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Hidden in plain sight:Morphological and phylogenetic evidence for Bouteloua arizonica,a species distinct from Bouteloua aristidoides(Poaceae,Chloridoideae)

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Plant Diversity 2021年第2期43卷 125-133页

作者： luis fernando cuellar-garrido Maria Elena Siqueiros-Delgado Herbario Luz Maria Villarreal de Puga Del Instituto de Botanica(IBUG) Departamento de Botanica y ZoologíaCentro Universitario de Ciencias Biologicas y AgropecuariasUniversidad de GuadalajaraCamino Ing.Ramon Padilla Sanchez 2100CP 45200ZapopanJaliscoMexico Departamento de Biologia Centro de Ciencias BioasicasUniversidad Autonoma de AguascalientesAvenida Universidad 940CP 20131AguascalientesMexico

Two varieties of Bouteloua aristidoides have been recognized,the widespread *** and the more narrowly distributed *** two varieties differ in inflorescence form even more than that seen between many other closely related species of *** therefore asked whether these taxa might be better regarded as distinct species.A total of 93 vouchers were studied by using morphometry(principal components analysis and statistical tests),leaf micromorphology,ancestral state reconstruction,and/or molecular(ITS,trnC-rpoB and trnT-L-F)phylogenetic *** from the ITS tree,all results supported elevation of *** *** to the rank of species,thus the new combination Bouteloua arizonica(***)***&Columbus *** ***.,is *** and combined chloroplast-nuclear molecular trees depicted *** as monophyletic(even in sympatric populations with ***)and reveals phylogenetic structure within *** for which the presence of new undescribed varieties of ***(different from ***)is *** differs from *** in having fewer branches per inflorescence,a bigger branch with more spikelets,and a shorter branch *** electron microscopy revealed the presence of papillae on leaves of *** as a clear *** mature plants of *** from seeds in a greenhouse revealed a strong cleistogamous nature for this species for which gene flow in sympatric populations with *** seems unlikely.A taxonomic treatment and distribution map for identification of *** is provided.

关键词： Ancestral state reconstruction Bouteloua arizonica Cleistogamy Morphology Phylogeny Sympatry

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Habitat-dependent breeding biology of the Blue Tit(Cyanistes caeruleus)across a continuous and heterogeneous Mediterranean woodland

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Avian Research 2023年第3期14卷 499-510页

作者： Jorge garrido-Bautista Carmen Hernandez-Ruiz Jose luis Ros-Santaella Eliana Pintus Nicola Bernardo Mar Comas Gregorio Moreno-Rueda Department of Zoology Faculty of SciencesUniversity of Granada18071GranadaSpain Tecnologías y Servicios Agrarios S.A. S.M.E.M.P.(Tragsatec)06800BadajozSpain Department of Veterinary Sciences Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences PragueKamýcka 12916500Prague 6-SuchdolCzech Republic Biological Station of Donana EBD-CSICAv.Americo Vespucio 2641092SevilleSpain Department of Biological Sciences Dartmouth College03755HanoverNHUSA

Mediterranean woodland environments are characterised by high spatial and temporal heterogeneity,which means the inhabiting species face a wide variety of selective *** may respond differently to habitat heterogeneity and so distinct eco-evolutionary scenarios may be responsible for the inter-habitat variability in reproductive strategies observed in certain *** inter-forest variability of some reproductive traits in passerines has been examined by comparing forest patches or separated ***,there is still little information regarding how such highly mobile animals adjust their breeding performance across continuous and heterogeneous *** we studied the reproductive performance of a population of Blue Tits(Cyanistes caeruleus) in an area of continuous Mediterranean woodland that included two mountain slopes and four different types of forest,ranging from deciduous oak forests to perennial non-oak *** studied the habitat heterogeneity and inter-forest phenotypic variation in terms of reproductive performance and adult and nestling biometry,besides also exploring the effects of ectoparasites on Blue Tit *** were laid earliest in deciduous Pyrenean Oak(Quercus pyrenaica) forests,while clutch size and the number of fledglings were highest in the humid Pyrenean Oak forest,which had the greatest tree coverage and most humid climate,and lowest in the coniferous Scots Pine(Pinus sylvestris) *** were no inter-forest differences in hatching(percentage of nests with at least one egg hatched) and fledging(percentage of nests in which at least one nestling fledged)***,there were no inter-forest differences in adult and nestling biometry,but adults that raised more fledglings had a lower body mass,while males whose females laid larger clutches had smaller *** ectoparasites did not affect Blue Tit reproduction,although Culicoides had a negative impact on nestling body *** results

关键词： Birds Breeding success Cavity-nesting birds Paridae Passerines Reproduction

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Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第17期29卷 2571-2599页

作者： Fernanda Villarruel-Melquiades María Eugenia Mendoza-garrido Claudia M García-cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón Javier Camacho Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)Mexico City 07360Mexico Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAVIPN)Mexico City 07360Mexico Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)Mexico City 14080Mexico Instituto Nacional de Medicina Genómica Instituto Nacional de Medicina Genómica(INMEGEN)Mexico City 14610Mexico

Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours *** mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related *** drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC ***,these therapies are ineffective in most cases due to late diagnosis and the development of tumour ***,novel pharmacological alternatives are urgently *** instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune ***,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC *** addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic ***,we review the current and novel pharmacological approaches to fight *** studies,as well as approved and ongoing clinical trials for liver cancer treatment,are *** pharmacological opportunities analysed here should lead to significant improvement in HCC therapy.

关键词： Liver cancer Systemic therapy Immunotherapy Drug repurposing Drug combinations Hepatocellular carcinoma

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Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality

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Asian Journal of Andrology 2018年第5期20卷 498-504页

作者： Marta Gianzo Itziar Urizar-Arenaza Iraia Munoa-Hoyos Zaloa Larreategui Nicolas garrido luis Casis Jon Irazusta Nerea Subiran Department of Physiology Faculty of Medicine and Nursery University of the Basque Country (UPV/EHU) Leioa Biscay 48940 Spain In Vitro Fertilization Laboratory IVI Bilbao Landabarri Promenade 1 Leioa Biscay 48940 Spain IVI Foundation IVI Valencia Local Police Square 3 Valencia 46015 Spain

Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed. Semen parameters, embryos quality, and blastocyst development were examined according to the World Health Organization standards and the Spanish Association of Reproduction Biology Studies criteria. The percentage of testicular angiotensin-converting enzyme-positive spermatozoa and the number of molecules per spermatozoon were analyzed by flow cytometry. Both parameters were inversely correlated with human sperm motility. Higher percentages of testicular angiotensin-converting enzyme-positive spermatozoa together with fewer enzyme molecules per spermatozoon were positively correlated with better embryo quality and development. Our results suggest that embryos with a higher implantation potential come from semen samples with higher percentages of testicular angiotensin-converting enzyme-positive cells and fewer enzyme molecules per spermatozoon. Based on these findings, we propose that testicular angiotensin-converting enzyme could be used to aid embryologists in selecting better semen samples for obtaining high-quality blastocysts during in vitro fertilization procedures.

关键词： angiotensin-converting enzyme ART embryonic development human sperm male fertility

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The Yukawa and Exponential Potentials for a Galaxy’s Spherical Central Bulge*

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Journal of Modern Physics 2023年第S1期14卷 1755-1761页

作者： José luis garrido Pestaña Departamento de Física Universidad de Jaén Campus Las Lagunillas Jaén Espa&#241a

By adding an extra term to the Newtonian potential, matter outside the orbit of a star adds to the gravitational acceleration acting on that star. In this work, we solve the Poisson equation for non-Newtonian potentials of a spherically symmetric distribution of mass. We derive equations for calculating the centripetal acceleration and velocity of galactic disk stars that are due to the Newtonian and exponential potentials of the galaxy’s central bulge.

关键词： Galaxies: Kinematics and Dynamics Gravitation General Physics (Physics Education)

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PM Diagram of the Transfer Function and Its Use in the Design of Controllers

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Journal of Mathematics and System Science 2015年第4期5卷 138-149页

作者： Santiago garrido luis Moreno Carlos Ⅲ University of Madrid Spain

This paper presents an enhanced Root Locus diagram that consists of the representation of the phase and the magnitude of the transfer function G（s） of a system. The magnitude is represented in decibels and the phase is represented by colors. It also presents how to use it to calculate different kinds of controllers. An important characteristic of this diagram is that permits to read the phase and the gain margins directly and the imaginary axis cut represents the Bode diagram. It is also possible to put the grid with damping ratio ξ and frequency ωn.

关键词： Root Locus PID controller Lead network Bode plot Phase margin Gain margin.

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Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics

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The Journal of Biomedical Research 2019年第5期33卷 333-342页

作者： Raul Eduardo Rivera Alejandra Zuluaga Karen Arango Itzjak Kadar Paola Andrea Pinillos luis fernando Montes Eugenia Catalina Cepeda Ernesto Gonzalez Pedro Antonio Alfonso Andrea Alejandra Villalba luis fernando Casanova Adolfo Perez Armando Roa Martha Jhoana Arias Jorge Orlando Francisco cuellar Lorena Pedraza Adiel Alberto Vasquez Blanca Lynne Suarez Beatriz LGomez Catalina De Bedout Luz Elena Cano Group of Investigation in Oral Health Faculty of DentistryAntonio Narino UniversityArmeniaQuindio 630001Colombia Medical and Experimental MycologyUnit Corporation for Biological Research(CIB)MedellinAntioquia 050034Colombia School of Medicine and Health Sciences Universidad del RosarioCarreraBogota 111221Colombia School of Microbiology University of AntioquiaMedellinAntioquia 050036Colombia.

The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28 S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history,oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans(52%), C. parapsilosis(17.9%), and ***(7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses(P<0.006), dental apparatuses(P=0.016) and O’Leary index(P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.

关键词： oral yeast Candida species microbial epidemiology

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MicroRNAs in biliary diseases

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World Journal of Gastroenterology 2012年第43期18卷 6189-6196页

作者： Patricia Munoz-garrido Maite García-Fernández de Barrena Elizabeth Hijona Miguel Carracedo JoséJ G Marín luis Bujanda Jesús M Banales Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpain Division of Oncology Research Schulze Center for Novel TherapeuticsMayo ClinicRochesterMN 55905United States Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpains Department of Liver and Gastrointestinal Diseases National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehdfunded by the Spanish CarlosⅢInstitute)08036 BarcelonaSpain Department of Physiology and Pharmacology Experimental Hepatology and Drug Targeting(HEVEFARM)Biomedical Research Institute of Salamanca(IBSAL)University of Salamanca37008 SalamancaSpain Ikerbasque Basque Foundation for Science48011 BilbaoSpain

Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.

关键词： miRNAs Cholangiopathies Cholangiocarcinoma Polycystic liver diseases Primary biliary cirrhosis

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Impact of the Transboundary Transport of Air Pollutants on Air Quality in Spain

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Journal of Environmental Protection 2012年第9期3卷 1167-1175页

作者： Marta G. Vivanco Inmaculada Palomino Juan luis garrido Ma ángeles González Gonzalo Alonso fernando Martín Centro de Investigaciones Energéticas Medioambientales y Teconológicas (CIEMAT) Air Pollution Unit Madrid Spain

Although compliance with the European limit values for air pollutants has been achieved over large parts in Spain, some challenges remain for O3 on the maximum daily 8-hour mean and information limit values, for particulate matter on the PM10 annual and daily limit values and for NO2 on annual and hourly limit values. Transboundary transport of air pollutants has started to be recognized as a mechanism affecting air quality. Nevertheless, as a consequence of the complexity of atmospheric chemistry it is not easy to determine the importance of this effect. Photochemical models constitute an adequate tool to address this challenge, allowing the identification of pollutant pathways and the quantifi- cation of the influence of long-range transport of air pollutants. In this paper we evaluate the influence of out-of-Spain emissions on this non-compliance picture by using the CHIMERE photochemical model. For this purpose the model was run at a 0.2?-horizontal resolution for a European domain. Although at this resolution not all the local effects can be captured, transboundary transport of air pollutants can be examined. Several simulations were performed considering different emission scenarios. To see all out-of-Spain emissions influence, all the emissions were set to zero, excepting those in Spain. This includes examining European and ships effects on air quality in Spain. A second simulation was performed setting to zero just European-countries emissions, to see the effect of Europe. The third and fourth simulations were carried out by setting to zero France and Portugal emissions respectively. Ozone has been found to be the pollutant more affected by this transboundary transport, in particular in the summer period. The model indicates that the incoming air masses contributed in 2009 to the non-compliance with the European normative regulating the maximum daily 8-hour mean.

关键词： Transboundary Transport Air Pollution

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Dark Future for Dark Matter

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Journal of Modern Physics 2020年第10期11卷 1589-1597页

作者： Donald H. Eckhardt José luis garrido Pestañ a Canterbury NH USA Departamento de Física Universidad de Jaén Campus Las Lagunillas Jaén Espa&ntilde a

The prevailing cosmological constant and cold dark matter (ΛCDM) cosmic concordance model accounts for the radial expansion of the universe after the Big Bang. The model appears to be authoritative because it is based on the Einstein gravitational field equation. However, a thorough scrutiny of the underlying theory calls into question the suitability of the field equation, which states that the Einstein tensor Gμv is a constant multiple of the stress-energy tensor Tμv when they both are evaluated at the same 4D space-time point: Gμv = 8πkTμv, where k is the gravitational constant. Notwithstanding its venerable provenance, this equation is incorrect unless the cosmic pressure is p = 0;but then all that remains of the Einstein equation is the Poisson equation which models the Newtonian gravity field. This shortcoming is not resolved by adding the cosmological constant term to the field equation, Gμv +Λ gμv =8πkTμv

关键词： Classical General Relativity General Relativity and Gravitation: Fundamental Problems and General Formalism Fundamental Aspects of Astrophysics Relativity and Gravitation Dark Energy Mathematical and Relativistic Aspects of Cosmology

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