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Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease:a Clinical randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 388-395页

作者： WANG Shaosong SUN Jingqing feng Qingyin LI bin WANG Xin YUAN Fan CUI Yingxue Department of acupuncture Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease(PD).METHODS:A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients *** electric acupuncture group was treated with electric acupuncture,while the control group was treated with Park needle *** groups were treated 5 times a week for a total of 4 weeks,and both groups completed 20 ***'s Parkinson's Pain Scale(KPPS)and visual analog scale(VAS)were used before and after treatment to evaluate the pain degree of *** shear wave elastography(SWE)and modified Ashworth score(MAS)were used to evaluate the changes of muscle ***'s comprehensive Score Scale(MDS-UPDRS,including UPDRS Ⅱ and UPDRS Ⅲ)was used to evaluate exercise *** Depression Scale(HAMD)score was used to evaluate the emotional changes of *** correlation analysis was used to explore the correlation between pain degree and muscle tone,exercise ability and ***:During the study,one case fell off in the control group,and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control *** treatment,Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment,while KPPS score,VAS score,UPDRS Ⅱ,UPDRS Ⅲ and modified Ashworth score were decreased,with statistical significance(P0.05).After treatment,KPPS score,VAS score,UPDRS Ⅱ and UPDRS Ⅲ,MAS,HAMD score,Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group(P<0.05).Spearman correlation analysis showed that KPPS score was positively correl

关键词： Parkinson disease muscle skeletal pain electroacupuncture muscle tention mood disorders randomized controlled trial

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Graphene reinforced nanoarchitectonics of 3D interconnected magnetic-dielectric frameworks for high-efficient and anti-corrosive microwave absorbers

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Journal of Materials Science & Technology 2024年第1期168卷 194-207页

作者： Chenchen liu Xiaofang feng Shuning liu Guo Lin Zhongxiang Bai Lingling Wang Ke Zhu Xiulan Li Xiaobo liu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China Sichuan Province Engineering Technology Research Center of Novel CN Polymeric Materials Chengdu611731China School of Chemical Engineering Northwest UniversityXi’an710069China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou510275China

The combination of high efficiency and environmental stability is vital to promote the commercial appli-cations of microwave absorption(MA)materials,yet remains challenging in the absence of facile ***,we put forward a graphene-reinforced construct approach for one-pot synthesis of 3D intercon-nected magnetic-dielectric frameworks via pre-functionalization and subsequent *** in-teractions among discrete precursors are capable of manipulating the confined growth and interfacial *** enhancements in MA properties are triggered in a straightforward manner us-ing ultralow feeding fractions of graphene oxide *** minimum reflection loss is up to-60.1 dB(99.9999%wave absorption)and the effective absorption bandwidth reaches 5.9 GHz(almost covering the Ku band).Remarkably,based on the optimization by ultralow concentrations of graphene,the as-prepared nanoarchitecture simultaneously integrates strong absorption,broad bandwidth,and low matching *** embedded graphene nanosheets serve as high-speed electron transmission channels and hollow resonance cavities,facilitating multimode attenuations and impedance-matching ***-while,the graphene-reinforced framework suppresses the corrosion of magnetic components,whose cor-rosion rate reduces by an order of *** study provides a simple procedure to boost magnetic-dielectric absorbers for comprehensive MA performances and enhanced corrosion resistance.

关键词： 3D Magnetic-dielectric framework Graphene nanosheet Microwave absorption Anti-corrosion

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No more free lunch:The increasing popularity of machine learning and financial market efficiency

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Economic and Political Studies 2024年第1期12卷 34-57页

作者： Jian feng Xin liu Faculty of Business and Economics The University of Hong KongHong Kong SARChina School of Finance Renmin University of ChinaBeijingChina

In this paper,we show that the increasing popularity of machine learning improves market *** analysing the performance of a set of popular machine learning-based investment strategies,we find that profits from these strategies experience significant declines since the wide adoption of machine learning techniques,especially for profits based on the more preferred method of neural *** declines mainly come from long *** the‘machine learning’Google search index as a proxy for machine learning-based trading intensity,we find that returns from the neural networks-based long–short and long-only strategies are weaker following high levels of machine learning intensity,while no relation is found between machine learning intensity and the short-only neural networks-based strategy.

关键词： Machine learning market efficiency mispricing neural networks arbitraging activities

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Liquid-mediated Ostwald ripening of Ag-based clusters supported on oxides

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Nano Research 2024年第6期17卷 4971-4978页

作者： Conghui liu Rongtan Li Yamei Fan Shiwen Li Xiaohui feng Lu feng Yanxiao Ning Qiang Fu School of Chemistry Dalian University of TechnologyDalian 116024China State Key Laboratory of Catalysis Chinese Academy of SciencesDalian Institute of Chemical PhysicsDalian 116023China

Reconstruction of supported nanocatalysts often occurs in gas-solid reactions and significantly affects the catalytic performance,yet it is much less explored in liquid-phase ***,we find that highly-dispersed Ag nanocatalysts,i.e.,AgOx clusters,supported on alumina,silica,and titania,can aggregate into larger Ag or Ag2O particles after immersing in liquid-phase media at room *** spontaneous aggregation of AgOx clusters in liquid water is attributed to liquid-phase Ostwald ripening through dissolution of AgOx clusters into water and subsequent redeposition to form Ag2O *** immersion into organic solvents such as ethanol leads to reduction of AgOx clusters and further growth into Ag *** work reveals that liquid-phase reaction media can induce substantial structural evolution of supported nanostructured catalysts,which should be carefully considered in liquid-solid interface catalytic reactions such as electrocatalysis,environmental catalysis,and organic synthesis in liquid phase.

关键词： Ag catalysts Ostwald ripening liquid phase media dissolution-deposition process

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Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

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Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-Qiang Huang Yuan-feng Li Yong liu Lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Multiperiod optimization of cooling water system with flexible topology network

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Green Chemical Engineering 2024年第4期5卷 461-472页

作者： Bo liu Ruimei Zhang Ye liu Yufei Wang Ali Almansoori Xiao feng School of Chemical Engineering and Environment China University of Petroleum Department of Chemical Engineering Khalifa University of Science and Technology CHN Energy Xinjiang Chemical Co.LTD School of Chemical Engineering & Technology Xi'an Jiaotong University

Cooling water systems(CWSs) are extensively utilized in various industries to eliminate the excess heat and converse energy. Studies on CWSs mainly concentrated on finding the optimal cooler network structure. In addition, some works also considered the optimal design under varied operation conditions. However, in these works, once the optimal design of the cooler's network is determined, its arrangement remains fixed and cannot be adapted to accommodate diverse operating conditions. In this work, a flexible topology network concept is proposed to make the adjustment of network structure possible under different operation conditions. The CWS with integrated air cooler and flexible topology network has better overall performance, represented by a mixed integer nonlinear programming(MINLP) model that require advanced tools such as GAMS software. Case studies revealed that the proposed methodology can realize better energy-saving performance, and improve the economic performance under varied operation conditions. The impact of critical flexible nodes on system configuration and economy is achieved by sensitivity analysis.

关键词： Cooling water systems Flexible network Multiperiod optimization Air cooler

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Upcycling electroplating sludge into bioengineering-enabled highly stable dual-site Fe-Ni_(2)P@C electrocatalysts for efficient oxygen evolution

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Nano Research 2024年第8期17卷 6984-6992页

作者： Jiawen liu Zunpeng Zuo feng Gao Kai Yi Jiahui Lin Mengye Wang Zhang Lin feng Huang State Key Laboratory of Optoelectronic Materials and Technologies School of MaterialsSun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry City University of Hong KongHong Kong 999077China School of Metallurgy and Environment Central South UniversityChangsha 410083China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

The advancement of bimetallic catalysts holds significant promise for the innovation of oxygen evolution reaction(OER)*** from adsorbate evolution mechanism(AEM)and lattice oxygen oxidation mechanism(LOM),the incorporation of dual active sites has the potential to foster novel OER pathways,such as the coupled oxygen evolution mechanism(COM),which can surpass the limitations of OER and elevate catalytic *** this study,uniformly distributed Fe/Ni dual-site Fe-Ni_(2)P@C electrocatalysts are crafted by upcycling metals in electroplating sludge via an eco-friendly and sustainable microbial engineering *** findings indicate that a substantial number of defects emerge at the Ni2P crystal during the OER process,laying the groundwork for lattice oxygen ***,the displacement of Ni/Fe in the crystal lattice intensifies the asymmetry of the electronic structure at the metal active sites,facilitating the deprotonation *** research introduces an innovative paradigm for the synthesis of effective and robust transition metal-based OER catalysts,with implications for sustainable energy generation technologies.

关键词： oxygen evolution reaction dual active sites adsorbate evolution mechanism lattice oxygen mechanism bioengineering

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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao liu Shu-feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-feng HUANG Xiang-feng LU bin LU Dong-feng GU Department of Epidemiology&Key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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Fucoxanthin improves serum lipids， liver metabolism and gut microbiota in hyperlipidemia mice

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Food Science and Human Wellness 2024年

作者： Yonghui Zhou Jingyi Zhang Kun Xu Weihao Zhang feng Chen bin liu bingbing Guo Faculty of Environment and Life， Beijing University & Technology Shenzhen Key Laboratory of Marine Microbiome Engineering， Institute for Carbon Neutrality， Institute for Advanced Study， Shenzhen University

Fucoxanthin， a kind of exclusively algae-derived carotenoids， could reduce lipid content and regulate gut microbiota composition in obese mice， showing potential in preventing hyperlipidemia. This study aimed to illustrate fucoxanthin efficacy in modulating lipid metabolism in serum and liver of high-fat-induced hyperlipidemia mice， as well as investigate the underlying association with gut microbiota changes. Results showed that fucoxanthin significantly reduced body weight gain and body white fat of the mice. In the serum， total triglycerides (TG)， total cholesterol (TC) contents were significantly decreased and high-density-lipoprotein cholesterol levels was significantly upregulated. Moreover， fucoxanthin remarkedly prevented lipid accumulation in the liver. Especially， metabolomics results showed that lipids and lipid-like molecules were significantly downregulated compared with the control， indicating the advance of hepatic lipid metabolism. Bile acids profile in the liver was also greatly changed by fucoxanthin. Meanwhile， fucoxanthin remodeled gut microbiota composition and promoted the relative abundance of Desulfovibrio， Blautia and Clostridia genera. Finally， correlation analysis revealed that these gut microbiota changes were closely related with hepatic metabolites/metabolism and serum lipids. Altogether， this study showed great potential of fucoxanthin in improving serum lipids profile， hepatic lipids and bile acids metabolism of hyperlipidemia mice， which was associated with gut microbiota alteration.

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Heat stress affects mammary metabolism by influencing the plasma flow to the glands

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1908-1917页

作者： Jia Zeng Diming Wang Huizeng Sun Hongyun liu feng‑Qi Zhao Jianxin liu Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhouChina Zhejiang Key Laboratory of Dairy Cow Genetic Improvement and Milk Quality Research Zhejiang UniversityHangzhouChina Department of Animal&Veterinary Sciences University of VermontBurlingtonVTUSA

Background Environmental heat stress(HS)can have detrimental effects on milk production by compromising the mammary *** plasma flow(MPF)plays a crucial role in nutrient supply and uptake in the mam-mary *** this experiment,we investigated the physiological and metabolic changes in high-yielding cows exposed to different degrees of HS:no HS with thermal-humidity index(THI)below 68(No-HS),mild HS(Mild-HS,68≤THI≤79),and moderate HS(Mod-HS,79

关键词： Dairy cow Heat stress Mammary metabolism Mammary plasma flow

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