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Chinese Journal of Chemical Engineering 2018年第7期26卷 1561-1569页

作者： Panpan Sun liyuan chen Lin Xu Wancheng Zhu Department of Chemical Engineering Qufu Normal University

A facile eco-friendly hydrothermal route （180 ℃, 12.0 h） has been developed for the first time to the uniform hierarchical porous MgBO2（OH） microspheres without the aid of any organic additive, surfactant or template, by using the abundant MgCl2·6H2O, H3BO3 and NaOH as the raw materials. The as-obtained porous microspheres exhibit a specific surface area of 94.752 mg·g-1, pore volume of 0.814 cm3.g-1, and ca. 84.0% of which have a diameter of 2.25-3.40 μm. The thermal decomposition of the porous MgBO2（OH） microspheres （650 ℃, 2.5 ℃. min-l） leads to the porous Mg2B2O5 rnicrospheres with well-retained morphology. When utilized as the adsorbents for the removal of CR from mimic waste water, the present porous MgBO2（OH） microspheres exhibit satisfactory adsorption capacity, with the maximum adsorption capacity qm of 309.1 mg-g-1, much higher than that derived from most of the referenced adsorbents. This opens a new window for the facile green hydrothermal synthesis of the hierarchical porous MgBO2（OH） microspheres, and extends the potential application of the 3D hierarchical porous metal borates as high-efficiency adsorbents for organic dyes removal.

关键词： Hierarchical porous microspheres Magnesium borate hydroxide Adsorption Congo red Hydrothermal

肥胖脂肪组织中巨噬细胞亚型与代谢性疾病的关系

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中国组织工程研究 2025年第13期29卷 2832-2841页

作者：赵玉晴王伟油惠娟陈立沅陈岩王清路杨风英山东体育学院运动与健康学院山东省济南市250102 山东省青岛体育训练中心山东省青岛市266023

背景:巨噬细胞亚型表现出组织异质性,脂肪组织巨噬细胞表型很大程度上受肥胖的影响,肥胖脂肪组织巨噬细胞导致的局部和系统炎症反应被认为是肥胖相关代谢性疾病的关键病理学原因。目的:通过总结脂肪组织巨噬细胞不同亚型炎症特点及其与... 详细信息

背景:巨噬细胞亚型表现出组织异质性,脂肪组织巨噬细胞表型很大程度上受肥胖的影响,肥胖脂肪组织巨噬细胞导致的局部和系统炎症反应被认为是肥胖相关代谢性疾病的关键病理学原因。目的:通过总结脂肪组织巨噬细胞不同亚型炎症特点及其与肥胖相关代谢性疾病的关系,为靶向特定巨噬细胞亚型探索肥胖相关代谢性疾病的防治策略提供参考依据。方法:检索中国知网、PubMed数据库相关文献,中文检索词为“肥胖,脂肪组织,脂肪组织巨噬细胞,巨噬细胞极化,代谢性疾病”;英文检索词为“obesity,adipose tissue,adipose tissue macrophages,macrophage polarization,metabolic diseases”,依据入选标准对检索结果进行录用或排除,最终纳入符合标准的91篇文献进行综述。结果与结论:①巨噬细胞具有组织异质性,正常情况下,脂肪组织巨噬细胞以抗炎M2型常驻巨噬细胞为主,维持组织炎症稳态;发生肥胖时,肥大脂肪细胞周围围绕大量外来浸润性巨噬细胞,并且大部分表现出促炎特点。因此,曾经被认为是促炎M1型的脂肪组织巨噬细胞实际上可能是多种促炎亚型的集合。对各种促炎亚型特点的进一步认识有助于深入了解肥胖脂肪组织炎症紊乱的机制。②肥胖情况下,外来浸润性巨噬细胞围绕在肥大脂肪细胞周围形成冠状结构,目前已发现冠状结构中有6种不同亚型,其中大部分表现出促炎特性,少数亚型具备抗炎特点,因此充分发挥抗炎亚型作用的同时抑制促炎亚型的分化可能是缓解肥胖脂肪组织炎症损害的新靶向。③已有研究发现M3、MMe、CD9^(+)、LAM脂肪组织巨噬细胞亚型参与动脉粥样硬化、糖尿病、胰岛素抵抗、癌症等代谢疾病的发生发展,DARC+和MFehi脂肪组织巨噬细胞亚型在治疗非酒精性脂肪肝、肥胖胰岛素抵抗、铁死亡相关代谢疾病中起到关键作用。上述研究进一步说明肥胖脂肪组织外来浸润巨噬细胞引起的炎症紊乱是肥胖诱发代谢性疾病的重要病理基础,对各种亚型特点的进一步深入研究具有重要的理论和现实意义。

关键词：脂肪组织巨噬细胞脂肪组织巨噬细胞亚型代谢性疾病肥胖巨噬细胞极化促炎抗炎

Emission factors of particulate matter, CO and CO_2 in the pyrolytic processing of typical electronic wastes

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Journal of Environmental Sciences 2019年第7期31卷 93-101页

作者： liyuan chen Chuanyang Cai Shuangyu Yu Yu Liu Shu Tao Wenxin Liu Key Laboratory for Earth Surface Processes College of Urban and Environmental Sciences Peking University

A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes(E-wastes), including printed wiring boards(PWBs)and plastic casings. The generated particulate matter(PM) of different particle sizes, carbon monoxide(CO) and carbon dioxide(CO_2) were determined, and the corresponding emission factors(EFs) were estimated. Finer particles with particle sizes of 0.4–2.1 μm accounted for78.9% and 89.3% of PM emitted by the pyrolytic processing of PWBs and plastic casings,respectively, and the corresponding EFs were 9.68 ± 4.81 and 18.49 ± 7.2 g/kg, *** EFs of CO and CO_2 from PWBs and plastic casings were 55.9 ± 26.9 and 1182 ± 439 g/kg,and 133.6 ± 34.6 and 2827 ± 276 g/kg, respectively. Compared with other emission sources,such as coal, biomass, and traffic exhaust, the EFs of E-wastes were relatively higher,especially for PM. There were significant positive correlations(p < 0.05) of the initial contents of carbon and nitrogen in PWBs with the related EFs of PM, CO, and CO_2, while the correlations for plastic casings were insignificant. The EFs of CO of PWBs were significantly positively correlated with the corresponding EFs of PM and the parent polycyclic aromatic hydrocarbons(PAHs); however, the same result was not observed for plastic casings.

关键词： Pyrolytic processing of electronic-wastes Particulate matter CO CO2 Emission factor

ENDPOINT BOUNDS FOR AN ANALYTIC FAMILY OF MAXIMAL FUNCTIONS

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Analysis in Theory and Applications 1994年第4期10卷 56-71页

作者： liyuan chen (Hangzhou University,china) 1. Department of Mathematics Hangzhou University 310028 Hangzhou P.R. China

In this paper,for the plane curve T=.we define an analytic family of maximal functions asso- ciated to T as M_2f(λ)=sup_n>oh^-1∫_R(h^(-1)1)dt, hereis a Schwartz function,z∈*** have proved the following result:For a certain class of curves in R^2,ifisoddin C_o^x(R).Then (a)M_z maps L^2 to L^2 if Rez>—3/2; (b)M_z maps H^1 to weak L^1(L^(1x))if Rez=-1: (c)M_z maps L^p to L^p.p if Rez=1/p 2.1oh^(-1)∫_k x_1-t,x_2-y(t)(h't)dt. thus our result include those in[1],[4]whenis odd in C_o^x(R).

关键词： ENDPOINT BOUNDS FOR AN ANALYTIC FAMILY OF MAXIMAL FUNCTIONS 脚口加一一彻一夕

Efficient separation of C_(4) olefins using tantalum pentafluor oxide anion-pillared hybrid microporous material

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Chinese Journal of Chemical Engineering 2022年第2期35卷 49-54页

作者： Bin Gao Zhaoqiang Zhang Jianbo Hu Jiyu Cui liyuan chen Xili Cui Huabin Xing Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China

With the increasing demand for synthetic rubber,the purification of 1,3-butadiene(C_(4)H_(6))is of great industrial ***,the successful removal of n-butene(n-C_(4)H_(8))and iso-butene(iso-C_(4)H_(8))from 1,3-butadiene(C_(4)H_(6))was realized by synthesizing a novel TaOF_(5)^(2-) anion-pillared ultramicroporous material TaOFFIVE-3-Ni(also referred to as ZU-96,TaOFFIVE=TaOF_(5)^(2-),3=pyrazine).Single-component adsorption isotherms show that TaOFFIVE-3-Ni can achieve the exclusion of n-C_(4)H_(8) and iso-C_(4)H_(8) in the low pressure region(0–30 kPa),and uptake C_(4)H_(6) with a high capacity of 92.78 cm^(3)·cm^(-3)(298 K and 100 kPa).The uptake ratio of C_(4)H_(6)/iso-C_(4)H_(8) on TaOFFIVE-3-Ni was 20.83(298 K and 100 kPa),which was the highest among the state-of-the-art adsorbents reported so *** the rotation of anion and pyrazine ring,the pore size changes continuously,which makes smaller-size C_(4)H_(6) enter the channel while larger-size n-C_(4)H_(8) and iso-C_(4)H_(8) are completely *** excellent breakthrough performance of TaOFFIVE-3-Ni shows great potential in industrial separation of C4 *** specific adsorption binding sites within ZU-96 was further revealed through the modeling calculation.

关键词： Adsorptive separation C4 olefin 13-Butadiene Anion-pillared hybrid microporous material

MYB106 is a negative regulator and a substrate for CRL3^(BPM) E3 ligase in regulating flowering time in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2021年第6期63卷 1104-1119页

作者： Liu Hong Fangfang Niu Youshun Lin Shuang Wang liyuan chen Liwen Jiang Center for Cell&Developmental Biology State Key Laboratory of AgrobiotechnologySchool of Life SciencesThe Chinese University of Hong KongShatinNew TerritoriesHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Shenzhen Technology University Shenzhen 518000China School of Chemical Biology&Biotechnology Peking University Shenzhen Graduate SchoolNanshan DistrictShenzhen 518055China

Flowering time is crucial for successful reproduction in plants, the onset and progression of which are strictly controlled. However, flowering time is a complex and environmentally responsive history trait and the underlying mechanisms still need to be fully characterized. Post-translational regulation of the activities of transcription factors(TFs) is a dynamic and essential mechanism for plant growth and development. CRL3 BPME3 ligase is a CULLIN3-based E3 ligase involved in orchestrating protein stability via the ubiquitin proteasome pathway. Our study shows that the mutation of MYB106 induced early flowering phenotype while over-expression of MYB106 delayed Arabidopsis flowering. Transcriptome analysis of myb106 mutants reveals 257 differentially expressed genes between wild type and myb106-1 mutants, including Flowering Locus T(FT) which is related to flowering time. Moreover, in vitro electrophoretic mobility shift assays(EMSA), in vivo chromatin immunoprecipitation quantitative polymerase chain reaction(ChIP-q PCR) assays and dual luciferase assays demonstrate that MYB106 directly binds to the promoter of FT to suppress its expression. Furthermore, we confirm that MYB106 interacts with BPM proteins which are further identified by CRL3 BPME3 ligases as the substrate. Taken together, we have identified MYB106 as a negative regulator in the control of flowering time and a new substrate for CRL3 BPM E3 ligases in Arabidopsis.

关键词： flowering time MYB transcription factor E3 ligase CUL3~(BPM)

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

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Frontiers of Medicine 2012年第2期6卷 195-203页

作者： liyuan chen Qifeng Dang chengsheng Liu Jun chen Lei Song Xiguang chen College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Department of Surgery the Commercial Staff&Workers Hospital of QingdaoQingdao 266011China

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion(SD)*** screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of *** dissolution of ibuprofen in urea was higher than in PEG4000 or ***,urea was selected as the carrier for the preparation of *** were characterized in terms of dissolution,differential scanning calorimetry(DSC),X-ray diffraction(XRD),scanning electron microscopy(SEM),and Fourier transform infrared(FTIR)*** dispersionbased(SDBT)and conventional(CT)tablets were prepared by the wet granulation *** antiinflammatory effect of SDBT was evaluated using the mouse ear edema test with *** vitro release results indicated that the ibuprofen dissolution rate was improved by the *** characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not *** displayed more significant anti-inflammatory effects than *** dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.

关键词： ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect

Improving herdsmen’s well-being through scenario planning:A case study in Xilinhot City,Inner Mongolia Autonomous Region

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Geography and Sustainability 2020年第3期1卷 181-188页

作者： Jiajia Liu Ganlin Huang Peng Jia liyuan chen Center for Human-Environment System Sustainability(CHESS) State Key Laboratory of Earth Surface Processes and Resource Ecology(ESPRE)Beijing Normal UniversityBeijing 100875China School of Natural Resources Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Beijing No.142 Middle School(Beijing Hongzhi Middle School) Beijing 100013China Department of Land Surveying and Geo‐Informatics The Hong Kong Polytechnic UniversityHong KongChina International Institute of Spatial Lifecourse Epidemiology(ISLE) Hong KongChina

Grassland ecosystems support well-being with food,shelter,income,and culture of *** the associa-tion between ecosystem services and human well-being has been widely studied,such association is understudied in grassland *** study aims to fill this gap through a case study of Xilinhot City,Inner Mongolia Autonomous Region,*** examined the association between grassland provisioning services and herds-men’s well-being between 1985 and 2015 through participatory observations,interviews,surveys,and Bayesian belief network *** the uncertainties of weather and sheep prices,we developed four scenarios to examine the future well-being of *** results show that the most important factor for herdsmen’s well-being was income,which is highly sensitive to the market price of sheep and *** the uncertainties of sheep prices and precipitation,scenario analysis revealed a divergence between income and *** herdsmen’s income is most likely to increase with low precipitation and increased sheep prices,their well-being is most likely to improve with abundant precipitation and increased sheep *** on our find-ings,we argue that developing alternative income sources(e.g.,tourism),reducing dependence on government subsidies through commercial insurance,and branding lamb with grassland ecosystem to alleviate the impact of price fluctuations would help improve herdsmen’s well-being in all scenarios.

关键词： Grassland Ecosystem service Well-being Bayesian belief network model Scenario planning Inner Mongolia

Plant E3 Ligases： Flexible Enzymes in a Sessile World

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Molecular Plant 2013年第5期6卷 1388-1404页

作者： liyuan chen Hanjo Hellmann Plant Stress Physiology School of Biological Sciences Abelson 435 PO Box 644236 Washington State University Pullman WA 99164-4236 USA

Since its discovery in the late 1970s, the ubiquitin proteasome pathway appears to be omnipresent in many research fields. Although originally discovered in animals, the pathway has a very central role in plants, which may be correlated to their sessile lifestyle. E3 ligases function as flexible and highly diverse key regulators within the path- way by targeting substrate proteins for ubiquitylation, and often proteolytic degradation via the 26S proteasome. This review provides a concise overview on the most common classes of E3 ligases so far described in plants, and emphasizes recent findings regarding these interesting and flexible enzymes and their diverse functions in plant biology.

关键词： E3 ligases plant development plant physiology ubiquitin proteasome pathway.

Occurrence of Aflatoxin B_(1),deoxynivalenol and zearalenone in feeds in China during 2018-2020

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Journal of Animal Science and Biotechnology 2022年第1期13卷 197-208页

作者： Ling Zhao Lei Zhang Zijian Xu Xingda Liu liyuan chen Jiefan Dai Niel Alexander Karrow Lvhui Sun Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Guilin Li Yuan Grain and Oil Food Group Co. LtdGuilin 541001GuangxiChina Jiangsu Aomai Bio-Technology Co. LtdNanjing 211226China Department of Agriculture of Sichuan Province Chengdu 610041China Department of Animal Biosciences University of GuelphN1G2W1GuelphCanada

Background:The current study was conducted to investigate the individual and combined occurrence of aflatoxin B_(1)(AFB_(1)),deoxynivalenol(DON)and zearalenone(ZEN)in feeds from various Provinces of China during 2018 to 2020.A total of 3,507 feed samples,including 2,090 feed ingredients and 1,417 complete feed samples,were collected from different areas of China for mycotoxins ***:The individual contamination of AFB_(1),DON and ZEN were present in more than 81.9%,96.4% and 96.9% of feed samples,respectively,with average concentration ranges of AFB_(1) between 1.2-27.4μg/kg,DON between 458.0-1,925.4μg/kg and ZEN between 48.1-326.8μg/***,0.9%,0.5% and 0.1% of feed ingredients,and 1.2-12.8%,0.9-2.9% and 0-8.9% of complete feeds for pigs,poultry and ruminants with AFB_(1),ZEN and DON that exceeded China’s safety standards,***,more than 81.5%of feed ingredients and 95.7% of complete feeds were co-contaminated with various combinations of these ***:This study indicates that the feeds in China were universally contaminated with AFB_(1),DON and ZEN during the past 3 *** findings highlight the significance of monitoring mycotoxin contaminant levels in the domestic animal feed,and the importance of carrying out feed administration and remediation strategies for mycotoxin control.

关键词： Aflatoxin B_(1) China Deoxynivalenol Feeds Zearalenone