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Zika threatens to become a huge worldwide pandemic

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 520-527页

作者： Alcides troncoso Department of Infectious Diseases School of MedicineUniversity of Buenos Aires

The Aedes aegypti mosquito which transmits Zika virus(as well as dengue, chikungunya and yellow fever) represents a high risk for global transmission. This virus comes from Africa, the Zika forest in Uganda, where it was discovered in 1947 in a rhesus monkey. In May 2015, the first local cases were recorded in Brazil, surpassing 1.5 million cases in December of the same year. By March 2016, local transmission of Zika was recognized in 34 countries. Its clinical condition is similar to dengue febrile illness, although *** final geographical distribution area is constantly expanding. Recently, it has been associated with cases of Guillain-Barre′ syndrome in Brazil, Colombia, El Salvador,Venezuela and Suriname. Microcephaly was documented in Brazil. This article discusses some factors that contributed to the spread of Zika virus in South America. Climate change associated with the events of the phenomenon of "El Ni?o" is also analyzed. The biggest concern is how quickly Zika is spreading around the world and that it could be far more dangerous than previously thought. Zika virus infection, by its explosive potential,has every chance of becoming a global pandemic.

关键词： Zika virus Arbovirus Emergence Aedes aegypti

Will there be a cure for HIV/AIDS? Making the dream a reality

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 441-442页

作者： Alcides troncoso Department of Infectious Diseases School of MedicineUniversity of Buenos Aires

It has been more than 30 years since AIDS was introduced in people's daily life, and it is a milestone that causes taboos, myths and prejudices. At that time, a patient told me his feelings, and he was very convincing: "I am horrified of living and afraid of dying." Three decades later, AIDS infection is not a death sentence anymore. First, doctors could make that infected patients did not die from the disease; then, that the medication which kept them alive was not so toxic. And finally, that the treatments were more comfortable. And once at this point, the possibility that the virus may disappear from the body is a more realistic goal than ever. The story of AIDS has changed and, for the first time, we can foresee in the short term the beginning of the end of the pandemic. Now it is not about whether the cure is possible or not, but about when we will have it. This current momentum, so hard to get, should be maintained. We have never been so close to achieving this goal. Although the end of the pandemic is close, this is not enough. It is worrying that some world leaders have absolved themselves of responsibility for not stopping or at least having understood the explosion of the pandemic as if it was a natural disaster. "Zero tolerance for HIV" requires a profound understanding of the stigma and discrimination of the infected people to finally get rid of the epidemic of fear and the devastation that the pandemic caused.

关键词： HIV AIDS Cure Prejudices

Ulcerated labial lesion

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 36-37页

作者： Bava Javier troncoso Alcides Department of Mycology University of La PlataArgentina Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineUniversity of Buenos AiresArgentina

CASE SUMMARY The patient,a 53 year old man,bom in the Province of Misiones(Argentina) where was rural worker and live in Buenos Aires outskirts from 30 years ago. This patient came from semi-tropical areas of Argentin... 详细信息

关键词：印江

Ebola outbreak in West Africa: a neglected tropical disease

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 255-259页

作者： Alcides troncoso Department of Infectious Diseases School of Medicine Buenos Aires University

Neglected tropical diseases(NTDs) are remediable injustices of our times. Poverty is the starting point, and the ultimate outcome, of NTD. Ebola is just one of many NTDs that badly need attention. Ebola exacerbates West Africa's poverty crisis. The virus spreading in Guinea,Liberia and Sierra Leone has led to food shortages and neglect of other devastating tropical illnesses. A health crisis that was ignored for months until it was out of control is now beginning to get the attention required, if not the resources. So far, the world′s nations have contributed far less than the $ 1 billion. The U.N. estimates would need to control the epidemic before it becomes endemic. Past outbreaks of Ebola have flared up in remote, forested communities, disconnected from much of the outside world. But the outbreak in West Africa has not slowed yet, and it worsens there the chances of it spreading to other countries. Ebola draws attention to NTD. Ebola is not only a health emergency, but also it′s a poverty *** current Global Ebola crisis presents a multitude of challenges in terms of our capacity to respond; the future is even less predictable. Ebola outbreak represents inequity in health as the occurrence of health differences considered unnecessary, avoidable, unfair, and unjust, thus adding a moral and ethical dimension to health inequalities. Health equity does not refer only to the fairness in the distribution of health or the provision of health care; rather, it is linked with the larger issues of fairness and justice in social arrangements.

关键词： Ebola Poverty Epidemic Health inequalities

Non habitual microscopic forms of Histoplasma capsulatum in disseminated disease

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Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 28-30页

作者： Bava AJ Garro S troncoso A University of La Plata Argentina Department of Infectious Diseases "Francisco J.Mutiiz" HospitalBuenos AiresArgentina School of Medicine University of Buenos AiresArgentina

This paper communicates the presence of aberrant microscopic forms of Histoplasma capsulatum in a sample obtained by scrapping of the skin lesion and stained with a rapid modification of the Grocott *** AIDS patient was treated with cream contained corticoids and antifungal and antibacterial antibiotics by an erroneous *** the etiologic diagnosis was achieved,oral itraconazol was administrated at the daily dose of 400 mg during at least six *** non habitual forms described in the literature as " aberrant variants", can be interpreted as an "adaptive phenomenon" of this termodimorphic fungal specie,as response of the ecologic alterations produced by antibiotic on the local antagonic bacterial microbiota,the deleterous activity of antifungal on the fungal cells and the local inmunodepression produced by the corticoids.

关键词： aberrant Histoplasma capsulatum AIDS associated histoplasmosis Endemic Mycoses and AIDS

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Zoonotic transmission of hepatitis E:Implications for public health worldwide

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 77-82页

作者： Analia Paiva Victoria Rebagliati Alcides troncoso Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineUniversity of Buenos AiresArgentina

Since the year 1982,the Hepatitis E virus(HEV),enteric transmission,has been widely spread in many tropical and subtropical *** has multiple routes of transmission,such as food or water contaminated with faecal matter,person-to-person transmission or by the ingestion of raw or undercooked *** is important to consider the significance of zoonotic infections propagation,both in endemic areas as well as in developed countries,where there have been some sporadic *** article summarizes the research conducted to date,which supports the zoonotic transmission of HEV,its risks and how they are often underestimated.

关键词： Human zoonosis HEV Public health

Giemsa and Grocott in the recognition of Histoplasma capsulatum in blood smears

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 418-420页

作者： Javier Bava Alcides troncoso Laboratory of Parasitology Infectious Diseases Muniz Hospital Department of Microbiology and Infectious Diseases School of MedicineUniversity of Buenos Aires

Objective:To facilitate the recognition of intracellular yeasts of Histoplasma capsulation and differentiate it from Leishmania amastigotes and other parasites,using the combination of Giemsa and a rapid modification of Grocott stains to peripheral blood smears in a hematological ***:The combination of both stains was applied consecutively(first Grocott and then Giemsa)to previously fixed peripheral blood *** was performed with 400x and 1000x,the latter using immersion ***:The yeasts of Histoplasma capsulatum were observed into the cytoplasm of leukocytes as brownish oval elements,with 3-4μm in ***:The combination of both techniques is a simple and fast method to facilitate recognition of intracellular yeasts and it is different from intracellular parasitic ***,it allows distinguishing the cell elements that are in the microscopic *** may be very helpful in those cases in which the presumptive diagnosis of histoplasmosis has not been established yet and where other more sophisticated methods are not available.

关键词： Histoplasmosis Peripheral blood smear Visceral leishmaniasis HIV

Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to alleviate the load of misfolded protein

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Neural Regeneration Research 2021年第8期16卷 1564-1565页

作者： Paulina troncoso-Escudero Claudio Hetz Rene L.Vidal Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Center for Geroscience Brain Health and MetabolismSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesUniversity of ChileSantiagoChile Center for Integrative Biology Faculty of SciencesUniversity MayorChile Buck Institute for Research on Aging NovatoCAUSA

Huntington's disease(HD) is an inherited autosomal dominant neurodegenerative disorder characterized by the development of adult-onset motor dysfunction,psychiatric disturbances and intellectual *** is associated with an expansion of CAG repeat sequence in the huntingtin gene(Htt).Exon 1 of Htt normally contains between 6 to 35 CAG repeats,whereas in patients affected with HD it contains more than 40 trinucleotides.

关键词： Huntington Therapeutic stasis