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Asian Journal of urology 2019年第4期6卷 373-376页

作者： Min Qu Xin Lu Lei Wang zhiyong liu yinghao sun xu Gao department of urology Changhai HospitalSecond Military Medical UniversityShanghaiChina

Priapism secondary to chronic myeloid leukemia(CML)is rarely observed in the ***,we present an 18-year-old patient with priapism for over 72 h due to *** interventions such as therapeutic aspiration and intracorporal injection of phenylephrine failed before a surgical corpora cavernosa-corpus spongiosum shunt was inserted to relieve *** hospitalization,bone marrow aspiration confirmed the diagnosis of CML.

关键词： Priapism Chronic myeloid leukemia Surgical cavernosacorpus spongiosum shunt

Natural orifice transluminal endoscopic surgery in urology: The Chinese experience

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Asian Journal of urology 2020年第1期7卷 1-9页

作者： Xiaofeng Zou Guoxi Zhang Tianpeng Xie Yuanhu Yuan Rihai Xiao Gengqing Wu Xiaoning Wang Hui xu Folin liu Yuting Wu Yunfeng Liao Quanliang liu yinghao sun Bo Yang Linhui Wang chuanliang xu Xiaofeng Gao department of urology First Affiliated Hospital of Gannan Medical UniversityResearch Center of Jiangxi Province for Engineering Technology of Calculus Prevention and ControlGanzhouChina department of urology Changhai HospitalSecond Military Medical UniversityShanghaiChina

Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in ***:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions(NOSE)were performed in *** animal experiments included five kidney biopsies,24 nephrectomies and six partial *** clinical surgeries included 12 transvaginal NOSE(TV-NOSE),266 hybrid transvaginal NOTES(TV-NOTES)and 27 pure *** TV-NOSE procedure was performed in five transumbilical laparoendoscopic single-site(U-LESS)nephrectomies,four suprapubic-assisted laparoendoscopic single-site surgery(SA-LESS)nephroureterectomies,and three laparoscopic radical *** hybrid TV-NOTES procedure included 210 nephrectomies,31 adrenalectomies,eight nephroureterectomies,13 partial nephrectomies,and four *** pure TV-NOTES procedure included five renal cyst decortications and 22 ***:A total of 29 animal experiments were successfully *** partial nephrectomy was converted to standard laparoscopic *** kidney biopsies and two nephrectomies were unsuccessful.A total of 297 clinical surgeries were successfully *** patients who underwent hybrid TV-NOTES were converted to open *** patients who underwent pure TV-NOTES were converted to *** were 22 major complications,16 occurred intraoperatively and six *** mean visual analog score(VAS)of 48 h after the operation was 2.5 points in TV-NOSE,2.3 points in hybrid TV-NOTES and 1.7 points in pure *** mean follow-up of 50.6(3.0-87.0)months showed that all patients were in good *** umbilicus scars were nearly invisible in TV-NOSE and hybrid *** vaginal incision healed ***:TV-NOSE and TV-NOTES are feasible,safe,and effective with little injury,low pain,fast recovery,and good cosmetic outcomes in properly selected *** are w

关键词： Minimally invasive surgery Laparoscopy Natural orifice transluminal endoscopic surgery Transvaginal surgery urology Chinese experience

Race-specific genetic risk score is more accurate than nonrace-specific genetic risk score for predicting prostate cancer and high-grade diseases

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Asian Journal of Andrology 2016年第4期18卷 525-529页

作者： Rong Na Dingwei ye Jun Qi Fang liu Xiaoling Lin Brian T Helfand Charles B Brendler Carly Conran Jian Gong Yishuo Wu xu Gao Yaqing Chen S Lilly Zheng Zengnan Mo Qiang Ding yinghao sun Jianfeng xu department of urology Huashan Hospital Fudan University Shanghai China Fudan Institute of urology Huashan Hospital Fudan University Shanghai China Program for Personalized Cancer Care NorthShore University HealthSystem Evanston Illinois USA Health Communication Institute School of Public Health Fudan University Shanghai China department of urology Shanghai Cancer Center Fudan University Shanghai China department of urology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Division of urology NorthShore University HealthSystem Evanston Illinois USA department of urology Shanghai Changhai Hospital The Second Military Medical University Shanghai China department of Medical Ultrasonic Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China

Genetic risk score （GRS） based on disease risk-associated single nucleotide polymorphisms （SNPs） is an informative tool that can be used to provide inherited information for specific diseases in addition to family history, However, it is still unknown whether only SNPs that are implicated in a specific racial group should be used when calculating GRSs. The objective of this study is to compare the performance of race-specific GRS and nonrace-specitic GRS for predicting prostate cancer （PCa） among 1338 patients underwent prostate biopsy in shanghai, china. A race-specific GRS was calculated with seven PCa risk-associated SNPs implicated in East Asians （GRS7）, and a nonrace-specific GRS was calculated based on 76 PCa risk-associated SNPs implicated in at least one racial group （GRS76）. The means of GRS7 and GRS76 were 1.19 and 1.85, respectively, in the study population. Higher GRS7 and GRS76 were independent predictors for PCa and high-grade PCa in univariate and multivariate analyses. GRS7 had a better area under the receiver-operating curve （AUC） than GRS76 for discriminating PCa （0.602 vs 0.573） and high-grade PCa （0.603 vs 0.575） but did not reach statistical significance. GRS7 had a better （up to 13% at different cutoffs） positive predictive value （PPV） than GRS76. In conclusion, a race-specific GRS is more robust and has a better performance when predicting PCa in East Asian men than a GRS calculated using SNPs that are not shown to be associated with East Asians.

关键词： Chinese genetic risk score genome-wide association study prostate cancer single nucleotide polymorphism

Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in china

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Asian Journal of Andrology 2020年第5期22卷 539-543页

作者： Da Huang Yi-Shuo Wu Ding-Wei ye Jun Qi Fang liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng xu Rong Na Jian-Feng xu Ying-Hao sun department of urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China department of urology Huashan HospitalFudan UniversityShanghai 200040China Fudan Institute of urology Huashan HospitalFudan UniversityShanghai 200040China department of urology Shanghai Cancer CenterFudan UniversityShanghai 200032China department of urology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Division of urology NorthShore University Health SystemEvanstonIL 60201USA Program for Personalized Cancer Care NorthShore University Health SystemEvanstonIL 60201US A Departm ent of urology Shanghai Changhai HospitalThe Second Military Medical UniversityShanghai 2CXD433China.

To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy *** 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to *** under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and *** regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa.

关键词： china prostate cancer prostate health index prostate volume

Age-specific PSA reference ranges in Chinese men without prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 100-103页

作者： Zhi-Yong liu Ying-Hao sun Chuan-Liang xu xu Gao Luo-Man Zhang Shan-Cheng Ren urology department Shanghai Changhai Hospital Medical Statistics department The Second Military Medical University Shanghai 200433 China

This study is to determine age-specific prostate-specific antigen （PSA） distributions in Chinese men without prostate cancer （PC） and to recommend reference ranges for this population after comparison with other studies. From September 2003 to December 2006, 9 374 adult men aged from 18 to 96 years agreed to participate in the study. After all cases of PC were excluded, 8 422 adult men participated in statistical analysis and were divided into five age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each age group. The age-specific PSA reference ranges are as follows： 4049 years, 2.15 ng mLl; 50-59 years, 3.20 ng mLl; 60-9 years, 4.10 ng mL^-1; 70-79 years, 5.37 ng mL^-1. The results indicate that the ethnic differences in PSA levels are obvious. The currently adopted Oesterling＇s age-specific PSA reference ranges are not appropriate for Chinese men. The reference ranges of this study should be more suitable to Chinese men.

关键词： age prostate cancer prostate-specific antigen

Transumbilical laparoendoscopic single-site surgery of simple nephrectomy of nonfunctioning kidney: a two-year experience

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Journal of Medical Colleges of PLA(china) 2011年第4期26卷 213-221页

作者： Wang Linhui Wu Zhenjie liu Bing Yang Qing Chen Wei Sheng Haibo xu Zunli Wang Cheng sun yinghao department of urology Changhai Hospital Second Military Medical University Shanghai 200433 China

Background： Laparoendoscopic single-site surgery （LESS） may serve as a potential alternative to conventional laparoscopy and is developing quickly, but still in its infancy. The study is to present our two-year experience in transumbilical LESS simple nephrectomy （LESS-SN） for non-functioning kidney, in an effort to evaluate its feasibility, clinical outcomes and potential advantages. Methods： From December 2008 to December 2010, a total of 11 patients with body mass index （BMI）≤30 underwent transumbilical TriPortTM LESS-SN by a single experienced urologist at our institution. The indications for nephrectomy included nonfunctioning kidney associated with ureteropelvic junction stricture （n=l）, ureteral calculi （n=6）, tuberculosis （n=3）, and ureteral stricture （n=l）. Patient demographics perioperative and follow-up data were prospectively collected and analyzed. Results： Ten procedures were successfully completed with one patient converted to open surgery due to uncontrollable bleeding. The mean operative time was 189.2 （ranging 100-320 min） with an estimated blood loss of 204.5 （ranging 50-1 000 ml）. There were two complications of bleeding （1- intra-, 1- post-）. The mean hospitalization after surgery was 7.9 d （ranging 4-17 d） With a regular follow-up of 1, 6, 12, and 24 months after surgery, all patients remained symptom-free with an intra-umbilical scar. Conclusion： Transumbilical LESS simple nephrectomy for nonfunctioning kidney can be accomplished with favorable surgical outcomes and a superiority of cosmesis. However, cases with chronic inflammation are not suitable for initial up-take and should only be attempted by the very experienced laparoscopist.

关键词： Laparoendoscopic Single-site Surgery, Laparoendoscopic single-site surgery Laparoscopy Nephrectomy

Synchronous bilateral laparoendoscopic single-site urological surgeries via the umbilicus:a report of 2 cases

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Journal of Medical Colleges of PLA(china) 2011年第6期26卷 345-352页

作者： Wang Linhui Wu Zhenjie liu Bing Yang Qing Sheng Haibo Chen Wei xu Zunli Wang Cheng sun yinghao department of urology Changhai Hospital Second Military Medical University Shanghai 200433 China

Objective： To describe two cases of bilateral transumbilical laparoendoscopic single-site（LESS） surgeries in a single operative session and assess the safety, feasibility and efficacy. Methods： One patient underwent right ureterolithotomy and left varicocelectomy, and the patient was performed with right simple nephrectomy for nonfunctioning kidney due to ureteral calculus and left ureterolithotomy using a novel multichannel TriPortTM via a single 2-3 cm transumbilical incision Results： The right-side ureterolithotomy and left-side varicocelectomy were finished in 229 minutes, with a total estimated blood loss of 50 hal. The right-side simple nephrectomy and left-side ureterolithotomy in the other patient were finished in 340 minutes, with a total estimated blood loss of 100 ml. There were no major complications. At the latest follow-up, both patients remained symptom-free and there were no evidences of recurrence. Both of them were delighted for the single scarConclusion： Synchronous LESS urologic procedure via a single umbilical incision is technically feasible, safe and efficacious with a promising potential

关键词： Laparoendosopic single-site surgery umbilicus Outcome

Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population

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Asian Journal of Andrology 2019年第6期21卷 592-597页

作者： Yi-Shuo Wu Xiao-Jian Fu Rong Na Ding-Wei ye Jun Qi Xiao-Ling Lin Fang liu Jian Gong Ning Zhang Guang-Liang Jiang Hao-Wen Jiang Qiang Ding Jianfeng xu Ying-Hao sun department of urology Huashan HospitalFudan UniversityShanghai 200040China urology Research Center Fudan UniversityShanghai 200040China Program for Personalized Cancer Care NorthShore University HealthSystemEvanstonIL 60201USA department of Surgery Huashan HospitalFudan UniversityShanghai 200040China department of urology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China department of urology Shanghai Cancer CenterFudan UniversityShanghai 200032China department of urology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China department of urology Changhai HospitalThe Second Military Medical UniversityShanghai 200433China

Risk prediction models including the Prostate Health Index(phi)for prostate cancer have been well established and evaluated in the Western *** aim of this study is to build phi-based risk calculators in a prostate biopsy population and evaluate their performanee in predicting prostate cancer(PCa)and high-grade PCa(Gleason score 27)in the Chinese *** developed risk calculators based on 635 men who underwent initial prostate ***,we validated the performance of prostate-specific antigen(PSA),phi,and the risk calculators in an additional observational cohort of 1045 *** observed that the phi-based risk calculators(risk calculators 2 and 4)outperformed the PSA-based risk calculator for predicting PCa and high-grade PCa in the training *** the validation study,the area under the receiver operating characteristic curve(AUC)for risk calculators 2 and 4 reached 0.91 and 0.92,respectively,for predicting PCa and high-grade PCa,respectively;the AUC values were better than those for risk calculator 1(PSA-based model with an AUC of 0.81 and 0.82,respectively)(all Pduced the number of unnecessary biopsies for PCa.

关键词： Chinese p2PSA prostate biopsy Prostate Health Index risk calculator

Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography

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Asian Journal of Andrology 2016年第4期18卷 633-638页

作者： Guo-Peng Yu Rong Na Ding-Wei ye Jun Qi Fang liu Hai-Tao Chen Yi-Shuo Wu Gui-Ming Zhang Jie-Lin sun Yao Zhu Li-Qun Huang Shan-Cheng Ren De-Ke Jiang S Lilly Zheng Hao-WenJiang Ying-Hao sun Qiang Ding Jianfeng xu Fudan Institute of urology Huashan Hospital Fudan University Shanghai China department of urology Huashan Hospital Fudan University Shanghai China department of urology Fudan University Shanghai Cancer Center and Department of Oncology Shanghai Medical College Fudan University Shanghai China department of urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Genetic Engineering School of Life Salience Fudan University Shanghai China Center for Cancer Genomics Wake Forest School of Medicine Winston-Salem North Carolina USA department of urology Shanghai Changhai Hospital Second Military Medical University Shanghai China Program for Personalized Cancer Care NorthShore University HealthSystem Evanston IL USA.

The [-2]proPSA （p2PSA） and its derivatives, the p2PSA-to-free PSA ratio （%p2PSA）, and the Prostate Health Index （PHI） have greatly improved discrimination between men with and without prostate cancer （PCa） in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination （DRE） and transrectal ultrasonography （TRUS） are negative. A prospective cohort of 261 consecutive patients in china with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen （tPSA）, free PSA, and p2PSA. For each patient, the free-to-total PSA ratio （%fPSA）, PSA density （PSAD）, p2PSA-to-free PSA ratio （%p2PSA）, and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve （AUC） and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml-1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in china.

关键词： [-2]proPSA prostate cancer Prostate Health Index prostate-specific antigen receiver operating curve