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Protective effect of nitric oxide induced by ischemic preconditioning on reperfusion injury of rat liver graft

World Journal of Gastroenterology 2004年第1期10卷 73-76页

作者： Jian-PingGong BingTu WeiWang YongPeng Shou-BaiLi lu-nanyan DepartmentofGeneralSurgery HuaxiHospitalSichuanUniversityChengdu610041SichuanProvinceChina DepartmentofGeneralSurgery theSecondAffiliatedHospitalofChongqingMedicalUniversityChongqing400010China

AIM: Ischemic preconditioning (IP) is a brief ischemic episode,which confers a state of protection against the subsequent long-term ischemia-reperfusion injuries. However, little is known regarding the use of IP before the sustained cold storage and liver transplantation. The present study was designed to evaluate the protective effect of IP on the long-term preservation of liver graft and the prolonged anhepatic-phase ***: Male Sprague-Dawley rats were used as donors and recipients of orthotopic liver transplantation. All livers underwent 10 min of ischemia followed by 10 min of reperfusion before harvest. Rat liver transplantation was performed with the portal vein clamped for 25 min. Tolerance of transplanted liver to the reperfusion injury and liver damage were investigated. The changes in adenosine concentration in hepatic tissue and those of nitric oxide (NO) and tumor necrosis factor (TNF) in serum were also ***: Recipients with IP significantly improved their one-week survival rate and liver function, they had increased levels of circulating NO and hepatic adenosine, and a reduced level of serum TNF, as compared to controls. Histological changes indicating hepatic injuries appeared improved in the IP group compared with those in control group. The protective effect of IP was also obtained by administration of adenosine,while blockage of the NO pathway using Nco-nitro-L-arginine methyl ester abolished the protective effect of ***: IP appears to have a protective effect on the long-term preservation of liver graft and the prolonged anhepatic-phase injuries. NO may be involved in this process.

关键词：一氧化氮缺血预处理再灌注损伤肝移植动物模型

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Prolongation of liver allograft survival by dendritic cells modified with NF_(-k)B decoy oligodeoxynucleotides

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World Journal of Gastroenterology 2004年第16期10卷 2361-2368页

作者： Ming-QingXu Yu-PingSuo Jian-PingGong Ming-ManZhang lu-nanyan DepartmentofGeneralSurgery WestChinaHospitalSichuanUniversityChengdu610041SichuanProvinceChina WestChinaSecondUniversityHospital SichuanUniversityChengdu610041SichuanProvinceChina

AIM: To induce the tolerance of rat liver allograft by dendritic cells (DCs) modified with NF-κB decoy oligodeoxynucleotides (ODNs).METHODS: Bone marrow (BM)-derived DCs from SD rats were propagated in the presence of GM-CSF or GM-CSF+IL-4 to obtain immature DCs or mature DCs. GM-CSF+IL-4-propagated DCs were treated with double-strand NF-κB decoy ODNs containing two NF-κB binding sites or scrambled ODNs to ascertain whether NF-κB decoy ODNs might prevent DC maturation. GM-CSF-propagated DCs, GM-CSF+NF-κB decoy ODNs or scrambled ODNs-propagated DCs were treated with LPS for 18 h to determine whether NF-κB decoy ODNs could prevent LPS-induced IL-12 production in DCs. NF-κB binding activities, costimulatory molecule (CD40, CD80, CD86) surface expression, IL-12 protein expression and allostimulatory capacity of DCs were measured with electrophoretic mobility shift assay (ENSA),flow cytometry, Western blotting, and mixed lymphocyte reaction (MLR), respectively. GM-CSF-propagated DCs, GM-CSF+IL-4 -propagated DCs, and GM-CSF+NF-κB decoy ODNs or scrambled ODNs-propagated DCs were injected intravenously into recipient LEW rats 7 d prior to liver transplantation and immediately after liver *** grading of liver graft rejection was determined 7 d after liver transplantation. Expression of IL-2, IL-4 and IFN-γ, mRNA in liver graft and in recipient spleen was analyzed by semiquantitative RT-PCR. Apoptosis of liver allograft-infiltrating cells was measured with TUNEL ***: GM-CSF-propagated DCs, GM-CSF+NF-κB decoy ODNs-propagated DCs and GM-CSF+ scrambled ODNs-propagated DCs exhibited features of immature DCs, with similar low level of costimulatory molecule(CD40, CD80,CD86) surface expression, absence of NF-κB activation,and few allocostimulatory activities. GM-CSF+IL-4-propagated DCs displayed features of mature DCs, with high levels of costimulatory molecule (CD40, CD80, CD86) surface expression, marked NF-κB activation, and significant allo

关键词：肝脏同种异体移植物树枝状细胞 NF-κB 脱氧核苷酸手术治疗

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On non-abelian extensions of 3-Leibniz algebras

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Frontiers of Mathematics in China 2024年第2期19卷 57-74页

作者： nanyan XU Yunhe SHENG School of Mathematics Jilin UniversityChangchun 130012China

In this paper,we study non-abelian extensions of 3-Leibniz algebras through Maurer-Cartan *** construct a differential graded Lie algebra and prove that there is a one-to-one correspondence between the isomorphism classes of non-abelian extensions in 3-Leibniz algebras and the equivalence classes of Maurer-Cartan elements in this differential graded Lie *** also the Leibniz algebra structure on the space of fundamental elements of 3-Leibniz algebras is *** is proved that the non-abelian extension of 3-Leibniz algebras induce the non-abelian extensions of Leibniz algebras.

关键词： 3-Leibniz algebras Leibniz algebra non-abelian extension Maurer-Cartan element

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Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG_1:A study of adolescents in a high risk region for hepatocellular carcinoma in China

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World Journal of Gastroenterology 2003年第10期9卷 2186-2193页

作者： TaoPeng Han-MingShen Zhi-MingLiu lu-nanyan Min-HaoPeng Le-QunLi Ren-XiangLiang Zong-LiangWei BarryHalliwell ChoonNamOng DepartmentofHepatobiliarySugery FirstAffiliatedHospitalofGuangxiMedicalUniversityNanning530021GuangxiZhuangAutonomousRegionChina DepartmentofCommunity OccupationalandFamilyMedicineNationalUniversityofSingaporeSingapore DepartmentofGeneralSurgery FirstAffiliatedHospitalofWestChinaUniversityofMedicalSciencesChengdu610041SichuanZhuangAutonomousRegionChina FusuiCancerResearchInstitute FusuiCounty532100GuangxiProvinceChina DepartmentofBiochemistry NationalUniversityofSingaporeSingapore

AIM: To study the oxidative DNA damage to adolescents of hepatocellular carcinoma (HCC) families in Guangxi Zhuang Autonomous Region, ***: Peripheral leukocytes' DNA 7, 8-dihydro-8-oxoguanine (8-oxoG) and repair enzyme hOGG1 were quantified by flow-cytometry. hOGG1-Cys326Ser single nucleotide polymorphism (SNP) was distinguished by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) ***: There was a positive correlation between 8-oxoG and repair enzyme hOGG1 expression (P＜0.001). HCC children (n=21) in Fusui county had a higher level of hOGG1(P＜0.01) and a lower level of 8-oxoG (P＜0.05) than the controls (n=63) in Nanning city. Children in Nanning exposed to passive-smoking had a higher hOGG1 expression (P＜0.05)than the non-exposers. 8-oxoG and hOGG1 were negatively correlated with body mass index, while hOGG1 was positively correlated with age. There was a peak of 8-oxoG level nearby the 12 year point. Individuals with the hOGG1 326Ser allele had a significantly marginal higher concentration of leukocyte 8-oxoG level than hOGG1 326Cys ***: This is the first report using flow-cytometry to simultaneously quantify both the DNA oxidative damage and its repairing enzyme hOGG1. The results provide new insights towards a better understanding of the mechanisms of oxidative stress in a population highly susceptible to hepatocarcinogenesis.

关键词：外周血白血球 DNA氧化损伤基因多态性肝细胞癌青年人高危因素

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基于振动能量耗散的间隔阻尼层式支重轮缓冲特性分析

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应用基础与工程科学学报 2012年第1期20卷 74-82页

作者：孙大刚卢南炎冯辰生徐铮太原科技大学机电工程学院山西太原030024

基于履带式工程车辆间隔阻尼层式支重轮振动能量的耗散,对支重轮的减振缓冲特性开展研究,建立其振动能量耗散模型.以310kW履带式推土机为应用对象,在3种典型工况下,建立间隔阻尼层式(阻尼层未间断)支重轮1/3实体有限元耗散模型.经计算发... 详细信息

基于履带式工程车辆间隔阻尼层式支重轮振动能量的耗散,对支重轮的减振缓冲特性开展研究,建立其振动能量耗散模型.以310kW履带式推土机为应用对象,在3种典型工况下,建立间隔阻尼层式(阻尼层未间断)支重轮1/3实体有限元耗散模型.经计算发现,间隔层与约束层粘接处和1/3阻尼层端面处的应力与耗散能均较大,易导致"热软化".采用约束层和阻尼层均间断的方式对支重轮结构进行改进,经计算表明改进后的支重轮总耗散能增大,其减振缓冲性能提高;且其应力与耗散能整体均匀对称分布,降低了"热软化"发生概率.

关键词：履带式车辆支重轮阻尼层间隔式缓冲

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Mckibben型气动人工肌肉缓冲座椅减振特性分析

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农业工程学报 2011年第7期27卷 146-150页

作者：孙大刚冯辰生宋勇章新卢南炎太原科技大学机械电子工程学院太原030024 西安理工大学机械与精密仪器工程学院西安710048

Mckibben型气动人工肌肉作为一种新型仿生气动执行元件,其力学特性与生物肌肉相似。以Mckibben型气动人工肌肉为履带式工程车辆座椅的缓冲执行器,建立起座椅缓冲减振模型;运用Simulink软件,并采用模糊PID控制对座椅的减振特性进行仿真... 详细信息

Mckibben型气动人工肌肉作为一种新型仿生气动执行元件,其力学特性与生物肌肉相似。以Mckibben型气动人工肌肉为履带式工程车辆座椅的缓冲执行器,建立起座椅缓冲减振模型;运用Simulink软件,并采用模糊PID控制对座椅的减振特性进行仿真。结果表明,在选定的4种工况下,Mckibben型气动肌肉缓冲座椅较传统座椅的垂直加速度和位移均有效减小,其缓冲减振效果明显。研究结果可为气动人工肌肉型缓冲座椅的研发提供参考。

关键词：工程车辆座椅减振气动人工肌肉仿真缓冲

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High-efficiency prediction method for helicopter global/ground noise based on near-field acoustic holography

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Chinese Journal of Aeronautics 2024年第7期37卷 271-284页

作者： Mengxue SHAO Yang lu Xice XU Jiaxin lu National Key Laboratory of Helicopter Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Noise reduction program design is an effective approach that relies on efficient noise prediction for reducing ground noise during *** existing noise prediction methods have the limitations of being computationally expensive or only applicable to *** this paper,a High-Efficiency Prediction Method(HEPM)for helicopter global/ground noise based on near-field acoustic holography is *** HEPM can predict the global noise based on acoustic modal analysis and has the advantages of high prediction accuracy and low time *** process is given as follows:firstly,the rotor noise on the holographic surface in the specified flight is obtained by simulations or ***,the global noise model,which maps time-domain noise to acoustic modes,is established based on near-field acoustic holography and Fourier acoustic analysis ***,combined with acoustic modal amplitude,the model established enables efficiently predicting the global/ground noise in the corresponding flight *** verify the accuracy of the prediction method,a simulation study is conducted in hovering and forward flight states using a model helicopter with a 2-meter rotor and Rotor Body Interaction(ROBIN)*** comparison of HEPM with numerical results shows that the average prediction errors of the global and ground noise are less than 0.3 dB and 0.2 dB,*** a region containing 100000 observers,the computation time of the HEPM is only one-fifth of that of the acoustic hemisphere method,demonstrating the rapidity of the proposed method.

关键词： Helicopter Rotor noise prediction Noise abatement procedure design Acoustic modal analysis Near-field acoustic holography

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brown rice

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Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi Kong Shenggao lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human *** our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated *** the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased *** vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction *** showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal *** on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy *** amino acids(AAs)in brown rice were determined by high-performance liquid *** contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of *** structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown *** formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

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Bayesian brain computing and the free-energy principle: an interview with Karl Friston

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National Science Review 2024年第5期11卷 87-89页

作者： Wenlian lu the Institute of Science and Technology for Brain-Inspired Intelligence of Fudan University

The free-energy principle entails the Bayesian brain hypothesis that can be implemented by many schemes considered in this field. The combination of multimodal brain imaging and free-energy minimization has shown promise in unraveling complex brain dynamics and understanding the interactions among distinct brain regions. The Bayesian mechanics of brain computing gives a unique route to understanding authentic(neuromimetic) intelligence and, more importantly, points towards the development of brain-inspired intelligence.

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