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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares luiz sinesio silva neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares luiz Sinésio silva neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

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Systematic Review on Ground-Based Cloud Tracking Methods for Photovoltaics Nowcasting

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American Journal of Climate Change 2024年第3期13卷 452-476页

作者： Juliana Marian Arrais Allan Cerentini Bruno Juncklaus Martins Thiago Zimmermann Loureiro Chaves Sylvio luiz Mantelli neto Aldo von Wangenheim PPGCC-INE UFSC Federal University of Santa Catarina Florianpolis Brazil INPE Brazilian National Institute for Space Research So Paulo Brazil

Renewable energies are highly dependent on local weather conditions, with photovoltaic energy being particularly affected by intermittent clouds. Anticipating the impact of cloud shadows on power plants is crucial, as clouds can cause partial shading, excessive irradiation, and operational issues. This study focuses on analyzing cloud tracking methods for short-term forecasts, aiming to mitigate such impacts. We conducted a systematic literature review, highlighting the most significant articles on cloud tracking from ground-based observations. We explore both traditional image processing techniques and advances in deep learning models. Additionally, we discuss current challenges and future research directions in this rapidly evolving field, aiming to provide a comprehensive overview of the state of the art and identify opportunities for significant advancements in the next generation of cloud tracking systems based on computer vision and deep learning.

关键词： Nowcasting Photovoltaic Image Processing

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CFD predictions for hazardous area classification

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Chinese Journal of Chemical Engineering 2019年第1期27卷 21-31页

作者： Andrey Oliveira de Souza Aurélio Moreira luiz Ant?nio Tavernard Pereira neto Ant?nio Carlos Brandao de Araujo Heleno Bispo da silva Sidinei Kebler da silva Jose Jailson Nicacio Alves Federal Institute of Education Science and Technology of Paraiba Petrobras-Petróleo Brasileiro S.A. Federal University of Campina Grande

This study aimed to describe a Computational Fluid Dynamics(CFD) procedure using the ANSYS CFX software 16.1 and Design of Experiments for the determination of volume and extension of explosive atmospheres due to fugitive emissions of flammable *** multidimensional statistical sampling technique Latin Hypercube was used, which defined 100 simulations of random methane gas leak *** CFD model proved to be robust in predicting the extension and volume of the explosive atmosphere for orifice diameters from 0.1 to2.5 mm, pressure from 0.1 MPa to 12 MPa and temperatures from 0 ℃ to 400 ℃.It was found that the calculation domain must be parameterized 8 m in length for each millimeter of the diameter of the source of release to ensure the *** order not to lose precision for very small diameters, the mesh was parameterized with 50 elements along the orifice *** was proved that gravity does not influence the extension and volume of the explosive atmosphere at sonic *** deviation from the ideal gas behavior in the reservoir,achieved by applying the Soave–Redlich–Kwong equation of state, also has not significantly influenced the extension and volume of the explosive *** results showed that the size of the explosive atmosphere varies directly with the diameter of the source emission and reservoir pressure, and inversely with the temperature of the *** diameter of the source is the parameter that has the major effect on the extension of the explosive atmosphere, followed by the pressure and lastly the temperature of the reservoir.

关键词： Computational Fluid Dynamics Computer simulation Safety Fugitive emissions Classified area Flammable gas cloud

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Neoarchean and Rhyacian TTG-Sanukitoid suites in the southern S?o Francisco Paleocontinent,Brazil:Evidence for diachronous change towards modern tectonics

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Geoscience Frontiers 2020年第5期11卷 1763-1787页

作者： Henrique Bruno Vitalino Elizeu Monica Heilbron Claudio de Morisson Valeriano Rob Strachan Mike Fowler Samuel Bersan Hugo Moreira Ivo Dussin luiz Guilherme do Eirado silva Miguel Tupinamba Julio Almeida Carla neto Craig Storey Universidade Do Estado Do Rio de Janeiro Faculdade de GeologiaTektosGrupo de Pesquisa Em GeotectonicaRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil University of Portsmouth School of Earth and Environmental SciencesBurnaby BuildingBurnaby RoadPortsmouthUK Universit€at Salzburg Department of Geography and GeologyKapitelgasse4-65020SalzburgAustria Universidade Federal de Ouro Preto Departamento de GeologiaCampus Morro Do CruzeiroOuro PretoMGBrazil Laboratorio de Geocronologia e Isotopos Radiog^enicos Universidade Do Estado Do Rio de JaneiroRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil

The southern portion of the Sao Francisco Palaeocontinent in Brazil is denoted by Archean nuclei and Paleoproterozoic magmatic arcs that were amalgamated during Siderian to Orosirian orogenic processes(ca.2.4-2.1 Ga).New isotopic U-Pb in zircon and Sm-Nd whole rock combined with major and trace element composition analyses constrain the crystallization history of the Neoarchean Piedade block(at ca.2.6 Ga)and the Paleoproterozoic Mantiqueira Complex(ca.2.1-1.9 Ga).These therefore display quite different magmatic histories prior to their amalgamation at ca.2.05 ***-Nd and Rb-Sr isotopes imply a mixed mantle-crustal origin for the samples in both units.A complete Palaeoproterozoic orogenic cycle,from subduction to collision and collapse,is recorded in the Piedade Block and the Mantiqueira *** to Orosirian subduction processes(ca.2.2-2.1 Ga)led to the generation of coeval(ca.2.16 Ga)TTG suites and sanukitoids,followed by late(2.10-2.02 Ga)high-K granitoids that mark the collisional *** collisional accretion of the Mantiqueira Complex against the Piedade Block at 2.08-2.04 Ga is also recorded by granulite facies metamorphism in the latter terrane,along the Ponte Nova suture *** collisional stage was closely followed by the emplacement of within-plate tholeiites at ca.2.04 Ga and by alkaline rocks(syenites and enriched basic rocks)at ca.1.98 Ga,marking the transition to an extensional tectonic *** discovery of two episodes of TTG and sanukitoid magmatism,one during the Neoarchean in the Piedade Complex and another during the Rhyacian in the Mantiqueira Complex,indicates that the onset of subduction-related melting of metasomatized mantle was not restricted to Neoarchean times,as generally believed,but persisted much later into the Paleoproterozoic.

关键词： Geodynamics High Ba–Sr granitoids Diachronous TTG-Sanukitoid transition Paleoproterozoic Mantiqueira complex

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Soil and altitude drive diversity and functioning of Brazilian Páramos(campo de altitude)

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Journal of Plant Ecology 2017年第5期10卷 771-779页

作者： Andreza Viana Neri Gladson Ramon Alves Borges João Augusto Alves Meira-neto luiz Fernando silva Magnago Ian Michael Trotter Carlos Ernesto GRSchaefer Stefan Porembski Departamento de Biologia Vegetal Laboratório de Ecologia e Evolução de PlantasUniversidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Departamento de Biologia Setor de Ecologia e ConservaçãoUniversidade Federal de LavrasLavrasMinas Gerais 37200-000Brazil Departamento de Economia Rural Universidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Departamento de Solos Universidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Allgemeine und Spezielle Botanik Institut für BiowissenschaftenUniversität RostockWismarsche Str.8D-18051 RostockGermany

Aims the vegetation on Brazilian Páramos consists of assemblages that are driven mainly by the influence of strong environmental *** is very important to understand the effect of environmental varia-tion on taxonomic diversity and on functional *** the lack of information about the functional diversity in Brazilian Páramos,we analyzed for the first time the effects of altitude and edaphic attributes on functional traits,as well as on taxonomic and functional *** also wanted to answer the questions:Which ecological strategies are favorable in high-altitude grassland?Does soil attributes determine distributions of traits in high-altitude grassland?considering the studied altitudinal gradient is altitude an important variable in the community assembly?Methods the study was conducted on three mountains:Mammoth(1850 m),Elephant(1790 m)and totem(1690 m)in Serra do Brigadeiro State Park,Minas Gerais State,*** mountains represent the‘Serra das cabeças’,a smaller ridge that is surrounded by the Atlantic Forest,one of the 25 hotspot of *** samples were taken using 100 plots of 1 m2 per mountain that were randomly *** plants except mosses were *** taxonomic diversity was evaluated using richness,Shannon diversity,effective number of species and Pielou *** the functional diver-sity,we considered the functional richness,functional evenness and functional *** linear models(GLM/Poisson and quasi-Poisson)were used to evaluate the effect of abiotic variables(altitude,soil depth and soil chemical attributes)on biotic variables(number of species and individuals,life form,dispersal and fruit type)and ordinary least squares regression to evaluate the effect of abiotic variables on the functional and taxonomic *** Findingsthe soil variables presented a considerable edaphic gradient associated with *** soil in Serra das cabeças plays an important role for the

关键词： mountain conservation vegetation islands functional diversity life form highland grassland functional traits

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High chromosomal evolutionary dynamics in sleeper gobies(Eleotridae)and notes on disruptive biological factors in Gobiiformes karyotypes(Osteichthyes,Teleostei)

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Marine Life Science & Technology 2021年第3期3卷 293-302页

作者： Simião Alefe Soares da silva Paulo Augusto de Lima-Filho Clóvis Coutinho da Motta-neto Gideão Wagner Werneck Félix da Costa Marcelo de Bello Cioffi luiz Antônio Carlos Bertollo Wagner Franco Molina Departamento de Biologia Celular e Genética Centro de BiociênciasUniversidade Federal do Rio Grande do NorteNatalRN59.078-970Brazil Instituto Federal de Ciência e Tecnologia do Rio Grande do Norte Santa CruzRN59200-000Brazil Departamento de Genética e Evolução Universidade Federal de São CarlosRodovia Washington LuísKm 235São CarlosSP13.565-905Brazil

The order Gobiiformes is made up of more than 2200 species,representing one of the most diverse groups among teleost *** biological causes for the tachytelic karyotype evolution of the gobies have not yet been fully *** we expanded cytogenetic data for the Eleotridae family,analyzing the neotropical species Dormitator maculatus,Eleotris pisonis,Erotelis smaragdus,and Guavina *** addition,a meta-analytical approach was followed for elucidating the karyotype diversification versus biological aspects(habitat and egg type)of the *** species *** and *** present 2n=46 acrocentric chromosomes(NF=46),*** 2n=46(36sm+4st+6a;NF=86),and ***,the most divergent karyotype,with 2n=52 acrocentric chromosomes(NF=52).Besides numeric and structural diversification in the karyotypes,the mapping of rDNAs and microsatellites also showed noticeable numerical and positional variation,supporting the high chromosomal evolutionary dynamism of these *** Gobiiformes,karyotype patterns which are more divergent from the basal karyotype(2n=46a)are associated with characteristics less effective to dispersion,such as the benthic *** adaptive characteristics,connected with the organization of the repetitive DNA content in the chromosomes,likely play a synergistic role in the remarkable karyotype diversification of this group.

关键词： Chromosome evolution Dispersive potential Goby Karyotype diversification Microsatellites rDNA

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Clinical outcomes of hospitalized patients with chikungunya fever: A retrospective analysis

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 183-186页

作者： Lucas Lobo Mesquita Enio Simas Macedo Sergio luiz Arruda Parente Filho Francisca Lillyan Christyan Nunes Beserra Evelyne Santana Girao Juliana Mandato Ferragut Roberto da Justa Pires neto Geraldo Bezerra da silva Junior Elizabeth De Francesco Daher School of Medicine Federal University of CearaFortalezaCearaBrazil Hospital Regional da Unimed FortalezaCearaBrazil Intensive Care Unit Hospital Sao CarlosFortalezaCearaBrazil Department of Public Health School of MedicineFederal University of CearaFortalezaCearaBrazil Public Health and Medical Sciences Post-Graduation Programs School of MedicineHealth Sciences CenterUniversity of Fortaleza.FortalezaCearaBrazil Medical Sciences Post Graduate Program Department of Internal MedicineSchool of MedicineFederal University of Ceara.FortalezaCearáBrazil

Objective:To describe the prognostic and clinical profile of hospitalized patients with chikungunya virus(CHIKV)infection focusing on renal ***:This is a cross-sectional study including all patients with confirmed chikungunya fever(CHIKF)admitted to 3 different highcomplexity hospitals in Fortaleza,Brazil between January 2016 and June *** analysis was carried out to evaluate correlation between clinical profile and ***:Fifty-five patients were included,with a median age of 77(IQR=21)years,and 23(41.82%)were ***-five patients(45.45%,25/55)developed acute kidney injury(AKI),and 15(60.00%,15/25)were classified as KDIGO 1,1(4.00%)as KDIGO 2,and 9(36.00%)as KDIGO *** overall mortality was 34.54%whilst AKI-related mortality was 64.00%(16/25).Both AKI and encephalitis were associated with higher *** who died were significantly older[82(IQR=12)years vs.70(IQR=28.75)years,P<0.001].In the multivariate analysis,abdominal pain was associated with an increased risk of severe AKI(OR=5.33,95%CI=1.11–25.64,P=0.037)and AKI was an independent risk factor of death(OR=12.06,95%CI=2.55–57.15,P=0.002).Recovery of renal function was similar among the different age ***:AKI is present in half of the study population and is an independent risk factor of ***,renal function should be carefully monitored in hospitalized patients with CHIKV infection.

关键词： Arbovirus infections Chikungunya fever Acute kidney injury Elderly Mortality

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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2440-2449页

作者： Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan luiz Coelho-silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-neto Fabiola Traina Department of Medical Images Hematologyand Clinical OncologyUniversity of Sao Paulo at Ribeirao Preto Medical SchoolRibeirao PretoSao PauloBrazil Center for Cell-Based Therapy Sao Paulo Research FoundationRibeirao PretoSao PauloBrazil Knight Cancer Institute Oregon Health&Science UniversityPortlandORUSA Howard Hughes Medical Institute PortlandORUSA Department of Internal Medicine University of Sao Paulo Medical SchoolSao PauloBrazil Department of Pharmacology Institute of Biomedical Sciences of the University of Sao PauloSao PauloBrazil

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN ***157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid ***,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic *** JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(p<0.05).NT157 treatment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(p<0.05).NT157 induced genotoxic stress in a JAK2/STAT-independent ***157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN.

关键词： JAK2 IGF1R neoplasms STAT3

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Chemical Composition of the Cashew Apple Bagasse and Potential Use for Ethanol Production

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Advances in Chemical Engineering and Science 2012年第4期2卷 519-523页

作者： Flávia Cristina dos Santos Lima Flávio luiz Honorato da silva Josivanda Palmeira Gomes José Mariano da silva neto Department of Chemical Engineering Center of Sciences and TechnologyFederal University of Campina GrandeCampina GrandeBrazil Department of Chemical Engineering Center of TechnologyFederal University of ParaibaJoao PessoaBrazil Department of Agricultural Engineering Center of Science and TechnologyFederal University of Campina GrandeCampina GrandeBrazil

On the world scene, the energy requirements are mainly based on fossil fuels, however, these compounds reserves are finite and their exploitation has caused serious environmental problems. As a consequence, the demand for alternative renewable sources has been intensified in substitution the rising demand for energy and raw materials. The biomass is emerging as one of the few sources that have potential to meet these challenges of sustainability, as is currently the largest energy resource in the world, and only carbon-rich material available on the planet, apart from fossils. Form, the cashew crop has great potential for technological development of alternative sources of energy, from its industrial waste processing cashew adding value to the product. In this sense, this paper aims to study the characterization of the cashew apple bagasse and to verify (by acid prehydrolysis) the potential of this material for ethanol production. Initially it was carried out physicochemical characterization of cashew bagasse used (pH, moisture content, soluble solids, sugars, cellulose, hemicellulose and lignin). Following it was carried prehydrolysis at 105℃ for 1h to obtain fermentable sugars. Analyses of the samples were carried out on HPLC the results showed the saccharification of biomass with glucose (1537.49 mg/L), xylose (3823.22 mg/L) and arabinose (7131.11 mg/L) as well as the capacity of the biomass for ethanol production.

关键词： Pre-Hydrolyze Ethanol Cashew Apple Bagasse

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