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Pose Planning for the End-effector of Robot in the Welding of Intersecting Pipes

Chinese Journal of Mechanical Engineering 2011年第2期24卷 264-270页

作者： liu yu zhao jing lu zhenyang chen shujun College of Mechanical Engineering and Applied Electronics Technology Beij＇ing University of Technology Beijing 100124 China

All-position robots are widely applied in the welding of complicated *** of intersecting pipes is one of the most typical *** welding seam is a complicated saddle-like space curve,which puts a great challenge to the pose planning of *** special robots designed specifically for this kind of tasks are rare in China and lack sufficient theoretical *** this paper,a systematic research on the pose planning for the end-effectors of robot in the welding of intersecting pipes is conducted. First,the intersecting curve of pipes is mathematically *** mathematical model of the most general intersecting curve of pipes is derived,and several special forms of this model in degraded situations are also discussed.A new pose planning approach of bisecting angle in main normal plane（BAMNP） for the welding-gun is proposed by using differential geometry and the comparison with the traditional bisecting angle in axial rotation plane（BAARP） method is also analytically *** optimal pose of the welding-gun is to make the orientation posed at the center of the small space formed by the two cylinders and the intersecting curve to help the welding-pool run *** BAMNP method can make sure the pose vertical to the curve and center between the two cylinders at the same time,therefore its performance in welding-technique is superior to the BAARP *** using the traditional BAARP method,the robot structure can become simpler and easier to be controlled,because one degree of freedom（DOF） of the robot can be *** the special case of perpendicular intersecting,an index is constructed to evaluate the quality of welding technique in the process of *** effect of different combination of pipe size on this index is also *** the basis of practical consideration,selection principle for BAARP and BAMNP is *** simulations of those two methods for a serial joint-type robot are made in MATLAB,and the simulation

关键词： pose planning robot all-position welding intersecting pipes bisecting angle welding quality

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Liquid Chromatographic Assay of Peptides Activity with Inhibiting Angiotensin Converting Enzyme

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Chemical Research in Chinese Universities 2010年第5期26卷 712-716页

作者： liu jing-bo yu Zhi-peng zhao Wen-zhu lu jing chen Feng LIN Song-yi Laboratory of Nutrition and Functional Food Jilin University Changehun 130062 P. R. China Department of Food Science and Human Nutrition Clemson University Clemson SC 29634 USA

A rapid, simple and interference-free method was developed to evaluate the inhibitory activity of hydrolyzed peptides from egg white protein against the angiotensin-converting enzyme. The total reaction volume was 60 μL, saving the cost. The assay was based on a HPLC separation and quantification of the synthetic substrate hippuryl-L-histidyl-L-leucine and its hydrolyzed product-hippuric acid; the separation was performed on a C18 column eluted by a mobile phase of acetonitrile/water（0.5% TFA） at a volume ratio of 25：75. At a signal to noise ratio（S/N） of 10, the detective limit of the quantitation of hippuric acid was （0.4600±0.0097） μmol/L. The standard curve shows a linear response with a slope of 49488 and a correlation coefficient of 0.9995. The assay was adequate for the study of ACE inhibition by Captopril and peptides derived from food protein, and showed a very good correlation with the previous methods.

关键词： Angiotensin converting enzyme HPLC Egg white protein Peptide

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Engineering in amino acid-functionalized double-layer heteropolymolybdates:from structural control to catalytic activity

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Rare Metals 2023年第10期42卷 3345-3353页

作者： lu-lu liu Yan-Hu Wang Xin-yu Xiao Ke-Wei Tong yue zhao Chao-Qin chen jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha410082China Testing and Analysis Center Hebei Normal UniversityShijiazhuang050024China

A reexamination of the structural constraints on the amino acid-functionalized heteropolymolybdates has afforded four polyanions,namely the double-layer [(SeO_(3))_(2)Mo_(12)O_(36)(CH_(3)COO)_(3)]^(7-)(1),[(SeO_(3))_(1.3)(HPO_(3))_(0.7)Mo_(12)O_(36)(NH_(3)CH_(2)COO)_(3)]^(4-)(2),[(SeO_(3))_(1.4)(HPO_(3))_(0.6)Mo_(12)O_(36)(LNH_(3)C_(2)H_(3)OHCOO)_(3)]^(4-)(3),and the mono-layer [(SeO_(3))-Mo_6O_(18)(L-NH_(3)C_(2)H_(3)OHCOO)_(3)]^(2-)(4),which were crystallized as the hydrated ammonium salts.

关键词： structural layer double

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Acupuncture-Neuroimaging Research Trends over Past Two Decades:A Bibliometric Analysis

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Chinese Journal of Integrative Medicine 2023年第3期29卷 258-267页

作者： zhao Ting-ting PEI Li-xia GUO jing liu Yong-kang WANG yu-hang SONG Ya-fang ZHOU Jun-ling chen Hao chen lu SUN Jian-hua Department of Acupuncture Rehabilitation The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Acupuncture and Moxibustion Disease Project Group of China Evidence-Based Medicine Center of Traditional Chinese Medicine Nanjing(210029)China Department of Radiology The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Acupuncture and Massage College Health and Rehabilitation CollegeNanjing University of Chinese MedicineNanjing(210023)China

Objective:To identify topics attracting growing research attention as well as frontier trends of acupuncture-neuroimaging research over the past two ***:This paper reviewed data in the published literature on acupuncture neuroimaging from 2000 to 2020,which was retrieved from the Web of Science *** Space was used to analyze the publication years,countries,institutions,authors,keywords,co-citation of authors,journals,and ***:A total of 981 publications were included in the final *** number of publications has increased in the recent 20 years accompanied by some ***,the most productive country was China,while Harvard University ranked first among institutions in this *** most productive author was Tian J with the highest number of articles(50),whereas the most co-cited author was Hui KKS(325).Evidence-Based Complementary and Alternative Medicine(92)was the most prolific journal,while Neuroimage was the most co-cited journal(538).An article written by Hui KKS(2005)exhibited the highest co-citation number(112).The keywords"acupuncture"(475)and"electroacupuncture"(0.10)had the highest frequency and centrality,*** magnetic resonance imaging(fMRI)ranked first with the highest citation burst(6.76).Conclusion:The most active research topics in the field of acupuncture-neuroimaging over the past two decades included research type,acupoint specificity,neuroimaging methods,brain regions,acupuncture modality,acupoint specificity,diseases and symptoms treated,and research *** research frontier topics were"nerve regeneration","functional connectivity","neural regeneration","brain network","fMRI"and"manual acupuncture".

关键词： acupuncture therapy neuroimaging bibliometric CiteSpace network

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A novel tissue engineered nerve graft constructed with autologous vein and nerve microtissue repairs a longsegment sciatic nerve defect

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Neural Regeneration Research 2021年第1期16卷 143-149页

作者： jing Wang Ya-Qiong Zhu yu Wang Hong-Guang Xu Wen-jing Xu yue-Xiang Wang Xiao-Qing cheng Qi Quan Yong-Qiang Hu Chang-Feng lu Yan-Xu zhao Wen Jiang chen liu Liang Xiao Wei lu chen Zhu Ai-yuan Wang Spine Research Center of Wannan Medical College Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution(Wannan Medical College)Department of Spine SurgeryYijishan HospitalThe First Affiliated Hospital of Wannan Medical CollegeWuhuAnhui ProvinceChina Department of Ultrasound Chinese PLA General HospitalBeijingChina Department of Orthopedic Surgery Key Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing Key Lab of Regenerative Medicine in OrthopedicsChinese PLA General HospitalBeijingChina Medical College of Nankai University TianjinChina The Neural Regeneration Co-Innovation Center of Jiangsu Province NantongJiangsu ProvinceChina Department of Anesthesiology the Second Affiliated Hospital of Inner Mongolia Medical UniversityHuhhotInner Mongolia Autonomous RegionChina Department of Orthopedic Surgery Yan’an University Affiliated HospitalYan’anShaanxi ProvinceChina Department of Orthopedic Surgery the First Affiliated Hospital of Medical CollegeShihezi UniversityShiheziXinjiang Uygur Autonomous RegionChina Department of Orthopedic Surgery The First Peoples’Hospital of Yunnan ProvinceKunmingYunnan ProvinceChina Department of Orthopedic Surgery Anhui Provincial HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaHeifeiAnhui ProvinceChina

Veins are easy to obtain,have low immunogenicity,and induce a relatively weak inflammatory ***,veins have the potential to be used as conduits for nerve ***,because of the presence of venous valves and the great elasticity of the venous wall,the vein is not conducive to nerve *** this study,a novel tissue engineered nerve graft was constructed by combining normal dissected nerve microtissue with an autologous vein graft for repairing 10-mm peripheral nerve defects in *** with rats given the vein graft alone,rats given the tissue engineered nerve graft had an improved sciatic static index,and a higher amplitude and shorter latency of compound muscle action ***,rats implanted with the microtissue graft had a higher density and thickness of myelinated nerve fibers and reduced gastrocnemius muscle atrophy compared with rats implanted with the vein ***,the tissue engineered nerve graft had a lower ability to repair the defect than autogenous nerve *** summary,although the tissue engineered nerve graft constructed with autologous vein and nerve microtissue is not as effective as autologous nerve transplantation for repairing long-segment sciatic nerve defects,it may nonetheless have therapeutic potential for the clinical repair of long sciatic nerve *** study was approved by the Experimental Animal Ethics Committee of Chinese PLA General Hospital(approval No.2016-x9-07)on September 7,2016.

关键词： in vivo injury motor neurological function peripheral nerve injury rat recovery regeneration repair

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Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo

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Frontiers of Medicine 2024年第5期18卷 896-910页

作者： Bo Li jing Zhang Yin yu Yinhua Li Yingying chen Xiaokun zhao Ang Li Lili zhao Mingzhu Li Zitong Wang Xuebo lu Wenjie Wu yueteng Zhang Zigang Dong Kangdong liu Yanan Jiang The Pathophysiology Department School of Basic Medical SciencesCollege of MedicineZhengzhou UniversityZhengzhou 450001 China China-US(Henan)Hormel Cancer Institute Zhengzhou 450003China Basic Medicine Sciences Research Center Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou 450001China Provincial Cooperative Innovation Center for Cancer Chemoprevention Zhengzhou UniversityZhengzhou 450001China Cancer Chemoprevention International Collaboration Laboratory Zhengzhou 450001China

Treatment options for patients with esophageal squamous cell carcinoma(ESCC)often result in poor prognosis and declining health-related quality of *** FDA-approved drugs for cancer chemoprevention is a promising and cost-efficient ***,we found that dronedarone,an antiarrhythmic drug,could inhibit the proliferation of ESCC ***,we conducted phosphorylomics analysis to investigate the mechanism of dronedarone-treated ESCC *** computational docking models and pull-down assays,we demonstrated that dronedarone could directly bind to CDK4 and CDK6 *** also proved that dronedarone effectively inhibited ESCC proliferation by targeting CDK4/CDK6 and blocking the G0/G1 phase through RB1 phosphorylation inhibition by in vitro kinase assays and cell cycle ***,we found that knocking out CDK4 and CDK6 decreased the susceptibility of ESCC cells to ***,dronedarone suppressed the growth of ESCC in patient-derived tumor xenograft models in ***,our study demonstrated that dronedarone could be repurposed as a CDK4/6 inhibitor for ESCC chemoprevention.

关键词： dronedarone CDK4/6 RB1 esophageal squamous cell carcinoma chemoprevention PDX model

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Coordination-regulated epitaxial growth for 2D/3D perovskite vertical alignment heterostructure

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Science Bulletin 2024年第20期69卷 3201-3205页

作者： Guoxiang zhao yuan chen Shan Cong lutao Li chen Wang Xinyu Du Ruirui liu jing lu yu liu Gaoyuan chen Sihan Zhang Liya Zhang Mark Hermann Rummeli Guifu Zou College of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215123China School of Advanced Energy Sun Yat-Sen UniversityShenzhen 518107China College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao 266590China Center for Electron Microscopy Institute for New Energy Materials and Low-Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Department of Fundamental Research Weiqiao Lightweight Research Center at SoochowSuzhou 215021China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China Institute of Environmental Technology VSB-Technical University of OstravaOstrava 70833Czech Republic Institute for Materials Chemistry IFW DresdenDresden 01069Germany

Metal halide perovskite heterostructures that combine twodimensional(2D)and three-dimensional(3D)perovskites with desirable charge and exciton behaviors at heterointerfaces have attracted much attention recently[1].The integration of 2D and3D perovskites combines the commendable efficiency with the exceptional stability[2].Unfortunately,the electrically insulating nature of bulky organic cations in 2D perovskites impedes the charge transport between the heterointerface[3].

关键词： perovskite combine charge

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Cryo-EM structures of a prokaryotic heme transporter CydDC

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Protein & Cell 2023年第12期14卷 919-923页

作者： chen Zhu Yanfeng Shi jing yu Wenhao zhao Lingqiao Li jingxi Liang Xiaolin Yang Bing Zhang Yao zhao Yan Gao Xiaobo chen Xiuna Yang lu Zhang luke W.Guddat Lei liu Haitao Yang Zihe Rao Jun Li Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300353China Innovative Centerfor Pathogen Research Guangzhou LaboratoryGuangzhou 510005China School of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneQLD 4072Australia

DearEditor,Heme is an essential cofactor required across all kingdoms of life utilized in numerous biological processes,including cellular *** is a prokaryotic ATP-binding cassette(ABC)transporter required for heme assembling in respiratory cytochrome bd oxidase(Georgiou et al.,1987;Poole et al.,1989),a promising target for drug discovery(Borisov et al.,2011).CydDC is thought to play a role in maintaining an optimum periplasmic redox poise that is required for the incorporation of heme cofactors(Yamashita et al.,2014).It also suggested that CydDC is involved in heme processing by mediating glutathione/cysteine translocation(Cook and Poole,2000;Cook et al.,2002),although a role in heme translocation seems unlikely(Yamashita et al.,2014).To date,CydDC has been shown to be important for disulfide bond formation,motility,respiration,and tolerance to nitric oxide and antibiotics(Poole et al.,2019).

关键词： utilized disulfide Poole

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Verification of Seasonal Prediction by the Upgraded China Multi-Model Ensemble Prediction System (CMMEv2.0)

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Journal of Meteorological Research 2024年第5期38卷 880-900页

作者： Jie WU Hong-Li REN Jianghua WAN jingpeng liu Jinqing ZUO Changzheng liu Ying liu yu NIE Chongbo zhao Li GUO Bo lu Lijuan chen Qing BAO jingzhi SU Lin WANG jing-Jia luO Xiaolong JIA Qingchen CHAO CMA Key Laboratory of Climate Prediction Studies National Climate CentreChina Meteorological Administration(CMA)Beijing 100081 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044 State Key Laboratory of Severe Weather and Institute of Tibetan Plateau Meteorology Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 CMA Earth System Modeling and Prediction Centre China Meteorological AdministrationBeijing 100081

Based on a combination of six Chinese climate models and three international operational models,the China multimodel ensemble(CMME)prediction system has been upgraded into its version 2(CMMEv2.0)at the National Climate Centre(NCC)of the China Meteorological Administration(CMA)by including new model members and expanding prediction products.A comprehensive assessment of the performance of the upgraded CMME during its hindcast(1993–2016)and real-time prediction(2021–present)periods is conducted in this *** results demonstrate that CMMEv2.0 outperforms all the individual models by capturing more realistic equatorial sea surface temperature(SST)*** exhibits better prediction skills for precipitation and 2-m temperature anomalies,and the improvements in prediction skill of CMMEv2.0 are significant over East *** superiority of CMMEv2.0 can be attributed to its better projection of El Niño–Southern Oscillation(ENSO;with the temporal correlation coefficient score for Niño3.4 index reaching 0.87 at 6-month lead)and ENSO-related *** for the real-time prediction in recent three years,CMMEv2.0 has also yielded relatively stable skills;it successfully predicted the primary rainbelt over northern China in summers of 2021–2023 and the warm conditions in winters of 2022/*** that,ensemble sampling experiments indicate that the CMMEv2.0 skills become saturated after the ensemble model number increased to 5–6,indicating that selection of only an optimal subgroup of ensemble models could benefit the prediction performance,especially over the extratropics,yet the underlying reasons await future investigation.

关键词： China multi-model ensemble(CMME)prediction system predictability source El Niño-Southern Oscillation(ENSO) real-time forecast verification

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Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis

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Biomedical and Environmental Sciences 2019年第4期32卷 260-271页

作者： WANG Long NIU jing Ya zhao Zhi yun LI Mian XU Min lu Jie Li WANG Tian Ge chen yu Hong WANG Shuang yuan DAI Meng LI Lin liu Shan Shan WANG Wei Qing XU yu BI yu Fang National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseasesand Department of Endocrine and Metabolic DiseasesRui-Jin HospitalShanghai Jiao Tong University School of Medicine

Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend lues for trend lues for interaction lusion The numbers of ideal CVH metrics showed a significant and inverse association with the risk of developing subclinical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants.

关键词： Cardiovascular health Subclinical atherosclerosis Cohort

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