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Valence Stabilization of Fe(II) Ions during Extended Gamma Irradiation of Their Aqueous Acidic Solutions Containing Phenol, Acetone, 4-Ethylpyridine or Hydrazine Hydrate

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World Journal of Nuclear Science and Technology 2015年第2期5卷 88-101页

作者： m. F. Barakat m. m. abdel hamid Nuclear and Radiological Control Authority Cairo Egypt Hot Labs Center Atomic Energy Authority Cairo Egypt

Valence stabilization of polyvalent ions in acidic solutions during gamma irradiation is an important issue in nuclear aqueous chemical technology. Radiolysis and self irradiation problems encountered during chemical reprocessing of nuclear fuel or during chemical separation of transuranium elements or fission products are extremely important. Consequently studies on valence stabilization of polyvalent ions in strong gamma irradiation fields are very useful. In our previous publications, the valence stabilization of Fe(II) ions in acidic solutions during continuous gamma irradiation was achieved by using an inorganic compound;such as sodium sulfite, or some organic additives such as aliphatic alcohols, aldehyds or acids prior to irradiation. It was found that the efficiency of valence stabilization depends on the amount and chemical structure of the added compounds. In the present work, valence stabilization of divalent iron during gamma irradiation was studied in presence of some organic additives, belonging to some other classes of organic compounds such as Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (heterocyclic amino compound) and Hydrazine hydrate (aliphatic amino compound) to complement our previous studies. The results showed that valence stabilization of Fe(II) in presence of these compounds depends also on the amount and chemical structure of the additive used. Some interaction mechanisms have been proposed.

关键词： Water Radiolysis Valence Stabilization Extended Gamma Irradiation Competitive Reactions Polyvalent Ions Protective Effects

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华盛顿免疫学和过敏反应性疾病咨询手册

Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma

丛书名：华盛顿医学咨询系列丛书

2005年

作者： Barbars Capes Jost Khaled m.abdel-hamid

本书介绍了过敏病人的诊疗方法、过敏性鼻炎和鼻窦炎、哮喘、过敏性眼病、昆虫过敏症、肥大细胞增多症、原发性免疫缺陷病等。

ISBN: (纸本)7543318350

本书介绍了过敏病人的诊疗方法、过敏性鼻炎和鼻窦炎、哮喘、过敏性眼病、昆虫过敏症、肥大细胞增多症、原发性免疫缺陷病等。

关键词：免疫性疾病变态反应病

来源：汇雅图书（南通市图书馆... 评论

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Hepatoma Research 2015年第1期1卷 147-154页

作者： Hanaa A.Hassan Hanaa m.Serag Nabil m.abdel-hamid mahmoud m.Amr Department of Zoology Division of PhysiologyFaculty of ScienceMansoura UniversityMansoura 35516Egypt Biochemistry Department Pharmacy CollegeKafr El-Sheikh UniversityKafr El-Sheikh 33516Egypt

Aim:Hepatocellular carcinoma(HCC)is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver *** objective of this study was to elucidate the synergistic effect and the role of chicory extract[inulin(IN)]as a chemo-sensitizer for cisplatin(CIS)treatment of ***:Five groups of rats were treated for 4 *** groups consisted of the control group,a group receiving thioacetamide(TAA)(200 mg/kg b.w)in drinking water,a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)in addition to TAA for 4 months,a group receiving oral doses of IN(10 mg/kg b.w)in addition to TAA for 4 months,and a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)and IN(10 mg/kg b.w)plus TAA for 4 ***:The current data exhibited increment of serum and liver enzyme(alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,creatine kinase,and lactate dehydrogenase)activity,serum lipid profi le levels(total lipids,total cholesterol,triglycerides,low-density lipoprotein,and very low-density lipoprotein),and a signifi cant increase inα-fetoprotein and bilirubin,accompanied with reduced total serum protein and albumin levels in a HCC rat ***,numerous alterations were detected in hepatic tissues of HCC rats,such as lymphocytic cell infi ltration,damage of hepatocytes,dilated congested central vein with degenerated endothelial cells,and congested blood sinusoids in addition to masson’s trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi *** of HCC rats with CIS or IN improved such deleterious effects,where IN is more effective than CIS,and the best effect can be observed in rats that received both CIS and ***:It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model.

关键词： Chicory cisplatin hepatocellular carcinoma inulin

A Novel Application in Green Chemical Processing Using Reject Brines and Carbon Dioxide as Raw materials

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Engineering（科研） 2013年第1期5卷 154-156页

作者： Hussein abdel-Aal K. m. Zohdy maha abdelkreem S. m.-S. abdel-hamid m. Bassyouni 不详

In this paper, the concept of “green processing” will be applied, while explaining the role of sustainable development strategy with respect to the environmental issue. Two parameters are considered in the study by utilizing carbon dioxide and reject brine from desalination plants as raw materials to produce valuable chemical products and partially desalinated water.

关键词： Desalination Brine Green Processing

The Increased Frequency of Carbapenem Resistant Non Fermenting Gram Negative Pathogens as Causes of Health Care Associated Infections in Adult Cancer Patients

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Journal of Cancer Therapy 2015年第10期6卷 881-888页

作者： Hadir A. El-mahallawy Rasha m. abdel hamid Safaa Shawky Hassan Samah Radwan magdy Saber Clinical Pathology Department National Cancer Institute Cairo University Giza Egypt medical Oncology Department National Cancer Institute Cairo University Giza Egypt

Background and Aim: multi drug resistant Non fermenting gram negative bacilli (NFGNB) have emerged as a major cause of health-care associated infections especially in immunocompromised hosts. The aim of the study was to investigate the prevalence of NFGNB as a cause of health-care associated infections (HAI) in cancer patients and determine their resistance pattern. Patients and methods: During the study period, 158 NFGNB isolates were collected. microscan Walk Away 9 was used for identification and testing for the metallo-β-lactamases (mBLs) was done by Imipenem-EDTA combined disk synergy test (CDST-IPm). Results: NFGNB represented 29.0% of infections caused by gram negative organisms. Carbapenem resistance, the multi-drug resistant (mDR) phenotype, and mBL production were documented in 70%, 63%, and 59% of NFGNB isolates, respectively. mDR-NFGNB rates were significantly higher among hospitalized patients, medical department and those with longer duration of hospital stay (p = 0.034, 0.026, 0.019;respectively) than non mDR-NFGNB. Conclusion: A high level of carbapenem and multi-drug resistance were detected among the non-fermenter pathogens isolated from hospitalized cases and were more frequently encountered in high risk adult cancer patients requiring longer duration of hospitalization. The mDR-NFGNB are constituting important causes of health-care associated infections in cancer patients.

关键词： multi Drug Resistant Organisms (mDRO) Non-Fermenting Gram Negative Bacilli (NF-GNB) metallo-β-Lactamases (mBL) Surgical Site Infections (SSI)

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

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World Journal of Gastroenterology 2007年第12期13卷 1828-1832页

作者： mS El-Raziky m El-Hawary G Esmat Am Abouzied N El-Koofy N mohsen S mansour A Shaheen m abdel hamid H El-Karaksy Departments of Pediatrics Cairo University Cairo Egypt Departments of Tropical medicine Cairo University Cairo Egypt Tropical medicine Research Institute Cairo Egypt

AIm: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. mETHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver ***: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children.

关键词： Hepatitis C virus Child Egypt Prevalence Transfusion Risk factor

Impact of past HBV exposure on virological response to combined interferon ribavirin therapy in patients with chronic HCV genotype 4

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Open Journal of Internal medicine 2011年第2期1卷 38-43页

作者： m. Said m. S. El-Raziky m. abdel-hamid Y. Saad m. Hashem S. Zakaria m. K. mohamed G. Esmat 不详

Aim: is to investigate if past exposure to HBV in chronic HCV infection promotes the progression of liver disease and influences Interferon (INF) response or not. methods: 185 patients with chronic HCV were recruited and randomized into 2 groups, group I was treated with PEG-IFN alfa-2b plus ribavirin and group II with 3 mU/TIW IFN alfa-2b plus ribavirin. All patients had HBsAg negative & patients had HBc Ab positive tested for HBsAb. Patients with HBc Ab (n = 37) were tested for serum HBV DNA. Pretreatment liver biopsy and Immunohistochemistry was performed for detection of HBsAg and HBcAg using monoclonal antibodies. Demographic and laboratory data were collected. Results: 70/185 (38%) patients had Anti-HBc, 37 (20%) had isolated anti-HBc and none of the 37 subjects with isolated anti-HBc had serum HBV DNA. Sustained Viral Response (SVR) was achieved in 32/70 (46%) and 46/115 (40%) in anti-HBc seropositive and seronegative patients respectively, in conventional IFN group SVR was 37% and 39% in past HBV exposed patients and unexposed respectively, in PEG IFN group SVR was 59% and 41% in past HBV exposed patients and unexposed respectively. Among anti-HBc and anti-HBs seropositive patients SVR was 10/12 [83%] and 4/21 [19%] p = 0.004 in PEG and conventional IFN respectively. marked fibrosis was diagnosed in 20% past HBV exposed patients versus 10% in unexposed patients (p = 0.01). Conclusion: past HBV exposure promotes the progression of liver disease but has no effect on the SVR to antiviral therapy in chronic HCV genotype 4 patients.

关键词： HCV Genotype 4 Past HBV Exposure Response To Interferon Therapy

厌氧真菌阿魏酸酯酶基因表达及其生物学功能研究

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厌氧真菌阿魏酸酯酶基因表达及其生物学功能研究

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

第十二届中国酶工程学术研讨会

作者：施其成 Ahmed m.abdel-hamid 李袁飞成艳芬 Isaac Cann 朱伟云国家动物消化道营养国际联合研究中心江苏省消化道营养与动物健康重点实验室南京农业大学消化道微生物研究室

本研究旨在表达纯化厌氧真菌的一种阿魏酸酯酶,并分析其相关特性和功能,为实现其在生产中应用提供理论依据。试验利用基因组学技术获取了能够在大肠杆菌（DE3）中高效表达的阿魏酸酯酶基因序列,将其导入表达质粒并在宿主菌株内表达后,... 详细信息

本研究旨在表达纯化厌氧真菌的一种阿魏酸酯酶,并分析其相关特性和功能,为实现其在生产中应用提供理论依据。试验利用基因组学技术获取了能够在大肠杆菌（DE3）中高效表达的阿魏酸酯酶基因序列,将其导入表达质粒并在宿主菌株内表达后,通过亲和层析、离子交换层析及凝胶过滤法得到纯化的重组酶蛋白。在此基础上,通过定点突变技术,对阿魏酸酯酶基因序列中编码酯酶及糖苷水解酶的功能区分别做定点突变,并获取相应的纯化酶蛋白,比较分析几种酶的基本特性及其对不同底物的降解能力。本研究阿魏酸酯酶的基因序列为1878bp,其编码的酶蛋白包含625个氨基酸,理论等电点为5.93,不稳定系数是15.36,为稳定性蛋白。该酶催化底物的最适温度及pH值分别为37°C和7.5,野生型阿魏酸酯酶（WT）、酯酶区突变酶（Tm1）及糖苷水解酶区突变酶（Tm2）的分子量分别为67.80KDa、67.78KDa和67.74KDa。多糖类底物降解结果显示,Tm1对多糖类底物的降解能力显著高于酶WT和酶Tm2（P＜0.05）,Tm2几乎丧失了对多糖类底物的降解能力。酯类物质及阿魏酰基低聚糖的降解结果显示,WT的降解能力均显著高于酶Tm1和Tm2（P＜0.05）;Tm1和Tm2都表现出极低的酯酶活性,且两者间差异不显著（P＞0.05）。综上,本研究成功地表达纯化出了厌氧真菌阿魏酸酯酶及其突变酶。通过定点突变发现,野生型阿魏酸酯酶中糖苷水解酶功能区的失活使得酶的多糖降解能力几乎丧失,但酯酶功能区的失活会显著增强酶对多糖类底物的降解,而两种突变酶在降解含酯键的底物上都表现出极低的活性。由此推测,在降解多糖类底物上,该酶的酯酶功能区会抑制糖苷水解酶功能区的活性。但在降解含酯键的底物上,这两个功能区表现出强烈的互作效应。

关键词：厌氧真菌阿魏酸酯酶定点突变酶生物学功能

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha J.Holdsworth Alistair J.Gunn Laura Bennet hamid Abbasi mātai medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia