检索结果-南通市图书馆

Development of PREDAC-H1pdm to model the antigenic evolution of influenza A/(H1N1)pdm09 viruses

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第4期38卷 541-548页

作者： mi liu Jingze liu Wenjun Song Yousong Peng Xiao Ding Lizong Deng Taijiao Jiang Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Institute of Systems Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100005China Suzhou Institute of Systems Medicine Suzhou215123China Guangzhou Laboratory Guangzhou510005China Bioinformatics Center College of BiologyHunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410082China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510120China

The Influenza A(H1N1)pdm09 virus caused a global pandemic in 2009 and has circulated seasonally ever *** the continual genetic evolution of hemagglutinin in this virus leads to antigenic drift,rapid identification of antigenic variants and characterization of the antigenic evolution are *** this study,we developed PREDAC-H1pdm,a model to predict antigenic relationships between H1N1pdm viruses and identify antigenic clusters for post-2009 pandemic H1N1 *** model performed well in predicting antigenic variants,which was helpful in influenza *** mapping the antigenic clusters for H1N1pdm,we found that substitutions on the Sa epitope were common for H1N1pdm,whereas for the former seasonal H1N1,substitutions on the Sb epitope were more common in antigenic ***,the localized epidemic pattern of H1N1pdm was more obvious than that of the former seasonal H1N1,which could make vaccine recommendation more ***,the antigenic relationship prediction model we developed provides a rapid determination method for identifying antigenic variants,and the further analysis of evolutionary and epidemic characteristics can facilitate vaccine recommendations and influenza surveillance for H1N1pdm.

关键词： H1N1pdm virus Antigenic relationship prediction Antigenic evolution Vaccine recommendation

Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2015年第7期58卷 687-693页

作者： liu mi SONG TingRui HUA Sha WU AiPing JIANG TaiJiao Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

Influenza virus can rapidly change its antigenicity, via mutation in the hemagglutinin(HA) protein, to evade host immunity. The emergence of the novel human-infecting avian H7N9 virus in China has caused widespread concern. However, evolution of the antigenicity of this virus is not well understood. Here, we inferred the antigenic epitopes of the HA protein from all H7 viruses, based on the five well-characterized HA epitopes of the human H3N2 virus. By comparing the two major H7 phylogenetic lineages, i.e., the Eurasian lineage and the North American lineage, we found that epitopes A and B are more frequently mutated in the Eurasian lineage, while epitopes B and C are more frequently mutated in the North American lineage. Furthermore, we found that the novel H7N9 virus(derived from the Eurasian lineage) isolated in China in the year 2013, contains six frequently mutated sites on epitopes that include site 135, which is located in the receptor binding domain. This indicates that the novel H7N9 virus that infects human may already have been subjected to gradual immune pressure and receptor-binding variation. Our results not only provide insights into the antigenic evolution of the H7 virus but may also help in the selection of suitable vaccine strains.

关键词： antigenic epitope antigenic evolution hemagglutinin influenza H7N9 virus

Safety Helmet Wearing Detection in Aerial Images Using Improved YOLOv4

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第8期72卷 3159-3174页

作者： Wei Chen mi liu Xuhong Zhou Jiandong Pan Haozhi Tan College of Civil Engineering Changsha University of Science and TechnologyChangsha410114China College of Civil Engineering Chongqing UniversityChongqing730000China College of Mechanical and Electrical Engineering Hunan Agricultural UniversityChangsha410128China Department of Civil and Environmental Engineering University of AucklandAuckland1010New Zealand

In construction,it is important to check whether workers wear safety helmets in real *** proposed using an unmanned aerial vehicle(UAV)to monitor construction workers in real *** the small target of aerial photography poses challenges to safety-helmet-wearing detection,we proposed an improved YOLOv4 model to detect the helmet-wearing condition in aerial photography:(1)By increasing the dimension of the effective feature layer of the backbone network,the model’s receptive field is reduced,and the utilization rate of fine-grained features is improved.(2)By introducing the cross stage partial(CSP)structure into path aggregation network(PANet),the calculation amount of themodel is reduced,and the aggregation efficiency of effective features at different scales is improved.(3)The complexity of the YOLOv4 model is reduced by introducing group convolution and the pruning PANet multi-scale detection mode for *** results show that the improved YOLOv4 model achieved the highest performance in the UAV helmet detection task,that the mean average precision(mAP)increased from83.67%of the original YOLOv4 model to 91.03%,and that the parameter amount of the model is reduced by 24.7%.The results prove that the improved YOLOv4 model can effectively respond to the requirements of real-time detection of helmet wearing by UAV aerial photography.

关键词： Safety-helmet-wearing detection unmanned aerial vehicle(UAV) YOLOv4

miR⁃204通过调控ZEB1抑制胃癌血管生成的机制研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

热带医学杂志 2024年第7期24卷 946-951,964,F0002页

作者：石颖鹏张栋林崔洁刘咪西安医学院第一附属医院全科医学科陕西西安710032 西安医学院第一附属医院消化内科陕西西安710032

目的探讨miR⁃204通过调控E盒结合锌指蛋白1(ZEB1)抑制胃癌血管生成的机制,为胃癌的治疗提供参考依据。方法采用TCGA数据库和免疫组化染色分析临床胃癌患者癌组织和癌旁组织样本中miR⁃204和ZEB1的表达水平;UALCAN数据库分析不同临床病理... 详细信息

目的探讨miR⁃204通过调控E盒结合锌指蛋白1(ZEB1)抑制胃癌血管生成的机制,为胃癌的治疗提供参考依据。方法采用TCGA数据库和免疫组化染色分析临床胃癌患者癌组织和癌旁组织样本中miR⁃204和ZEB1的表达水平;UALCAN数据库分析不同临床病理分期和淋巴转移胃癌患者中miR⁃204和ZEB1的表达水平,以及二者与患者总生存期(OS)的相关性。血管生成实验检测人脐静脉内皮细胞(HUVEC)经miR⁃204过表达和敲减HGC⁃27细胞的条件培养基培养后血管生成能力的变化;Western blot检测miR⁃204对HGC⁃27细胞中ZEB1、VEGFR1和VEGFR2蛋白表达的影响。结果TCGA数据库和免疫组化染色结果显示,与癌旁组织相比,胃癌组织中miR⁃204表达明显降低,而ZEB1表达明显上调,差异均有统计学意义(t=16.398、14.284,P均miR⁃204在不同临床病理分期和淋巴转移胃癌患者中的表达较正常组织均显著降低(F=17.184、18.633,P均miR⁃204过表达条件培养基培养后的血管生成能力明显降低(PmiR⁃204敲减条件培养基培养后的血管生成能力显著上调(PmiR⁃204高表达可显著抑制HGC⁃27细胞中ZEB1的表达,并诱导VEGF/VEGFR信号通路失活(PmiR⁃204表达上调可通过诱导ZEB1/VEGF/VEGFR信号通路失活抑制胃癌血管生成。

关键词：胃癌 miR⁃204 E盒结合锌指蛋白1

在线全文

学校读者我要写书评

暂无评论

压载水生物检测技术概述

中国口岸科学技术 2024年第8期6卷 28-33页

作者：于滢泉张涛刘迪杜建森刘蜜鞠成飞青岛国际旅行卫生保健中心(青岛海关口岸门诊部) 青岛266073 青岛海关青岛266073 荣成海关荣成264300

为减少由船舶压载水和沉积物转移导致的有害水生物和病原微生物传播,更好地保护海洋生态系统,国际海事组织发布了《国际船舶压载水和沉积物控制与管理公约》,对压载水经过处理后应达到的排放标准进行了规定。本文对检测压载水是否达到... 详细信息

为减少由船舶压载水和沉积物转移导致的有害水生物和病原微生物传播,更好地保护海洋生态系统,国际海事组织发布了《国际船舶压载水和沉积物控制与管理公约》,对压载水经过处理后应达到的排放标准进行了规定。本文对检测压载水是否达到排放标准的生物检测技术进行了总结归纳,对各种检测技术的优缺点进行分析,对未来应当加强研究的方向进行了展望,旨在为海关系统制定监管标准、推荐检测方法、促进技术创新与科研发展提供参考。

关键词：压载水水生物病原微生物检测

奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的效果比较

在线全文

学校读者我要写书评

暂无评论

中国实用医刊 2024年第1期51卷 90-93页

作者：刘咪贺娜闫红林蒋宝玲西安医学院第一附属医院消化内科西安710077 延安市中医医院腔镜中心延安716000

目的比较奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的临床效果。方法随机对照研究。抽取2022年3月至2023年3月西安医学院第一附属医院收治的慢性胃炎患者92例,按随机数字表法分为对照组与观察组,每组46例。对照组采用奥美拉唑三... 详细信息

目的比较奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的临床效果。方法随机对照研究。抽取2022年3月至2023年3月西安医学院第一附属医院收治的慢性胃炎患者92例,按随机数字表法分为对照组与观察组,每组46例。对照组采用奥美拉唑三联疗法,观察组采用雷贝拉唑三联疗法,两组均持续用药2周。比较两组临床疗效、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-2R(IL-2R)]、胃功能[胃泌素、胃动素、人表皮生长因子(EGF)、生长抑素]及不良反应。结果观察组临床总有效率(97.83%,45/46)高于对照组(82.61%,38/46),P0.05)。结论与奥美拉唑三联疗法相比,雷贝拉唑三联疗法对慢性胃炎的治疗效果更佳,利于减轻炎症反应,改善胃功能,且具有较好安全性。

关键词：胃炎奥美拉唑雷贝拉唑三联疗法临床疗效不良反应

Wall Cracks Detection in Aerial Images Using Improved Mask R-CNN

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第10期73卷 767-782页

作者： Wei Chen Caoyang Chen mi liu Xuhong Zhou Haozhi Tan mingliang Zhang College of Civil Engineering Changsha University of Science and TechnologyChangsha410114China College of Civil Engineering Chongqing UniversityChongqing730000China Department of Civil and Environmental Engineering University of AucklandAuckland1010New Zealand Hunan Construction Engineering Group Co.Ltd. Changsha410004China

The present paper proposes a detection method for building exterior wall cracks since manual detection methods have high risk and low *** proposed method is based on Unmanned Aerial Vehicle(UAV)and computer vision ***,a crack dataset of 1920 images was established using UAV to collect the images of a residential building exterior wall under different lighting ***,the average crack detection precisions of different methods including the Single Shot MultiBox Detector,You Only Look Once v3,You Only Look Once v4,Faster Regional Convolutional Neural Network(R-CNN)and Mask R-CNN methods were ***,the Mask R-CNN method with the best performance and average precision of 0.34 was ***,based on the characteristics of cracks,the utilization ratio of Mask R-CNN to the underlying features was improved so that the average precision of 0.9 was *** was found that the positioning accuracy and mask coverage rate of the proposed Mask R-CNN method are greatly ***,it will be shown that using UAV is safer than manual detection because manual parameter setting is not *** addition,the proposed detection method is expected to greatly reduce the cost and risk of manual detection of building exterior wall cracks and realize the efficient identification and accurate labeling of building exterior wall cracks.

关键词： Exterior wall cracks object detection mask R-CNN DenseNet

基于AIE效应的内源性硫化氢荧光探针的研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辽宁大学学报（自然科学版） 2024年第2期51卷 130-140页

作者：刘冰弥宫达诚田璐生慧辽宁大学药学院辽宁沈阳110036 辽宁大学司法鉴定研究院辽宁沈阳110036 辽宁新药研发重点实验室辽宁沈阳110036 辽宁大学物理学院辽宁沈阳110036

合理设计监测内源性硫化氢的荧光探针分子有助于充分了解其生理和病理功能.目前,在研的检测硫化氢的小分子荧光探针多存在聚集诱导猝灭效应,因此克服此缺陷的聚集诱导发光效应荧光探针的研究受到越来越多的关注.本文结合研究实践简要综... 详细信息

合理设计监测内源性硫化氢的荧光探针分子有助于充分了解其生理和病理功能.目前,在研的检测硫化氢的小分子荧光探针多存在聚集诱导猝灭效应,因此克服此缺陷的聚集诱导发光效应荧光探针的研究受到越来越多的关注.本文结合研究实践简要综述了近几年具有聚集诱导发光效应的化学反应型硫化氢活体成像荧光探针的研究进展及设计思想并进行展望,以期对该领域研究提供一些借鉴和思考.

关键词：内源性硫化氢聚集诱导发光效应聚集诱导猝灭效应荧光探针活体成像

Texture evolution of commercial pure Ti during cold rolling and recrystallization annealing

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

International Journal of minerals,Metallurgy and Materials 2012年第6期19卷 530-535页

作者： Hai-tao Jiang Ji-xiong liu Zhen-li mi Ai-min Zhao Yan-jun Bi Metallurgical Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China

X-ray diffraction （XRD） was employed to analyze the texture evolution of commercial pure （CP） Ti during cold rolling and re- crystallization annealing. The texture components were measured by electron backscattered diffraction （EBSD） after recrystallization an- nealing. The CP Ti tends to form a texture with the basal pole tilted 30°-40° away from the normal direction toward the transverse direction. The texture of the initial hot-rolled plate can be classified into three kinds, i.e., the pyramid texture （1013）[5230] and （2021）[1015], the basal plane texture （0001）[2110], and the stronger_prism_texture （1120）[0001]. After cold rolling and annealing （700℃,60 min）,_the main texture components are the cold-rolled texture （1125）[1123] and the recrystallized texture （1013）[5230]. The texture （2021）[1015] is in- herited from the texture of the initial hot-rolled plate with the decrease of orientation density gradually. The volume contents of the cold-rolled texture {2115}（0110） and the recrystallized texture {1013}（1210） are calculated by EBSD. After recrystallization annealing, the specimen is rich in the recrystallized texture and inherits some of texture components from the cold-rolled texture. When the annealing time is prolonged, the anisotropic value decreases.

关键词： titanium cold rolling recrystallization annealing textures