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Source apportionment and specific-source-site risk of quinolone antibiotics for effluent-receiving urban rivers and groundwater in a city, China

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Journal of Environmental Sciences 2024年第10期144卷 185-198页

作者： Yu Zhao Yuanmeng Song lulu Zhang Bo Zhao Mengqi Lu Jiansheng Cui Wenzhong Tang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of ScienceBeijing 100085China College of Environment Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050000China University of Chinese Academy of Sciences Beijing 100049China

There is a large surface-groundwater exchange downstream ofwastewater treatment plants(WWTPs),and antibiotics upstream may influence sites downstream of ***,samples from 9 effluent-receiving urban rivers(ERURs)and 12 groundwater sites were collected in Shijiazhuang City in December 2020 and April *** ERURs,8 out of 13 target quinolone antibiotics(QNs)were detected,and the total concentration of QNs in December and April were 100.6-4,398 ng/L and 8.02–2,476 ng/L,*** groundwater,all target QNs were detected,and the total QNs concentration was 1.09–23.03 ng/L for December and 4.54–170.3 ng/L for *** distribution of QNs was dissimilar between ERURs and *** QN concentrations were weakly correlated with land use types in the *** results of a positive matrix factorization model(PMF)indicated four potential sources of QNs in both ERURs and groundwater,and WWTP effluents were the main source of *** December to April,the contribution of WWTP effluents and agricultural emissions increased,while livestock activities *** value decomposition(SVD)results showed that the spatial variation of most QNs was mainly contributed by sites downstream(7.09%-88.86%)of ***,a new method that combined the results of SVD and PMF was developed for a specific-source-site risk quotient(SRQ),and the SRQ for QNs was at high level,especially for the sites downstream of *** temporal variation,the SRQ for WWTP effluents,aquaculture,and agricultural emissions ***,in order to control the antibiotic pollution,more attention should be paid to WWTP effluents,aquaculture,and agricultural emission sources for the benefit of sites downstream of WWTPs.

关键词： Source apportionment Singular value decomposition Positive matrix factorization model Quinolone antibiotics(QNs) Specific-source-site risk quotient(SRQ) WWTP effluents

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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

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上海市某区域老年群体轻度认知功能障碍的发生情况及其影响因素分析

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上海医学 2024年第1期47卷 18-25页

作者：刘亚林陆媛徐圣明周路路薛娅雅李凯翟佳燚黄武全陆晓瑜于德华上海市嘉定区嘉定镇街道社区卫生服务中心全科医疗科上海201899 同济大学附属杨浦医院全科医学科上海市嘉定区南翔镇社区卫生服务中心全科医疗科上海市浦东新区潍坊社区卫生服务中心

目的分析上海市嘉定区嘉定镇60岁及以上老年人轻度认知功能障碍(MCI)的发生情况,探究影响MCI发生的相关因素,为制订MCI人群的干预措施提供理论依据。方法本研究采用横断面调查研究的方法,选取2020年5—7月在上海市嘉定区嘉定镇社区卫生... 详细信息

目的分析上海市嘉定区嘉定镇60岁及以上老年人轻度认知功能障碍(MCI)的发生情况,探究影响MCI发生的相关因素,为制订MCI人群的干预措施提供理论依据。方法本研究采用横断面调查研究的方法,选取2020年5—7月在上海市嘉定区嘉定镇社区卫生服务中心参加健康体检的60岁及以上老年人群,共4962人。根据纳排标准,应用简单随机抽样的方法,共抽取目标人数860人。其中,48人拒绝接受调查或部分调查,接受全部调查者为812人。采用问卷调查收集受试者的基本信息、人口学资料、慢性病类型、生活行为方式等。根据Petersen标准,结合蒙特利尔认知评估基础量表(montreal cognitive assessment basic,MoCA-B量表)、日常生活能力量表(activity of daily living scale,ADL)、临床痴呆量表(clinical dementia rating scale,CDR)评估受试者MCI发生情况。受试者的MCI由精神卫生中心精神科医师进行最后确诊。计算MCI的发生率,观察MCI发生的影响因素。结果在接受全部调查的812人中,收回有效问卷791份,有效率97.41%。根据Petersen标准,在791人中,符合MCI诊断标准192人,认知正常者563人,共755人纳入分析。对于60岁及以上受试者,随年龄增长,MCI发生率显著增高(χ^(2)=19.120,P12年时,受试者的MCI发生率显著增高(χ^(2)=21.670,P<0.01);子女数越多,MCI发生率越高,差异有统计学意义(χ^(2)=11.460,P<0.01);与以脑力劳动为主的受试者相比,以体力劳动为主的受试者MCI发生率显著增高(χ^(2)=22.110,P<0.01)。中心型肥胖的受试者MCI发生率较非中心型肥胖的受试者显著增高(χ^(2)=4.661,P=0.031)。有糖尿病的受试者MCI发生率显著高于无糖尿病者(χ^(2)=6.012,P=0.014);有忌口、仍在吸烟的受试者的MCI发生率较无忌口、不吸烟或已戒烟者显著增高(χ^(2)=7.807、44.555,P=0.005或<0.001),而会说外语、锻炼频率高的受试者MCI发生率较不会说外语、锻炼频率低者显著降低(χ^(2)=3.962、17.014,P=0.047、0.001)。将上述单因素分析中有统计学意义的变量(年龄、教育年限、子女数、职业属性、中心型肥胖、糖尿病、有忌口、吸烟、会外语、锻炼频率)作为自变量,是否发生MCI作为因变量,进行二元logistic回归分析;结果显示,以体力劳动为主(OR=2.525,95%CI为1.618~3.939,P<0.001)、有忌口(OR=1.529,95%CI为1.045~2.237,P<0.05)、吸烟(OR=1.845,95%CI为1.479~2.302,P<0.001)是MCI发生的危险因素,锻炼频率高(OR=0.845,95%CI为0.742~0.964,P<0.05)是MCI发生的保护因素。结论上海市嘉定区嘉定镇社区老年人群MCI发生率较高,职业属性、有忌口、锻炼频率、吸烟是MCI发生的影响因素。

关键词：轻度认知功能障碍老年群体影响因素

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硅-磷阻燃剂对热塑性聚氨酯弹性体阻燃性能的影响

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高分子材料科学与工程 2018年第11期34卷 79-85页

作者：周陆陆杜建新杨荣杰北京理工大学材料学院国家阻燃材料工程技术研究中心北京100081

采用一种含硅阻燃剂——笼形八苯基硅倍半氧烷(OPS)与含磷阻燃剂聚磷酸铵(APP)或二乙基次膦酸铝(ADP)复配制备了阻燃热塑性聚氨酯弹性体(TPU)。结果表明,OPS对TPU的热稳定性有一定的影响,当OPS的质量分数为15%时,能明显改善燃烧过程中... 详细信息

采用一种含硅阻燃剂——笼形八苯基硅倍半氧烷(OPS)与含磷阻燃剂聚磷酸铵(APP)或二乙基次膦酸铝(ADP)复配制备了阻燃热塑性聚氨酯弹性体(TPU)。结果表明,OPS对TPU的热稳定性有一定的影响,当OPS的质量分数为15%时,能明显改善燃烧过程中的熔滴现象; OPS/APP和OPS/ADP复合阻燃体系,均可以大幅提升TPU的阻燃性能,且APP效果要明显优于ADP; TPU/10%OPS/5%APP体系的综合性能最优,热释放速率峰值从1339 k W/m2降低至489k W/m^2,降幅达到了63.5%,总烟释放量也从3425 m^2/m^2降到1884 m^2/m^2,降幅达到了45.0%;燃烧残余量为18%,锥量测试后的炭层更加致密、坚硬。

关键词：聚氨酯弹性体笼形八苯基硅倍半氧烷聚磷酸铵二乙基次膦酸铝

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Analysis prognostic roles of histone deacetylases mRNA expression in ovarian cancer

Analysis prognostic roles of histone deacetylases mRNA expre...

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2018年浙江省医学会妇产科学与围产医学学术年会暨2018年浙江省医师协会妇产科医师分会学术年会

作者： lulu zhou Xiaohui Xu Hailing Liu Xiaoli Hu Wenwen Zhang Miaomiao Ye Xueqiong Zhu Department of Obstetrics and Gynecology the Second Affiliated Hospital of Wenzhou Medical University

Objective:Histone deacetylases participate in epigenetic regulations and are essential to modulate the dynamic balance of histone acetylation and deacetylation in *** deacetylases are considered to be associated with angiogenesis,cell proliferation and survival in several *** the expression and distinct prognostic value of histone deacetylases in ovarian cancer haven’ t been well *** the present study,the Kaplan-Meier plotter online database was used to access the overall survival prognostic values of histone deacetylases(HDAC1-11) mRNA expression in ovarian cancer and investigate a relationship between histone deacetylases and the clinicopathological parameters for the ovarian cancer patients,such as histology subtypes,clinical stages,grades and TP53 *** analysis showed that over-expression of HDAC1,HDAC2,HDAC4,HDAC5 and HDAC11 were related to poor overall survival in all ovarian cancer patients,especially the high level of HDAC2,HDAC4 and HDAC11 were correlated to a worse overall survival for serous ovarian cancer *** HDAC7,HDAC8 and HDAC10 were found to be significantly associated with a better outcome in all ovarian cancer patients,particularly the HDAC8 and HDAC10 had a favorable overall survival for serous ovarian cancer *** Conclusion,HDACs may play a significant role in the prognosis of ovarian cancer and individual histone deacetylases may contribute to different prognosis in ovarian cancer patients.

关键词： ovarian cancer prognosis HDACs Kaplan-Meier plotter

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含磷纳米复合物/聚氨酯弹性体复合材料的制备与阻燃性能

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高分子材料科学与工程 2018年第11期34卷 114-119页

作者：周陆陆杜建新杨荣杰北京理工大学材料学院国家阻燃材料工程技术研究中心北京100081

将自制的DOPO-MMT纳米复合物添加到聚氨酯弹性体中,得到新型聚氨酯弹性体复合材料。并分别与添加了DOPO、蒙脱土(MMT)和DOPO与MMT的物理混合物等的3种体系的阻燃效果作了对比研究,探讨了各体系的阻燃性能及阻燃机理。研究表明,使用纳米... 详细信息

将自制的DOPO-MMT纳米复合物添加到聚氨酯弹性体中,得到新型聚氨酯弹性体复合材料。并分别与添加了DOPO、蒙脱土(MMT)和DOPO与MMT的物理混合物等的3种体系的阻燃效果作了对比研究,探讨了各体系的阻燃性能及阻燃机理。研究表明,使用纳米复合的DOPO-MMT阻燃剂,阻燃效果要明显优于单独添加DOPO、MMT和物理混合的DOPO和MMT阻燃剂。这是因为DOPO-MMT在聚氨酯中实现了MMT纳米级别的分散,DOPO的气相阻燃和MMT的凝聚相阻燃共同作用抑制了燃烧过程,使得聚氨酯复合材料的UL-94垂直燃烧达到V-2级别,锥形量热测试中有最低的热释放速率和热释放量,材料获得了良好的阻燃效果。

关键词：聚氨酯弹性体 DOPO—MMT纳米复合物纳米阻燃

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Legal Guarantee for the Elderly’s Right to Work——A Comparative Analysis Based on Age Discrimination in the Employment Act

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The Journal of Human Rights 2022年第3期21卷 530-552页

作者：周露露 LIU Haile(Translated) Guangzhou University Institute for Human Rights 不详

In the context of the deepening of the population aging,many countries have begun to rectify age discrimination in labor and employment to ensure that the elderly enjoy equal and adequate right to *** accordance with relevant laws and regulations,the legal norms of age discrimination in employment are highly similar in different ***,there are differences in exemption clauses and legal *** far,three major regulatory modes have taken shape respectively in the United States,europe and *** still lags behind in legislation against age discrimination in employment,so extraterritorial governance experiences should be taken for reference to promote relevant legislation based on intergenerational solidarity and cooperation in a timely manner,so as to provide a legal guarantee for the elderly on the right to work and the handling of population *** should also use human rights discourse to summarize and express its own solutions and take an active part in the process of signing the international instruments on human rights specialized for the elderly.

关键词： age discrimination in employment the rights of the elderly international human rights law

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The NAC Transcription Factor ANAC089 Modulates Seed Vigor through the ABI5-VTC2 Module in Arabidopsis thaliana

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1101-1116页

作者： Yuan Tian lulu Zhi Ping Li Xiangyang Hu Shanghai Key Laboratory of Bio-Energy Crops School of Life SciencesShanghai UniversityShanghai200444China

Seed viability is an essential feature for genetic resource conservation as well as sustainable crop ***-term storage induces seed viability deterioration or seed aging,accompanied by the accumulation of toxic reactive oxygen species(ROS)to suppress seed *** deterioration treatment(CDT)is a gen-eral approach for mimicking seed *** transcription factor ANAC089 was previously reported to modulate seed primary *** this study,we evaluated the ability of ANAC089 to control seed viability during *** with that in the wild-type line,the mutation of ANAC089 signiﬁcantly increased H_(2)O_(2),thereby reducing seed viability after CDT,while the overexpression of ANAC089 reduced H_(2)O_(2) and improved seed long-evity,indicating a critical role for ANAC089 in maintaining seed viability through H_(2)O_(2) signaling.A series of stu-dies have shown that ANAC089 targets and negatively regulates the level of ABI5,an important transmitter of abscisic acid(ABA)signals,to affect seed viability after ***,ABI5 negatively regulated the expres-sion of VTC2,which is involved in the biosynthesis of the antioxidant ascorbic acid and H_(2)O_(2) *** a result,ANAC089 attenuates the generation of H_(2)O_(2),thereby enhancing seed viability through the ABI5-VTC2 module during the seed aging *** together,our results reveal a novel mechanism by which ANAC089 enhances seed viability by coordinating ABI5 and VTC2 expression,ultimately preventing the overac-cumulation of H_(2)O_(2),which would have led to reduced seed viability.

关键词： Arabidopsis seed aging ANAC089 ABI5 VTC2 H_(2)O_(2)

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Recent progresses of exosome-liposome fusions in drug delivery

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Chinese Chemical Letters 2024年第2期35卷 107-117页

作者： lulu Zheng Bo Hu Deyao Zhao Wenjing Liu Qing Liu Yuanyu Huang Shaobo Ruan School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical TechnologyKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Beijing Key Laboratory of Drug Resistance Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research Instituteand Beijing Chest HospitalCapital Medical UniversityBeijing 101149China

Exosomes are membrane-bound nanoscale extracellular vesicles,which produced by almost all *** to the excellent biocompatibility,long circulation time as well as low immunogenicity,exosomes as naturally-derived drug delivery carriers have experienced explosive growth over the past ***,issues such as insufficient loading efficiency,heterogeneous delivery efficiency,uncontrollable targeting ability,and low production limit their wide ***,the emerging exosome-liposome fusion strategy has become a potential approach to solve such ***,this review mainly focuses on the currently developed exosome-liposome fusion strategy and their application in drug delivery as well as disease *** review aims to shed light on the advantages of fusion strategy in drug delivery and provides a better understanding for more rational *** current challenge and future perspective regarding their clinical translation and application will also be discussed.

关键词： Exosome Liposome Membrane fusion Drug delivery Disease treatment

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MULTIFRACTAL ANALYSIS OF CONVERGENCE EXPONENTS FOR PRODUCTS OF CONSECUTIVE PARTIAL QUOTIENTS IN CONTINUED FRACTIONS

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Acta Mathematica Scientia 2024年第4期44卷 1594-1608页

作者： lulu FANG Jihua MA Kunkun SONG Xin YANG School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing210094China School of Mathematics and Statistics Wuhan UniversityWuhan 430072China Key Laboratory of Computing and Stochastic Mathematics(Ministry of Education) School of Mathematics and StatisticsHunan Normal UniversityChangsha 410081China

For each real number x∈(0,1),let[a_(1)(x),a_(2)(x),…,a_n(x),…]denote its continued fraction *** study the convergence exponent defined byτ(x)=inf{s≥0:∞∑n=1(a_(n)(x)a_(n+1)(x))^(-s)<∞},which reflects the growth rate of the product of two consecutive partial *** a main result,the Hausdorff dimensions of the level sets ofτ(x)are determined.

关键词： continued fractions product of partial quotients Hausdorff dimension

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