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Ultrasound-propelled Janus Au NR-mSiO_(2) nanomotor for NIR-II photoacoustic imaging guided sonodynamic-gas therapy of large tumors

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Science China Chemistry 2021年第12期64卷 2218-2229页

作者： Jiamin Ye Qinrui Fu Luntao liu Lanlan Chen Xuan Zhang Qingqing Li zhi Li Lichao Su Rong Zhu Jibin Song Huanghao Yang MOE key Laboratory for Analytical Science of Food Safety and Biology Ministry of EducationCollege of ChemistryFuzhou UniversityFuzhou350108China

Varieties of contrast agents have been developed for photoacoustic(PA)and ultrasound(US)imaging of cancers in ***,access of traditional contrast agents into the sites of tumors has been principally through passive infiltration without any external force,preventing their deep penetration into the tissues of the tumors,and hindering the use of PA and US for deep tumor *** concept of micro/nanomotors has been the focus of increasing attention as active theranostic agents due to their active movement in particular fluids,thereby conducting assigned ***,US-propelled Janus mesoporous SiO_(2)partially coated gold nanorods(Au NR-mSiO_(2))were fabricated for deep tumor NIR-II PA imaging and synergistic sonodynamic-gas *** US irradiation,2,2-azobis[2-(2-imidazolin-2-yl)propane]dihydrochloride(AIPH)loaded in mSiO_(2)(Au NR-mSiO_(2)/AIPH)generated N_(2)microbubbles with high efficiency to achieve nanomotor *** to the deep penetration of US,the nanomotors exhibited a capability to travel deep within sites of tumors,providing enhanced PA/US imaging inside the ***,the nanomotor based cancer therapy was demonstrated through synergistic N_(2)gas and sonodynamic *** US-propelled nanomotors demonstrated a novel strategy for the simultaneous PA/US dual imaging deep within tumor tissues and precise therapy of large tumors.

关键词： nanomotor NIR-Ⅱphotoacoustic imaging ultrasound sonodynamic therapy gas therapy

Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods

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Protein & Cell 2010年第5期1卷 453-458页

作者： Jing Su Yang Li Neil Shaw Weihong Zhou Min Zhang Hao Xu Bi-Cheng Wang zhi-Jie liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences Nankai UniversityTianjin 300071China School of Life Sciences Anhui UniversityHefei 230039China Department of Biochemistry and Molecular Biology University of GeorgiaAtlantaGA 30605USA

Sometimes crystals cannot diffract X-rays beyond 3.0Åresolution due to the intrinsic flexibility associated with the *** resolution diffraction data not only pose a challenge to structure determination,but also hamper interpretation of mechanistic *** of a 25.6 kDa non-Pfam,hypothetical protein,PF2046,diffracted X-rays to 3.38Åresolution.A combination of SeMet derived heavy atom positions with multiple cycles of B-factor sharpening,multi-crystal averaging,restrained refinement followed by manual inspection of electron density and model building resulted in a final model with a R value of 23.5(R_(free)=24.7).The asymmetric unit was large and consisted of six molecules arranged as a homodimer of *** of the structure revealed the presence of a RNA binding domain suggesting a role for PF2046 in the processing of nucleic acids.

关键词： low resolution diffraction PF2046 Bfactor sharpening a homodimer of trimers

Moisture sorption characteristics of freeze-dried human platelets

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 210-218页

作者： Meng-jie XU Guang-ming CHEN Ju-li FAN Jin-hui liu Xian-guo XU Shao-zhi ZHANG Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China key Laboratory of Blood Safety Research Ministry of Health Blood Center of Zhejiang Province Hangzhou 310006 China

Freeze-drying is a promising method for a long-term storage of human *** moisture sorption characteristics of freeze-dried human platelets(FDHPs) were studied in this *** moisture sorption isotherms of FDHPs and freeze-dried lyophilization buffer(FDLB) were measured at 4,25,and 37°*** experimental data were fitted to Brunauer-Emmett-Teller(BET) and Guggenheim-Anderson-de Boer(GAB) *** were no sig-nificant statistical differences(P>0.05) between the sorption characteristics of FDHPs and FDLB at 4 and 25°C,while FDHPs absorbed more water at 37°*** net isosteric heat of sorption was *** heat for FDHPs showed an abnormal negative value at low moisture contents when 25 and 37°C data were *** sorption experiments were carried out at 25°C with environmental water activity controlled at 0.75,0.85,and *** moisture diffusion coefficient was fitted to be 8.24×10 -12 m 2 /s when experimental data at initial time were *** results would be helpful in choosing prehydration and storage condition for FDHPs.

关键词： Human platelets Freeze-drying Sorption Moisture

Annealing and optical homogeneity of large ZnGeP_(2) single crystal

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Rare Metals 2022年第9期41卷 3214-3219页

作者： Li-Qiang Cao Bei-Jun Zhao Shi-Fu Zhu Bao-Jun Chen zhi-Yu He Deng-Hui Yang Hui liu Hu Xie College of Materials Science and Engineering Sichuan UniversityChengdu610064China

A high-quality ZnGeP_(2)(ZGP)single crystal with large size ofΦ30 mm×80 mm was grown by a modified vertical Bridgman *** wafers were annealed with ZGP polycrystalline powder for 300 h at 550,600 and 650℃,*** as-grown and annealed crystals were characterized by X-ray diffraction(XRD)analysis,Fourier transform infrared spectroscopy(FTIR),IR microscope and energy-dispersive spectroscopy(EDS).Results show that the quality of all wafers is improved evidently after annealing and the optimum annealing temperature obtained is 600℃.The IR transmittance of the wafer measured by FTIR is up to 56.78%at wavelength of 2.0μm nearby and exceeds 59.00%in the wavelength range of 3.0-8.0μ*** deviations from stoichiometry decrease,and the homogeneity of the crystal is also improved after *** this paper,scanning infrared map was proposed as a new nondestructive method to evaluate optical quality and homogeneity of crystal through comparing the IR transmittance with the three-dimensional IR spectral contour map.

关键词： ZnGeP_(2)crystals Annealing Infrared transmittance Scanning infrared map Optical homogeneity

A Series of Variable Separation Solutions and New Soliton Structures of （2＋1）-Dimensional Korteweg-de Vries Equation

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Communications in Theoretical Physics 2006年第3X期46卷 403-406页

作者： XU Chang-zhi Department of Physics Jinhua Education College Jinhua 321000 China

Variable separation approach is introduced to solve the （2＋1）-dimensional KdV equation. A series of variable separation solutions is derived with arbitrary functions in system. We present a new soliton excitation model （24）. Based on this excitation, new soliton structures such as the multi-lump soliton and periodic soliton are revealed by selecting the arbitrary function appropriately.

关键词： variable separation approach (2+1)-dimensional KdV equation new soliton excitation

Aging precipitation characteristics and tensile properties of Al-Zn-Mg-Cu alloys with different additional Zn contents

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Rare Metals 2021年第8期40卷 2160-2166页

作者： Kai Wen Bai-Qing Xiong Yong-An Zhang Xi-Wu Li zhi-Hui Li Li-Zhen Yan Hong-Wei Yan Hong-Wei liu State key Laboratory of Nonferrous Metals and Processes GRIMAT Engineering Institute Co.LTD.Beijing101407China GRINM Group Co. LTD.Beijing100088China

The increase in zinc content in Al-Zn-Mg-Cu alloys provides an effective method to enhance the *** electron microscopy(TEM)and tensile test were employed to analyze the microstructure and tensile properties,respectively,of Al-9.3 Zn-2.0 Mg-1.8 Cu alloy(9.3 Zn alloy)and Al-9.8 Zn-2.0 Mg-1.8 Cu alloy(9.8 Zn alloy)with single-and double-stage aging *** results showed that the two alloys possessed a closed strength under single-stage peak-aging *** for double-stage aging treatment,9.8 Zn alloy had a higher strength values than 9.3 Zn alloy under the same aging *** the second step aging time prolonging,the strength gap was *** main precipitates for the two alloys with single-stage peak-aging state were GP zones andη’phase,while there were a majority ofη’phases andηphases for the two alloys under typical double-stage over-aging *** double-stage overaging state,the proportion of precipitate with large size for9.3 Zn alloy was larger than that for 9.8 Zn ***,a more obvious trend was revealed for the double-stage overaging *** gap of strength between the two alloys was explained by the difference of precipitation characteristics via interaction mechanism between precipitates and dislocations.

关键词： Zn content Al-Zn-Mg-Cu alloy Precipitation characteristics Tensile properties

Comparative analysis of GF-1,HJ-1,and Landsat-8 data for estimating the leaf area index of winter wheat

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Journal of Integrative Agriculture 2017年第2期16卷 266-285页

作者： LI He CHEN Zhong-xin JIANG zhi-wei WU Wen-bin REN Jian-qiang liu Bin Tuya Hasi key Laboratory of Agri-informatics Ministry of Agriculture/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences National Meteorological Information Center China Meteorological Administration

Using simultaneously collected remote sensing data and field measurements, this study firstly assessed the consistency and applicability of China high-resolution earth observation system satellite 1 （GF-1） wide field of view （WFV） camera, environment and disaster monitoring and forecasting satellite （H J-l） charge coupled device （CCD）, and Landsat-8 opera- tional land imager （OLI） data for estimating the leaf area index （LAI） of winter wheat via reflectance and vegetation indices （VIs）. The accuracies of these LAI estimates were then assessed through comparison with an empirical model and the PROSAIL radiative transfer model. The effects of radiation calibration, spectral response functions, and spatial resolution on discrepancies in the LAI estimates between the different sensors were also analyzed. The results yielded the following observations：（1） The correlation between reflectance from different sensors is relative good, with the adjusted coefficients of determination （R2） between 0.375 to 0.818. The differences in reflectance are ranging from 0.002 to 0.054. The correlation between VIs from different sensors is high with the R2 between 0.729 and 0.933. The differences in the VIs are ranging from 0.07 to 0.156. These results show the three sensors＇ images can all be used for cross calibration of the reflectance and VIs. （2） The four VIs from the three sensors are all demonstrated to be highly correlated with LAI （R2 between 0.703 and 0.849）. The linear models associated with the 2-band enhanced vegetation index （EVI2）, which feature the highest R2 （higher than 0.746） and the lowest root mean square errors （RMSE）（less than 0.21）, were selected to estimate the winter wheat LAI. The accuracy of the estimated LAI from Landsat-8 was the highest, with the relative errors （RE） of 2.18% and an RMSE of 0.13, while the H J-1 was the lowest, with the RE of 2.43% and the RMSE of 0.15. （3） The inversion errors in the different sensors＇ LAI estimates using the PROSAIL mode

关键词： GF-1 WFV H J-1 CCD Landsat-80LI leaf area index PROSAIL vegetation indices

Models to predict sunlight-induced photodegradation rates of contaminants in wastewater stabilisation ponds and clarifiers

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Water Science and Engineering 2019年第4期12卷 293-297页

作者： Xi-zhi Niu Department of Chemical and Environmental Engineering and Arizona Laboratory for Emerging Contaminants University of Arizona

Two kinetic models were established for conservative estimates of photodegradation rates of contaminants under sunlight irradiation,in particular for wastewater stabilisation ponds and clarifiers in conventional wastewater treatment *** two models were designated for(1)contaminants with high photolytic rates or high photolytic quantum yields,whose photodegradation is unlikely to be enhanced by aquatic photosensitisers;and(2)contaminants withstanding direct photolysis in sunlit waters but subjected to indirect *** effortlessly intelligible prediction procedure involves sampling and analysis of real water samples,simulated solar experiments in the laboratory,and transfer of the laboratory results to realise water treatment using the prediction *** similar models have been widely used for laboratory studies,this paper provides a preliminary example of translating laboratory results to the photochemical fate of contaminants in real waters.

关键词： Sunlight irradiation Photodegradation Contaminants Stabilisation ponds Solar water treatment

Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons

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Journal of Molecular Cell Biology 2018年第5期10卷 402-410页

作者： Qun Wei Yi-Feng Gu Qing-Jun Zhang Helena Yu Yan Peng kevin W. Williams Ruitao Wang Kajiang Yu Tiemin liu zhi-Ping liu Department of Surgical Oncology and Institute of Clinical Medicine Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou 310016 China Department of Internal Medicine UT Southwestern Medical Center Dallas TX 75235 USA Department of Pathology UT Southwestern Medical Center Dallas TX 75235 USA Department of Intensive Care Unit The Third Affiliated Hospital Harbin Medical University Harbin 150081 China Sate key Laboratory of Genetic Engineering School of Life Sciences Department of Endocrinology and Metabolism Zhongshan Hospital Collaborative Innovation Center for Genetics and Development Fudan University Shanghai 200438 China Department of Molecular Biology UT Southwestern Medical Center Dallas TX 75235 USA

Leptin receptor （LepRb） signaling pathway in the hypothalamus of the forebrain controls food intake and energy expenditure in response to an altered energy state. Defects in the LepRb signaling pathway can result in leptin-resistance and obesity. Leucine zipper transcription factor like 1 （Lztfl1）/BBS17 is a member of the Bardet-Biedl syndrome （BBS） gene family. Human BBS patients have a wide range of pathologies including obesity. The cellular and molecular mechanisms underlying Lztfl1-regulated obesity are unknown. Here, we generated Lztfl1lf/f mouse model in which Lztfl1 can be deleted globally and in tissue-specific manner. Global Lztfl1 deficiency resulted in pleiotropic phenotypes including obesity. Lztfl1^-/- mice are hyperphagic and showed similar energy expenditure as WT littermates. The obese phenotype of Lztfl1-/- mice is caused by the loss of Lztfl1 in the brain but not in the ***1-/- mice are leptin-resistant. Inactivation of Lztfl1 abolished phosphorylation of Stat3 in the LepRb signaling pathway in the hypothalamus upon leptin stimulation. Deletion of Lztfl1 had no effect on LepRb membrane localization. Furthermore, we observed that Lztfl1-/- mouse embryonic fibroblasts （MEFs） have significantly longer cilia than WT MEFs. We identified several proteins that potentially interact with Lztfl1. As these proteins are known to be involved in regulation of actin/cytoskeleton dynamics, we suggest that Lztfl1 may regulate leptin signaling and ciliary structure via these proteins. Our study identified Lztfl1 as a novel player in the LepRb signaling pathway in the hypothalamus that controls energy homeostasis.

关键词： obesity BBS leptin-resistance cilia actin/cytoskeleton