Serum levels of chemokines in adolescents with major depression treated with fluoxetine

作     者：Francisco Rafael de la Peña Carlos Cruz-Fuentes Lino Palacios Manuel Iván Girón-Pérez Emilio Medina-Rivero Maria Dolores Ponce-Regalado Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva JoséLuis Maldonado-García María C Jiménez-Martínez Lenin Pavón 

作者机构：Adolescent ClinicClinical ServicesNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Psychiatric GeneticsClinical Research BranchNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Universidad Autónoma de NayaritLaboratorio de InmunotoxicologíaBoulevard Tepic-Xalisco s/nCd de la Cultura Amado NervoTepic 63000Mexico Centro Nayarita de Innovación y Transferencia de Tecnología A.C.Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad NayaritCalle Tres s/n.Cd IndustrialTepic 63000NayaritMexico Unidad de Desarrollo e Investigación en BioprocesosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalUnidad Profesional Lázaro CárdenasMexico City 11340Mexico Departamento de Ciencias de SaludCentro Universitario de los AltosUniversidad de Guadalajara Av Rafael Casillas Aceves No.1200Tepatitlán de MorelosJalisco47610Mexico Laboratory of PsychoimmunologyNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Immunology and Research UnitInstitute of Ophthalmology“Conde de Valenciana Foundation”Mexico City 06800Mexico Department of BiochemistryFaculty of MedicineNational Autonomous University of MexicoMexico City 04510Mexico 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2020年第10卷第8期

页      面：175-186页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Secretaria de Ciencia Tecnología e Innovación No.0048/2014 

主　　题：Adolescents Major depression Chemokine Fluoxetine Interferon gammainduced protein-10 

摘      要：BACKGROUND Major depressive disorder(MDD)is a global health issue that affects 350 million people of all *** between 2%and 5.6%of affected individuals are adolescents,research on young patients is *** inflammatory response contributes to the onset of depression,and in adult MDD patients,symptom severity has been linked to chemokine *** To determine the differences in circulatory levels of chemokines in healthy volunteers(HVs)and adolescents with MDD,and assess the changes induced by fluoxetine *** The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale(HDRS).The serum levels of monocyte chemoattractant protein-1(MCP-1),macrophage inflammatory protein(MIP)-1α,MIP-1β,interleukin(IL)-8,interferon gamma-induced protein(IP)-10,and eotaxin were measured in patients and *** In all cases,significant differences were detected in circulating chemokine levels between patients before treatment and HVs(P0.0001).All chemokines decreased at 4 wk,but only MCP-1 and IL-8 significantly differed(P0.05)between 0 wk and 4 *** the patients,all chemokines rose to their initial concentrations by 8 wk vs 0 wk,but only IP-10 did so significantly(P0.05).All patients experienced a significant decrease in HDRS scores at 4 wk(P0.0001)and 8 wk(P0.0001)compared with 0 *** Despite the consumption of fluoxetine,patients had significantly higher chemokine levels,even after considering the improvement in HDRS *** high levels of eotaxin,IP-10,and IL-8 partially explain certain aspects that are affected in MDD such as cognition,memory,and learning.