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Inhibition of Rac1 activity in the hippocampus impairs forgetting of contextual fear memory

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Inhibition of Rac1 activity in the hippocampus impairs forge...

Synthesis and Study of Two-Photon Induced Fluorescence of Novel Dyes

中国神经科学学会第十届全国学术会议

作者： lz jiang RR Mao QX Zhou YX Yang J Cao YQ Ding LJ Li L Xu Mental Health Institute The 2nd Xiangya Hospitaland Key Lab of Psychiatry and Mental Health of Hunan ProvinceCentral South University Key Lab of Animal Models and Human Disease Mechanisms Kunming Institute of Zoologythe Chinese Academy of Sciences

Posttraumatic stress disorder（PTSD） is marked by a hypermnesia of the *** of GTPase Rac is recently suggested to impair forgetting of initially acquired memory in *** we examined whether inhibition of Racl activity in the rat hippocampus could contribute to a hypermnesia of contextual *** found that spaced but not massed training of contextual fear conditioning caused inhibition of Racl activity and a heightened contextual *** marked contrast,massed but not spaced extinction training immediately after retrieval caused robust Racl activity and more extinction of the contextual ***,the unchanged Racl activity by massed training and robust Racl activity by massed extinction traimng were botb inhibited with the intrahippocampal injection of the Racl inhibitor NSC23766,and resulted in both heightened and less extinction of the contextual ***,we suggest that inhibition of Racl activity in the hippocampus impairs forgetting of contextual fear memory,and thereby may lead to a hypermnesia of the pathological fear in PTSD.

关键词： posttraumatic stress disorder hippocampus GTPase Racl forgetting contextual fear memory

来源： cnki会议评论

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Chinese Chemical Letters 1999年第12期10卷 0-0,0-0页

作者： Wu, lz Tang, XJ jiang, MH Tung, CH Chinese Acad Sci Inst Chem Ctr Mol Sci Beijing 100080 Peoples R China Chinese Acad Sci Inst Photog Chem Beijing 100101 Peoples R China Shandong Univ Inst Crystal Mat Jinan 250100 Peoples R China

The synthesis and upconverted fluorescent properties of three novel organic compoundswith the structure: donor/bridge/acceptor are reported. The dyes show strong upconvertedfluorescence.

关键词： Two-photon upconveFted fluorescence synthesis of new dyes.Recived##8 22 July 1999

Effect of carbon addition on the microstructure and mechanical properties of CoCrFeNi high entropy alloy

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Science China(Technological Sciences) 2018年第1期61卷 117-123页

作者： HUANG TianDang jiang Li ZHANG ChangLiang jiang Hui LU YiPing LI TingJu Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University ofTechnologv Dalian 116024 China School of Mechanical Engineering. Dalian University of Technology Dalian 116024 China

The effects of C element on the microstructure and properties of CoCrFeNiC,. high entropy alloys （x denoted the atomic fraction of C element at 0, 0.05, 0.1, 0.2, 0.3, and 0.5） were investigated. The equal molar CoCrFeNi alloy with FCC structure exhibits high ductility but weak strength. With the addition of C element, both the hardness and strength of the CoCrFeNiCx high entropy alloys increase as well as the wear resistance. The solution strengthening and the lbrmation of hard carbide phase are the main thctor for the improved strength, hardness and wear resistance of CoCrFeNiC~ high entropy alloys.

关键词： high entropy alloys carbon mechanical properties wear resistance

Effect of Niobium on Microstructure and Properties of the CoCrFeNb_xNi High Entropy Alloys

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Journal of Materials Science & Technology 2017年第7期33卷 712-717页

作者： Hui jiang Li jiang Dongxu Qiao Yiping Lu Tongmin Wang Zhiqiang Cao Tingju Li Key Laboratory of Solidification Control and Digital Preparation Technology （Liaoning Province） School of Materials Science and Engineering Dalian University of Technology Dalian 116024. China

A series of CoCrFeNb_xNi（x values in molar ratio, x = 0, 0.25, 0.45, 0.5, 0.75, 1.0 and 1.2） high entropy alloys（HEAs） was prepared to investigate the alloying effect of Nb on the microstructures and mechanical properties. The results indicate that the prepared CoCrFeNb_xNi（x 〉 0） HEAs consist of a simple FCC solid solution phase and a Laves phase. The microstructures of the alloys change from an initial single-phase FCC solid solution structure（x = 0） to a hypoeutectic microstructure（x = 0.25）, then to a full eutectic microstructure（x = 0.45） and finally to a hypereutectic microstructure（0.5 〈 x 〈 1.2）. The compressive test results show that the Nb0.45（x = 0.45） alloy with a full eutectic microstructure possesses the highest compressive fracture strength of 2558 MPa and a fracture strain of 27.9%. The CoCrFeNi alloy exhibits an excellent compressive ductility, which can reach 50% height reduction without fracture. The Nb0.25 alloy with a hypoeutectic structure exhibits a larger plastic strain of 34.8%. With the increase of Nb content, increased hard/brittle Laves phase leads to a decrease of the plasticity and increases of the Vickers hardness and the wear resistance. The wear mass loss, width and depth of wear scar of the Nb1.2（x = 1.2） alloy with a hypereutectic structure are the lowest among all alloy systems, indicating that the wear resistance of the Nb1.2 alloy is the best one.

关键词： Alloy design Microstructure Mechanical properties Wear resistance

Gas Film Disturbance Characteristics Analysis of High-Speed and High-Pressure Dry Gas Seal

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1226-1233页

作者： CHEN Yuan jiang Jinbo PENG Xudong Engineering Research Center of Process Equipment and lts Re-manufacturing of Ministry of Education Zhejiang University of Technology Hangzhou 310000 China

The dry gas seal（DGS） has been widely used in high parameters centrifugal compressor, but the intense vibrations of shafting, especially in high-speed condition, usually result in DGS＇s failure. So the DGS＇s ability of resisting outside interference has become a determining factor of the further development of centrifugal compressor. However, the systematic researches of which about gas film disturbance characteristics of high parameters DGS are very little. In order to study gas film disturbance characteristics of high-speed and high-pressure spiral groove dry gas seal（S-DGS） with a flexibly mounted stator, rotor axial runout and misalignment are taken into consideration, and the finite difference method and analytical method are used to analyze the influence of gas film thickness disturbance on sealing performance parameters, what＇s more, the effects of many key factors on gas film thickness disturbance are systematically investigated. The results show that, when sealed pressure is 10.1MPa and seal face average linear velocity is 107.3 m/s, gas film thickness disturbance has a significant effect on leakage rate, but has relatively litter effect on open force; Excessively large excitation amplitude or excessively high excitation frequency can lead to severe gas film thickness disturbance; And it is beneficial to assure a smaller gas film thickness disturbance when the stator material density is between 3.1 g/cm3 to 8.4 g/cm3; Ensuring sealing performance while minimizing support axial stiffness and support axial damping can help to improve dynamic tracking property of dry gas seal. The proposed research provides the instruction to optimize dynamic tracking property of the DGS.

关键词： high-speed and high-pressure dry gas seal gas film thickness disturbance dynamic tracking property

The Superiority of Bayes Estimators in a Multivariate Linear Model with Respect to Normal-Inverse Wishart Prior

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Acta Mathematica Sinica,English Series 2015年第6期31卷 1003-1014页

作者： Kai XU Dao jiang HE School of Statistics and Management Shanghai University of Finance and Economics School of Mathematics and Computer Science Anhui Normal University

In this paper, the multivariate linear model Y = XB＋e, e ～ Nm×k（0, ImΣ） is considered from the Bayes perspective. Under the normal-inverse Wishart prior for （BΣ）, the Bayes estimators are derived. The superiority of the Bayes estimators of B and Σ over the least squares estimators under the criteria of Bayes mean squared error （BMSE） and Bayes mean squared error matrix （BMSEM） is shown. In addition, the Pitman Closeness （PC） criterion is also included to investigate the superiority of the Bayes estimator of B.

关键词： Normal-inverse Wishart distribution matrix t distribution Bayes estimator least' squaresestimator Pitman closeness criterion BMSE and BMSEM criteria

Metabolic reprogramming in triple-negative breast cancer

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Cancer Biology & Medicine 2020年第1期17卷 44-59页

作者： Zhanyu Wang Qianjin jiang Chenfang Dong Department of Surgical Oncology(Breast Center)of The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhou 310058China

Since triple-negative breast cancer(TNBC)was first defined over a decade ago,increasing studies have focused on its genetic and molecular *** diagnosed with TNBC,compared to those diagnosed with other breast cancer subtypes,have relatively poor outcomes due to high tumor aggressiveness and lack of targeted *** reprogramming,an emerging hallmark of cancer,is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands;maintain the redox balance;and further promote oncogenic signaling,cell proliferation,and *** the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of ***,we review the metabolic reprogramming of glycolysis,oxidative phosphorylation,amino acid metabolism,lipid metabolism,and other branched pathways in TNBC and explore opportunities for new biomarkers,imaging modalities,and metabolically targeted therapies.

关键词： Metabolic reprogramming triple-negative breast cancer aerobic glycolysis Warburg effect cancer stem cell targeted therapy

Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis

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Zoological Research 2019年第3期40卷 146-150页

作者： Xin-jiang Lu Jiong Chen Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Ningbo Zhejiang 315211 China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo University Ningbo Zhejiang 315211 China

Macrophages exist in most tissues and play a variety of functions in *** fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate *** to whole genome duplication and en vironme ntal adaptati on,teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals.A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in *** this review,we summarize the differences in polarizati on and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.

关键词： Teleost Monocytes/Macrophages Phagocytosis Cytokine producti on Comparative immunology

Determinant formula and a realization for the Lie algebra W(2,2)

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Science China Mathematics 2018年第4期61卷 685-694页

作者： Wei jiang Yufeng Pei Wei Zhang Department of Mathematics Changshu Institute of Technology Department of Mathematics Shanghai Normal University School of Mathematics and Statistics Beijing Institute of Technology

In this paper, an explicit determinant formula is given for the Verma modules over the Lie algebra W(2, 2). We construct a natural realization of a certain vaccum module for the algebra W(2, 2) via the Weyl vertex algebra. We also describe several results including the irreducibility, characters and the descending filtrations of submodules for the Verma module over the algebra W(2, 2).

关键词： Lie algebra Verma module highest weight representation W(2 2) algebra vertex algebra