Metabolic reprogramming in triple-negative breast cancer

作     者：Zhanyu Wang Qianjin Jiang Chenfang Dong Zhanyu Wang;Qianjin Jiang;Chenfang Dong

作者机构：Department of Surgical Oncology(Breast Center)of The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Pathology and PathophysiologyZhejiang University School of MedicineHangzhou 310058China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2020年第17卷第1期

页      面：44-59页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Key Program of Zhejiang Provincial Natural Science Foundation(Grant No.LZ17H160002) National Natural Science Foundation of China(Grant No.81972456 and 81772801) the National Key R&D Program of China(Grant No.2016YFC1303200) the Fundamental Research Funds for Central Universities of China(to C.D.) the Thousand Young Talents Plan of China(to C.D.) 

主　　题：Metabolic reprogramming triple-negative breast cancer aerobic glycolysis Warburg effect cancer stem cell targeted therapy 

摘      要：Since triple-negative breast cancer(TNBC)was first defined over a decade ago,increasing studies have focused on its genetic and molecular *** diagnosed with TNBC,compared to those diagnosed with other breast cancer subtypes,have relatively poor outcomes due to high tumor aggressiveness and lack of targeted *** reprogramming,an emerging hallmark of cancer,is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands;maintain the redox balance;and further promote oncogenic signaling,cell proliferation,and *** the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of ***,we review the metabolic reprogramming of glycolysis,oxidative phosphorylation,amino acid metabolism,lipid metabolism,and other branched pathways in TNBC and explore opportunities for new biomarkers,imaging modalities,and metabolically targeted therapies.