Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

作     者：Jean Fidèle Nnang Essone Tatiana Harly Mba Aki Angue Mounir Belmalih Rosalie Nkiéma Ludmila Betty Eke Ndouo Emmanuel Anyunzoghe Nathan Ekegue Félix Ovono Abessolo 

作者机构：Department of Physiology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Physiological Functional Exploration and Physical Medicine Services Owendo University Hospital Center Owendo Libreville Gabon Department of Ophthalmology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Mother-Child University Hospital Center Libreville Gabon Department of Biochemistry-Chemistry Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Department of Epidemiology Biostatistics and Medical Informatics Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Faculty of Pharmacy University of Health Sciences Owendo Libreville Gabon 

出 版 物：《World Journal of Neuroscience》 (神经科学国际期刊（英文）)

年 卷 期：2020年第10卷第1期

页      面：42-67页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Chronic Severe Glaucoma Neuroglobin Neuroprotective-Properties 

摘      要：Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG+. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG+ and 45 controls (CG-). The chi-2 test compared the proportions, and Spearman’s test studied the correlations between quantitative variables (p Results: CmNgb was 4.1 in CG+, versus 2.3 in CG- (p = 1.52 × 10-5). CmGpx was 1144.7 in CG+, versus 752.8 in GC- (p = 0.0199). CmHIF-1α was 4.1 in CG+, versus 3.5 in CG- (p = 0.4530). CmCyt C was 2303.26 in CG+, versus 1750.44 in CG- (p = 0.0450). In CG+, there was a correlation between CmNgb and CmGpx (r = 0.417;p = 0.004), CmNgb and CmHIF-1α (r = 0.644;p = 1.8 × 10-6), and between CmHIF-1α and CmGpx (r = 0.447;p = 0.002), CmHIF-1α and CmCyt C (r = 0.371;p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126;p = 0.370), as well as CmGpx and CmCyt C (r = 0.102;p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress biomarkers were found between CG+ and CG-, as well as their correlations, suggesting that neuroglobin overexpression is related to its anti-apoptotic, anti-oxidative, and anti-hypoxic properties.