Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting

作     者：Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Walter Cazzaniga Edoardo Pozzi Federico Belladelli Filippo Pederzoli Massimo Alfano Costantino Abbate Emanuele Montanari Luca Valsecchi Enrico Papaleo Paola Vigano Patrizia Rovere-Querini Suks Minhas Francesco Montorsi Andrea Salonia Luca Boeri;Paolo Capogrosso;Eugenio Ventimiglia;Walter Cazzaniga;Edoardo Pozzi;Federico Belladelli;Filippo Pederzoli;Massimo Alfano;Costantino Abbate;Emanuele Montanari;Luca Valsecchi;Enrico Papaleo;Paola Viganò;Patrizia Rovere-Querini;Suks Minhas;Francesco Montorsi;Andrea Salonia

作者机构：Division of Experimental Oncology/Unit of UrologyURIIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of UrologyFoundation IRCCS Ca'Granda-Ospedale Maggiore PoliclinicoUniversity of MilanVia Della Commenda 15Milan 20122Italy University Vita-Salute San RaffaeleVia Olgettina 60Milan 20131Italy Department of Obstetrics and GynaecologyIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of Genetics and Cell BiologyReproductive Sciences LaboratoryIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Division of ImmunologyTransplantation and Infectious Diseases Department of MedicineIRCCS Ospedale San RaffaeleVia Olgettina 60Milan 20131Italy Department of UrologyImperial Healthcare NHS TrustCharing Cross HospitalFulham Palace RoadHammersmithLondon W68RFUK 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2021年第23卷第5期

页      面：501-509页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：hypogonadism male infertility orchidometer Prader semen analysis testicular volume 

摘      要：Testicular volume(TV)is considered a good clinical marker of hormonal and spermatogenic *** reference values for TV measures in infertile and fertile men are *** aimed to assess references values for TV in white-European infertile men and fertile *** analyzed clinical and laboratory data from 1940(95.0%)infertile men and 102(5.0%)fertile *** were matched by age using propensity score *** was assessed using a Prader orchidometer(PO).Circulating hormones and semen parameters were investigated in every *** statistics,Spearman s correlation,and logistic regression models tested potential associations between PO-estimated TV values and clinical *** operating characteristic(ROC)curves were used to find TV value cutoffs for oligoasthenoteratozoospermia(OAT)and nonobstructive azoospermia(NOA)status in infertile *** median testicular volume was smaller in infertile than that of fertile men(15.0 ml vs 22.5 ml;P0.001).TV positively correlated with total testosterone,sperm concentration,and progressive sperm motility(all P≤0.001)in infertile *** multivariable logistic regression analysis,infertile status(P0.001)and the presence of left varicocele(P0.001)were associated with TV15 *** volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status,*** conclusion,infertile men have smaller testicular volume than fertile *** positively correlated with total testosterone,sperm concentration,and progressive motility in infertile men,which was not the case in the age-matched fertile counterparts.