartmentalized structure to mimic the structure of musculoskeletal tissue.

关键词： tropoelastin PCL musculoskeletal tissue engineering plasma immersion ion implantation electrospinning anisotropy hierarchical

modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg michael B.morris marcela m.m.bilek Anyu Zhang Behnam Akhavan Simon Fleming maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter medical Research Institute(HmRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

老年人的不合理用药与多重用药计算机工具虽可辅助制定处方,但合理开具处方的关键是医、患、社会的多方合作

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英国医学杂志中文版 2020年第11期23卷 627-628页

作者： Doron Garfinkel Aaron bilek 蒋子涵(译) Center for Appropriate medication Use Sheba Medical CenterTel HashomerIsrael Geriatric division Tel Aviv Sourasky Medical CenterIsrael 中国医学科学院北京协和医院消化科

虽然不合理用药和多重用药现象十分普遍,但并未得到社会关注。此外,尽管有无数人承受着该现象带来的负面影响,尤其是老年人首当其冲,但这一问题仍没有通行且有效的解决方法。

关键词：不合理用药计算机工具多方合作老年人负面影响处方

Effect of TiO_2 and ZrO_2 reinforcements on properties of Al_2O_3 coatings fabricated by thermal flame spraying

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Transactions of Nonferrous metals Society of China 2016年第5期26卷 1345-1352页

作者： Rassim YOUNES mohand Amokrane BRADAI Abdelhamid SADEDDINE Youcef mOUADJI Ali bilek Abderrahim BENABBAS Laboratory of mechanics Materials and Energetic Faculty of Technology University of Bejaia Laboratory of mechanics Faculty of Engineering Sciences Campus Chaabet-ErsasUniversity of Constantine mechanical Laboratory of Structure and Energetic Mechanical Engineering DepartmentUniversity of Tizi-Ouzou Laboratory Processes for materials Energy Water and Environment Faculty of Science and TechnologyUniversity of Bouira

The alumina composite coatings reinforced with 25% ZrO2 （denoted as AZ-25） and 3% TiO2 （denoted as AT-3） were deposited on low carbon steel using a thermal flame spraying. The microstructure, phase composition, microhardness and tribological properties of the coatings were investigated. The XRD results of the coatings reinforced by TiO2 （AT-3） revealed the presence of α-Al2O3 phase as matrix and new metastable phases of α-Al2O3 and α-Al2O3. However, the coatings reinforced by ZrO2 （AZ-25） consist of α-Al2O3 as matrix, q-ZrO2 and m-ZrO2. In most studied conditions, the AT-3 coating displays a better tribological performance, i.e., lower coefficient of frictions and wear rates, than the AZ-25 coating. It was also found that the microhardness of the coatings was decreased with the reinforcement of ZrO2 and increased with TiO2.

关键词： thermal spraying coatings reinforcements friction coefficient wear rate

2004年12月26日苏门答腊—安达曼特大地震

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世界地震译丛 2005年第6期36卷 5-14页

作者： T.LAY H.KANAmORI C.J.AmmON m.NETTLES S.N.WARD R.C.ASTER S.L.BECK S.L.bilek m.R.BRUDZINSKI R.BUTLER H.R.DESHON G.EKSTRm K.SATAKE S.SIPKIN 石玉涛中国地震局地震预测研究所

发生在2004年12月26日（mw=9．1～9．3级）和2005年3月28日（mw=8．6级）的地震是过去40年中最大的两次地震，它们在欧亚大陆板块的东南部和印度-澳大利亚板块之间裂开一条长达1600km的断层。其中第一次地震引发的海啸吞噬了28．3万多... 详细信息

发生在2004年12月26日（mw=9．1～9．3级）和2005年3月28日（mw=8．6级）的地震是过去40年中最大的两次地震，它们在欧亚大陆板块的东南部和印度-澳大利亚板块之间裂开一条长达1600km的断层。其中第一次地震引发的海啸吞噬了28．3万多人的性命。苏门答腊岛班达亚奇附近的断层滑动了15m，但是在其北边，沿着尼科巴群岛和安达曼群岛，断层快速滑动的距离则小了很多。海啸和测地学的观测表明，在50min或更长的时间范围内北部的断层发生了更多的缓慢滑动。

关键词：苏门答腊大地震断层滑动大陆板块澳大利亚时间范围东南部测地学海啸群岛