检索结果-南通市图书馆

Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy

International Journal of Ophthalmology(English edition) 2022年第1期15卷 89-97页

作者： Harris Sultan Rithwick Rajagopal Prabakar Kumar Rao Kisha Deslee Piggott Michael A Paley lynn marisa hassman Albert S.Li Brigid Marshall Rajendra Shridhar Apte John Hardesty Department of Ophthalmology Washington UniversitySt.LouisMO 63110USA Department of Medicine Division of RheumatologyWashington UniversitySt.LouisMO 63110USA Department of Ophthalmology and Visual Sciences University of Maryland School of MedicineBaltimoreMD 21201USA

AIM:To evaluate differences in microparticle profiles in vitreous samples between diabetic and non-diabetic eyes undergoing ***:Un-masked cross-sectional series of 34 eyes undergoing *** specimens were collected and processed to evaluate for membrane integrity(DAPI),apoptosis(Annexin-V),and endothelial-cell origin(V-Cadherin).A BD LSR II flow cytometer was used for analysis and standardized sub-micron-sized beads were used for size ***:Thirty-four specimens underwent *** levels of Annexin-V were found on microparticles from specimens in which blood had entered the vitreous(n=12)compared to those without blood(n=22;52.3%±30.7%vs 19.6%±27.2%,P=0.002).Patients with diabetes having surgery with hemorrhage(n=7)had greater expression of Annexin-V than those without hemorrhage(n=8;62.1%±31.7%vs 18.9%±20.9%,P=0.009).However,in patients with non-diabetic vitreous hemorrhage,the level of Annexin-V expression was not significantly different compared to other disease processes(38.6%±25.7%,n=5 vs 20.0%±30.9%,n=14,P=0.087).CONCLUSION:Increased expression of the apoptotic marker,Annexin-V is detected on vitreous microparticles in diabetes-related vitreous *** evaluating vitreous hemorrhage in patients without diabetes,the apoptotic signal is not significantly *** in patients with diabetes,and improvement in visual outcomes,may be related to the removal of a serumderived,pro-apoptotic *** investigation is warranted in order to identify the molecular characteristics of microparticles that regulate disease.

关键词： cell-derived microparticles vitrectomy vitreous diabetes mellitus apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bacillary layer detachment presenting with posterior scleritis:case report

引用

Annals of Eye Science 2022年第3期7卷 67-71页

作者： Gregory W.Bligard Andrew R.Lee lynn M.hassman Department of Ophthalmology and Visual Sciences Washington University in St.Louis School of MedicineSt.LouisMOUSA

Background:Bacillary layer detachment(BALAD)is a phenomenon characterized by fluid accumulation at the myoid region of the inner photoreceptor segments identifiable on optical coherence tomography(OCT)*** finding has been recently described in patients with diverse primary diagnoses which share the common feature of serous exudation in the posterior ***,thus far there have been very few reports in the literature of BALAD in patients with posterior *** Description:A 16-year-old male presented with unilateral vision changes that acutely worsened overnight to significant unilateral vision *** was eventually diagnosed with idiopathic posterior scleritis with associated BALAD on *** to other reported cases of BALAD,he experienced anatomic restoration of the outer retina followed by good visual recovery after treatment with high dose steroid,ultimately with complete recovery of both retinal anatomy and vision within 4 ***:This case provides further evidence that posterior scleritis can be a cause of *** rapid presentation and excellent visual and anatomical outcome of this case is entirely consistent with known descriptions of BALAD in a variety of other conditions,further supporting the categorization of BALAD as an entity which retinal specialists should be able to recognize as distinct from other forms of intraretinal fluid,retinal detachment,and retinoschisis.

关键词： Case report bacillary layer detachment(BALAD) photoreceptor scleritis inner segment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：