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Radial Applanation Tonometry as an Adjuvant Tool in the Noninvasive Arterial Stiffness and Blood Pressure Assessment

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World Journal of Cardiovascular Diseases 2014年第5期4卷 225-235页

作者： lucas jose sa da fonseca Marco Antonio Mota-Gomes Luiza ARabelo Laboratorio de Reatividade Cardiovascular Setor de Fisiologia e FarmacologiaInstituto de Ciências Biologicas e da SaudeUniversidade Federal de AlagoasMaceioBrazil Centro de Pesquisas Clinicas do Hospital do Coracao de Alagoas—HCOR-AL MaceioBrazil Max-Delbruck-Center for Molecular Medicine BerlinGermany

Since antiquity, the human arterial pulse represents an important parameter in the clinical assessment. Besides being routinely assessed in the medical practice, such pulse is not observed in its completeness yet, once many of the data obtained through it cannot be evaluated using conventional methods. Taking into account such methods, the measurement of arterial blood pressure using sphygmomanometry, although broadly widespread in the assessment and follow-up of patients who require accompaniment of their cardiovascular status, is not able to properly guide about parameters related to the central hemodynamic status, the latter most strongly associated with cardiovascular risk. Such incapability is due to the centrifugal augmentation of the pressures taken at different points of the arterial bed, based on the properties of the closed arterial system through which the blood flow travels. In this context, methodologies capable of assessing central parameters estimated using the pulse wave analysis, such as applanation tonometry, represent a promising adjuvant for evaluating patients with cardiovascular diseases, by providing detailed information concerning hemodynamic parameters otherwise inaccessible. In this scenario, the present review focuses on the applanation tonometry and its assessment on the radial artery, highlighting the importance of this method in the cardiovascular assessment, as well as its relevance in the clinical practice, when determining parameters peripherally obtained capable of estimating the central hemodynamic status.

关键词： Arterial Pulse Arterial Stiffness Noninvasive Assessment Radial Tonometry Cardiovascular Risk

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Resection of Intracranial Giant Cavernous Malformation: Case Report and Literature Review

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Surgical Science 2024年第2期15卷 28-35页

作者： Vinicios Rivelli da fonseca Cleverson Martins Kill Mariana Alcantara Hugo Fialho Leonnan De sa Oliveira Lucidio Souza Filho Department of Neurosurgery Hospital Santa Rita Belo Horizonte Brazil

Cerebral cavernous malformations are a rare and congenital vascular malformation that can present as a challenge in neurosurgical management. The term “giant cerebral cavernous malformations” still does not have a clear definition in the literature, with a wide variety of results. It is known, however, that there is an association between the size of the cavernoma and postoperative sequelae, especially in those with a size greater than 3 cm in its largest diameter. We present a case report of resection of a giant brain cavernoma measuring approximately 8 cm in its largest diameter, emphasizing on clinical presentation, diagnoses and postoperative evolution. Additionally, we performed a comprehensive review of the existing literature on the subject, addressing the epidemiology, pathophysiology, diagnostic methods, treatment options, and prognosis associated with this condition.

关键词： Cavernous Malformation Cerebral Cavernous Malformation Giant Cavernous Malformation Cavernous Hemangioma Cavernous Angioma Cavernoma Giant Cavernoma

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Hepatocellular carcinoma-the role of the underlying liver disease in clinical practice

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World Journal of Gastroenterology 2024年第19期30卷 2488-2495页

作者： Angelo Zambam de Mattos Isadora Zanotelli Bombassaro Arndt Vogel jose D Debes Department of Internal Medicine Universidade Federal de Ciências da Saúde de Porto AlegreRSPorto Alegre 90020090Brazil Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegreRSPorto Alegre 90050-170Brazil Division of Gastroenterology Hepatology University of TorontoHannover M5R 0A3Canada Department of Medicine University of MinnesotaMinneapolisMN 55455United States

Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated *** particular type of cancer has the distinctive characteristic of mostly happening in individuals with an underlying liver *** makes the management of patients more challenging,since physicians must take into consideration two different conditions,the chronic liver disease and the *** underlying liver disease has several implications in clinical practice,because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC,obstacles in surveillance,and differences in the efficacy of the treatment against HCC.A shift in the prevalence of liver diseases has been evident over the last few years,with viral hepatitis gradually losing the leading position as cause of HCC and metabolic dysfunction-associated steatotic liver disease gaining ***,in an era of personalized medicine,it is imperative that physicians are aware of the underlying liver disease of individuals with HCC and its impact in the management of their tumors.

关键词： Hepatocellular carcinoma Etiology Epidemiology Surveillance Therapy

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Ecophysiological acclimatization to cyclic water stress in Eucalyptus

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Journal of Forestry Research 2020年第3期31卷 797-806页

作者： Rogerio de Souza Noia Junior Genilda Canuto Amaral jose Eduardo Macedo Pezzopane Mariana Duarte Silva fonseca Ana Paula Camara da Silva Talita Miranda Teixeira Xavier Department of Biosystems Engineering EsaLQ University of Sao PauloPiracicabaSao PauloBrazil Department of Forestry Sciences NEDTEC Federal University of Espirito SantoJero nimo MonteiroEspirito SantoBrazil

Drought is considered the main environmental factor limiting productivity in eucalyptus plantations in Brazil. However, recent studies have reported that exposure to water deficit conditions enables plants to respond to subsequent stresses. Thus, this study investigates the ecophysiological acclimatization of eucalyptus clones submitted to recurrent water deficit cycles. Eucalyptus seedlings were submitted to three recurrent water deficit cycles and anatomical, morphological and physiological changes were analyzed. The results were:(1) Eucalyptus seedlings responded to water deficits by directing carbohydrates to root and stem growth;(2) Size and number of stomata were reduced;(3) Stomatal conductance decreased which allowed the plants to reduce water losses through transpiration,increasing instantaneous water use efficiency;(4) The relationship between gas exchanges and available water contents allowed the seedlings to uptake the retained soil water athigher tensions;and,(5) Physiological recovery from subsequent water deficits became faster. As a result of these changes, the eucalyptus seedlings recovered from the same degree of water stress more rapidly.

关键词： Carbon partition Drought Gas exchange Morpho-physiological changes Photosynthetic apparatus

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Teletandem as a Way of Enhancing Language Learning Between Brazilian and German Students

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Sino-US English Teaching 2014年第10期11卷 767-776页

作者： Suelene Vaz da Silva Francisco jose Quaresma de Figueiredo Warde da fonseca-Zang Instituto Federal de Educagao Ciencia e Tecnologia de Goias Goiania Brazil Universidade Federal de Goias Goiania Brazil Instituto Federal de Educao Ciencia e Tecnologia de Goias Goiania Brazil

This paper aims at investigating the teletandem learning interactions between a group of Brazilian students from Instituto Federal de Educagao, Ciencia e Tecnologia do Estado de Goias, Brazil, and a group of foreign students from two German universities. In this study, the Brazilian students helped their foreign partners with Portuguese learning and were helped by them in the English learning. The participants used a synchronous computer software called Openmeetings and also an electronic dictionary as a complementary tool. Adopting a qualitative perspective in the data collection and analysis, this case study was conducted in the second semester of 2010. The data were collected by means of conversation sessions through Openmeetings and were analyzed in the light of studies on sociocultural theory as well as on tandem/teletandem language learning researches. The data analyses showed that the participants used English as an anchoring language to work with Portuguese and English itself, and German was introduced in the teletandem sessions. The data also showed that the whiteboard and the electronic dictionary were used as complementary resources to the use of audio and video for the language learning process the participants engaged in.

关键词： language learning Openmeetings teletandem

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Animal models applied to acute-on-chronic liver failure:Are new models required to understand the human condition?

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World Journal of Clinical Cases 2022年第9期10卷 2687-2699页

作者： Jaciara Fernanda Gomes Gama Liana Monteiro da fonseca Cardoso Jussara Machado Lagrota-Candido LuizAnastacio Alves Laboratory of Cellular Communication Oswaldo Cruz InstituteOswaldo Cruz FoundationRio de Janeiro 21045900Rio de JaneiroBrazil Laboratory of Immunopathology Department of ImmunobiologyFluminense Federal UniversityNiteroi 24210-200Rio de JaneiroBrazil

The liver is a multifaceted organ;its location and detoxifying function expose this organ to countless ***-on-chronic failure liver(ACLF)is a severe syndrome that affects the liver due to acute decompensation in patients with chronic liver *** infection environment,ascites,increased liver enzymes and prothrombin time,encephalopathy and fast-evolving multiorgan failure,leading to death,usually accompany *** pathophysiology remains poorly *** this context,animal models become a very useful tool in this regard,as understanding;the disease may be helpful in developing novel therapeutic methodologies for ***,although animal models display several similarities to the human condition,they do not represent all ACLF manifestations,resulting in significant *** initial liver cirrhosis framework followed by the induction of an acute decompensation by administering lipopolysaccharide and D-Ga IN,potentiating liver damage supports the methodologies applied to induce experimental *** entire methodology has been described mostly for ***,a quick Pub Med database search indicates about 30 studies concerning ACFL models and over 1000 regarding acute liver failure *** findings demonstrate the clear need to establish easily reproducible ACFL models to elucidate questions about this quickly established and often fatal syndrome.

关键词： Liver disease Acute-on-chronic liver failure Cirrhosis Acute decompensate event Translational study Animal models

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Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?

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BIOCELL 2021年第3期45卷 461-481页

作者： AMYLLY saNUELLY da PAZ MARTINS saMARA BOMFIM GOMES CAMPOS MARÍLIA OLIVEIRA fonseca GOULART FABIANA ANDRÉA MOURA Programa de Pós-Graduação da Rede Nordeste de Biotecnologia(RENORBIO) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Ciências da saúde(PPGCS) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Química e Biotecnologia(PPGQB/UFAL) Campus A.C.SimõesAvenida Lourival Melo Motas/nTabuleiro dos MartinsMaceióAL 57072-970Brazil Programa de Pós-Graduação em Nutrição(PPGNU/UFAL) Programa de Pós-Graduação em Ciências Médicas(PPGCM/UFAL)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil

Inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and *** manifestations can occur and affect several organs,including the liver and bile ducts,joints,skin,eyes,and less frequently,the heart,brain,and kidneys,increasing the risk of morbidity and *** repercussions may be associated with the activity or severity of *** present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations,aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.

关键词： Oxidative stress Microbiota Bacterial translocation Ulcerative colitis Crohn disease

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Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

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World Journal of Gastroenterology 2021年第12期27卷 1161-1181页

作者： Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla jose Otavio Costa Auler Jr Maria jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque Division of Anesthesiology Hospital das ClínicasUniversity of São Paulo School of MedicineSão Paulo 05403-000Brazil Department of Anesthesiology AC Camargo Cancer CenterSão Paulo 01509-010Brazil Department of Gastroenterology Discipline of Liver and Gastrointestinal TransplantationLaboratory of Medical Investigations LIM37 Hospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil Department of Liver Transplantation AC Camargo Cancer CenterSão Paulo 01525-901Brazil Department of Gastroenterology Division of Liver and Gastrointestinal TransplantHospital das ClinicasUniversity of São Paulo School of MedicineSão Paulo 05402-000Brazil

BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young *** and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver *** To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing *** We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative *** receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/***,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be *** High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up *** a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the *** a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection ***,Cox hazard regr

关键词： Liver transplantation Child Blood transfusion Outcome Liver cirrhosis Mortality

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护理干预促进慢性呼吸困难患者自我管理的研究进展:整合性综述

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International Journal of Nursing Sciences 2024年第2期11卷 241-257,I0003页

作者： Helga Rafael Henriques Andreia Correia Tatiana santos jose Faria Diana Sousa Joana Portela Joana Teixeira Nursing School of Lisbon LisbonPortugal CIDNUR-Nursing Research Innovation and Development Centre of LisbonLisbonPortugal Unidade de Hemodi-alise de Torres Vedras-Nephrocare Torres VedrasPortugal Unidade de Cuidados Continuados na AMETIC Torres VedrasPortugal Unidade Local de saúde sao jose Cardiology DepartmentLisbonPortugal Unidade Local de saúde da Arrabida General Surgery DepartmentSetúbalPortugal

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CINAHL、Cochrane图书馆和乔安娜布... 详细信息

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CINAHL、Cochrane图书馆和乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库。对纳入研究进行数据提取和综合,研究人员采用Rayyan文献管理软件筛选标题及摘要,并依据JBI研究质量评估工具进行方法学质量评估。结果共纳入18项研究。这些研究探讨了针对慢性呼吸困难的各种干预措施,包括药物干预(氧气疗法和吸入疗法)和非药物方法(教育计划、呼吸练习、液体摄入管理、身体感知技术、同伴支持、情商培训和网络应用程序的使用)。这些干预措施减轻了患者情绪困扰,可以使患者在自我管理方面变得独立自主。结论促进复杂慢性病患者对慢性呼吸困难的自我管理需要采取综合方法,但目前研究中没有充分考虑到针对患者行为改变的干预措施,需要进一步开展相关研究完善干预措施。

关键词：慢性疾病呼吸困难护理病人自我管理

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Quality of life,depression and anxiety in potential living liver donors for pediatric recipients:A retrospective single center experience

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World Journal of Hepatology 2022年第10期14卷 1899-1906页

作者： Paula K Reine Flavia Feier Eduardo Antunes da fonseca Rosely G Hernandes Joao Seda-Neto Department of Psychology Hospital Sirio-LibanesSao Paulo 01308901Brazil Department ofLiver Transplantation Santa Casa de Porto AlegrePorto Alegre 90020090Brazil Department of Liver Transplantation Hospital Sirio-LibanesSao Paulo 01308901Brazil

BACKGROUND Living donor liver transplantation is a safe alternative for patients on a liver transplant *** evaluation goes beyond physical variables to include social,emotional,and ethical *** role of pre-donation sociopsychological evaluation of the donor candidate is as important to the success of the procedure as is the medical *** implies recovery from the operation and pro-mpt engagement in pre-transplant professional and social activities,without leading to psychological or physical *** profiling of potential living liver donors(PLLD)and evaluation of quality of life(QOL)can influence *** To evaluate the socio-demographics and psychological aspects(QOL,depression,and anxiety)of PLLD for pediatric liver transplantation in a cohort of 250 *** This was a retrospective cohort study of 250 PLLD who underwent psychological pre-donation evaluation between 2015 and *** the recipients were *** Beck anxiety inventory,Beck depression inventory,and 36-item short-form health survey(SF-36)scores were used to evaluate anxiety(Beck anxiety inventory),depression(Beck depression inventory),and QOL,*** A total of 250 PLLD were *** of them were women(54.4%),and the mean age was 29.2±7.2 years.A total of 120(48.8%)PLLD were employed at the time of evaluation for donation;however,most had low income(57%earnedsaid they would feel relieved if a deceased donor became *** PLLD had a low prevalence of anxiety and *** foundation for effective and sa

关键词： Liver transplantation Children Outcomes Living donation

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