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General synthesis of MXene by green etching chemistry of fluoride-free Lewis acidic melts

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Rare Metals 2020年第11期39卷 1237-1238页

作者： lu-yang xiu Zhi-Yu Wang Jie-Shan Qiu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian116024China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing100029China

The MXene has emerged as a rising star on the horizon of material science due to widespread applications ranging from energy and catalysis to biomedicine[1,2].These two-dimensional(2D)transition metal carbides/nitrides well collect a variety of attractive properties such as rich surface chemistry,high hydrophily,and metallic conductivity that are difficultly attained for all in conventional 2D atomic crystals[3,4].

关键词： chemistry fluoride synthesis

Investigation on influencing factors of 5-HMF content in Schisandra

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第6期8卷 439-445页

作者： XU Qing LI Ying-hua lu xiu-yang Institute of Pharmaceutical Engineering Zhejiang University Hangzhou 310027 China Department of Internal Medicine Hospital of Zhejiang University Hangzhou 310027 China

In order to investigate the influencing factors of 5-hydroxymethyl-2-furaldehyde （5-HMF） content in Schisandra, confirm the theory of 5-HMF deriving mainly from Schisandra processing course, and give some suggestions about the Schisandra processing method, the 5-HMF contents in decoctions of Schisandra under different heating temperature, decocting time, soaking time, processing methods and treatment with different solvents before decocting the Schisandra were measured by RP-HPLC method. The results showed that there is great difference of 5-HMF level in decoctions from differently processed Schisandra and unprocessed Schisandra; decocting time of 60 rain has some effects on 5-HMF level in decoctions and there is certain quantity 5-HMF in processed Schisandra itself and very little 5-HMF in unprocessed Schisandra. Heating time, heating temperature and treating solvents all have effect on 5-HMF level in decoction of Schisandra. 5-HMF in Schisandra was mainly from processing course. Both long heating time and high heating temperature can increase 5-HMF level in Schisandra. The production of 5-HMF in Schisandra may have some relationships with some polar components, which can dissolve in water, ethanol and acetone, especially in ethanol. To control processing temperature, processing time and treatment with some solvent is very important for controlling 5-HMF level in Schisandra.

关键词： Schisandra process Heating temperature Heating time 5-Hydroxymetyl-2-furaldehyde (5-HMF)

Decreased peripheral mtDNA in methamphetamine use disorder

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Science China(Life Sciences) 2022年第3期65卷 648-650页

作者： Ling-Yan Su Yuan Li Qianjin Liu Lijin Jiao Jing Shen lu-xiu yang Ti-Fei Yuan Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyKunming 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghai 200030China Hubei Shizishan Drug Rehabilitation Center Wuhan 426070China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226019China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Dear Editor,Methamphetamine(METH)is the most prevalent addictive psychostimulant in *** use disorder(MUD)and its associated disorders constitute a significant burden to the affected individuals and their families(Paulus and Stewart,2020).Neurotransmitter system aberrations,mitochondrial dysfunction,oxidative stress,and inflammasome activation have been involved in METH-induced neurotoxicity(Shin et al.,2018;Wang et al.,2015;Wei et al.,2020).

关键词： China Stewart

GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14

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Cellular & Molecular Immunology 2024年第6期21卷 561-574页

作者： Qianjin Liu Lijin Jiao Mao-Sen Ye Zhiyu Ma Jinsong Yu Ling-Yan Su Wei-Yin Zou lu-xiu yang Chang Chen Yong-Gang Yao Key Laboratory of Genetic Evolution&Animal Models and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan ProvinceKunming Institute of ZoologyChinese Academy of Sciences650201KunmingYunnanChina Kunming College of Life Science University of Chinese Academy of Sciences650204KunmingYunnanChina Key Laboratory of Biomacromolecules(CAS) National Laboratory of BiomacromoleculesCAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences100101BeijingChina KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of Sciences650201KunmingYunnanChina National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of Sciences650201KunmingChina

Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous ***,the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely *** this study,we demonstrated that S-nitrosoglutathione reductase(GSNOR)deficiency in macrophages leads to significant increases in the Nlrp3 and Il-1βexpression levels and interleukin-1β(IL-1β)secretion in response to NLRP3 inflammasome ***,in vivo experiments utilizing Gsnor^(−/−)mice revealed increased disease severity in both lipopolysaccharide(LPS)-induced septic shock and dextran sodium sulfate(DSS)-induced colitis ***,we showed that both LPS-induced septic shock and DSS-induced colitis were ameliorated in Gsnor^(−/−)Nlrp3^(−/−)double-knockout(DKO)***,GSNOR deficiency increases the S-nitrosation of mitogen-activated protein kinase 14(MAPK14)at the Cys211 residue and augments MAPK14 kinase activity,thereby promoting Nlrp3 and Il-1βtranscription and stimulating NLRP3 inflammasome *** findings suggested that GSNOR is a regulator of the NLRP3 inflammasome and that reducing the level of S-nitrosylated MAPK14 may constitute an effective strategy for alleviating diseases associated with NLRP3-mediated inflammation.

关键词： GSNOR S-nitrosation NLRP3 inflammasome MAPK14 Septic shock Colitis

A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease,impairs lysosomal function,and facilitates amyloid-p pathology and cognitive decline

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2920-2935页

作者： Rongcan luo Yu Fan Jing yang Maosen Ye Deng-Feng Zhang Kun Guo Xiao Li Rui Bi Min Xu lu-xiu yang Yu Li Xiaoqian Ran Hong-Yan Jiang Chen Zhang Liwen Tan Nengyin Sheng Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnanChina State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Department of Psychiatry The First Affiliated Hospital of Kunming Medical UniversityKunmingChina Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Mental Health Institute of the Second Xiangya Hospital Central South UniverstyChangshaChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnanChina CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Alzheimer’s disease(AD)is characterized by progressive synaptic dysfunction,neuronal death,and brain atrophy,with amyloid-p(Ap)plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue,which all lead to loss of cognitive *** mutations in the well-known AD causal genes including APP,PSEN1,and PSEN2 impair a variety of pathways,including protein processing,axonal transport,and metabolic *** we identified a missense variant rs117916664(c.896T>C,***299Ser[p.N299S])of the acetyl-CoA acyltransferase 1(ACM1)gene in a Han Chinese AD family by whole-genome sequencing and validated its association with early-onset familial AD in an independent *** in vitro and in vivo evidence showed that ACAA1 p.N299S contributes to AD by disturbing its enzymatic activity,impairing lysosomal function,and aggravating the Ap pathology and neuronal loss,which finally caused cognitive impairment in a murine *** findings reveal a fundamental role of peroxisome-mediated lysosomal dysfunction in AD pathogenesis.

关键词： Alzheimer amyloid lysosomal

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近临界水中苯乙腈无催化水解反应动力学

高校化学工程学报 2009年第2期23卷 252-257页

作者：石超君吕秀阳浙江大学化学工程与生物工程学系浙江杭州310027

为了开发苯乙酸的绿色制备工艺,系统地研究了近临界水中苯乙腈的无催化水解反应动力学。在研究了实验数据的重现性以及苯乙腈初始浓度对反应动力学影响之后,系统地测定了523.15～563.15K下苯乙腈及其分解的中间产物苯乙酰胺的水解反应... 详细信息

为了开发苯乙酸的绿色制备工艺,系统地研究了近临界水中苯乙腈的无催化水解反应动力学。在研究了实验数据的重现性以及苯乙腈初始浓度对反应动力学影响之后,系统地测定了523.15～563.15K下苯乙腈及其分解的中间产物苯乙酰胺的水解反应动力学数据,结果表明苯乙腈水解反应是典型的连串反应,以苯乙酰胺为中间产物,且能高选择性地得到最终产物苯乙酸。并以一级连串反应动力学模型对实验数据进行了拟合,得到了苯乙腈和苯乙酰胺水解反应活化能分别为64.4kJ·mol-1和82.4kJ·mol-1。论文工作为苯乙酸的绿色制备提供了重要的基础数据,同时能为其他腈类物质在近临界水中的水解提供参考。

关键词：近临界水苯乙腈苯乙酸无催化水解:反应动力学

Infectivity of SARS-CoV-2 and protection against reinfection in rats

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Zoological Research 2022年第6期43卷 945-948页

作者： Dandan Yu yanghaopeng Long Ling Xu Jian-Bao Han Jiawei Xi Jianlin Xu lu-xiu yang Xiao-Li Feng Qing-Cui Zou Wang Qu Jiangwei Lin Ming-Hua Li Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be infected with the SARS-CoV-2 prototype. Our results showed direct experimental evidence of the infectivity of SARS-CoV-2 infection, subsequent pathogenicity, and protection against reinfection in rats.

关键词： infection rats acute

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超临界甲醇中的化学反应

现代化工 2009年第12期29卷 26-30页

作者：吴晓宇吕秀阳浙江大学化学工程与生物工程学系浙江杭州310027

在介绍超临界甲醇特性的基础上,综述了近年来超临界甲醇中的有机化学反应、高分子降解回收和生物质再资源化等方面的研究现状与进展,分析了目前超临界甲醇研究中存在的主要问题,并对研究的主要方向进行了展望。

关键词：超临界甲醇化学反应有机合成再资源化

固体废弃物在超/近临界水中连续分解装置的研制

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高校化学工程学报 2001年第1期15卷 40-45页

作者：吕秀阳迫田章义铃木基之浙江大学二次资源化工国家专业实验室浙江杭州310027 东京大学生产技术研究所

利用超/近临界水具有的特性，探索固体废弃物在超/近临界水中的再资源化技术。由于固体废弃物的排出量非常庞大，只有同时引入连续过程才能进行有效处理。建立了一套近中试规模的固体物料在高温高压水中连续分解的反应装置，固体物料与... 详细信息

利用超/近临界水具有的特性，探索固体废弃物在超/近临界水中的再资源化技术。由于固体废弃物的排出量非常庞大，只有同时引入连续过程才能进行有效处理。建立了一套近中试规模的固体物料在高温高压水中连续分解的反应装置，固体物料与水混成浆料供给反应器，解决了某些固体物料向高温高压反应器中的连续输送问题，浆料的固含量可达10%(wt)以上。并对模式物质——纤维素和木质素；实物——米糠、豆腐渣和稻壳等进行了连续分解实验，运行结果稳定。本工作证实了通过将固体废弃物与水混成浆料的方式，实现固体废弃物在超/近临界水中连续处理的可能性。

关键词：超/近临界水固体废弃物再资源化连续分解装置