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Science China Mathematics 2006年第11期49卷 1662-1682页

作者： luk hing-sun Department of Mathematics Lady Shaw Building The Chinese University of Hong KongShatinN THong KongChina

This paper gives an explicit formula for calculating the Webster pseudo torsion for a strictly pseudoconvex pseudo-hermitian hypersurface. As applications, we are able to classify some pseudo torsion-free hypersurface... 详细信息

关键词： pseudo Herrnitian manifolds torsion formula torsion-free hypersufaces.

Place-and Age-Responsive Disaster Risk Reduction for Hong Kong:Collaborative Place Audit and Social Vulnerability Index for Elders

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International Journal of Disaster Risk Science 2017年第2期8卷 121-133页

作者： Yi sun Pui hing Chau Moses Wong Jean Woo CUHK Jockey Club Institute of Ageing The Chinese University of Hong Kong Department of Building and Real Estate The Hong Kong Polytechnic University School of Nursing The University of Hong Kong Department of Medicine and Therapeutics The Chinese University of Hong Kong

This study reformulates the concept and contents of disaster risk reduction(DRR) in Hong Kong through an explorative study on collaborative place audit(CPA) and social vulnerability index(SVI) for *** believe that DRR should be place-and ***,DRR needs to go beyond technical concerns and address vulnerability and risk encountered in the built environment where an individual is located.A place-centered DRR begins with an assessment of person–environment relations from an interdependent *** becomes a significant scale at which to address vulnerability and risks across a range of environmental,socioeconomic,and institutional factors.A CPA is a ground-level assessment tool that identifies vulnerability and risk in the built and social *** audit encourages collaboration in problem solving that uses social capital to effect decisionmaking change in hierarchies and policy *** DRR facilitates distinguishing living-alone elders from the general *** perspective addresses varying degrees of vulnerability due to social and communicational isolation,poverty,disability,being sent to hospital and/or receiving institutional care,as well as lack of access to primary ***,SVI,based oncompound indicators,is developed to assess the differentiation of vulnerability across the territory with particular reference to the *** two approaches,namely,CPA and SVI,build community capacity to develop a resilient city,as well as to provide evidence-based recommendations that improve government-led disaster preparedness and contingency plans.

关键词： Disaster risk reduction Hong Kong Place audit Social capital Social vulnerability

Molecular diagnosis of hepatocellular carcinoma:trends in biomarkers combination to enhance early cancer detection

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Hepatoma Research 2019年第3期5卷 20-33页

作者： Tiong sun Chia Kwong Fai Wong John M.luk Arbele Limited Hong Kong Science&Technology ParkShatinNew TerritoriesHong Kong

Despite of the advances in clinical imaging and applied research in proteomic biomarkers,liver cancer,especially hepatocellular carcinoma remains detected at the very late and advanced stages when curable treatments are unavailable and *** this regard,there are still huge unmet medical needs in developing and clinically validating those high-potential protein biomarkers preferably in liquid biopsy *** review provides a glimpse of emerging biomarkers together with detection tools and techniques which are potentially commercially available to the *** also discuss several diagnostic biomarkers having therapeutic potential for developing first-in-class medicines.

关键词： Hepatocellular carcinoma biomarkers targets α-fetoprotein cadherin-17 Yes-associated protein AXL Trop2

Mortality in relation to changes in physical activity in middle-aged to older Chinese:An 8-year follow-up of the Guangzhou Biobank Cohort Study

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Journal of Sport and Health Science 2021年第4期10卷 430-438页

作者： Yingyue Huang Chaoqiang Jiang Lin Xu Weisen Zhang Feng Zhu Yali Jin Kar Keung Cheng Tai hing Lam School of Public Health Sun Yat-sen UniversityGuangzhou 510080China Molecular Epidemiology Research Centre Guangzhou No.12 HospitalGuangzhou 510620China School of Public Health the University of Hong KongHong Kong 999077China Institute of Applied Health Research University of BirminghamBirmingham B152TTUK

Background:Physical activity(PA)is generally *** from developed countries in the West have shown that maintenance of adequate PA or increasing PA are associated with lower mortality *** is unclear whether these associations apply to an older Chinese ***,we examined the changes in PA prospectively among a middle-aged and older Chinese population over an average of 4 years and explored their subsequent mortality ***:Metabolic equivalent scores of PA among participants in the Guangzhou Biobank Cohort Study were *** were divided into 3 groups related to PA level,and changes in PA were classified into 9 *** on vital status and causes of death from March 2008 to December 2012(the first repeated examination)until December 31,2017,was obtained via record linkage with the Death ***:Of 18,104 participants aged 61.21±6.85 years(mean±SD),1461 deaths occurred within 141,417 *** to participants who maintained moderate PA,those who decreased PA from moderate or high levels to a low level had increased risks for all-cause mortality(hazard ratio(HR)=1.47,95%confidence interval(95%CI):1.11-1.96).Participants who maintained a high level of PA(HR=0.83,95%CI:0.70-0.98)or increased PA from low to high levels(HR=0.71,95%CI:0.52-0.97)showed lower all-cause mortality *** who maintained low PA levels showed a higher all-cause mortality risk,whereas those who increased their PA levels showed a non-significantly lower *** results were found for cardiovascular disease ***:Even at an older age,maintaining a high PA level or increasing PA from low to high levels results in lower mortality risks,suggesting that substantial health benefits might be achieved by maintaining or increasing engagement in adequate levels of *** increased risk of maintaining a low PA level or decreasing PA to a low level warrants the attention of public health officials and clinic

关键词： All-cause mortality Cardiovascular disease mortality Change in physical activity

Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients

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American Journal of Analytical Chemistry 2011年第2期2卷 142-151页

作者： Wan Chan Shuhai Lin Stella sun Hongde Liu John M. luk Zongwei Cai 不详

In this study, liquid chromatography/quadrupole time of flight mass spectrometry (LC/QTOFMS) was employed for investigating the metabolome of the sera collected from hepatocellular carcinoma (HCC) patients before and 3 to 5 months after partial hepatectomy. To investigate the changes in metabolic phenotypes after the hepatic resection, principal components analysis (PCA) and support vector machine (SVM) were performed for the data grouping and classification. Based on the obtained SVM model, mass spectrometry spectra, database searching as well as the confirmation from authentic standards, several differentiating metabolites were tentatively identified. To improve visualization, z-score plot and heat map display were performed, which exhibited the changes in concentration of the metabolites. As a result, depletion of circulating carnitine, reduced amino acid biosynthesis and increased rate of lipid peroxidation were observed. Meanwhile, up-regulation of hypoxanthine indicated that purine metabolism might serve as the salvage pathway. Collectively, the results reflected metabolic responses to surgical operation in HCC patients, suggesting perturbation of energy metabolism may occur in 3 to 5 months after the partial hepatectomy.

关键词： Metabolomics Analysis Partial Hepatectomy Hepatocellular Carcinoma LC-MS

Turbulent flows over real heterogeneous urban surfaces:Wind tunnel experiments and Reynolds-averaged Navier-Stokes simulations

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Building Simulation 2021年第5期14卷 1345-1358页

作者： Wai-Chi Cheng Chun-Ho Liu Yat-Kiu Ho Ziwei Mo Zhangquan Wu Wenye Li Lilian Y.L.Chan W.K.Kwan hing Tuen Yau School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSun Yat-sen UniversityZhuhaiChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina Department of Mechanical Engineering The University of Hong KongHong KongChina Information Technology Services The University of Hong KongHong KongChina

Wind tunnel experiment and steady-state Reynolds-averaged Navier-Stokes(RANS)approaches are used to examine the urban boundary layer(UBL)development above Kowloon Peninsula,Hong Kong Special Administrative Region(HKSAR).The detailed urban morphology is resolved by computational fluid dynamics(CFD)and is fabricated by 3D-printing(reduced scale)for wind tunnel *** from the majority existing results based on idealized,homogeneous urban geometries,it was found that the wind and turbulence in the UBL over downtown Kowloon are characterized by the wake behind several high-rise *** particular,local maxima of turbulence kinetic energy(TKE)and shear stress are found at the roof level of those high-rise *** the downstream region where the flows are already adjusted to the urban surfaces,the urban roughness sublayer(URSL)can be further divided into two layers based on the structures of the mixing length/m,effective drag Dx and dispersive *** the lower URSL(z<100 m),lm is rather uniform,and the Reynolds stress and dispersive stress are *** the upper URSL(100 m z s 300 m),on the contrary,lm is peaked at the mid-height and the magnitude of dispersive stress is smaller than that of the Reynolds stress(<30%).The effective drag Dx is negligible in the upper URSL.

关键词： computational fluid dynamics(CFD) real urban morphology urban boundary layer(UBL) urban canopy model(UCM) wind tunnel experiments

Delayed diagnosis of 22q11.2 deletion syndrome in an adult Chinese lady

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Chinese Medical Journal 2012年第16期125卷 2945-2947页

作者： SHEA Yat-fung LEE Chi-ho Harinder Gill CHOW Wing-sun LAM Yui-ming luk Ho-ming LAM Stephen Tak-sum CHU Leung-wing Department of Medicine Queen Mary Hospital the University ofHong Kong Hong Kong China Clinical Genetic Service Department of Health The Government of Hong Kong Special Administrative Region Hong Kong China

We report a 32 year-old Chinese lady with history of tetralogy of Fallot, presented to us with chest pain due to hypocalcemia secondary to hypoparathyroidism. With her dysmerphic facial features and intellectual disability 22q11.2 deletion was suspected and confirmed by genetic study. Clinicians should consider the diagnosis of DiGeorge syndrome in adult patient with past medical history of congenital heart disease, facial dysmorphism, intellectual disability and primary hypoparathyroidism.

关键词： hypocalcemia DiGeorge syndrome adult

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假性Budd-Chiari综合征2例

世界华人消化杂志 2008年第27期16卷 3131-3133页

作者：李异玲孙明军傅宝玉中国医科大学附属第一医院消化内科辽宁省沈阳市110001

假性Budd-Chiari综合征多发生于酒精性肝病的患者,其彩超和CT检查类似于Budd-Chiari综合征,而选择性下腔静脉造影无异常发现.本文报告2例患者均因腹胀、乏力入院.入院后进行查体、实验室检查、超声、肝脏增强CT和下腔静脉造影检查,最后... 详细信息

假性Budd-Chiari综合征多发生于酒精性肝病的患者,其彩超和CT检查类似于Budd-Chiari综合征,而选择性下腔静脉造影无异常发现.本文报告2例患者均因腹胀、乏力入院.入院后进行查体、实验室检查、超声、肝脏增强CT和下腔静脉造影检查,最后确诊为假性Budd-Chiari综合征,此病罕见.

关键词：假性Budd-Chiari综合征超声肝脏增强CT 下腔静脉造影

Effect of temperature and moisture on soil organic carbon mineralization of predominantly permafrost peatland in the Great hing'an Mountains,Northeastern China

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Journal of Environmental Sciences 2010年第7期22卷 1057-1066页

作者： Xianwei Wang Xiuzhen Li Yuanman Hu Jiujun Lv Ju sun Zongmei Li Zhifeng Wu Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate School of Chinese Academy of Sciences Beijing 100039 China Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun 130012 China

Boreal peatlands represent a large global carbon pool. The relationships between carbon mineralization, soil temperature and moisture in the permafrost peatlands of the Great hing＇an Mountains, China, were examined. The CO2 emissions were measured during laboratory incubations of samples from four sites under different temperatures （5, 10, 15, and 20℃） and moisture contents （0%, 30%, 60%, 100% water holding capacity （WHC） and completely water saturated）. Total carbon mineralization ranged from 15.51 to 112.92 mg C under the treatments for all sites. Carbon mineralization rates decreased with soil depth, increased with temperature, and reached the highest at 60% WHC at the same temperature. The calculated temperature coefficient （Q10） values ranged from 1.84 to 2.51 with the soil depths and moisture. However, the values were not significantly affected by soil moisture and depth for all sites due to the different peat properties （P 〉 0.05）. We found that the carbon mineralization could be successfully predicted as a two-compartment function with temperature and moisture （R^2 〉 0.96） and total carbon mineralization was significantly affected by temperature and moisture （P 〈 0.05）. Thus, temperature and moisture would play important roles in carbon mineralization of permafrost peatlands in the Great hing＇an Mountains, indicating that the permafrost peatlands would be sensitive to the environment change, and the permafrost peatlands would be potentially mineralized under future climate change.

关键词： Great hing'an Mountains permafrost peatland mineralization climate change

青春期发动时相对男生抑郁、焦虑及问题行为的影响

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中国健康心理学杂志 2016年第5期24卷 775-779页

作者：粟丹凌辉孙中平湖南师范大学教育科学学院心理学系湖南长沙410081

目的：探索不同青春发动时相对男生的抑郁、焦虑及问题行为的影响.方法：使用问卷调查法,随机抽取湖南地区431名11~17岁的男生,并对问卷结果进行数据分析.结果：①男生的青春期开始时间存在显著差异,较少部分的男生属于青春期开始时间... 详细信息

目的：探索不同青春发动时相对男生的抑郁、焦虑及问题行为的影响.方法：使用问卷调查法,随机抽取湖南地区431名11~17岁的男生,并对问卷结果进行数据分析.结果：①男生的青春期开始时间存在显著差异,较少部分的男生属于青春期开始时间提前（13.92%）和延迟（22.74%）,大部分属于适时（63.33%）;②抑郁得分在青春期开始时间提前、适时与延迟的3种类型上（F=1.61,P〉0.05）无显著性差异;③焦虑总得分（F=8.02,P〈0.001）及其状态（F=5.95,P〈0.01）和特质（F=9.27,P〈0.001）两维度上存在显著性差异,提前组的焦虑得分显著高于适时组和延迟组,适时组和延迟组的得分差异不显著;④学习适应不良（F=5.31,P〈0.01）、攻击行为（F=3.58,P〈0.05）、违纪行为（F=9.29,P〈0.001）等在青春期开始时间上差异显著,提前组的学习适应不良和攻击行为显著高于适时组和延迟组,适时组和延迟组的得分差异不显著.提前组的违纪行为显著高于适时组和延迟组,适时组显著高于延迟组.结论：青春期发动时相能够影响男生的焦虑、学习适应不良、攻击行为和违纪行为,而对抑郁、退缩、神经质和考试焦虑的影响不明显.

关键词：青春期发动时相男生抑郁焦虑问题行为