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Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts

Journal of Animal Science and Biotechnology 2012年第1期3卷 25-31页

作者： Helena emilia CCC Manso Helio C Manso Filho luiz e de carvalho Marianne Kutschenko eduardo T Nogueira Malcolm Watford department of Animal Sciences Rural Federal University of PernambucoRecifePE52171-900Brazil departament of Animal Sciences Federal University of CearáFortalezaCE60020-181Brazil Ajinomoto do Brazil S oPauloSP04015-001Brazil department of Nutritional Sciences Rutgers UniversityNew BrunswickNJ08901USA.

Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut （2.5% by weight mixed into daily feed） provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased （P 〈 0.05） in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose （P 〈 0.05） during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend （P = 0.053）. Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development.

关键词： glutamate glutamine lactation milk pig skeletal muscle

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Duration and intensity of rainfall events with the same erosivity change sediment yield and runoff rates

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International Soil and Water Conservation Research 2021年第1期9卷 69-75页

作者： Wilk Sampaio de Almeida Steffen Seitz luiz Fernando Coutinho de Oliveira Daniel Fonseca de carvalho Agronomy department Federal Institute of EducationScience and Technology of RondôniaCampus AriquemesRO 257km 13AriquemesRO76870-000Brazil department of Geosciences University of TübingenTübingenGermany Federal University of Lavras Department of Water Resources and Sanitation37200-000LavrasMGBrazil Federal Rural University of Rio de Janeiro Engineering DepartmentBR 465km 723897-000SeropédicaRJBrazil

The effect of different rainfall patterns on surface runoff,infiltration and thus soil losses and sediment concentrations are still in the focus of current *** most simulated rainfall experiments,pre-cipitation is applied at a fixed intensity for a fixed ***,the impact of rainfall patterns on soil erosion processes may be different varying the rainfall duration and intensity that produces an event with similar rainfall erosivity ***-five rainfall events were applied on micro-scale runoff plots in a soil covered with corn straw to evaluate the sediment yield and runoff *** different rainfall types were composed by association of duration(Dur)and intensity(IP)with the same erosivity *** Dur varied from 38 to 106 min and the IP varied from 75.0 to 44.6 mm h^(-1).The sediment yield varied from 1.89±1.26 g m^(-2) to 4.02±2.66 g m^(-2) and runoff ranged from 16.9±8.74 mm to 32.63±10.67 mm with highest rates occurring with high intensity and low *** highest rainfall intensity provides the maximum sediment yield(0.138 g m^(-2) min^(-1))and runoff rates(0.87 mm min^(-1)).The time to start surface runoff varied from 14 to 19.2 min and it was longer in treatments with longer durations and low precipitation *** difference was found in the amount of sediments applying rain with the same erosivity and different associations of duration and ***,the intensity and duration of the rain,with the same erosivity,altered the amount and time of *** rainfall experiments with con-stant intensity and fixed time,the erosion rates depend on the duration of the applied ***,the results of this study can contribute to the development of new perspectives in the design of water erosion experiments with simulated rain considering the duration,intensity and also the association of these variables to produce rainfall that delivery the same soil erosion capacity.

关键词： Simulated rainfall Rainfall pattern Water erosion Soil loss

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Dipole (hyper)polarizabilities of neutral silver clusters

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Chinese Physics B 2016年第12期25卷 217-222页

作者： Francisco e Jorge luiz G M de Macedo departarnento de Fisica Universidade Fedoral do Espirito Santo 29060-900 Vitoria Brazil Unidade Academica de Fisica Universidade Federal de Campina Grande 58429-900 Campina Grande Brazil Faculdade de Biotecnologia ICB Universidade Federal do Para 66075-110 Belem Brazil

At the Douglas-Kroll-Hess （DKI4） level, the B3PW91 functional along with the all-eleclron relativistic basis sets of valence triple and quadruple zeta qualities are used to determine the structure, stability, and electronic properties of the small silver clusters （Agn, n ≤ 7）. The results presented in this study are in good agreement with the experimental data and theoretical values obtained at a higher level of theory from the literature. Static polarizability and hyperpolarizability are also reported. It is verified that the mean dipole polarizability per atom exhibits an odd-even oscillation and that the polarizability anisotropy is directly related to the cluster shape. In this article, the first study of hyperpolarizabilities of small silver clusters is presented. except for the monomer, the second hyperpolarizabilities of the silver clusters are significantly larger than those of the copper clusters.

关键词： B3PW91 functional all-electron basis sets non-relativistic and DKH2 calculations silver clusters,dipole (hyper)polarizabilities

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Distal renal tubular acidosis:genetic causes and management

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World Journal of Pediatrics 2019年第5期15卷 422-431页

作者： Sílvia Bouissou Morais Soares luiz Alberto Wanderley de Menezes Silva Flávia Cristina de carvalho Mrad Ana Cristina Simoes e Silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Prof.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Background Distal renal tubular acidosis(dRTA)is a kidney tubulopathy that causes a state of normal anion gap metabolic acidosis due to impairment of urine *** review aims to summarize the etiology,pathophysiology,clinical findings,diagnosis and therapeutic approach of dRTA,with emphasis on genetic causes of *** sources Literature reviews and original research articles from databases,including PubMed and Google *** searching was performed to identify additional studies about *** dRTA is characterized as the dysfunction of the distal urinary acidification,leading to metabolic *** pediatric patients,the most frequent etiology of dRTA is the genetic alteration of genes responsible for the codification of distal tubule channels,whereas,in adult patients,dRTA is more commonly secondary to autoimmune diseases,use of medications and *** with dRTA exhibit failure to thrive and important laboratory alterations,which are used to define the *** oral alkali and potassium supplementation can correct the biochemical defects,improve clinical manifestations and avoid nephrolithiasis and *** dRTA is a multifactorial disease leading to several clinical *** and laboratory alterations can be corrected by alkali replacement therapy.

关键词： Renal tubular acidosis Distal tubule physiology Metabolic acidosis Gene mutations Proton pump

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Stepped machine learning for the development of mineral models: Concepts and applications in the pre-salt reservoir carbonate rocks

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energy and AI 2021年第1期3卷 167-179页

作者： Lucas Abreu Blanes de Oliveira luiz Felipe Niedermaier Custodio Thais Bortotti Fagundes Carina Ulsen Cleyton de carvalho Carneiro Petrobras–Petroleo Brasileiro S.A. Avenida Henrique Valadares 28CentroRio de Janeiro20231-030 Rio de JaneiroBrazil Universidade de Sao Paulo USPEscola PolitecnicaPraça Narciso de AndradeVila MathiasSantosSão Paulo 11013-560Brazil

Understanding rock mineralogy is essential for formation evaluation,improving the calculation of porosity and hydrocarbon *** primary method to obtain the mineralogy from a well is by applying a model to the geochemical tool’s chemical ***,creating a mineralogical model presents challenges such as the minerals’chemical composition and the decision to include a mineral in the *** traditional application of machine learning can make mineral models less realistic since conventional training is developed based on a set of minerals with different occurrences,lowering some minerals’*** present research proposes the stepped machine learning(SML),a stepped way to use machine learning to create a mineralogical model from chemical and mineralogical data.A database was assembled with the elemental concentration obtained with XRF analyses and the mineral concentrations obtained with XRD *** chemical elements were Al,Ca,Fe,K,Mg,Mn,Na,Si,and *** minerals were calcite,dolomite,quartz,clays,K-feldspar,plagioclase,and *** algorithms were tested:MLP,GAN,Random Forest,and XGBoost,with XGBoost showing the best *** was applied,where a mineral model results are used to train a subsequent *** allowed for a significant improvement in some models,notably to clays with an increase in R 2 from 0.597 to 0.853,quartz an increase from 0.673 to 0.869,and calcite,from 0.758 to 0.862.A decrease in the mean squared error of these minerals’models was also *** model was applied to the geochemical logs from three wells drilled in the Brazilian pre-salt,and the results were compared with XRD *** SML model was able to honor the mineral concentrations for different *** is demonstrated that the integration between machine learning tools and geological knowledge in SML was crucial for creating a representative mineralogical model.

关键词： minerals quartz reservoir

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Bartter's syndrome:clinical findings,genetic causes and therapeutic approach

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World Journal of Pediatrics 2021年第1期17卷 31-39页

作者： Flavia Cristina carvalho Mrad Sílvia Bouissou Morais Soares luiz Alberto Wanderley de Menezes Silva Pedro Versiani dos Anjos Menezes Ana Cristina Simoes-e-Silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Backgound Bartter's syndrome(BS)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's *** sources Literature reviews and original research articles were collected from database,including PubMed and *** According to the time of onset and symptoms,BS can be classified into antenatal and classic *** studies have identified different subtypes of *** types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),***-of-function mutations of Barttin CLCNK type accessory beta subunit cause BS type Ⅳ*** mutations of CLCNKB and CLCNKA cause BS type Ⅳ*** type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGe family member *** gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of *** clinical and biochemical alterations in BS include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to *** focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin e2 *** early diagnosis and treatment of BS may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease.

关键词： Bartter's syndrome Hypercalciuria Hypokalemia Metabolic alkalosis Nephrocalcinosis

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How to improve colon cancer screening rates

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 484-491页

作者： luiz Ronaldo Alberti Diego Paim carvalho Garcia debora Lucciola Coelho David Correa Alves de Lima Andy Petroianu department of Surgery Federal University of Minas Gerais Medical Sciences of Minas Gerais

Colorectal carcinoma is a common cause of death throughout the world and may be prevented by routine control, which can detect precancerous neoplasms and early cancers before they undergo malignant transformation or metastasis. Three strategies may improve colon cancer screening rates: convince the population about the importance of undergoing a screening test; achieve higher efficacy in standard screening tests and make them more available to the community and develop new more sensitive and efficacious screening methods and make them available as routine tests. In this light, the present study seeks to review these three means through which to increase colon cancer screening rates.

关键词： Colon cancer screening Colon cancer Screening test

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ASYMPTOTIC HOMOGeNIZATION IN A PARABOLIC SeMILINeAR PROBLeM WITH PeRIODIC COeFFICIeNTS AND INTeGRABLe INITIAL DATA

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Acta Mathematica Scientia 2013年第5期33卷 1275-1292页

作者： Rogerio luiz Quintino de OLIVeIRA JUNIOR Instituto de Matema'tica e estat' stica Universidade do Estado do R.de Janeiro Rua S ao Francisco Xavier524 - Pavilha o Reitor Joa o Lyra Filho 6oandar bl.B 20559-900 Rio de Janeiro R.J. Brazil

In this paper, we study the large time behavior of solutions of the parabolic semilinear equation δtu-div（a（x）△↓u） = -｜u｜^αu in （0,∞） × R^N, where α 〉 0 is constant and a∈ Cb^1（R^N） is a symmetric periodic matrix satisfying some ellipticity *** an integrable initial data u0 and α ∈ （2/N, 3/N）, we prove that the large time behavior of solutions is given by the solution U（t, x） of the homogenized linear problem δtU-div（a^h△↓U）=0,U（0） = C, where a^h is the homogenized matrix of a（x）, C is a positive constant and δ is the Dirac measure at 0.

关键词： homogenization similinear parabolic equation integrable initial data matrix with periodic coefficient large time behavior

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： edison Iglesias de Oliveira Vidal luiz Fernando Alvarenga Ribeiro Marco Antonio de carvalho-Filho Fernanda Bono Fukushima Internal Medicine department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil Surgical Specialties and Anesthesiology department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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Cerium alleviates drought-induced stress in Phaseolus vulgaris

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Journal of Rare earths 2020年第3期38卷 324-331页

作者： Olívia Graziela Gelioli Salgado Jéssica Cristina Teodoro Joyce Pereira Alvarenga Cynthia de Oliveira Teotonio Soares de carvalho Débora Domiciano Paulo eduardo Ribeiro Marchiori luiz Roberto Guimaraes Guilherme department of Soil Science Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil department of Biology Federal University of LavrasCP 3037Campus UFLALavras37200-000Brazil

extreme drought events are expected to be one of the main challenges for tropical agriculture and,consequently,for global food *** this reason,it is urgent to develop strategies to increase water use efficiency,as well as to increase crops’ ability to cope with *** rare earth elements(Rees) are known to alleviate damages in plants under abiotic stresses,we hypothesized that addition of Ce^3+to nutrient solution would promote the growth of common bean,especially under simulated drought *** test this hypothesis,we conducted an experiment evaluating the effect of six Ce^3+concentrations on the development and physiological traits of common bean grown in nutrient solution under normal condition and under induced drought stress,caused by the addition of polyethylene glycol6000 to the nutrient *** results show that Ce^3+alleviates water stress in common bean plants,increasing their survival rate and *** addition,Ce^3+application increases photosynthesis rate,chlorophyll content and water use efficiency under water ***,we observe no significant effect of Ce^3+on plants growing under normal ***,Ce3+seems to be a promising attenuator of drought stress for common bean.

关键词： Water stress Polyethylene glycol Rare earth elements Cerium nitrate Mitigation Common bean

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