Moisture sorption characteristics of freeze-dried human platelets

作     者：Meng-jie XU Guang-ming CHEN Ju-li FAN Jin-hui LIU Xian-guo XU Shao-zhi ZHANG 

作者机构：Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Key Laboratory of Blood Safety Research Ministry of Health Blood Center of Zhejiang Province Hangzhou 310006 China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2011年第12卷第3期

页      面：210-218页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 0702[理学-物理学] 

基　　金：Project supported by the Natural Science Foundation of Zhejiang Province,China(No.Y1090409) the Doctoral Fund of Ministry of Education of China(No.20070335145) 

主　　题：Human platelets Freeze-drying Sorption Moisture 

摘      要：Freeze-drying is a promising method for a long-term storage of human *** moisture sorption characteristics of freeze-dried human platelets(FDHPs) were studied in this *** moisture sorption isotherms of FDHPs and freeze-dried lyophilization buffer(FDLB) were measured at 4,25,and 37°*** experimental data were fitted to Brunauer-Emmett-Teller(BET) and Guggenheim-Anderson-de Boer(GAB) *** were no sig-nificant statistical differences(P0.05) between the sorption characteristics of FDHPs and FDLB at 4 and 25°C,while FDHPs absorbed more water at 37°*** net isosteric heat of sorption was *** heat for FDHPs showed an abnormal negative value at low moisture contents when 25 and 37°C data were *** sorption experiments were carried out at 25°C with environmental water activity controlled at 0.75,0.85,and *** moisture diffusion coefficient was fitted to be 8.24×10 -12 m 2 /s when experimental data at initial time were *** results would be helpful in choosing prehydration and storage condition for FDHPs.