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magnetic Configuration Effects on Fast Ion Losses Induced by Fast Ion Driven Toroidal Alfvén Eigenmodes in the Large Helical Device

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Plasma Science and Technology 2012年第4期14卷 269-272页

作者： K.OGAWA m.isobe K.TOI F.WATANABE D.A.SPONG A.SHImIZU m.OSAKABE D.S.DARROW S.OHDACHI S.SAKAKIBARA LHD Experiment Group Department of Energy Science and Engineering Nagoya University National Institute for Fusion Science Graduate School of Energy Science Kyoto University Oak Ridge National Laboratory Oak Ridge Princeton Plasma Physics Laboratory Princeton University

Beam-ion losses induced by fast-ion-driven toroidal Alfven eigenmodes （TAE） were measured with a scintillator-based lost fast-ion probe （SLIP） in the large helical device （LHD）. The SLIP gave simultaneously the energy E and the pitch angle X=arccos（v///v） distribution of the lost fast ions. The loss fluxes were investigated for three typical magnetic configurations of Rax-vac=3.60 m, 3.75 m. and 3.90 m, where Rax-vac is the magnetic axis position of the vacuum field. Dominant losses induced by TAEs in these three configurations were observed in the E/X regions of 50-190 keV/40°, 40-170 keV/25°, and 30-190 keV/30°, respectively. Lost-ion fluxes induced by TAEs depend clearly on the amplitude of TAE magnetic fluctuations, Rax-vac and the toroidal field strength Bt. The increment of the loss fluxes has the dependence of （bTAE/Bt）s. The power s increases from s = 1 to 3 with the increase of the magnetic axis position in finite beta plasmas.

关键词： toroidal Alfven eigenmode fast ion loss the large helical device

Contribution of the Large Helical Device Plasmas to Alfvén Eigenmode Physics in Toroidal Plasmas

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Plasma Science and Technology 2009年第4期11卷 377-380页

作者： K. TOI m. isobe m. OSAKABE F. WATANABE K. OGAWA T. TOKUZAWA A. SHImIZU T. IDO K. IDA, T. ITO S. mORITA K. NAGAOKA K. NARIHARA m. NISHIURA S. OHDACHI S. SAKAKIBARA K. TANAKA LHD Experiment Group National Institute for Fusion Science Toki 509-5292 Japan Department of Energy Engineering and Science Nagoya University Nagoya 464-8601 Japan

In the large helical device （LHD） having three dimensional configuration, Alfven eigenmodes （AEs） destabilized by energetic ions are widely investigated using neutral beam heated plasmas with monotonic and non-monotonic rotational transform （l/2π） profiles. In a plasma with monotonic l/2π-profile, core-localized toroidicity-induced Alfven eigenmode （TAE） as well as global one are often observed. With the increase in the averaged toroidal beta value, defined as the ratio of total plasma pressure to toroidal magnetic pressure, core-localized TAE with low toroidal mode number becomes global. In a relatively high beta plasma with monotonic l/2π-profile, two TAEs with different toroidal mode number often interact nonlinearly and generate another modes through three wave coupling. In a plasma with non-monotonic l/2π-profile generated by intense counter neutral beam current drive, reversed shear Alfven eigenmode （RSAE） and geodesic acoustic mode （CAm） excited by energetic ions were observed for the first time in a helical plasma. Nonlinear coupling was also observed between RSAE and GAm.

关键词： alpha particles Alfven eigenmodes geodesic acoustic mode helical/stellarator

Observation of mHD Instabilities Driven by Energetic Electrons in the Large Helical Device

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Plasma Science and Technology 2015年第4期17卷 276-279页

作者： mitsutaka isobe Kunihiro OGAWA Akihiro SHImIZU masaki OSAKABE Shin KUBO K.TOI the LHD Experiment Group National Institute for Fusion Science Toki 509-5292Japan Department of Fusion Science The Graduate University for Advanced Studies(SOKENDAI)Toki 509-5292Japan Department of Energy Engineering and Science Nagoya UniversityNagoya 464-8463Japan

Coherent magnetic fluctuations in an acoustic range of frequency have been regularly observed in low-density（n_e〈0.2×10^（19）m^（-3））plasmas with strong second harmonic electron cyclotron resonance heating（ECRH）on the Large Helical *** X-ray measurements indicated that energetic electrons are generated in these ECRH *** magnetic fluctuations are suppressed in higher density discharges where energetic electrons are not *** ECRH power modulation experiment indicated that the observed magnetohydrodynamic（mHD）mode has an acoustic nature rather than an Alfvenic nature.

关键词： LHD ECRH energetic electron mHD instability

Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells

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分子细胞生物学报:英文版 2011年第2期3卷 91-98页

作者： Zhao Cheng Sachiko Ito Naomi Nishio Hengyi Xiao Rong Zhang Haruhiko Suzuki Yayoi Okawa Toyoaki murohara Ken-ichi isobe Department of Immunology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan Laboratory for Geriatrics State Key Laboratory of BiotherapySichuan UniversityChengdu 610041China Department of Functioning Activation National Institute for Longevity SciencesNational Center for Geriatrics GerontologyAichi 463-0003Japan Department of Cardiology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan

If induced pluripotent stem(iPS)cells are to be used to treat damaged tissues or repair organs in elderly patients,it will be necessary to establish iPS cells from their *** determine the feasibility of using this technology with elderly patients,we asked if it was indeed possible to establish iPS cells from the bone marrow(Bm)of aged *** cells from aged C57BL/6 mice carrying the green fluorescence protein(GFP)gene were cultured with granulocyte macrophage-colony stimulating factor(Gm-CSF)for 4 *** factors(Oct3/4,Sox2,Klf4 and c-myc)were introduced into the Bm-derived myeloid(Bm-m)*** efficiency of generating iPS cells from aged Bm cultured in Gm-CSF was ***,we succeeded in obtaining Bm-m-iPS cells from aged C57BL/6 mice,which carried *** Bm-m-iPS cells expressed SSEA-1 and Pou5f1 and were positive for alkaline phosphatase *** iPS cells did make teratoma with three germ layers following injection into syngeneic C57BL/6 mice,and can be differentiated to three germ layers in *** co-culturing with OP9,the Bm-m-iPS cells can be differentiated to the myeloid *** differentiated Bm-m-iPS cells proliferated well in the presence of Gm-CSF,and lost expression of Nanog and Pou5f1,at least in part,due to methylation of their *** the contrary,Tnf and Il1b gene expression was upregulated and their promoters were hypomethylated.

关键词： induced pluripotent stem cells aged mouse bone marrow myeloid cells gene expression methylation ChIP assay

Study of first orbit losses of 1 meV tritons using the Lorentz orbit code in the LHD

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Plasma Science and Technology 2019年第2期21卷 21-25页

作者： Kunihiro OGAWA mitsutaka isobe Takeo NISHITANI Sadayoshi mURAKAmI Ryosuke SEKI Hideo NUGA Neng PU masaki OSAKABE LHD Experiment Group National Institute for Fusion Science National Institutes of Natural Sciences SOKENDAI (The Graduate University for Advanced Studies) Kyoto University Kyoto-city

Shot-integrated measurement of the triton burnup ratio has been performed in the Large Helical Device. It was reported that the triton burnup ratio, defined as total DT neutron yield divided by total DD neutron yield, increases significantly in inward shifted configurations. To understand the magnetic configuration dependence of the triton burnup ratio, the first orbit loss fraction of 1 meV tritons is evaluated by means of the Lorentz orbit code for various magnetic configurations. The first orbit loss of 1 meV tritons is seen at t of less than 10-5 s and loss points of the triton are concentrated on the side of the helical coil case where the magnetic field is relatively weak. The significant decrease of the first orbit loss fraction by 15% is obtained with the inward shift of the magnetic axis position from 3.90 to 3.55 m. It is found that the decrease of first orbit loss is due to the reduction of the first orbit loss of transition and helically trapped tritons.

关键词： the Large Helical Device tritons energetic ion first orbit loss Lorentz orbit code

Immunological aspects of age-related diseases

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World Journal of Biological Chemistry 2017年第2期8卷 129-137页

作者： Ken-ichi isobe Naomi Nishio Tadao Hasegawa Department of Food Science and Nutrition Nagoya Woman’s University Department of Bacteriology Nagoya City University Graduate School of Medical Sciences

The proportion of elderly people rises in the developed countries. The increased susceptibility of the elderly to infectious diseases is caused by immune dysfunction, especially T cell functional decline. Age-related hematopoietic stem cells deviate from lymphoid lineage to myeloid lineage. Thymus shrinks early in life, which is followed by the decline of na?ve T cells. T-cell receptor repertoire diversity declines by aging, which is caused by cytomegalovirus-driven T cell clonal expansion. Functional decline of B cell induces antibody affinity declines by aging. many effector functions including phagocytosis of myeloid cells are down regulated by aging. The studies of aging of myeloid cells have some controversial results. Although m1 macrophages have been shown to be replaced by antiinflammatory(m2) macrophages by advanced age, many human studies showed that pro-inflammatory cytokines are elevated in older human. To solve this discrepancy here we divide age-related pathological changes into two categories. One is an aging of immune cell itself. Second is involvement of immune cells to age-related pathological changes. Cellular senescence and damaged cells in aged tissue recruit pro-inflammatory m1 macrophages, which produce pro-inflammatory cytokines and proceed to agerelated diseases. Underlying biochemical and metabolic studies will open nutritional treatment.

关键词： Elderly people Damage associated molecular patterns Immune dysfunction Lymphoid lineage myeloid lineage Shrinkage of thymus Cytomegalovirus Age-related tissue damage Cellular senescence Pro-inflammatory

日本江户时期诸藩及个人文库中国烟粉小说的收藏情况

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上海师范大学学报（哲学社会科学版） 2010年第2期39卷 67-76页

作者：矶部彰东北大学亚洲研究中心

日本江户时代,德山藩、佐伯藩、秋田藩烟粉小说的收藏,与诸藩和个人文库相比呈现着特殊的状况。在德山、佐伯两藩,不仅收藏了中国烟粉小说,而且还有烟粉色彩很浓的中国戏曲,从中显示了以反映毛利元次和毛利高标个人意识为特征的搜集书... 详细信息

日本江户时代,德山藩、佐伯藩、秋田藩烟粉小说的收藏,与诸藩和个人文库相比呈现着特殊的状况。在德山、佐伯两藩,不仅收藏了中国烟粉小说,而且还有烟粉色彩很浓的中国戏曲,从中显示了以反映毛利元次和毛利高标个人意识为特征的搜集书籍的方针。江户中期白话小说类的搜集情况,似乎与唐话学的流行存在着某种关联。作者以诸藩和个人文库所藏目录为线索,对清代出版较多的以烟粉小说为主的中国白话小说,以及多以爱情内容为中心的戏曲类作品的收藏情况进行了调查,希望能为江户时代日本人与烟粉小说,进而为与中国小说、戏曲关系的研究提供一些资料。

关键词：烟粉小说江户时期诸藩大名家儒者汉籍分布

母亲孕期膳食维生素A摄入量与先天性膈膜疝的发生呈负相关:日本环境与儿童研究

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母亲孕期膳食维生素A摄入量与先天性膈膜疝的发生呈负相关:日本环...

Calcitriol-induced hypercalcemia in a patient with granulomatous mycosis fungoides and end-stage renal disease

作者： michikawa T Yamazaki S Sekiyama m Kuroda T Nakayama SF isobe T Kobayashi Y Iwai-Shimada m Suda E Kawamoto T Nitta H Japan Environment and Children’s Study Group

目前对先天性膈膜疝(congenital diaphragmatic hernia,CDH)的发病机理还很不了解。但是,维生素A似乎在膈膜的发育过程具有重要作用。以往的病例对照研究报道,母亲膳食维生素A摄入量与CDH的发生风险密呈负相关。但是,据我们所知,还没有... 详细信息

目前对先天性膈膜疝(congenital diaphragmatic hernia,CDH)的发病机理还很不了解。但是,维生素A似乎在膈膜的发育过程具有重要作用。以往的病例对照研究报道,母亲膳食维生素A摄入量与CDH的发生风险密呈负相关。但是,据我们所知,还没有任何前瞻性研究证据支持该观点。本研究的目的是检验母亲膳食维生素A摄入量是否与CDH发生存在关联。作者分析了来自日本全国出生队列的基线数据,该出生队列研究(2011-2014)包括了89658例生产单胎活婴的母亲(生产时平均年龄为31.2岁)。

关键词：摄入量维生素孕期膳食先天性

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World Journal of Nephrology 2013年第2期2卷 44-48页

作者： Takamasa Iwakura Naro Ohashi Naoko Tsuji Yoshitaka Naito Shinsuke isobe masafumi Ono Tomoyuki Fujikura Takayuki Tsuji Yukitoshi Sakao Hideo Yasuda Akihiko Kato Toshiharu Fujiyama Yoshiki Tokura Yoshihide Fujigaki First Department of medicine Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Blood Purification Unit Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Department of Dermatology Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan

An 86-year-old man, diagnosed as having mycosis fungoides in may 2008 and treated with repeated radiation therapy, was admitted to our hospital for initiation of hemodialysis due to end-stage renal disease(ESRD) in April 2012. On admission, his corrected serum calcium level was 9.3 mg/d L, and his intact parathyroid hormone level was 121.9 pg/mL(normal range 13.9-78.5pg/mL), indicating secondary hyperparathyroidism due to ESRD. After starting hemodialysis, urinary volume diminished rapidly. The serum calcium level increased(12.7 mg/dL), and the intact parathyroid hormone level was suppressed(m L), while the 1,25-dihy-droxyvitamin D3(calcitriol) level increased(114 pg/mL, normal range: 20.0-60.0 pg/m L) in June 2012. The possibilities of sarcoidosis and tuberculosis were ruled out. Skin biopsies from tumorous lesions revealed a diagnosis of granulomatous mycosis fungoides. The serum soluble interleukin-2 receptor levels and the degrees of skin lesions went in parallel with the increased serum calcium and calcitriol levels. Therefore, the patient was diagnosed as having calcitriol-induced hypercalcemia possibly associated with granulomatous mycosis fungoides. Granulomatous mycosis fungoides is rare, and its association with calcitriol-induced hypercalcemia has not been reported. Careful attention to calcium metabolism is needed in patients with granulomatous mycosis fungoides, especially in patients with ESRD.

关键词： Calcitriol-induced hypercalcemia Granulomatous mycosis