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MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

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Genes & Diseases 2024年第4期11卷 124-127页

作者： junxia luo Yun Li Yong Lv Xin Li Bing Qin Chuanfang Cheng Xiaorong Liu Weiping Liao Jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole *** encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental *** were reported in only one *** association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

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Sensitivity of Commercial Enzyme Inhibition Colorimetric Pesticide Residue Rapid Test Kit to a Variety of Pesticides

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Asian Agricultural Research 2024年第8期16卷 29-32页

作者： junxia luo Qianqian ZHAO Lumei DUAN Yanzhen LI Huifang QIAO Zhipei DOU Jianbo ZHAO Zhengzhou Product Quality Inspection and Testing Center Zhengzhou 450006China Jiaozuo Product Quality Inspection and Testing Center Kaifeng 454000China Kaifeng Product Quality Inspection and Testing Center Kaifeng 454000China Zhengzhou Agricultural Technology Extension Center Zhengzhou 450002China

[Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural products.[Methods]The sensitivity of 28 kinds of pesticides was determined by using the commercially available enzyme inhibition colorimetric rapid detection kit with Hendu brand.[Results]There was a significant difference in the sensitivity of the kit to each pesticide,and the kit was more sensitive to dichlorvos among the 28 pesticides *** sensitivity to methyl isosalifos,dimethoate,isocarbophos,fenthion and phorate was poor,and the sensitivity to quinalphos was different between 3.0 and 2.5 mL.[Conclusions]The large difference of the sensitivity of the enzyme inhibition-colorimetric rapid detection kit for pesticide residues to different kits is a reason for the false positive and false negative test results of the kit,which needs to be considered by relevant personnel.

关键词： Enzyme inhibition-colorimetry Reagent kit Pesticide Inhibition rate Sensitivity

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Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report

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Acta Epileptologica 2021年第1期3卷 24-29页

作者： junxia luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao Neurology Department Qilu Children’s Hospital of Shandong UniversityJinanChina Functional Neurosurgery Department Qilu Children’s Hospital of Shandong UniversityJinanChina

Background:Leucine-rich glioma-inactivated protein 1(LGI1)antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy,which is associated with autoimmunity against the neuronal plasma membrane *** characteristic symptoms of this disease are memory dysfunction,seizures,faciobrachial dystonic seizures,cognitive deficits,neuropsychiatric disturbances,and intractable *** diagnosis of this disease mainly depends on the presence of anti-LGI1 antibody in serum or cerebrospinal fluid of ***1 antibody encephalitis has been reported mostly in adults,with rare occurrences in *** presentation:In this report,we described a 4-year-old girl with typical *** types included focal seizures and generalized tonic-clonic *** electroencephalogram findings showed focal *** magnetic resonance imaging(MRI)showed *** cerebrospinal fluid(CSF)levels of cells,glucose,and chloride were within the normal range,and the culture did not reveal growth of any *** of serum LGI1-Ab was positive,while the tests for autoimmune encephalitis antibody series in CSF were *** seizures of the patient were completely controlled after the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs(AEDs),and the mental state almost returned to ***:To our knowledge,the patient described here may be the youngest case of LGI1 antibody encephalitis reported to *** with the LGI1 antibody-associated encephalitis may present only with single symptoms such as epileptic seizures and have good response to the therapy of immunoglobulin,methylprednisolone and antiepileptic *** case report will provide hints for pediatricians in the diagnosis and treatment of LGI1-antibody encephalitis.

关键词： Autoimmune encephalitis LGI1 antibody Seizures Electroencephalogram

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侧流层析技术应用于真菌毒素检测的研究进展

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农产品质量与安全 2024年第3期 32-40页

作者：罗俊霞申战宾杨华段鹿梅刘雪平张启成赵建波郑州市产品质量检验检测中心郑州450006 郑州市农业技术推广中心郑州450002

近年来,侧流层析技术经过不断的完善和发展,其识别原件和示踪标记物有较大更新,该技术应用于真菌毒素检测的研究越来越多。本文基于侧流层析技术在真菌毒素检测方面的研究文献,梳理了各种识别原件和示踪标记物在真菌毒素检测中的应用,... 详细信息

近年来,侧流层析技术经过不断的完善和发展,其识别原件和示踪标记物有较大更新,该技术应用于真菌毒素检测的研究越来越多。本文基于侧流层析技术在真菌毒素检测方面的研究文献,梳理了各种识别原件和示踪标记物在真菌毒素检测中的应用,指出未来侧流层析技术应用于多种真菌毒素同时检测时应该关注的重点。

关键词：真菌毒素侧流层析技术识别原件示踪标记物前处理

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我国农药最大残留限量标准中鳞茎类蔬菜限量指标的发展与分析

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生物灾害科学 2024年第3期47卷 423-431页

作者：罗俊霞赵建波申战宾赵倩倩杨华刘雪平陈璐潘玲郑州市产品质量检验检测中心河南郑州450006 郑州市农业技术推广中心河南郑州450002 焦作市产品质量检验检测中心河南焦作454000

【目的】全面了解GB 2763《食品安全国家标准食品中农药最大残留限量》中鳞茎类蔬菜的相关指标现状及发展历史,为鳞茎类蔬菜农药限量指标的制定提供参考。【方法】基于历版GB 2763《食品安全国家标准食品中农药最大残留限量》中鳞茎类... 详细信息

【目的】全面了解GB 2763《食品安全国家标准食品中农药最大残留限量》中鳞茎类蔬菜的相关指标现状及发展历史,为鳞茎类蔬菜农药限量指标的制定提供参考。【方法】基于历版GB 2763《食品安全国家标准食品中农药最大残留限量》中鳞茎类蔬菜的相关数据,同我国农药信息网数据相结合,对鳞茎类蔬菜的农药最大残留限量(MRLs)及其每日允许摄入量(ADI)、检测方法等进行了梳理和分析。【结果】GB 2763经过近20年的发展,鳞茎类蔬菜的MRLs已经涉及180种农药的246项限量,但以组限量居多;该类蔬菜已制定MRL农药的ADI修订较多,部分农药的ADI经过了2次修订;MRL修订的农药较少;MRLs的制定同农药登记严重脱节,且标准中无农药助剂的相关检测方法和数据。【结论】应补充、完善和细化该类蔬菜的MRLs,推动出台该类蔬菜“一律标准”,且加强研究该类蔬菜的检测方法,助力该类蔬菜质量安全水平的提高。

关键词：鳞茎类蔬菜农药最大残留限量每日允许摄入量农药登记检测方法农药助剂

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植物生长调节剂和除草剂在葡萄上的登记应用现状分析

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生物灾害科学 2024年第2期47卷 274-283页

作者：罗俊霞赵建波申战宾杨华周晓浦段鹿梅张启成潘玲郑州市产品质量检验检测中心河南郑州450006 郑州市农业技术推广中心河南郑州450002 开封市产品质量检验检测中心河南开封475000

【目的】了解葡萄上植物生长调节剂和除草剂的登记和使用现状,为葡萄的安全生产提供依据。【方法】基于我国农药信息网登记的植物生长调节剂、除草剂数据和新修订的《GB2763—2021食品安全国家标准食品中农药最大残留限量》《NY/T 393—... 详细信息

【目的】了解葡萄上植物生长调节剂和除草剂的登记和使用现状,为葡萄的安全生产提供依据。【方法】基于我国农药信息网登记的植物生长调节剂、除草剂数据和新修订的《GB2763—2021食品安全国家标准食品中农药最大残留限量》《NY/T 393—2020绿色食品农药使用准则》中相关信息,结合葡萄生产实际,对中国植物生长调节剂和除草剂在葡萄上的登记与应用情况进行梳理和分析。【结果】葡萄上登记的植物生长调节剂共有26种有效成分、146个产品,其中传统剂型占97.26%、低毒产品占76.03%、所登记植物生长调节剂产品的毒性与其有效成分的含量没有关系,且其作用较为混乱;除草剂有3种有效成分、7个单剂产品。《限量标准》中有3种植物生长调节剂和26种除草剂制定了在葡萄上的限量,葡萄上登记的植物生长调节剂及除草剂品种同《限量标准》和《准则》存在严重脱节。【结论】建议尽快制定《准则》中A级绿色食品生产允许使用的除草剂及植物生长调节剂的限量,各相关部门加强引导与指导,提高果农的安全意识,使果农在《条例》的框架下安全选择、使用植物生长调节剂和除草剂,以提高葡萄质量安全。

关键词：葡萄植物生长调节剂除草剂登记应用安全生产

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Matrix Effects of Fourteen Organophosphorus Pesticides Residues in Nine Kinds of Vegetable Matrices

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Plant Diseases and Pests 2014年第1期5卷 39-44页

作者： Zhao Jianbo Li Deyu Yu Qiaolan Du Fengshan luo junxia Zhengzhou Gardening Workstation Zhengzhou Inspection Center of Agricultural Product Quality

The matrix effects of 14 organophosphorus pesticides in 9 kinds of vegetables matrices were preliminarily studied by gas chromatography/flame photomet- ric detection（FPD） in the paper. The matrix effects of 14 organophosphoms pesticides in 9 kinds of vegetable matrices at 0.05, 0.1 and 0.2 mg/L were compared, respectively. The results showed that matrix enhancement effect and matrix attenuation effect existed in all cases, while matrix effects did not have strong correlation with concentrations of pesticides, but were related to species of vegetables and structure and polarity of pesticides.

关键词： Gas chromatography Vegetable Pesticide residue Matrix effects Concentration

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基于HACCP建立大蒜生产良好农业规范

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中央民族大学学报（自然科学版） 2024年第2期33卷 26-31页

作者：罗俊霞申战宾杨华段鹿梅刘雪平张启成潘玲赵建波郑州市产品质量检验检测中心河南郑州450006 郑州市农业技术推广中心河南郑州450002

本文根据大蒜生产实际,对大蒜生产的各个环节进行危害分析,确定关键控制点;将生产者、消费者、动植物、环境作为一个有机整体,寻求大蒜生产和环境保护之间的平衡;采用对关键控制点进行动态管理并详细记录、存档,建立大蒜生产良好农业规... 详细信息

本文根据大蒜生产实际,对大蒜生产的各个环节进行危害分析,确定关键控制点;将生产者、消费者、动植物、环境作为一个有机整体,寻求大蒜生产和环境保护之间的平衡;采用对关键控制点进行动态管理并详细记录、存档,建立大蒜生产良好农业规范,实现通过纸质台账可追溯大蒜生产全过程;目的是提高大蒜质量安全水平和其在出口贸易中的竞争力。

关键词：大蒜生产危害分析关键控制点良好农业规范质量控制溯源

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Analysis of Pesticide Residues in Vegetables by Enzyme Inhibition Colorimetric Kit

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Asian Agricultural Research 2022年第8期14卷 28-31,38页

作者： Jie ZHANG Gang ZHANG Zhanbin SHEN Lumei DUAN Wei ZHANG junxia luo Jianbo ZHAO Zhengzhou Agricultural Product Quality Testing and Distribution Center Zhengzhou 450006China Zhengzhou Agricultural Technology Extension Centre Zhengzhou 450006China Henan Hengsheng Testing Technology Co. Ltd.Xinzheng 451100China

[Objectives]The paper was to understand the detection effect of commercial enzyme inhibition colorimetric kit.[Methods]Six brands of kits were used to detect pesticide residues in *** detection results were compared with those of 50 kinds of organophosphorus pesticides and 10 kinds of carbamate pesticides detected by chromatography and mass *** to different thresholds,the test results of different kits were evaluated,and the false positive rate,false negative rate and coincidence rate of each kit were *** test results of commercial enzyme inhibition colorimetric kits were compared and analyzed.[Results]The detection effect of kit D was the best among the 6 brands of kits,and the coincidence rate was the highest under the 7 *** was a certain relationship between the detection effect of commercial enzyme inhibition colorimetric kit and the determination threshold of positive *** false positive rate decreased with the increase of determination threshold,and the false negative rate increased with the increase of determination threshold,but the coincidence rate with chromatography and mass spectrometry can not reach 100%.When the threshold was set to 20%,the effect was the *** coincidence rate of 3 brands of kits with the results of chromatography and mass spectrometry was the highest,and none of the 6 kits involved in the comparison had the lowest coincidence rate under this threshold.[Conclusions]It is suggested to modify the threshold values in national standard and trade standard.

关键词： Kit Pesticide False positive False negative Accuracy Determination threshold

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Leucine-rich,glioma inactivated-1 antibody mediated autoimmune encephalitis in a 4-year-old girl:a case report

Leucine-rich,glioma inactivated-1 antibody mediated autoimmu...

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第七届CAAE脑电图与神经电生理大会

作者： junxia luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao Qilu Children’s Hospital of Shandong University

＜正＞Leucine-rich,glioma inactivated-1（LGI-1） antibody-mediated encephalitis is a subtype of autoimmune encephalopathy associated with autoimmunity against the neuronal plasma membrane *** characteristic symptoms o...

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