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Serum levels of chemokines in adolescents with major depression treated with fluoxetine

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World Journal of Psychiatry 2020年第8期10卷 175-186页

作者： Francisco Rafael de la Peña Carlos Cruz-Fuentes Lino Palacios Manuel Iván Girón-Pérez Emilio medina-Rivero Maria Dolores Ponce-Regalado Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva Joséluis Maldonado-García María C Jiménez-Martínez Lenin Pavón Adolescent Clinic Clinical ServicesNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Psychiatric Genetics Clinical Research BranchNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Universidad Autónoma de Nayarit Laboratorio de InmunotoxicologíaBoulevard Tepic-Xalisco s/nCd de la Cultura Amado NervoTepic 63000Mexico Centro Nayarita de Innovación y Transferencia de Tecnología A.C.Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit Calle Tres s/n.Cd IndustrialTepic 63000NayaritMexico Unidad de Desarrollo e Investigación en Bioprocesos Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalUnidad Profesional Lázaro CárdenasMexico City 11340Mexico Departamento de Ciencias de Salud Centro Universitario de los AltosUniversidad de Guadalajara Av Rafael Casillas Aceves No.1200Tepatitlán de MorelosJalisco47610Mexico Laboratory of Psychoimmunology National Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Immunology and Research Unit Institute of Ophthalmology“Conde de Valenciana Foundation”Mexico City 06800Mexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico City 04510Mexico

BACKGROUND Major depressive disorder(MDD)is a global health issue that affects 350 million people of all *** between 2%and 5.6%of affected individuals are adolescents,research on young patients is *** inflammatory response contributes to the onset of depression,and in adult MDD patients,symptom severity has been linked to chemokine *** To determine the differences in circulatory levels of chemokines in healthy volunteers(HVs)and adolescents with MDD,and assess the changes induced by fluoxetine *** The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale(HDRS).The serum levels of monocyte chemoattractant protein-1(MCP-1),macrophage inflammatory protein(MIP)-1α,MIP-1β,interleukin(IL)-8,interferon gamma-induced protein(IP)-10,and eotaxin were measured in patients and *** In all cases,significant differences were detected in circulating chemokine levels between patients before treatment and HVs(P<0.0001).All chemokines decreased at 4 wk,but only MCP-1 and IL-8 significantly differed(P<0.05)between 0 wk and 4 *** the patients,all chemokines rose to their initial concentrations by 8 wk vs 0 wk,but only IP-10 did so significantly(P<0.05).All patients experienced a significant decrease in HDRS scores at 4 wk(P<0.0001)and 8 wk(P<0.0001)compared with 0 *** Despite the consumption of fluoxetine,patients had significantly higher chemokine levels,even after considering the improvement in HDRS *** high levels of eotaxin,IP-10,and IL-8 partially explain certain aspects that are affected in MDD such as cognition,memory,and learning.

关键词： Adolescents Major depression Chemokine Fluoxetine Interferon gammainduced protein-10

Reversible Immobilization of Chelating Affinity Surfactants on Reversed Phase Adsorbents for Protein and Peptide Separations under Metal Affinity Chromatography

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American Journal of Analytical Chemistry 2014年第14期5卷 932-944页

作者： Omar González-ortega Roberto Guzmán Chemical and Environmental Engineering Department The University of Arizona Tucson USA Bioprocess Engineering Department Autonomous University of San Luis Potosí San Luis Potosí México

Alkyl-bound silica was modified using chelating surfactants and the resulting adsorbent was used in immobilized metal affinity chromatography of proteins and peptides. Brij-76, a non-ionic amphiphilic surfactant with an alkyl moiety and an ethylene oxide chain, was reversible adsorbed to alkyl silica (C18). The hydroxyl group at the end of the ethylene oxide chain was chemically modified previously with an iminodiacetate functionality as chelating agent of transitional metal ions. Cu(II) was studied as immobilized ion for the adsorption of peptides and proteins. Three chromatographic supports were prepared having different Cu(II) capacities. For a low Cu(II) capacity case, the generated adsorbent behaved as a controlled access media preventing the adsorption of large molecular weight proteins, such as BSA, while small peptides, such as Angiotensin III, or amino acids could be retained. For a medium and high Cu(II) capacity, the synthesized adsorbent no longer behaved as a controlling access media and all molecules in this study, either large or small, were retained by the immobilized ion. Nonetheless, most of the BSA was strongly retained by the system and a pH change did not remove any of the adsorbed BSA while the small molecules were removed by the same pH change.

关键词： IMAC Brij Chelating Surfactant Restricted Access Media Alkyl-Bound Silica

Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1519-1533页

作者： Danaé Samara Sánchez-Sandoval Omar González-ortega Mara Fernanda Navarro-Martínez Juan Marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-Guerra Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México

The emerging contaminants(ECs)are organic compounds including *** products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living *** is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged *** is the commonest postoperative analgesic,and it is highly consumed without *** recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising *** this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was *** major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of *** degradation by light was also *** maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 *** did not show growth inhibition due to the presence of *** results obtained point to the promissory application of *** as a bioremediation system for diclofenac removal.

关键词： Adsorption emerging contaminants microalgae pharmaceuticals phycoremediation photodegradation

Variants Of Human Papillomavirus Types 16,18,45,31 And 58 In Mexico

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Variants Of Human Papillomavirus Types 16,18,45,31 And 58 In...

Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit

24th International Papillomavirus Conference and Clinical Workshop

作者： Elena E Hernandez-Ramon Ingrid Y medina-Martinez Mercedes Solis-Trejo Eligia Juarez-Torres Edgar Roman-Bassaure Avissai Alcantara-Vazcluez Patricia Alonso-Viveros luis A Macias-Olvera Jaime Berumen Genomic Medicine Unit Genomic Medicine Unit Hospital General de Mexico Genomic Medicine Unit Hospital General de Mexico Genomic Medicine Unit Hospital General de Mexico Oncology Service Hospital General de Mexico Pathology Service Hospital General de Mexico Pathology Service Hospital General de Mexico Genomic Medicine Unit Hospital General de Mexico Genomic Medicine Unit Hospital General de Mexico

＜正＞Human papillomavirus infection has been considered as the major risk factor for cervical cancer In developing countries,this is the most common cancer among women In Mexico,the incidence of cervical cancer is 44...

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Horticulture Research 2019年第1期6卷 1638-1654页

作者： JoséG.Vallarino Delphine M.Pott Eduardo Cruz-Rus luis Miranda Juan J.medina-Minguez Victoriano Valpuesta Alisdair R.Fernie JoséF.Sánchez-Sevilla Sonia Osorio Iraida Amaya Department of Molecular Biology and Biochemistry Instituto de Hortofruticultura Subtropical y Mediterránea“La Mayora”University of Málaga–Consejo Superior de Investigaciones Científicas(IHSM-UMA-CSIC)Campus de Teatinos29071 MálagaSpain Max-Planck-Institut für Molekulare Pflanzenphysiologie Am Mühlenberg 114476 Potsdam-GolmGermany Genómica y Biotecnología Centro de MálagaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140 MálagaSpain Ingeniería y Tecnología Agroalimentaria Centro Las Torres-TomejilInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)Alcaládel RíoSevillaSpain Ingeniería y Tecnología Agroalimentaria Centro de HuelvaInstituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)HuelvaSpain

Improvement of nutritional and organoleptic quality of fruits is a key goal in current strawberry breeding *** ratio of sugars to acids is a determinant factor contributing to fruit liking,although different sugars and acids contribute in varying degrees to this complex trait.A segregating F1 population of 95 individuals,previously characterized for several fruit quality characters,was used to map during 2 years quantitative trait loci(QTL)for 50 primary metabolites,L-ascorbic acid(L-AA)and other related traits such as soluble solid content(SSC),titratable acidity(TA),and pH.A total of 133 mQTL were detected above the established thresholds for 44 *** 12.9%of QTL were detected in the 2 years,suggesting a large environmental influence on primary metabolite *** objective of this study was the identification of key metabolites that were associated to the overall variation in SSC and *** it was observed in previous studies,a number of QTL controlling several metabolites and traits were co-located in homoeology group V(HG V).mQTL controlling a large variance in raffinose,sucrose,succinic acid,and L-AA were detected in approximate the same chromosomal regions of different homoeologous linkage groups belonging to HG *** genes for selected mQTL are proposed based on their co-localization,on the predicted function,and their differential gene expression among contrasting F1 progeny ***-seq analysis from progeny lines contrasting in L-AA content detected 826 differentially expressed genes and identified Mannose-6-phosphate isomerase,FaM6PI1,as a candidate gene contributing to natural variation in ascorbic acid in strawberry fruit.

关键词： straw breeding trait

Biocompatibility and electrochemical evaluation of ZrO_(2) thin films deposited by reactive magnetron sputtering on MgZnCa alloy

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Journal of Magnesium and Alloys 2021年第6期9卷 2019-2038页

作者： Benjamín Millán-Ramos Daniela Morquecho-Marín Phaedra Silva-Bermudez David Ramírez-ortega Osmary Depablos-Rivera Julieta García-López Mariana Fernández-Lizárraga JoséVictoria-Hernández Dietmar Letzig Argelia Almaguer-Flores Sandra E.Rodil Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado en Ciencia e Ingeniería de Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina RegenerativaInstituto Nacional de Rehabilitación Luis Guillermo IbarraCDMX 14389Mexico Posgrado en Ciencias Médicas Odontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico Instituto de Ciencias Aplicadas y Tecnologia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCDMX 11340Mexico Institute of Material and Process Design Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Magnesium Innovation Centre MagIC Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Laboratorio de Biointerfases Facultad de OdontologíaDivisión de Estudios de Posgrado e InvestigaciónUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be ***_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and *** this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was ***-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss *** results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the *** ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare ***,the ZrO_(2)coating prevents the adhesion and biofilm formation of ***.

关键词： Zirconium dioxide Magnetron sputtering Short-term degradation H_(2)evolution

Bubble Column Reactor Fluid-dynamic Evaluation at Pilot-plant for Residue and Extra-heavy Crude Oil Upgrading Technology

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Journal of Chemistry and Chemical Engineering 2015年第3期9卷 176-190页

作者： Ricardo Sardella Palma Zacarias luis Paiva Miguel medina Henry Infrastructure and Upgrading Department PDVSA-Intevep Los Teques-Miranda 1201 Venezuela Refining Department PDVSA-Intevep Los Teques-Miranda 1201 Venezuela

Bubble column reactors are multiphase contacting devices used in a wide variety of industrial application. Inrtevep S. A. is working on developing technologies to convert heavy and extra-heavy crude oil using this type of reactors. Volumetric gas hold up, flow pattern, average gas bubble size, average interfacial area, RTD (residence time distribution), dispersion coefficient, Péclet number are important design parameters for a proper scale up of them. Several cold model experiments have been proposed to determine the previously mentioned parameters at atmospheric conditions, using a plexiglas bubble column reactor at pilot plant scale unit (12 cm diameter). It was also evaluated our own design of internal trays (plates) in the reactor. Air-tap water and air-light oil systems have been used. A wide operating condition range was applied, superficial gas velocity between 0.5-10 cm/s, liquid flowrate between 15-65 l/h. Generally speaking, working without internal trays was found that gas hold up increase along the reactor and it was possible to identify heterogeneous bubble, transition and turbulent flow pattern areas for the air-light oil system. Average gas bubble size increase along the reactor at bubble regime from 2-5 mm but at turbulent regime, stay oscillating between 1-3 mm. Average interfacial area increases exponentially with superficial gas velocity at any reactor height, till 1,412 m2/m3 for the air-light oil system but, at bubble flow regime, the average interfacial area is lower than 100 m2/m3, which negatively impact the reactor performance. Internal trays in the reactor always increase gas hold up at any condition or system used. Residence time distributions curves, Péclet numbers and dispersion coefficients founded, show that this reactor with this kind of design internal trays still tends to be a complete mixing reactor under the operating conditions used.

关键词：鼓泡塔反应器试验装置流体动力 Peclet数超稠油停留时间分布完全混合反应器气泡尺寸

Multinational Measles Outbreak in Post-Elimination Era,Involves Three Countries of North America and a European Country in a Short Transmission Chain

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World Journal of Vaccines 2015年第2期5卷 79-87页

作者： Cuitláhuac Ruiz-Matus Lorena Suárez-Idueta Ilse Herbas-Rocha Jose luis Diaz-ortega Edith Cruz-Ramírez Abraham Ramírez-Jurado Irma Lopez-Martínez Jose Cruz Rodríguez-Martínez Jose Alberto Díaz-Quinonez General Directorate of Epidemiology Ministry of HealthMexico CityMexico National Center for Health of Children and Adolescents Ministry of HealthMexico CityMexico National Institute of Public Health Mexico CityMexico Institute for Epidemiological Diagnosis and Reference Ministry of Health MexicoMexico CityMexico State Health Services Quintana RooMexico

Background: Four measles cases in Canada and one in the United States are linked to international importation of measles in Playa del Carmen, Quintana Roo, Mexico. Objective: To describe characteristics of transmission and not spillover to local population in Mexico. Material and Methods: The outbreak investigation was based on active search of cases and in the rapid monitoring of vaccination coverage in children aged 1 - 7 years old. Laboratory confirmation by Enzyme-Linked Immunosorbent Assay (ELISA) and molecular detection by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) assay in throat swab and urine were done. Results: One transmission chain with three generations of cases was identified. The primary case was a 9-year-old boy who was infected in Wales, UK. His sisters aged 7 and 15 years old respectively, were the first generation of cases in Mexico. The second generation was related to the imported cases, and affected two Canadian tourists and an American woman aged 39 years old. A third generation occurred in Canada and affected an infant of 15 months of age and his sister aged 4 years old. The genotype D8 which was circulating in UK was identified in these patients. One probable case was detected in Quintana Roo, but was discarded by laboratory testing. The coverage with at least one dose of Measles-Mumps-Rubella (MMR) vaccine ranged from 95% to 99.5%. Conclusion: International travelers with no history of vaccination are at risk of acquiring measles even in countries that have interrupted endemic transmission. The high immunization coverage of measles containing vaccine could explain the absence of cases in Mexican population. Highlights: Multinational measles outbreak in a country without endemic transmission. The findings exhibit the importance of immunization in international travelers in the post-elimination era.

关键词： Measles Multinational Outbreak Transmission in Post-Elimination Era Genotype D8

Management of primary achalasia: The role of endoscopy

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World Journal of Gastrointestinal Endoscopy 2015年第6期7卷 593-605页

作者： Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique medina-Chuliá Digestive Diseases Unit General University Hospital of Valencia

Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment.

关键词： Achalasia Endoscopic treatment Dilation Botulinum toxin Myotomy