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Lymphoepithelioma-like hepatocellular carcinoma: Case report and review of the literature

World Journal of Gastroenterology 2015年第36期21卷 10468-10474页

作者： Andrea Cacciato Insilla Pinuccia Faviana luca emanuele pollina Paolo De Simone Laura Coletti Franco Filipponi Daniela Campani Department of Surgical MedicalMolecular Pathology and Critical AreaDivision of Surgical PathologyUniversity Hospital of Pisa Department of Surgical MedicalMolecular Pathology and Critical AreaDivision of Liver Surgery and TransplantationUniversity Hospital of Pisa

Lymphoepithelioma-like hepatocellular carcinoma(LELHCC) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. Here,a case of LEL-HCC is described. An 81-year-old woman with a chronic hepatitis C infection was referred to the general surgery department of our hospital in August 2013 with a diagnosis of HCC. A past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. After a needle biopsy,the lesion was diagnosed as HCC. The patient underwent surgery with a liver segmentectomy. Two additional nodes on the gastric wall were detected during the surgical operation. The histology of the removed specimen showed a poorly differentiated HCC with significant lymphoid stroma. Immunohistochemical studies revealed that the epithelial component was reactive for CK CAM5.2,CK8,CK18,CEA(polyclonal) and was focally positive for hepar-1 and that the lymphoid infiltrate was positive for CD3,CD4 and CD8. The tumor cells were negative for Epstein-Barr virus. The gastric nodes were ultimately determined to be two small gastrointestinal stromal tumors(GISTs).The synchronous occurrence of HCC and GIST is another very uncommon finding rarely described in the literature. Here,we report the clinicopathological features of our case,along with a review of the few cases present in the literature.

关键词： Lymphoepithelioma Lymphoepithelioma-like Hepatocel

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Use of zebrafish embryos as avatar of patients with pancreatic cancer:A new xenotransplantation model towards personalized medicine

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World Journal of Gastroenterology 2020年第21期26卷 2792-2809页

作者： Gregorio Di Franco Alice Usai Niccola Funel Matteo Palmeri Ida Elena Rosamaria Montesanti Matteo Bianchini Desirée Gianardi NiccolòFurbetta Simone Guadagni Enrico Vasile Alfredo Falcone luca emanuele pollina Vittoria Raffa luca Morelli General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Department of Biology University of PisaPisa 56127Italy Division of Surgical Pathology Department of Laboratory of MedicineHospital-University of PisaPisa 56124Italy Division of Medical Oncology Pisa University HospitalPisa 56124Italy Department of Translational Research and New Technologies in Medicine and Surgery University of PisaPisa 56124Italy EndoCAS(Center for Computer Assisted Surgery) University of PisaPisa 56124Italy

BACKGROUND The response to chemotherapy treatment of patients with pancreatic ductal adenocarcinoma(PDAC)is difficult to predict and the identification of patients who most likely will benefit from aggressive chemotherapy approaches is *** concept of personalized medicine has emerged in the last years with the objective to tailor the medical treatment to the individual characteristics of each patient,and particularly to the tumor biology of each *** need for invivo xenotransplantation models for cancer patients has increased exponentially,and for this reason zebrafish avatars have gained *** studies were conducted also with PDAC *** To develop a simple,not expensive,diffusible zebrafish embryo model as avatar for patients affected by *** Tumor tissue was taken from the surgical specimen by the *** its fragmentation into small pieces,they are stained with *** pieces of stained tissue were transplanted into the yolk of wt AB zebrafish embryos with a glass capillary *** were incubated at 35°C in E3 medium supplemented with 1%Pen/Strep in the presence or absence of drugs for the following days in respect of the treatment plan(Gemcitabine;Gemcitabine and Oxaliplatin;Gemcitabine and nab-Paclitaxel;5-Fluorouracil and Folinic acid and Oxaliplatin and Irinotecan).The response of zebrafish xenografts to the chemotherapy options has been analyzed by monitoring the fluorescent stained area at 2 h post injection(hpi),1 d and 2 d post injection(dpi).In each time point,the mean size of the stained area was measured by ImageJ and it was normalized with respect to the 1 dpi time point mean relative tumor area(RTA).We evaluated the effect of the chemotherapy exposition comparing the mean RTA of each treated subgroup and the control group and evaluating the percentage reduction of the mean RTA by comparing each treated subgroup with the control *** Between July 2018 and October 2019,a t

关键词： Pancreatic ductal adenocarcinoma Zebrafish embryos Personalized medicine Xenotransplantation Chemotherapy efficacy Avatar of oncological patients

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Detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma

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World Journal of Gastroenterology 2021年第42期27卷 7324-7339页

作者： Matteo Bianchini Maria Anita Giambelluca Maria Concetta Scavuzzo Gregorio Di Franco Simone Guadagni Matteo Palmeri NiccolòFurbetta Desirée Gianardi Niccola Funel Claudio Ricci Raffaele Gaeta luca emanuele pollina Alfredo Falcone Caterina Vivaldi Giulio Di Candio Francesca Biagioni Carla Letizia Busceti luca Morelli Francesco Fornai General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Human Anatomy Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Division of Surgical Pathology Department of SurgicalMedicalMolecular Pathology and Critical AreaUniversity of PisaPisa 56124Italy Division of Medical Oncology Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy IRCCS Neuromed Istituto Neurologico MediterraneoPozzilli 86077Italy EndoCAS(Center for Computer Assisted Surgery) University of PisaPisa 56124Italy

BACKGROUND Recent evidences have shown a relationship between prion protein(PrPc)expression and pancreatic ductal adenocarcinoma(PDAC).Indeed,PrPc could be one of the markers explaining the aggressiveness of this ***,studies investigating the specific compartmentalization of increased PrPc expression within PDAC cells are lacking,as well as a correlation between ultrastructural evidence,ultrastructural morphometry of PrPc protein and clinical *** data,as well as the quantitative stoichiometry of this protein detected by immuno-gold,provide a significant advancement in understanding the biology of disease and the outcome of surgical *** To analyze quantitative stoichiometry and compartmentalization of PrPc in PDAC cells and to correlate its presence with prognostic data METHODS Between June 2018 and December 2020,samples from pancreatic tissues of 45 patients treated with pancreatic resection for a preoperative suspicion of PDAC at our Institution were *** the frozen section excluded a PDAC diagnosis,or the nodules were too small for adequate sampling,patients were ruled out from the present *** blotting was used to detect,quantify and compare the expression of PrPc in PDAC and control tissues,such as those of non-affected neighboring pancreatic tissue of the same *** quantify the increase of PrPc and to detect the subcellular compartmentalization of PrPc within PDAC cells,immuno-gold stoichiometry within specific cell compartments was analyzed with electron ***,an analysis of quantitative PrPc expression according to prognostic data,such as cancer stage,recurrence of the disease at 12 mo after surgery and recurrence during adjuvant chemotherapy was *** The amount of PrPc within specimen from 38 out of 45 patients was determined by semi-quantitative analysis by using Western blotting,which indicates that PrPc increases almost three-fold in tumor pancreatic tissue compared with healthy panc

关键词： Pancreatic ductal adenocarcinoma Prion protein Western blotting Electron microscopy Cellular compartmentalization Neuroinvasion

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Amino-functionalized magnetic nanoparticles for CO_(2) capture

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International Journal of Smart and Nano Materials 2021年第4期12卷 472-490页

作者： emanuele Oddo Ruggiero M.Pesce Marco Derudi luca Magagnin Department of Chemistry Materials and Chemical Engineering“G.Natta”MilanoItaly

CO_(2)accumulation is inducing an effect of global *** using solid sorbents is proving as an effective strategy for CO_(2)capture and *** aim of this study was to develop amino-functionalized magnetic nanoparticles by depositing various amines through coprecipitation or *** characteristics were studied through SEM,BET and XRD analyses,evidencing coarse particles with low crystallinity and surface areas of 100–150 m2 g−1,while FT-IR confirmed CO_(2)interacting with *** load of functional group,particles stability,and CO_(2)sorption capacity were assessed through elemental and thermogravimetric *** was found that loads of functional groups ranging from 1.6 to 6.1 wt.%.were deposited,and most samples showed sound stability up to 100°*** capacities were in the range 0.2–1.5 g gNH2−1,the highest being 1.46 g gNH2−1 forɛ-aminocaproic *** sample also exhibited good recyclability,with a performance drop of 11%after many ***_(2)uptake decreased with increasing temperature in the range 25–45°C,suggesting a chemical bond between CO_(2)and *** functionalized particles could thus be an interesting solution for CO_(2)capture and utilization thanks to fast kinetics,recyclability,and ease of separation.

关键词： Adsorption carbon dioxide CO_(2)activation aminofunctionalization magnetic nanoparticles

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Event Scenario Analysis for the Design of Rockslide Countermeasures

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Journal of Mountain Science 2014年第6期11卷 1521-1530页

作者： GIGLI Giovanni INTRIERI emanuele LOMBARDI luca NOCENTINI Massimiliano FRODELLA William BALDUCCI Marco VENANTI luca Domenico CASAGLI Nicola Department of Earth Science University of Studies of Florence Area Progetto Associati Studio Geologi Associati

The Torgiovannetto quarry(Assisi municipality,central Italy) is an example of a site where the natural equilibrium was altered by human activity,causing current slope instability phenomena which threaten two roadways important for the local *** quarry front,having a height of about 140 m,is affected by a 182,000 m3 rockslide developed in intensely fractured limestone and is too large to be *** 2003 some tension cracks were detected in the vegetated area above the quarry upper *** then on,several monitoring campaigns were carried out by means of different instrumentations(topographic total station,extensometers,inclinometers,ground-based interferometric radar,laser scanner and infrared thermal camera),allowing researchers to accurately define the landslide area and *** latter's major displacements are localized in the eastern *** deformational field appears to be related to the seasonal *** landslide hazard associated with the worst case scenario was evaluated in terms of magnitude,intensity and triggering *** the definition of the possible runout process the DAN 3D code was *** simulation results were used in order to design and construct a retaining ***,in order to preserve both the safety of the personnelinvolved in its realization and of the roadways users,an early warning system was *** early warning system is based on daily-averaged displacement velocity *** alarm level is reached if the prediction based on the methods of Saito(1969) and Fukuzono(1985) forecasts an imminent rupture.

关键词： Risk scenarios Risk management Landslides Monitoring Rock avalanche

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Tissue microarray-chip featuring computerized immunophenotypical characterization more accurately subtypes ampullary adenocarcinoma than routine histology

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World Journal of Gastroenterology 2020年第43期26卷 6822-6836页

作者： Matteo Palmeri Niccola Funel Gregorio Di Franco Niccolo Furbetta Desiree Gianardi Simone Guadagni Matteo Bianchini luca E pollina Claudio Ricci Marco Del Chiaro Giulio Di Candio luca Morelli General Surgery Unit Department of Translational Research and New Technologies in Medicine and SurgeryUniversity of PisaPisa 56124Italy Division of Surgical Pathology University-Hospital of PisaPisa 56124Italy Department of Surgical MedicalMolecular Pathology and Critical AreaUniversity of PisaPisa 56124Italy Department of Surgery University of ColoradoDenverCO 80045United States

BACKGROUND Ampullary adenocarcinomas(AACs)are heterogeneous tumors currently classified into three important sub-classes(SC):Intestinal(INT),Pancreato-Biliary(PB)and Mixed-Type(MT).The different subgroups have similar clinical presentation and are treated by pancreatoduodenectomy with curative ***,they respond differently to chemotherapy and have different prognostic *** SC are often difficult to identify with conventional histology *** clinical outcome of all three remains unclear,particularly for *** To identify two main subtypes of AACs,using an immunohistochemical(IHC)score based on CDX2,CK7 and *** Tissue samples from 21 patients who had undergone resection of AAC were classified by HE histology and IHC expression of CDX2,CK7 and CK *** IHC score was obtained for each marker by counting the number of positive cells(0=no stained cells;150%)and their intensity(1=weak;2=moderate and 3=strong).A global score(GS)was then obtained by summation of the IHC scores of each *** MT tumors were grouped either with the INT or PB group based on the predominant immuno-molecular phenotype,obtaining only two AACs *** overall survival in INT and PB patients was obtained by Kaplan-Meier *** Histological parameters defined the AACs subtypes as follows:15%INT,45%PB and 40%*** IHC expression and the GS,75%and 25%of MT samples were assigned to either the INT or the PB *** mean value of the GS was 9.5(range 4-16).All INT samples had a GS above the average,distinct from the PB samples which had a GS score significantly below the average(P=0.0011).The INT samples were identified by high expression of CDX2 and CK20,whereas PB samples exhibited high expression of CK7 and no expression of CK20(P=0.0008).The INT group had a statistically significant higher overall survival than in the PB group(85.7 mo vs 20.3 mo,HR:8.39;95%CI:1.38 to 18.90;P=0.0152).CONCLUSION The combination of histopathological a

关键词： Ampullary adenocarcinoma Histo-molecular phenotype Prognostic CK7 CK20 CDX2

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Candidate genes have sex-specific effects ontiming of spring migration and moult speedin a long-distance migratory bird

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Current Zoology 2017年第5期63卷 479-486页

作者： Gaia BAZZI Stefano PODOFILLINI emanuele GATTI luca GIANFRANCESCHI Jacopo G. CECERE Fernando SPINA Nicola SAINO Diego RUBOLINI Dipartimento di Bioscienze Universita degli Studi di Milano via Celoria 26 Milan 1-20133 Italy ISPRA--Istituto Superiore per la Protezione e la Ricerca Ambientale via Ca Fornacetta 9 Ozzano dell'EmiliaB0 1-40064 Italy

The timing of major life-history events, such as migration and moult, is set by endogenous circa-dian and circannual clocks, that have been well characterized at the molecular level. Conversely,the genetic sources of variation in phenology and in other behavioral traits have been sparsely ad-dressed. It has been proposed that inter-individual variability in the timing of seasonal events mayarise from allelic polymorphism at phenological candidate genes involved in the signaling cascadeof the endogenous clocks. In this study of a long-distance migratory passerine bird, the willowwarbler Phylloscopus trochilus, we investigated whether allelic variation at 5 polymorphic loci of 4candidate genes （Adcyapl, Clock, Crebl, and Npas2）, predicted 2 major components of the annualschedule, namely timing of spring migration across the central Mediterranean sea and moultspeed, the latter gauged from ptilochronological analyses of tail feathers moulted in the Africanwinter quarters. We identified a novel Clockgene locus （Clock region 3） showing polyQ polymorph-ism, which was however not significantly associated with any phenotypic trait. Npas2 allele sizepredicted male （but not female） spring migration date, with males bearing longer alleles migratingsignificantly earlier than those bearing shorter alleles. Crebl allele size significantly predicted male（but not female） moult speed, longer alleles being associated with faster moult. All othergenotype-phenotype associations were statistically non-significant. These findings provide newevidence for a role of candidate genes in modulating the phenology of different circannual activ-ities in long-distance migratory birds, and for the occurrence of sex-specific candidate gene effects.

关键词： Adcyapl, avian migration, candidate genes, clock, phenology, ptilochronology.

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Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men

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Asian Journal of Andrology 2019年第5期21卷 478-485页

作者： luca Boeri Paolo Capogrosso Eugenio Ventimiglia Filippo Pederzoli Walter Cazzaniga Francesco Chierigo Federico Deho emanuele Montanari Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS San Raffaele HospitalMilan 20132Italy Department of Urology Foundation IRCCS Ca'Granda Maggiore Policlinico HospitalUniversity of MilanMilan 20122Italy University Vita-Salute San Raffaele Milan 20132Italy

We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's *** from 189 in fertile men were an a *** analysis,serum hormones,and sperm DNA fragmentation(SDF)were *** status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descriptive statistics and logistic regression models were *** all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,*** addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,*** concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),***,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/*** concomitant,+S/+D status has an even greater detrimental effect on semen parameters.

关键词： alcohol con sumption cigarette smoki ng in fertility risk factors seme n an alysis

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Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting

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Asian Journal of Andrology 2021年第5期23卷 501-509页

作者： luca Boeri Paolo Capogrosso Eugenio Ventimiglia Walter Cazzaniga Edoardo Pozzi Federico Belladelli Filippo Pederzoli Massimo Alfano Costantino Abbate emanuele Montanari luca Valsecchi Enrico Papaleo Paola Vigano Patrizia Rovere-Querini Suks Minhas Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of Urology Foundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of MilanVia Della Commenda 15Milan 20122Italy University Vita-Salute San Raffaele Via Olgettina 60Milan 20131Italy Department of Obstetrics and Gynaecology IRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Genetics and Cell Biology Reproductive Sciences LaboratoryIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Immunology Transplantation and Infectious Diseases Department of MedicineIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of Urology Imperial Healthcare NHS TrustCharing Cross HospitalFulham Palace RoadHammersmithLondon W68RFUK

Testicular volume(TV)is considered a good clinical marker of hormonal and spermatogenic *** reference values for TV measures in infertile and fertile men are *** aimed to assess references values for TV in white-European infertile men and fertile *** analyzed clinical and laboratory data from 1940(95.0%)infertile men and 102(5.0%)fertile *** were matched by age using propensity score *** was assessed using a Prader orchidometer(PO).Circulating hormones and semen parameters were investigated in every *** statistics,Spearman's correlation,and logistic regression models tested potential associations between PO-estimated TV values and clinical *** operating characteristic(ROC)curves were used to find TV value cutoffs for oligoasthenoteratozoospermia(OAT)and nonobstructive azoospermia(NOA)status in infertile *** median testicular volume was smaller in infertile than that of fertile men(15.0 ml vs 22.5 ml;P<0.001).TV positively correlated with total testosterone,sperm concentration,and progressive sperm motility(all P≤0.001)in infertile *** multivariable logistic regression analysis,infertile status(P<0.001)and the presence of left varicocele(P<0.001)were associated with TV<15 *** volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status,*** conclusion,infertile men have smaller testicular volume than fertile *** positively correlated with total testosterone,sperm concentration,and progressive motility in infertile men,which was not the case in the age-matched fertile counterparts.

关键词： hypogonadism male infertility orchidometer Prader semen analysis testicular volume

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Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction:outcomes of a tertiary referral center and predictors of early prosthetic infection

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Asian Journal of Andrology 2022年第1期24卷 32-39页

作者： Franco Palmisano luca Boeri Riccardo Ievoli Josvany Sánchez-Curbelo Matteo Giulio Spinelli Andrea Gregori Antonio Maria Granata Eduard Ruiz-Castane emanuele Montanari Joaquim Sarquella-Geli ASST Fatebenefratelli-Sacco Department of UrologyLuigi Sacco University HospitalMilan 20157Italy IRCCS Foundation Ca’Granda Ospedale Maggiore Policlinico Department of UrologyUniversity of MilanMilan 20122Italy Department of Economics and Management University of FerraraFerrara 44121Italy FundacióPuigvert Department of AndrologyUniversity of BarcelonaBarcelona 08025Spain

We aimed to evaluate ten-year outcomes of penile prosthesis(PP)implantation for the treatment of erectile dysfunction and to assess predictors of early prosthetic infection(EPI).We identified 549 men who underwent 576 PP placements between 2008 and *** and multivariate analyses were used to identify potential predictors of *** EPI predictive nomogram was ***-five(6.1%)cases of EPI were recorded with an explant rate of 3.1%.In terms of satisfaction,82.0%of the patients defined themselves as“satisfied,”while partner’s satisfaction was 88.3%.Diabetes(P=0.012),longer operative time(P=0.032),and reinterventions(P=0.048)were associated with EPI risk,while postoperative ciprofloxacin was inversely associated with EPI(P=0.014).Rifampin/gentamicin-coated 3-piece inflatable PP(r/g-c 3IPP)showed a higher EPI risk(P=0.019).Multivariate analyses showed a two-fold higher risk of EPI in diabetic patients,redo surgeries,or when a r/g-c 3IPP was used(all P<0.03).We showed that diabetes,longer operative time,and secondary surgeries were the risk factors for *** ciprofloxacin was associated with a reduced risk of EPI,while r/g-c 3IPP had higher EPI rates without an increased risk of PP *** further validation,the proposed nomogram could be a useful tool for the preoperative counseling of PP implantation.

关键词： Boston Coloplast Titan three-piece penile prosthesis erectile dysfunction impotence Inhibizone patient satisfaction penile prosthesis prosthesis infection rifampin soaking

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