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Strategy for a Fast and Simple Method for Trace Determination of Senecionine and Senecionine N-Oxide in Honey Using LVI in HPLC-MS/MS

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American Journal of Analytical Chemistry 2014年第10期5卷 681-687页

作者： lizandra czermainski bretanha Marcel Piovezan Alysson Fernandez Vasques Sako Moacir Geraldo Pizzolatti Gustavo Amadeu Micke Departamento de Química Universidade Federal de Santa Catarina Florianópolis Brazil

The aims of this study were to develop an HPLC-MS/MS method for the trace determination of senecionine (SEN) and senecionine N-oxide (SENNOX) in honey samples with simple dilution and to optimize the strategy for large volume injection (LVI). In the method development, the quantity of sugar, injection volume and sample pH were optimized to increase the efficiency and the retention factor of the analytes. Figures of merit of the proposed method include: good linearity (R2 > 0.99), limits of detection of 57 and 59 ng·kg﹣1 for SEN and SENNOX, respectively, and recovery in the range of 83.4% - 123%. The values for the instrumental precision in relation to the retention time and peak area were 0.65% and 7.1%, respectively, and for the intra-day precision they were greater than 0.95% and 9.7% for SEN and SENNOX, respectively. The LVI-HPLC-MS/MS procedure developed was applied to honey samples prepared by simple dilution with deionized water (1:8 w/w) and the pH was adjusted to 9.5 with NH4OH. The sample volume injected was 100 μL;concentrations in natural and industrialized honey were ﹤LOQ - 1071.3 μg·kg﹣1 for SEN and ﹤LOD - 16.9 μg·kg﹣1 for SENNOX.

关键词： Large Volume Injection HPLC-MS/MS Honey Senecionine Senecionine N-Oxide

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Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

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Journal of Biosciences and Medicines 2017年第2期5卷 39-48页

作者： Aldo S. de Oliveira Inês M. C. Brighente Rafael G. Lund Luana C. Llanes Ricardo J. Nunes lizandra C. bretanha Rosendo Augusto Yunes Pedro H. A. Carvalho Juliana S. Ribeiro Department of Chemistry Center of Physical and Mathematical Sciences Federal University of Santa Catarina Florian&oacute polis SC Brazil Oral Microbiology Laboratory Faculty of Dentistry Federal University of Pelotas Pelotas Brazil

This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested;however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.

关键词： Napthoquinones Antifungal Candida albicans Antioxidant

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