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A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Unconditionally Secure Oblivious Polynomial Evaluation:A Survey and New Results

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Journal of Computer Science & Technology 2022年第2期37卷 443-458页

作者： louis Cianciullo Hossein Ghodosi College of Science and Engineering James Cook UniversityTownsvilleQLD 4811Australia

Oblivious polynomial evaluation(OPE)is a two-party protocol that allows a receiver,R to learn an evaluation f(α),of a sender,S's polynomial(f(x)),whilst keeping both a and f(x)*** protocol has attracted a lot of attention recently,as it has wide ranging applications in the field of *** this article we review some of these applications and,additionally,take an in-depth look at the special case of information theoretic ***,we provide a current and critical review of the existing information theoretic OPE protocols in the *** divide these protocols into two distinct cases(three-party and distributed OPE)allowing for the easy distinction and classification of future information theoretic OPE *** addition to this work,we also develop several modifications and extensions to existing schemes,resulting in increased security,flexibility and ***,we also identify a security flaw in a previously published OPE scheme.

关键词： oblivious polynomial evaluation unconditionally secure information theoretic

A Geometric Problem and the Hopf Lemma. II

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Chinese Annals of Mathematics,Series B 2006年第2期27卷 193-218页

作者： louis NIRENBERG Dedicated to the memory of Shiing-Shen Chern

A classical result of A. D. Alexandrov states that a connected compact smooth n-dimensional manifold without boundary, embedded in R^n＋1, and such that its mean curvature is constant, is a sphere. Here we study the problem of symmetry of M in a hyperplane Xn＋1 =constant in case M satisfies： for any two points （X^1, ^↑Xn＋1）, （X^1, Xn＋1） on M, with Xn＋1 〉^↑Xn＋1, the mean curvature at the first is not greater than that at the second. Symmetry need not always hold, but in this paper, we establish it under some additional conditions. Some variations of the Hopf Lemma are also presented. Several open problems are described. Part I dealt with corresponding one dimensional problems.

关键词： Hopf Lemma Maximum principle Moving planes Symmetry Mean curvature

Where medicine meets the boundaries of manhood and womanhood

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Asian Journal of Andrology 2011年第5期13卷 669-672页

作者： louis Gooren VU University Medical Center Amsterdam 1081HV TheNetherlands

We are defined by sexual dimorphism. Male and female, the sexes we are （and are perceived to be）, affect how we feel, how we behave and how we interact with others. We look around and see all complex creatures, including ourselves, as either male or female. This is so much a part of our daily existence that it reinforces the idea of man- hood and womanhood as expressions of a natural order. We regard this division into two sexes as one of the great eternal verities and tend to experience the difference between the sexes as rather absolute. Subjectively, man and woman are seen as opposites, poles apart and mutually exclusive forms of human existence.

关键词： manhood womanhood

Fhe significance of testosterone for fair participation ol he female sex in competitive sports

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Asian Journal of Andrology 2011年第5期13卷 653-654页

作者： louis Gooren VU Un versity Medical Center Amsterdam 1081HV TheNetherlands

Sex segregation in competitive sports is regarded as fair. Before puberty, boys and girls hardly differ in height, muscle and bone mass. Pubertal testosterone exposure leads to an ultimate average greater height in men of 12-15 centimeters, larger bones, greater musde mass, increased strength and higher hemoglobin levels. Post-pubertal androgen ablation reverses, at least in part, previous anabolic effects of testosterone on musde,1 bone mineral density and hemoglobin, but the bones remain longer and have a wider diameter. As testosterone administra- tion produces a dose-dependent increase in muscle mass and maximal voluntary strength,2＇3 exogenous androgens are banned as performance-enhancing drugs.4 Men with testosterone deficiency are allowed to receive testosterone replacements which do not raise blood testosterone levels above the normal male range,5＇6

关键词： significance testosterone levels

Textures and melt-crystal-gas interactions in granites

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Geoscience Frontiers 2015年第5期6卷 635-663页

作者： Jean-louis Vigneresse GeoRessources UMR 7339Universite de Lorraine

Felsic intrusions present ubiquitous *** result from the differential interactions between the magma components(crystal,melt,gas phase) while it flows or when the flow is perturbed by a new magma *** most obvious structure consists in fabrics caused by the interactions of rotating grains in a flowing viscous *** magma inputs through dikes affect the buk massif flow,considered as global within each mineral facies.A review of the deformation and flow types developing in a magma chamber identifis the patterns that could be *** determines their controlling parameters and summarizes the tools for their ***,a brief review of the theology of a complex multiphase magma identifies and suggests interactions between the different *** specific responses each component presents lead to instability *** particular,the change in vorticity orientation,associated with the switch between monoclinic to triclinic flow is a cause of many *** are preferentially *** include fabric development,shear zones and flow *** depend of the underlying rheology of interacting ***,enclaves,schlieren and ladder dikes result from the interactions between the magma components and changing boundary ***,pegmatites,unidirectional solidification textures and miarolitic cavities result from the interaction of the melt with a gaseous *** illustrations examine what is relevant to the bulk flow,local structures or boundary *** each case a field observation illustrates the *** discussion reformulates instability observations,suggesting new trails for ther description and interpretation in terms of local departure to a bulk flow.A brief look at larger structures and at their evolution tries to relate these instabilities on a broader *** helical structures of the Ricany pluton,Czech Republic and by the multiple granitic intrusions of Dolbe

关键词： Granitic magma Instabilities Triclinic flow Struct

Addressing ore formation and exploration

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Geoscience Frontiers 2019年第4期10卷 1613-1622页

作者： Jean-louis Vigneresse GéoRessources UMR 7339Université de Lorraine

Common base and noble metals represent an important economic factor in the actual industrial *** instance the world resources for copper are actually estimated for about the next 30 years *** situation requires rethinking the way major ore deposits form,leading to new guides for *** present paper briefly examines the processes leading to ore formation,in relation with granitic or granodioritic *** identifies the importance of metal enrichment during the magmatic *** the magma chamber that forms porphyry intrusions,metals may incorporate to first formed crystals,becoming inert;concentrate into the residual melt of a mush;or segregate by diffusion into the exsolved magmatic volatile phase(MVP)into which they are transported and precipitated.A competition results between elements partitioning and ***,a specific Peclet number for each metal(Cu,Au,Ag,Mo,W,Sn,and REE)controls the ratio between the diffusive and the advective *** diffusivity in the melt shows differential behavior relative to a threshold of about10 13 m2/*** with slower diffusivity values(***)will not ***,fast diffusive metals(Au,Ag,Cu)may rapidly incorporate the MVP,provided an adequate component(halogens or S)is attractive for *** chemistry of the MVP escaping the magma induces different alteration *** relative content in F,Cl or S,attested by the composition of biotites and apatites,links with the preferential content of metals in o re deposits,representing a valuable tool for *** the model is replaced in a set of coupled mechanical-chemical instabilities,within a three phase material.

关键词： Porphyry ore deposits Metals concentration processes Exploration Alteration pattern

Machine learning for enumeration of cell colony forming units

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 315-322页

作者： louis Zhang Department of Molecular Biosciences College of Natural SciencesUniversity of Texas at AustinAustin TX 78713-8058USA

As one of the most widely used assays in biological research,an enumeration of the bacterial cell colonies is an important but time-consuming and labor-intensive *** speed up the colony counting,a machine learning method is presented for counting the colony forming units(CFUs),which is referred to as *** cellcounting program processes digital images and segments bacterial *** algorithm combines unsupervised machine learning,iterative adaptive thresholding,and local-minima-based watershed segmentation to enable an accurate and robust cell *** to a manual counting method,CFUCounter supports color-based CFU classification,allows plates containing heterologous colonies to be counted individually,and demonstrates overall performance(slope 0.996,SD 0.013,95%CI:0.97–1.02,p value<1e-11,r=0.999)indistinguishable from the gold standard of point-and-click *** CFUCounter application is open-source and easy to use as a unique addition to the arsenal of colony-counting tools.

关键词： Colony forming unit Enumeration Image analysis Blue/white screen Colony count

Should cross-sex hormone treatment of transsexual subjects vary with ethnic group？

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Asian Journal of Andrology 2014年第6期16卷 809-810页

作者： louis J Gooren Department of Endocrinology VU University MedicalCenter Amsterdam the Netherlands Androconsult ChiangMai Thailand

Guidelines for cross-sex hormone treatment of transsexual people have been developed, but no attention has been paid to the specifics of ethnic groups. South East （SE） Asian male-to-female （MtoF） transsexual people may be able to transition to the female sex with lower doses of estrogens/progestins than Caucasians thus reducing health risks. Female-to-male （FtoM） may virilize less profoundly with standard doses of androgens, but this is probably sufficient to pass acceptably as men in view of the less pronounced sex differences in physique in Asians compared with Caucasians. It is timely that studies in Asians are conducted to get a better insight into their specific needs and risks of cross-sex hormone treatment.

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