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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova Maria V.Zhukova Elena V.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

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World Journal of Neuroscience 2020年第1期10卷 42-67页

作者： Jean Fidèle Nnang Essone Tatiana Harly Mba Aki Angue Mounir Belmalih Rosalie Nkiéma ludmila Betty Eke Ndouo Emmanuel Anyunzoghe Nathan Ekegue Félix Ovono Abessolo Department of Physiology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Physiological Functional Exploration and Physical Medicine Services Owendo University Hospital Center Owendo Libreville Gabon Department of Ophthalmology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Mother-Child University Hospital Center Libreville Gabon Department of Biochemistry-Chemistry Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Department of Epidemiology Biostatistics and Medical Informatics Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Faculty of Pharmacy University of Health Sciences Owendo Libreville Gabon

Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG+. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG+ and 45 controls (CG-). The chi-2 test compared the proportions, and Spearman’s test studied the correlations between quantitative variables (p Results: CmNgb was 4.1 in CG+, versus 2.3 in CG- (p = 1.52 × 10-5). CmGpx was 1144.7 in CG+, versus 752.8 in GC- (p = 0.0199). CmHIF-1α was 4.1 in CG+, versus 3.5 in CG- (p = 0.4530). CmCyt C was 2303.26 in CG+, versus 1750.44 in CG- (p = 0.0450). In CG+, there was a correlation between CmNgb and CmGpx (r = 0.417;p = 0.004), CmNgb and CmHIF-1α (r = 0.644;p = 1.8 × 10-6), and between CmHIF-1α and CmGpx (r = 0.447;p = 0.002), CmHIF-1α and CmCyt C (r = 0.371;p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126;p = 0.370), as well as CmGpx and CmCyt C (r = 0.102;p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress biomarkers were found between CG+ and CG-, as well as their correlations, suggesting that neuroglobin overexpression is related to its anti-apoptotic, anti-oxidative, and anti-hypoxic properties.

关键词： Chronic Severe Glaucoma Neuroglobin Neuroprotective-Properties

Aspects of International Public Procurement Regulation

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International Relations and Diplomacy 2019年第8期7卷 356-362页

作者： Pavla Neumannová ludmila Stěrbová University of Economics PragueCzech Republic

The public procurement market is classified as one of the most important segments of the world economy with share of 7-18%in the world *** importance of this segment leads to continuous *** the existing legislative framework,the share of cross-border public procurement remains limited due to several obstacles including discrimination in public procurement that was raised by governments as one of the non-tariff barriers to international *** of the European Commission or the European Bank for Reconstruction and Development(EBRD)indicate that there are many other obstacles to entry to international public procurement *** obstacles are discussed in the first chapter of this *** goal of this paper is to review aspects of international public procurement regulation and find ways of eliminating the obstacles through this ***,the second,third,and fourth chapters of the paper analyse the WTO Government Procurement Agreement(GPA),the United Nations Commission on International Trade Law(UNCITRAL)Model Law on Public Procurement,and the role of regional trade agreements.

关键词： cross-border public procurement Government Procurement Agreement revised GPA World Trade Organization UNCITRAL

Cecum Dieulafoy＇s Lesion Presenting with Recurrent Lower Gastrointestinal Bleeding： Case Report

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 254-258页

作者： ludmila Resende Guedes Silas Castro de Carvalho Vitor Nunes Arantes Arthur Manoel Braga de Albuquerque Gomes Daniel Antonio de Albuquerque Terra Nathalia da Silva Braga Nicoly Eudes da Silva Dias Endoscopy Unit of Alfa Institute of Gastroenterology at Hospital das Clinicas da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte MG 30130100 Brazil

Introduction： Gastrointestinal Dieulafoy＇s lesion is a rare entity, of unknown etiology, and corresponds to an arterial malformation at the submucosal space that can be a source of life-threatening hemorrhage. We report a case of a Cecum Dieulafoy＇s bleeding lesion that was managed endoscopically with a favorable outcome. Case report： Female, 70-year-old, diagnosed with type 2 diabetes, hypothyroidism, and chronic heart failure associated with rheumatic mitral stenosis, submitted to biological valve replacement in 2006 and with permanent atrial fibrillation using vitamin K antagonist anticoagulant for thrombosis prophylaxis. Her background includes a stroke in 2004 without any permanent disability. In 2016, the patient experienced voluptuous and painless lower gastrointestinal bleeding with severe acute anemia, requiring hospital admission, fluid resuscitation and blood transfusion. Urgent colonoscopy revealed a small reddish vascular malformation at the cecum with oozing active bleeding, about 3 mm in size. Initially argon plasma coagulation was performed with satisfactory and immediate hemostasis. One week later, she recurred with hematochezia. The lesion at the cecum was reassessed and it was possible to notice a large caliber vessel surrounded by a normal appearance mucosa, compatible with Dieulafoy＇s lesion and it was treated with an endoscopic clip placement with a good long-term response. Conclusion： Endoscopy is the method of choice for diagnosis of Dieulafuy＇s lesion and may provide efficient treatment with mechanical hemostasis such as endoclip placement with a high success rate.

关键词： Dieulafoy's lesion lower gastrointestinal bleeding endoscopy endoscopic clip

Comparative Analysis of Biotissue Laser Resection Using Strongly Absorbing Optical Fiber Tips

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Optics and Photonics Journal 2015年第1期5卷 1-5页

作者： Daria S. Kuznetsova Maria M. Karabut Vadim V. Elagin Maria A. Shakhova Vladimir I. Bredikhin Olga S. Baskina ludmila B. Snopova Andrey V. Shakhov Vladislav A. Kamensky Lobachevsky State University of Nizhni Novgorod National Research University Nizhny Novgorod Russia Otolaryngology Clinic N.A. Semashko Nizhny Novgorod Regional Clinical Hospital Nizhny Novgorod Russia Institute of Applied Physics of the Russian Academy of Sciences Nizhny Novgorod Russia Central Research Laboratory Nizhny Novgorod State Medical Academy Nizhny Novgorod Russia The Department of Otorhinolaryngology Nizhny Novgorod State Medical Academy Nizhny Novgorod Russia

We present a laser resection technique to be used when biotissue is heated by laser radiation to the temperature of material softening and then moved apart by the lateral edge of the optical fiber with a strongly absorbing tip. The absorbing tip allows the decrease in the power of effective cutting of the laser scalpel at the wavelength of 0.97 μm. And it changes the resection speed as well as the characteristics of the damage of the tissues adjacent to the incision in experiments on model media and experimental animals.

关键词： Laser Resection Silica Fibers Strongly Absorbing Coating Histology

Rabies outbreak in Brazil: first case series in children from an indigenous village

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Infectious Diseases of Poverty 2023年第4期12卷 103-103页

作者： Dilceu Silveira Tolentino Júnior Maryana Santos Vasconcelos Marques Amanda Krummenauer Magda Machado Saraiva Duarte Silene Manrique Rocha Mariana Gontijo de Brito ludmila Ferraz de Santana Roberto Carlos de Oliveira Eliseu Miranda de Assis Kellyn Kessiene de Sousa Cavalcante Carlos Henrique Alencar Postgraduate Program in Technology Environment and SocietyFederal University of the Jequitinhonha e Mucuri ValleysTeófilo OtoniMGBrazil Special Indigenous Health District of Minas Gerais and Espírito Santo Ministry of HealthGovernador ValadaresMGBrazil Brazil Field Epidemiology Training Program Ministry of HealthHealth and Environment Surveillance SecretariatBrasíliaDFBrazil Health Surveillance Secretariat Ministry of HealthBrasíliaDFBrazil State Department of Health of Minas Gerais Coordination of ZoonosesBelo HorizonteMGBrazil Postgraduate Program in Integrated Territory Management Vale do Rio Doce UniversityGovernador ValadaresMGBrazil Federal Institute of Bahia EunápolisBABrazil Postgraduate Program in Public Health Federal University of CearáFortalezaCEBrazil

BackgroundHuman rabies outbreak transmitted by bats continues to be a relevant public health problem not only in the Amazon region. The disease has affected one of the areas with the greatest poverty in southeastern Brazil, a region inhabited by the Maxakali indigenous *** presentationWe describe four cases of rabies among indigenous children that occurred in the indigenous village of Pradinho, municipality of Bertópolis, Minas Gerais, Brazil. Cases were notified between April and May 2022, all of whom died on average eight days after the first symptoms. All cases were observed in rural residents under 12 years of age. The probable form of exposure was through bat bites. The predominant symptoms were prostration, fever, dyspnea, sialorrhea, tachycardia, and altered level of consciousness. Half of the cases underwent late and/or incomplete post-exposure rabies prophylaxis, however, the other half underwent pre-exposure rabies prophylaxis, with only one case completing the scheme and another undergoing the adapted Milwaukee Protocol (Recife Protocol). All cases ended in *** was the first rabies outbreak among indigenous people in Brazil. Among the manifested clinical forms in the series, there was a disease atypical presentation in at least one case. We suggest active surveillance and an intercultural educational campaign to prevent new cases.

关键词： Rabies Outbreak Indigenous population Low income Brazil

Potential therapeutic targets identified by integrated miRNA and mRNA expression profiling in Chagas disease:miRNA-associated pathology Development and Immune Response pathways

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Potential therapeutic targets identified by integrated miRNA...

第十届全国免疫学学术大会

作者： ludmila Rodrigues Pinto Ferreira Frederico Moraes Ferreira Monique Andrade Baron Darlan da Silva Candido Laurie Laugier Sandrine Cabantous Amanda Farage Frade Ronaldo Honorato Barros Santos Christophe Chevillard Jorge Kalil Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor) University of Sao PauloSchool of Medicine Division of Clinical Immunology and Allergy University of Sao Paulo School of Medicine Universidade Santo Amaro (UNISA) INSERM U906 Aix-Marseille University AMU Faculte de Medecine Division of Transplantation Heart Institute (InCor) University of Sao PauloSchool of Medicine

Chronic Chagas Cardiomyopathy (CCC) is the severe manifestation of Chagasdisease, caused by infection with the protozoan parasite Trypanosoma *** is characterized by myocardial inflammation, arrhythmias, heart

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捷克中医药发展现状与分析

国际中医中药杂志 2021年第3期43卷 219-223页

作者：胥静 ludmila Bendova Nesvadbova Tao Livia Kusnierova canova Petra Urikova 魏竞竞赵静杨龙会许家杰曹洪欣中国中医科学院中医临床基础医学研究所2009年行业专项办公室北京100700 中国中医科学院眼科医院北京100040 捷克布拉格中医门诊 17000 捷克牡丹诊所全科医师诊所布拉格17000 捷克麦勒诺瓦斯联合会卢哈乔维采76326 捷克自执业医生卢科夫76317 中国中医科学院西苑医院北京100091 北京中医药大学 100029 中国中医科学院北京100700 美国洛杉矶加州大学东西医学中心 90024 中华中医药学会北京100029

捷克作为欧洲内陆的议会共和制国家,实施强制保险模式以保障民众健康。导致人口死亡的主要疾病为缺血性心脏病、脑卒中和肺癌,而糖尿病、AD及COPD近年来发病率显著增加。捷克的传统医学包括巴赫花疗法、特异性免疫调节自我疗法、法国耳... 详细信息

捷克作为欧洲内陆的议会共和制国家,实施强制保险模式以保障民众健康。导致人口死亡的主要疾病为缺血性心脏病、脑卒中和肺癌,而糖尿病、AD及COPD近年来发病率显著增加。捷克的传统医学包括巴赫花疗法、特异性免疫调节自我疗法、法国耳针治疗等。中医药在捷克具有一定的接受度,尤其是针灸已在神经性疾病中得到广泛应用。但中草药在捷克的使用受到限制,且中医药执业尚未合法化。建议深化多层次、多领域交流合作,并通过加强高水平中医药学位教育,加大中药与非药物疗法宣传和普及力度,推动中医药在捷克的发展。

关键词：医学传统捷克中医药保险健康国际合作发展现状

Assessment of Educational Videos on the Prevention and Management of Infant Diarrhea:Documental Study

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Health 2015年第9期7卷 1215-1223页

作者： Elizamar Regina da Rocha Mendes Jardeliny Correa da Penha ludmila Alves do Nascimento Leidiane Minervina Moraes de Sabino Emanuella Silva Joventino Adria Marcela Vieira Ferreira Olinda Costa Mota Teixeira Maria de Fátima Pereira de Sousa Galvao Lorena Barbosa Ximenes Federal University of Ceará FortalezaBrazil Federal University of Piauí FlorianoBrazil University of International Integration of African-Brazilian Lusophony RedencaoBrazil

Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;stimulation for learning/motivation and cultural fit. Method: Documentary study, which evaluated six educational videos from an adapted and validated tool, the Suitability Assessment of Materials. Three nurses evaluated the videos. Data were processed using the Statistical Package for the Social Sciences, version 17.0, and presented in tables and graphics. Results: It was found that 4 (66.6%) of the educational videos were classified as appropriate, ranging from 60% to 63.3% of full approval, and 2 (33.3%) were assessed as higher, reaching up to 83.3% to 90% approval. Considering the socioeconomic and cultural contexts of the videos to the audience, they assigned notes ranging from 6 to 9 in a rating ranging from 0, the minimum score, to 10, the highest score. Conclusion: The educational videos were considered adequate, with positive results about the content on the prevention and management of infant diarrhea, being appropriate for the target audience. As a result, greater credibility is ratified as the use thereof, since these resources can contribute to health promotion and prevention of diarrhea in children.

关键词： Diarrhea Infantile Educational Technology Child Health