Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to alleviate the load of misfolded protein

作     者：Paulina Troncoso-Escudero Claudio Hetz Rene L.Vidal Paulina Troncoso-Escudero;Claudio Hetz;Rene L.Vidal

作者机构：Biomedical Neuroscience InstituteFaculty of MedicineUniversity of ChileSantiagoChile Center for GeroscienceBrain Health and MetabolismSantiagoChile Program of Cellular and Molecular BiologyInstitute of Biomedical SciencesUniversity of ChileSantiagoChile Center for Integrative BiologyFaculty of SciencesUniversity MayorChile Buck Institute for Research on AgingNovatoCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第8期

页      面：1564-1565页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by Agencia Nacional de Investigación y Desarrollo (ANID) and Fondo de Financiamiento de Centros de Investigación en áreas Prioritarias (FONDAP), No. 15150012 (to CH and RLV) Millennium Institute, No. P09015-F (to CH and RLV) Fondo de fomento al desarrollo científico (FONDEF), No. ID16I10223, D11E1007 (to CH) Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT), No. 1180186 (to CH) and 1191003 (to RLV) U.S.Air Force Office of Scientific Research 20RT0419 Michael J Fox For Parkinson’s Research Target Validation ID 12473.01 (to CH) and Consejo Nacional de Ciencia y tecnología (CONICYT), No. 21160843 (to PTE) 

主　　题：Huntington Therapeutic stasis 

摘      要：Huntington s disease(HD) is an inherited autosomal dominant neurodegenerative disorder characterized by the development of adult-onset motor dysfunction,psychiatric disturbances and intellectual *** is associated with an expansion of CAG repeat sequence in the huntingtin gene(Htt).Exon 1 of Htt normally contains between 6 to 35 CAG repeats,whereas in patients affected with HD it contains more than 40 trinucleotides.