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Psychology Research 2018年第8期8卷 388-396页

作者： Simon Pedro Izcara Palacios Karla lorena Andrade Rubio Universidad Autonoma de Tamaulipas Ciudad Victoria Mexico

Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

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World Journal of Vaccines 2023年第2期13卷 13-32页

作者： Victoria Delicado-Useros Esther Navarro-Rodenas Indalecio-M Sánchez-Onrubia Carmen Ortega-Martínez Antonia Alfaro-Espín Juan-D Pérez-Serra Francisco García-Alcaraz Julia Lozano-Serra lorena Robles-Fonseca Teresa Pérez-Domenech Nursing Faculty Castilla-La Mancha University Nursing & Society Research Group Albacete Spain Emergency Department General Hospital Almansa Spain Emergency Department General Hospital Albacete Spain Nursing Faculty Nursing & Society Research Group Universidad de Castilla-La Mancha Albacete Spain Emergency Department Son Espasses Universitary Hospital Palma de Mallorca Spain Departament of Clinical Microbiology in Albacete General Hospital Albacete Spain

Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.

关键词： Acquired Immunity SARS-CoV-2 Vaccine IgG level Healthcare Workers COVID-19 Incidence Rate

Crohn's disease and clinical management today:How it does?

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World Journal of Methodology 2023年第5期13卷 399-413页

作者： Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Jessica Oliveira de Souza Nascimento Bruna Teixeira da Costa Luciano Hasimoto Malheiro Marcel Silva Luz lorena Sousa de Carvalho Cleiton da SilvaSantos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Crohn’s Disease(CD)is an Inflammatory Bowel Disease and is characterized by an immune-mediated *** etiology results from the interaction between genetic,enviromental and microbial *** pathophysiology,it involves high levels of interleukin(IL)-12,IL-17,and Th1 profile,along with loss of tolerance mechanisms,an increase in pro-inflammatory interleukins,beyond the possibility to affect any part of the gastrointestinal *** symptoms include abdominal pain,chronic diarrhea,weight loss,anorexia,and fatigue,as well as blood in the stool or ***,conditions comprising musculoskeletal,cutaneous,ocular,hepatic,and hematological alterations may be associated with this scenario and extra-intestinal presentation,such as erythema nodosum,anterior uveitis,osteoporosis,and arthritis can also ***,clinical history,exams as fecal calprotectin,ileocolonocopy,and capsule endoscopy can be performed in the diagnosis investigation,along with treatments to induce and maintain *** this sense,anti-inflammatory drugs,such as corticosteroids,immunomodulators,and biological agents,as well as surgery and non-pharmacological interventions plays a role in its *** aim of this review is to bring more current evidence to clinical management of CD,as well as to briefly discuss aspects of its pathophysiology,surveillance,and associated disorders.

关键词： Crohn's disease Inflammatory bowel diseases Diagnosis Treatment Immunomodulation Biological agents

Clinical Follow-Up Nursing Quality in Child Health

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Health 2015年第10期7卷 1235-1242页

作者： Fábia Barbosa de Andrade Tainara lorena dos Santos Ferreira Tiago Jose Barbosa de Andrade Jéssica Isabelle dos Santos Dutra Dídia de Oliveira Pereira Brenda Kalyny Silva Brenda Kalyny Silva Ingrid Katianne Marques Araújo Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil University Center of Joao Pessoa(UNIPe) Joao PessoaBrazil

Objective: The present work aims to evaluate the impact of the activities of nursing consultations on health conditions of children served in Clínica de Enfermagem Salvando Vidas com Educa??o. Methods: This is an exploratory, descriptive study with a quantitative approach, realized from January through December 2012, at the Clínica de Enfermagem (Nursing Clinic), in the Santa Cruz County, Rio Grande do Norte’s countryside, Brazil. Results: The obtained results showed a significant correlation between the type of pathology and final treatment proven by the value of p = 0.000;as for assessed 60%, more than half were discharged;the most prevalent diseases were the association between cutaneous and gastric with 11% who were discharged and, lastly, the association between gastric and respiratory with 7% discharged. Conclusion: Thus, the activities developed by the project are not restricted to the examination during the nursing consultation, since educational activities are planned from the data obtained in those consultations.

关键词： Child Nursing School Care

Clinical relevance of the use of Dentoxol® for oral mucositis induced by radiotherapy: A phase II clinical trial

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World Journal of Clinical Oncology 2022年第10期13卷 813-821页

作者： Sebastián Solé Sergio Becerra Claudia Carvajal Piero Bettolli Hernán Letelier Alejandro Santini lorena Vargas Alexander Cifuentes Francisco Larsen Natalia Jara Jorge Oyarzún Eva Bustamante Benjamín Martínez David Rosenberg Tomas Galván Department of Radiotherapy Radiomedicine InstituteAmérico Vespucio Norte 1314 Vitacura7630370SantiagoChile National Institute of Cancer SantiagoServicio de Salud Metropolitano NorteAv Profesor Zañartu 1010Independencia8380455SantiagoChile Oncologic Institute Arturo López Pérez Foundation JoséManuel Infante 805Providencia7500691SantiagoChile Hospital Base Valdivia Bueras 1003 s/n XIV Región5100238ValdiviaChile Oncologic Center of Antofagasta Los Pumas 10255Antofagasta1267348AntofagastaChile Universidad Mayor SantiagoAv Libertador Bernardo O´Higgins 20138340585SantiagoChile Ingalfarma Dr Manuel Barros Borgoño 71Oficina 1308Providencia7500593SantiagoChile

BACKGROUND Severe oral mucositis associated with cancer therapy is a frequent complication that may affect a patient's systemic condition,resulting in interruption and/or prolongation of cancer ***®is a medical solution in the form of a mouthwash that has been shown to result in statistically significant improvement in the prevention of severe oral ***,knowing the measures of the clinical significance of this therapy is important for accurate *** describe the clinical impact of Dentoxol®use in severe oral *** Clinical significance was measured using the results obtained in a randomized controlled clinical trial previously conducted by the same group of *** measures of clinical significance evaluated were the absolute risk or incidence,relative risk,absolute risk reduction,relative risk reduction,number needed to treat,and odds *** The data obtained show that the impact of Dentoxol®on reducing the severity of oral mucositis has important clinical *** The results of this study justify the incorporation of Dentoxol®mouth rinse into clinical protocols as a complement to cancer therapy to prevent and/or treat oral mucositis secondary to radiotherapy.

关键词： Clinical trial Dentoxol Oral mucositis Prevention Radiotherapy Treatment

Oral Health and Self-Perception in the Elderly

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Health 2014年第21期6卷 3045-3053页

作者： Walda Viana Brígido de Moura Iris do Ceu Clara Costa Fábia Barbosa de Andrade Tainara lorena dos Santos Ferreira Andréa Silvia Walter de Aguiar Gabriela Eugenio de Sousa Furtado Maria Eneide Leitao de Almeida Department of Dentistry Federal University of Ceará(UFC)FortalezaBrazil Department of Dentistry Federal University of Rio Grande do Norte(UFRN)NatalBrazil Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

Background: Investigating self-perception of oral health among the elderly may contribute towards changing public health and assistance policies in the area. Methods: The present study assessed the oral health status (tooth decay, need for treatment, periodontal status, use of and need for dental prosthesis, soft tissue alterations and self-perception of oral health) of 102 elderly people from two community groups in Fortaleza, Ceará State, Brazil. Results: Mean age was 69.9 years and 82.4% were female. Mean DMFT was 30.17 with a predominant missing component;63.7% were edentulous. Regarding prosthesis, 29.4% and 67.6% of elderly patients did not use upper and lower dentures respectively, while 66.7% and 78.4% required some type of upper and lower prosthesis respectively. Among valid sextants, 44.3% presented dental calculus and 34.3% presented loss of attachment from 6 to 8 mm. Soft tissue alterations were found in 58.8%. Despite of precarious clinical conditions and dental treatment needs, good oral health perception was found (49%), as well as satisfaction with the appearance of teeth and gums (60.8%). Conclusion: Subjects displayed unsatisfactory oral health conditions, accumulated over time and resulting from the lack of policies favoring this age group. There is a need for oral rehabilitation that enables the recovery of function and esthetics among the elderly, restoring their self-esteem and improving social interaction.

关键词： Oral Health The Elderly Epidemiology Self-Image

Associated or Concomitant Diseases Influence Significantly the Health-Sickness Concept in Celiacs

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Open Journal of Epidemiology 2017年第2期7卷 139-158页

作者： Eduardo Cueto Rúa Maria Teresita Gonzalez Villar Ricardo Wright Claudia Losada Gómez Karol Martínez María Arregui Luciana Guzmán Cecilia Zubiri Viviana Bernedo Anabella Zosi lorena Menéndez Lucas Ruiz Leopoldo Mancinelli María Urrutia Ricardo Drut School of Medical Sciences La Plata National University La Plata Argentina

It is well-known that feeling to be a healthy or sick person most probably results from the mind than from the body. We all know healthy people who feel sick and vice versa. We were interested in the health and sickness feeling of celiac people, their autorating of these feelings and its conditioning factors as well as their expectations. In this paper we present the results of an inquiry to evaluate these situations. We performed a descriptive, transversal and prospective study for 2 years to groups of celiacs and their families. They received a closed inquiry to be completed before the beginning of the talk. The inquiry included personal data and the co-existence of associated or concomitant (AoC) diseases. Most of the sample’s patients felt to be a healthy person (86.8%). Mothers see their children as healthy and the auto rated criteria is significantly better than the adult celiac person (“t”= -6.024 (p = 0.000)). AoC diseases influenced negatively in the feeling of being healthy and strongly decreased the autorating. Longer time passed on treatment reflects an increase feeling of health and of the autorating. In people with AoC diseases and who feel sick, the increased time of treatment did not show significant differences. People with “gluten sensitivity” felt sicker and auto rated themselves with a lower number than celiacs. Many pediatric gastroenterologists notice that the newly agreed definition of celiac disease, referring it as “autoimmune, chronic, incurable, and multisystemic”, results in a very negative character of the condition which might compromise the future labour of this people as well as their admittance to different health insurance systems.

关键词： Associated Conditions Celiac Disease Feeling Gluten-Free Diet Gluten Intolerance Quality of Life Health/Sickness Pain Self-Qualification

Performance Comparison among Trained Judges and Panels for the Evaluation of “Cuajada” Type Fresh Cheese in Two Regions from Oaxaca in México

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Food and Nutrition Sciences 2011年第10期2卷 1166-1179页

作者： lorena Guadalupe Ramón Canul Emmanuel de Jesús Ramírez Rivera Rodrigo Santiago Cabrera Fátima Karina Delgado Vidal José Manuel Juárez Barrientos María Hernández Cervantes Juliana López Velázquez Tania Gómez Alvarado 不详

Four “cuajada” type fresh cheeses were evaluated by two trained panels in different regions from Oaxaca in Mexico (Instituto Tecnológico de Comitancillo (ITC) and Universidad del Mar (UMAR)). Each panel was integrated by six judges. Analysis of variance (ANOVA) in conjunction with principal component analysis (PCA) and the Rv coefficient were used to identify similarities and consensus among trained judges and panels. The ANOVA results revealed that the judges from ITC performed significantly better (P < 0.05) in discrimination and repetitivity, while both panels showed a similar effect in discrimination. The PCA determined some similarities in the position of cheeses in the sensory space, while Rv revealed that judges and panels were consensual. In conclusion, statistical resources determined that both panels were discriminating and that similarities in the positioning of cheeses in the sensory space were found.

关键词： AFM ANOVA Cuajada Type Fresh Cheese PCA Training Panelists

Phytochemical bioprospecting, antioxidant, antimicrobial and cytotoxicity activities of saline extract from Tithonia diversifolia(Hemsl) *** leaves

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Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 245-253页

作者： Bruno Rafael Barboza Bárbara Rafaela da Silva Barros Bárbara de Azevedo Ramos Maiara Celine de Moura Thiago Henrique Napoleao Maria Tereza dos Santos Correia Luana Cassandra Breitenbach Barroso Coelho Iranildo José da Cruz Filho Ana Maria Souto Maior Túlio Diego da Silva Leylianne de Cássia Rodrigues Nerys Edson Renan Barros de Santana Cláudia Sampaio de Andrade Lima Virgínia Maria Barros de lorena Cristiane Moutinho Lagos de Melo Department of Antibiotics Biosciences Centre Federal University of Pernambuco Department of Biochemistry Biosciences Centre Federal University of Pernambuco Center for Strategic Techmologies of the Northeast Department of Biophysics Biosciences Centre Federal University of Pernambuco Aggeu Magalhaes Institute IAM/FIOCRUZ

Objective:To evaluate antimicrobial and antioxidant properties of saline extract from Tithonia diversifolia leaves by phytochemical bioprospecting,and investigate its safety against animal ***:The saline extract was prepared,with NaCl(0.15 M),by constant stirring of the dried and pulverized leaves,followed by volume reduction by *** extract was phytochemical characterized using ultra-performance liquid chromatography,and total phenol and flavonoid analysis also was *** antioxidant capacity was determined through DPPH*radical,the antimicrobial property was evaluated against standard bacteria and fungi,and the viability assays were performed against mice ***:Fifteen compounds were identified belonging to two main classes terpenoids and *** extract showed 22.185 mg GAE/g of total phenolic compounds and 3.220 mg QE/g of ***,extract showed higher antioxidant ability similar to butylated hydroxytoluene a standard molecule[(3.042±0.019)mg AAE/g and(4.12±0.10)mg AAE/g to saline extract and butylated hydroxytoluene,respectively].The antimicrobial assays demonstrated that the extract had a significant antifungal potential against Candida species and could be used with safety against mice splenocytes,in concentrations lower than 50μg/mL,promoting higher proliferation in these ***:Saline extract from Tithonia diversifolia leaves presents potential antioxidant,antifungal properties and induces immunostimulation in mice splenocytes.

关键词： Tithonia diversifolia Extract Antioxidant Antifungal properties Immunostimulation