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Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients with Chronic HCV Infection

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 125-132页

作者： xiaoqing liu Peng Hu Department of Infectious Diseases Institute for Viral HepatitisThe Key Laboratory of Molecular Biology for Infectious Dis-easesChinese Ministry of EducationThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Hepatitis C virus(HCV)infection is a major cause of end-stage liver disease,including decompensated cirrhosis and hepatocellular *** 95%of patients with HCV infection have achieved sustained virologic response at 12 weeks under the treatment of several pan-genotypic regimens approved for patients with HCV *** glecaprevir/pibrentasvir(G/P)regimen has some features that distinguish it from others and is the only 8-week regimen approved for treatment-naive patients and patients experienced in regimens containing(peg)interferon,ribavirin,and/or sofosbuvir,without an HCV NS3/4A protease inhibitor or NS5A inhibitor(except those with genotype 3).This review aims to summarize the efficacy and safety of G/P in HCV-infected patients from clinic trials and real-world studies,including those who have historically been considered difficult to cure.

关键词： Hepatitis C Mavyret Glecaprevir Pibrentasvir Treatment outcome

Vinyl Groups Containing Tetraphenylethylene Derivatives as Fluorescent Probes Specific for Palladium and the Quenching Mechanism

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Chinese Journal of Chemistry 2021年第6期39卷 1599-1605页

作者： xiaoqing liu Yuxuan Shang Zhong-Ren Chen Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518005China Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhenGuangdong 518055China

We previously reported that a series of tetraphenylethylene(TPE)-containing all-hydrocarbon conjugated polymers exhibited a specific fluorescence quenching by palladium ions(Pd^(2+)).To understand the quenching mechanism,herein we investigate the quenching behaviors of three TPE derivatives in the presence of Pd^(2+).Each TPE derivative,consisting of TPE unit and terminal vinyl groups,shows an aggregation-induced emission(AIE)and its fluorescence turns off specifically to Pd^(2+).The sensitivity is enhanced with increasing numbers of vinyl groups in the *** time-resolved fluorescence measurement,a dynamic quenching is observed where the fluorescence lifetime is reduced with Pd^(2+).Specifically,the quenching occurs via the electron transfer in the excited states,as suggested by the disappearance of the stimulated emission band in transient absorption spectra.A theoretical calculation on the excited states identifies intermolecular electron transfer from TPE derivatives to Pd,especially for electron-rich TPE *** mechanism can be general for the design of novel AIE active chemosensors.

关键词： Aggregation-induced emission Fluorescent probes Palladium detection Electron transfer Time-resolved spectroscopy

Synthesis of multifunctional monomers from rosin for the properties enhancement of soybean-oil based thermosets

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Science China(Technological Sciences) 2017年第9期60卷 1332-1338页

作者： liu Yuan LI Chao DAI JinYue JIANG YanHua liu xiaoqing ZHU Jin Ningbo Institute of Material Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China Engineering Research Center for Materials Protection of Wear and Corrosion of Guizhou Province Guiyang University Guiyang 550005 China University of Chinese Academy of Sciences Beijing 100049 China

Two kinds of rosin derivatives, （2-hydroxy-3-（methacryloyloxy）propyl 7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a- decahydrophenanthrene-1-carboxylate）（HMPIDDC） and （（（7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenan- thren-1-yl）methyl）azanediyl）bis（2-hydroxypropane-3,1-diyl）bis（2-methylacrylate）（IDOMAHM） were synthesized under mild and easy to implement conditions. The two derivatives were employed as the rigid monomers to copolymerize with acrylated epoxidized soybean oil （AESO）, as so to improve the performance of the cured resins. The chemical structures of HMPIDDC and IDOMAHM were confirmed by nuclear magnetic resonance （NMR） and Fourier Transform Infrared （FT-IR） before copolymerization. The curing behaviors of pristine AESO, AESO/HMPIDDC blend, and AESO/IDOMAHM blend were monitored by differential scanning calorimetry （DSC）. Moreover, the thermal and mechanical properties of the cured resins were evaluated by universal mechanical testing, dynamic mechanical analysis （DMA） and thermogravimetric analysis （TGA）. The results demonstrated that after the introduction of HMPIDDC and IDOMAHM, the glass transition temperature and mechanical properties of the copolymerized resin were significantly increased. In one word, HMPIDDC and IDOMAHM showed dramatic potential to be used as bio-based compounds to improve the properties of soybean-oil based thermosets.

关键词： rosin derivatives bio-based compound rigid monomer thermosets

Partial surface phase transformation of Li_(3)VO_(4) that enables superior rate performance and fast lithium-ion storage

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Tungsten 2019年第4期1卷 276-286页

作者： xiaoqing liu Liping Li Guangshe Li State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

Li_(3)VO_(4) is a promising electrode material for next-generation lithium-ion batteries(LIBs)due to its excellent specific capac-ity(592 mAh g^(−1)),suitable discharge voltage(0.5-1.0 V),and moderate volume change upon charge/discharge,while it still suffers from low electronic conductivity that usually gives a poor rate capability,low initial coulombic efficiency,and large polarization,imposing a challenge on its practical *** this work,a partial surface phase transformation of Li_(3)VO_(4) was initiated via a freeze-drying method followed by a heat treatment in inert *** this method,Li_(3)VO_(4) was integrated with a conductive layer LiVO_(2) and carbon *** synergistic effect among Li_(3)VO_(4),LiVO_(2) layer,and carbon matrix was systematically studied by optimizing the treatment *** treated at 600°C in Ar,Li_(3)VO_(4)-based composite delivered outstanding electrochemical properties,as expressed by a specific capacity(689 mAh g^(−1) at 0.1 A g^(−1) after 100 cycles),rate performance(i.e.,448 mAh g^(−1) at 2 A g^(−1)),and longtime cycle stability(523 mAh g^(−1) after 200 cycles at 0.2 A g^(−1)),which are superior to those without LiVO_(2) conductive layer when treated at the same temperature in *** findings reported in this work may offer novel hints of preparing more advanced anodes and promote the applications of vanadate materials such as Li_(3)VO_(4) for next-generation lithium-ion batteries.

关键词： Li_(3)VO_(4) LiVO_(2) Rate performance Electronic conductivity Li^(+)diffusion

Chiral Macrocyclic AIEgens from BINOL and Tetraphenylethene via Tailoring Chirality of Luminescent Molecular Propellers

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Chinese Journal of Chemistry 2022年第20期40卷 2393-2399页

作者： Yitong Wang xiaoqing liu Hongkun Li Xindong liu Lei Wang Yi liu Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdong518060 China Institute of Critical Materials for Integrated Circuits Shenzhen PolytechnicShenzhenGuangdong518055 China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu215123 China Centre for AIE Research Shenzhen UniversityShenzhenGuangdong518060 China

Herein,a pair of chiral macrocyclic luminogens derived from chiral 1,1-bi(2-naphthol)(BINOL)and tetraphenylethenes(TPEs)have been prepared with high yield via intramolecular McMurry coupling,in which the preferential helicity of propeller-shaped TPE units can be tuned via choosing proper chiral BINOL *** preferential chiral geometry of the macrocyclic luminogen was unambiguously confirmed by X-ray crystal crystallography and theoretical calculation,whereas the variable-temperature NMR spectra and chiral HPLC analysis further verified the intramolecular *** two chiral macrocyclic luminogens both exhibit obvious aggregation-induced emission behavior and mechanochromic luminescence ***,aggregation attenuated CD signals and circularly polarized luminescence were observed for these two chiral macrocylic luminogens in THF-water mixture and PMMA *** results had paved a new approach toward constructing chiral aggregation-induced emission luminogens(AIEgens)and their structural engineering.

关键词： Aggregation-induced emission Chirality Macrocycles Circularly polarized luminescence Luminescence

Properties of a New Dental Photocurable Resin based on the Expanding Monomer and Threecomponent Photoinitiator System

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Journal of Wuhan University of Technology(Materials Science) 2014年第2期29卷 384-390页

作者：付静 liu Wenjia liu xiaoqing Sapna laxmi tuladhar WAN Qianbing 王航 State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Department of Prosthodontics West China College of Stomatology Sichuan University

The purpose of this study was to use. a three-component photoinitiation system comprising 1wt% CQ （camphorquinone）, 2wt% DMAEMA （2-（dimethylamino） ethyl meth acrylate） and 2wt% ph^2I^＋PF6^- （diphenyliodonium hexafluorophosphate） to initiate the copolymerization of the matrix resins which combine bisphenol-S-bis （3-methacrylate-2-hydroxy propyl） ether （BisS-GMA） with the expanding monomer unsaturated spiro orthoesters 2-methylene-l,4,6-tdspiro[4,4] nonane （MTOSN）, for minimizing the volumetric shrinkage that generally occurs during polymerization. It was hypothesized that MTOSN would expand volumetrically during polymerization under the three-component photoinitiator system and further reductions in volumetric shrinkage would be obtained. The performance study which consists of degree of conversion and condition of the ring-opening reactions of MTOSN, volumetric shrinkage and mechanical properties including tensile bond strength, compressive strength and Vicker＇s hardness were carried out respectively by Fourier transfer infrared, the dilatometer and the universal testing machine. The results supported that the dental composites based on the expanding monomer and three-component photoinitiator system engendered a greater decrease of volumetric shrinkage and better mechanieal properties.

关键词： 2-methylene-1, 4, 6-trispiro [4, 4] nonane light-curing dental matrix resin volumetric shrinkage mechanical properties

Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy

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Nano Research 2020年第4期13卷 1111-1121页

作者： Jialing Hu Fuan Wang Feng liu Wentong Sun Qunying Jiang Yahua liu Yun Zhao xiaoqing liu Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Metastasis remains the primary cause for mortality of breast *** advances in current therapeutic agents,patients with metastatic breast cancer still have poor *** hypoxia,a key microenvironment factor,is emerging as an attractive target to prevent metastasis and is also involved with resistance to ***,we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided *** cancer cells,the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1 a to inhibit tumor metastasis,and enhances the efficacy of photodynamic *** nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in ***,the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in v ivo in a breast cancer mouse model with satisfying *** study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers.

关键词： nanomedicine hypoxia breast cancer metastasis supplemental oxygenation phototherapy

Assembling Fe_(2)O_(3)/BiOCl Composite for Highly Effective Degradation of Water Pollutants under Visible-Light Irradiation

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China Petroleum Processing & Petrochemical Technology 2022年第1期24卷 59-67页

作者： liu xiaoqing Wang Zisha Hu Yuxing Wang Haifang School of Environment and Safety Engineering North University of ChinaTaiyuan 030051 Beijing Aerospace Institute for Metrology and Measurement Technology Beijing 100076

Fe_(2)O_(3)was synthesized by the solvothermal method,and the synthesized Fe_(2)O_(3)was added in the process of preparing BiOCl by hydrolysis,and then Fe_(2)O_(3)/BiOCl photocatalytic materials with different composite ratios were *** optimal Fe_(2)O_(3)/BiOCl(1Fe/50Bi)sample showed a highest photocatalytic efficiency for cationic dyes(Rhodamine B)and anionic dye(methyl orange)degradation irradiated with visible light,as compared with that of a bare BiOCl ***,radical capturing experiments indicated that the photo-induced holes(h^(+)) is the main active species.X-ray powder diffraction and ultraviolet-visible diffuse reflectance spectroscopy were used to characterize the structural and optical properties,which proved that Fe_(2)O_(3)was successfully composited to the BiOCl surface and effectively reduced the bandgap of *** importantly,the optimal 1Fe/50Bi sample shows the highest photocatalytic efficiency for tetracycline(TC)degradation(98%)irradiated with visible light,as compared with that of a bare BiOCl ***,the Fe_(2)O_(3)/BiOCl photocatalyst have potential applications in environmental purification.

关键词： Fe_(2)O_(3) BiOCl composite photocatalytic

A Label-Free Deoxyribozyme Sensor for m^(6)A Demethylase Activity Detection

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Chinese Journal of Chemistry 2024年第9期42卷 951-956页

作者： Xiuyuan Wang Shusheng Yu Yuqiu He Fuan Wang xiaoqing liu College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China

A label-free deoxyribozyme(DNAzyme)biosensor for m^(6) demethylase activity detection is *** demethylase FTO(Fat mass and obesity-associated protein),an important m^(6) demethylase of ALKBH demethylase family is present,the m^(6) group is specifically demethylated,and the cleavage activity of DNAzyme is *** allows the cleavage product that contains G-quadruplex sequence to bind to thioflavin T(ThT)and generate fluorescence *** biosensor shows high specificity and sensitivity,and fast reaction *** study demonstrates a new design of allosteric DNAzyme for *** method represents the first label-free nucleic acid biosensor for FTO assay,providing a feasible route towards inhibitors screening.

关键词： DNAzyme Analytical methods Biosensing m^(6)A demethylation Fluorescence