Development of PREDAC-H1pdm to model the antigenic evolution of influenza A/(H1N1)pdm09 viruses

作     者：Mi Liu Jingze Liu Wenjun Song Yousong Peng Xiao Ding Lizong Deng Taijiao Jiang Mi Liu;Jingze Liu;Wenjun Song;Yousong Peng;Xiao Ding;Lizong Deng;Taijiao Jiang

作者机构：Jiangsu Institute of Clinical ImmunologyThe First Affiliated Hospital of Soochow UniversitySuzhou215006China Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100005China Suzhou Institute of Systems MedicineSuzhou215123China Guangzhou LaboratoryGuangzhou510005China Bioinformatics CenterCollege of BiologyHunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha410082China State Key Laboratory of Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou510120China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2023年第38卷第4期

页      面：541-548页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China (32070678) the National Key Research and Development Program of China (2021YFC2302001) 

主　　题：H1N1pdm virus Antigenic relationship prediction Antigenic evolution Vaccine recommendation 

摘      要：The Influenza A(H1N1)pdm09 virus caused a global pandemic in 2009 and has circulated seasonally ever *** the continual genetic evolution of hemagglutinin in this virus leads to antigenic drift,rapid identification of antigenic variants and characterization of the antigenic evolution are *** this study,we developed PREDAC-H1pdm,a model to predict antigenic relationships between H1N1pdm viruses and identify antigenic clusters for post-2009 pandemic H1N1 *** model performed well in predicting antigenic variants,which was helpful in influenza *** mapping the antigenic clusters for H1N1pdm,we found that substitutions on the Sa epitope were common for H1N1pdm,whereas for the former seasonal H1N1,substitutions on the Sb epitope were more common in antigenic ***,the localized epidemic pattern of H1N1pdm was more obvious than that of the former seasonal H1N1,which could make vaccine recommendation more ***,the antigenic relationship prediction model we developed provides a rapid determination method for identifying antigenic variants,and the further analysis of evolutionary and epidemic characteristics can facilitate vaccine recommendations and influenza surveillance for H1N1pdm.