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Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population

引用

Asian Journal of urology 2019年第1期6卷 114-121页

作者： Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong jiangping Gao Kewei ma Yajun xiao Sheng Zhang Hongyi jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong liu Danfeng Xu Xin Gao Yongguang jiang Weimin Gan Guang Sun Qing Wang Yanhui liu jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi lulin ma jianzhong Shou Yuping Dai jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei jianbo Wu Weiling Fu Zhiping Wang jianbo Liang department of urology Peking University First HospitalBeijingChina Institute of urology Peking UniversityBeijingChina National Urological Cancer Center BeijingChina Air Force General hospital PLABeijingChina department of urology Peking Union Medical College HospitalBeijingChina department of urology Beijing Chao-Yang HospitalBeijingChina department of urology Armed-Police General HospitalBeijingChina department of urology Shanxi Medical University First HospitalTaiyuanChina department of urology Hebei Medical University Second HospitalShijiazhuangChina department of urology The General Hospital of the People’s Liberation ArmyBeijingChina department of urology First Affiliated Hospital of Jilin UniversityChangchunChina department of urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Pathology The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina department of urology The Second Xiangya Hospital of Central South UniversityChangshaChina department of urology General Hospital of Guangzhou Military Command of PLAGuangzhouChina department of urology West China School of MedicineChengduChina department of urology Shangdong Province-owned HospitalJinanChina department of urology Peking University Shenzhen HospitalShenzhenChina department of urology The Central Hospital of Jinan CityJinanChina department of urology Shanghai Changzheng HospitalShanghaiChina department of urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of urology Beijing Anzhen Hospital of Capital Medical UniversityBeijingChina department of urology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina department of urology The Second Hospital of Tianjin Medical UniversityTianjinChina department of urology People’s Hospital of Xinjiang Uygur Autonomous RegionWulumuqiChina department of urology Guangdong General HospitalGuangzhouChina department of urology The First Affil

Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder ***:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December *** operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology ***:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised ***,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(plues of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and *** sensitivity using FISH was obtained in high grade and muscle invasive tumors.

关键词： Bladder transitionalcell carcinoma Fluorescence in situ hybridization Detection Grade Stage

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