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Cancer Communications 2024年第4期44卷 455-468页

作者： Jing Zheng Tao Wang Yunpeng Yang Jie Huang Jifeng Feng Wu zhuang jianhua Chen Jun Zhao Wei Zhong Yanqiu Zhao Yiping Zhang Yong Song Yi Hu zhuang Yu Youling Gong Yuan Chen Feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi Zhou Kewei ma jian Fang Weineng Feng Yunpeng liu Zhendong Zheng Gaofeng Li Huijie Wang Shundong Cang Ning Wu Wei Song xiaoqing liu Shijun Zhao Lieming Ding Giovanni Selvaggi Yang Wang Shanshan xiao Qian Wang Zhilin Shen jianya Zhou jianying Zhou Li Zhang department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong jiang Yan jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu luo Ba Zhi-Wei Cao Xu-Ping xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng liu xiao-Bo Cui Sheng-Nan Ye Zheng liu Yu Xu xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng jian-Feng liu Graduate School of Beijing university of Chinese Medicine BeijingChina department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

一期输尿管软镜联合经皮肾镜治疗鹿角形结石合并脓肾的疗效和安全性

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中华泌尿外科杂志 2020年第4期41卷 267-271页

作者：刘余庆邱敏刘可卢剑肖春雷马潞林北京大学第三医院泌尿外科北京100191

目的探讨一期输尿管软镜(FURS)联合经皮肾镜取石术(PCNL)治疗鹿角形结石合并脓肾的可行性、有效性和安全性。方法回顾性分析北京大学第三医院2017年5月至2019年12月采用一期FURS联合PCNL治疗的13例鹿角形结石合并脓肾患者的病例资料,男7... 详细信息

目的探讨一期输尿管软镜(FURS)联合经皮肾镜取石术(PCNL)治疗鹿角形结石合并脓肾的可行性、有效性和安全性。方法回顾性分析北京大学第三医院2017年5月至2019年12月采用一期FURS联合PCNL治疗的13例鹿角形结石合并脓肾患者的病例资料,男7例,女6例。年龄52.5(33~68)岁。临床表现为间断发热9例,腰部不适6例,肉眼血尿1例,2例无明显临床表现。8例合并糖尿病。CT检查示完全型鹿角形结石6例,部分型7例;结石位于左侧7例,右侧6例;4例伴中/重度肾积水,9例伴轻度肾积水。影像学检查评估结石负荷(1070.9±397.0)(507.4~1809.5)mm^2。13例术前均行尿细菌培养及药敏试验。4例住院时有发热症状者术前留置患侧输尿管支架管≥1周。所有病例术前应用抗菌药物≥1周,待感染症状及感染相关指标恢复正常后接受手术治疗。手术采用全麻,患者取改良Valdivia体位。先经尿道置入FURS到达患侧肾盂,B超及FURS引导下在患侧腋中线和肩胛旁线之间、12肋下建立经皮肾标准通道,单通道PCNL下采用负压吸引装置吸出脓液并处理视野范围内的结石,再联合FURS处理其他肾盏结石。术中PCNL穿刺成功后,均可见肾内浑浊脓性尿液排出,留取肾内尿液送检细菌培养及药敏试验。本组13例均经术中肾盂尿细菌培养结果确诊为脓肾。术后常规留置输尿管支架管和肾造瘘管,继续抗感染治疗。术后第1~3天行影像学检查,评估结石清除率,残留结石≥4 mm为有意义的结石残留。结果本组13例手术均顺利完成,手术时间(94.2±21.8)(65~135)min。一期结石清除率76.9%(10/13)。术后6例出现全身炎症反应综合征,无脓毒血症及≥Clavien-DindoⅢ级并发症发生。术后中位随访12(3~24)个月,4例患侧结石复发,2例患侧轻度肾萎缩,随访期间无患侧上尿路感染复发。结论FURS联合PCNL是治疗鹿角形结石合并脓肾的有效方法,具有良好的疗效和安全性。

关键词：肾结石鹿角形肾结石肾盂积脓经皮肾镜取石术输尿管软镜联合内镜

"点线面体"四维法钬激光前列腺剜除术治疗良性前列腺增生的临床研究

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中华外科杂志 2019年第3期57卷 194-199页

作者：郝一昌肖春雷卢剑刘可刘余庆马潞林北京大学第三医院泌尿外科 100191

目的总结"点线面体"四维法钬激光前列腺剜除术治疗良性前列腺增生的手术经验。方法回顾性分析2016年12月至2017年11月在北京大学第三医院泌尿外科接受"点线面体"四维法钬激光前列腺剜除术治疗的60例良性前列腺增生患者的临床资料。年龄(... 详细信息

目的总结"点线面体"四维法钬激光前列腺剜除术治疗良性前列腺增生的手术经验。方法回顾性分析2016年12月至2017年11月在北京大学第三医院泌尿外科接受"点线面体"四维法钬激光前列腺剜除术治疗的60例良性前列腺增生患者的临床资料。年龄(73.8±8.0)岁(范围:60~96岁),体重指数(23.2±3.6)kg/m2(范围:14.9~31.1kg/m^2),前列腺体积(64.5±36.9)ml(范围:15.5~197.9ml)。手术由同一名泌尿外科医师实施。(1)以精阜为定位点,其外上方45°侧叶内侧缘与精阜连线的中点为突破点,"爆破划桨法"寻找包膜,并在精阜前方将两侧的包膜平面相连。(2)通过"扇面坑道法"保持平面,从5点钟和7点钟方向将中叶和两侧叶分割,将中叶的腺体先剜除并推入膀胱。(3)在经过精阜正上方12点钟方向的向前下倾斜的冠状断面上,半弧形提前离断尿道黏膜,在精阜上方汇合并向膀胱颈部延伸形成"倒Y"形沟槽,将左右叶完全分割。(4)分别剜除两侧叶,并将膀胱内剜除下来的腺体粉碎吸出。记录患者术前术后国际前列腺症状评分和生活质量评分、手术时间、血红蛋白下降值、留置尿管时间和术后住院时间。用前列腺体积除以剜切时间计算剜切效率,用前列腺体积除以粉碎时间计算粉碎效率。手术前后指标比较采用配对t检验。结果60例手术均获得成功,其中1例因粉碎设备故障,改行经尿道前列腺电切术取出前列腺组织标本。手术时间(115.2±52.9)min(范围:25~276min),剜切效率(0.81±0.35)ml/min(范围:0.17~1.58ml/min),粉碎效率(6.60±4.28)ml/min(范围:0.89~17.42ml/min),血红蛋白下降(15.9±12.3)g/L(范围:-10~57g/L),留置尿管时间(5.2±2.9)d(范围:0.8~19.8d);术后住院时间(5.0±1.5)d(范围:1.9~11.9d)。患者术后IPSS评分[(10.92±6.98)分比(23.37±7.49)分,t=10.357,P=0.000]和QOL评分[(1.75±1.62)分比(4.53±1.47)分,t=9.373,P=0.000]较术前明显改善。术后并发症包括:4例发热(>38.5℃),1例急性附睾炎,1例膀胱黏膜损伤,1例术后活动性出血接受输血治疗。结论"点线面体"四维法钬激光前列腺剜除术治疗良性前列腺增生较为安全并可获得较满意的临床效果。

关键词：前列腺增生经尿道前列腺切除术激光疗法

Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

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World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng jiang Yue-Jie Zheng Lei Zhou lu-Zhao Feng Lin ma Bao-Ping Xu Hong-Mei Xu Wei liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun luo Zhi-Sheng liu Sai-Nan Shu jian-She Wang Yi jiang Yun-xiao Shang Miao liu Li-Wei Gao zhuang Wei Guang-Hua liu Gang liu Wei Xiang Yu-Xia Cui Gen lu Min lu xiao-Xia lu Run-Ming Jin Yan Bai Le-Ping Ye Dong-Chi Zhao A-Dong Shen Xiang ma Qing-Hua lu Feng-Xia Xue jian-Bo Shao Tian-You Wang Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** may 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by National Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

输尿管软镜治疗上尿路结石后全身炎症反应综合征的预测模型

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中华泌尿外科杂志 2016年第12期37卷 923-927页

作者：刘余庆卢剑刘可郝一昌肖春雷马潞林北京大学第三医院泌尿外科 100191

目的分析输尿管软镜钬激光碎石术治疗上尿路结石后发生全身炎症反应综合征（Systemic inflammatory response syndrome,SIRS）的相关因素,建立预测术后重症感染风险的列线图预测模型.方法回顾性分析2014年1月至2016年5月我中心457例... 详细信息

目的分析输尿管软镜钬激光碎石术治疗上尿路结石后发生全身炎症反应综合征（Systemic inflammatory response syndrome,SIRS）的相关因素,建立预测术后重症感染风险的列线图预测模型.方法回顾性分析2014年1月至2016年5月我中心457例输尿管软镜治疗上尿路结石患者的临床资料.男302例,女155例.年龄20 ～76岁,平均49.9岁.最大结石直径12～22mm,平均（16.5±3.0）mm.51例（11.2％）术前出现结石相关感染性发热.根据术后是否发生SIRS将患者分为两组,通过单因素分析和多因素Logistic回归分析评价患者发生SIRS的围手术期独立危险因素,根据回归系数绘制相应的列线图预测模型.结果本组457例中,27例（5.9％）术后发生SIRS,多变量Logistic回归分析结果显示,结石相关发热病史（OR=1.5569,P=0.009）、术前未置支架管（OR=1.4004,P=0.004）、导入鞘外径较小（F13～14）（OR=1.1120,P=0.016）、术中存在感染表现（OR=2.0176,P=0.000）,以及感染性结石（OR=1.0981,P=0.013）是术后SIRS发生的独立预测危险因素.列线图模型在建模样本中的一致系数为0.845,而在验证样本中的一致系数为0.79,并表现出较好的符合度.结论术前结石相关发热病史、术中存在感染表现,以及感染性结石、术前未置支架管、导入鞘外径较小,可以显著增加输尿管软镜治疗上尿路结石术后的SIRS发生率.根据患者临床资料,应用列线图有助于预测术后SIRS风险.

关键词：输尿管软镜碎石术,激光全身炎症反应综合征危险因素列线图

Mortality and Morbidity of Extremely Low Birth Weight Infants in the mainland of China： A Multi-center Study

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Chinese Medical Journal 2015年第20期128卷 2743-2750页

作者： Hui-Jia Lin Li-Zhong Du xiao-lu ma Li-Ping Shi Jia-Hua Pan xiao-Mei Tong Qiu-Ping Li jian-Guo Zhou Bing Yi Ling liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru lu xiao-Hong liu Hong liu Zhen-Lang Lin Li liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi zhuang department of Neonatal Intensive Care Unit Children's Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310053 China department of Neonatology Anhui Provincial Hospital Hefei Anhui 230001 China department of Pediatrics Peking University Third Hospital Beijing 100191 China department of Neonatology BaYi Children's Hospital of the General Military Hospital of Beijing People's Liberation Army Beijing 100000 China department of Neonatology Children's Hospital of Fudan University Shanghai 200032 China department of Neonatology Gansu Provincial Maternity and Children-care Hospital Lanzhou Gansu 730050 China department of Neonatotogy Guiyang Maternal and Child Health Care Hospital Guiyang Guizhou 550003 China department of Neonatology Women and Children Hospital of Guangdong Province Guangzhou Guangdong 510010 China department of Neonatology Guangxi Maternal and Child Health Hospital Nanning Guangxi 530003 China department of Neonatology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510150 China department of Neonatology Harbin Children's Hospital Harbin Heilongjiang 150010 China department of Neonatology Children's Hospital of Hebei Province Shijiazhuang Hebei 050031 China department of Neonatology Hunan Children's Hospital Changsha Hunan 410007 China department of Neonatology Hubei Maternity and Child Heath Hospital Wuhan Hubei 430070 China department of Pediatrics Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China department of Neonatology The First Hospital of Jilin University Changchun Jilin 130021 China department of Neonatology Jiangxi Provincial Children's Hospital Nanchang Jiangxi 330006 China department of Pediatric First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China department of Neonatotogy Nanjing Children's Hospital of Nanjing Medical University Nanjing Jiangsu 320100 China De

Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW）〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

关键词： Extremely Low Birth Weight Infant Mortality National Survey

Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese： a multi-center investigation in China

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Chinese Medical Journal 2010年第1期000卷 18-22页

作者： HE Quan-ying FENG Jing ZHANG Xi-long LIANG Zong-an HUANG Shao-guang KANG jian WANG Guang-fa ZHANG Li-qiang ma Li-jun, WANG Bei, LIN Qi-chang, ZHANG Jing-nong, liu Hui-guo, luO Yuan-ming,liu jian-hong, WANG Shi, xiao Gao-hui, lu Gan, ZHANG Jin, FENG Xue-wei and CHEN Bao-yuan ma Li-jun WANG Bei LIN Qi-chang ZHANG Jing-nong liu Hui-guo luO Yuan-ming liu jian-hong WANG Shi xiao Gao-hui lu Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan department of Respiratory Diseases Beijing University People'sHospital Beijing 100044 China department ofRespiratory Diseases Tianjin Medical University GeneralHospital Tianjin 300052 China department of Respiratory Diseases First Affiliated Hospital ofNanjing Medical University Nanjing 210029 China department of Respiratory Diseases Huaxi Hospital SichuanUniversity Chengdu Sichuan 610041 China department of Respiratory Diseases Ruijin Hospital S-hanghaiJiao Tong University School of Medicine Shanghai 200025 China department of Respiratory Diseases First AffiliatedHospital of China Medical University Shenyang Liaoning110001 China department of Respiratory Diseases Peking University First Hospital Beijing 100034 China department of Respiratory Diseases Peking University ThirdHospital Beijing 100083 China department ofRespiratory Diseases Henan Provincial People's HospitalZhengzhou Henan 450003 China department ofRespiratory Diseases Second Affiliated Hospital of ShanxiMedical University Taiyuan Shanxi 030001 China department of Respiratory Diseases First Affiliated Hospital ofFujian Medical University Fuzhou Fujian 350005 China department of Respiratory Diseases Union Hospital TongjiMedical College Huazhong University of Science and TechnologyWuhan Hubei 430022 China department ofRespiratory Diseases Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Wuhan Hubei430030 China Guangzhou Institute of RespiratoryDisease First Affiliated Hospital of Guangzhou Medical CollegeGuangzhou Guangdong 510120 China department ofRespiratory Diseases Guangxi Zhuang Autonomous RegionPeople's Hospital Nanning Guangxi 530021 China department of Respiratory Diseases Central Hospital of ShenyangMedical College Shenyang Liaoning 110024 China department of Respiratory Diseases Beijing Gongan HospitalBeijing 100006 China department of RespiratoryDiseases Jiangsu Senility Hospital Nanjing Jiangsu 210024China department of Respiratory Disea

Background Epidemiologic studies have shown an independent and definite association between obstructive sleep apnea （OSA） and hypertension. This study aimed to define the association between daytime blood pressure and severity of OSA in Chinese population in mainland of China. Methods Twenty university hospital sleep centers in mainland of China were invited by the Chinese Medical Association （Cma） to participate in this epidemiologic study and 2297 consecutive patients （aged 18-85 years; 1981 males and 316 females） referred to these twenty sleep centers for evaluation of OSA between January 2004 and April 2006 were prospectively enrolled. Nocturnal polysomnography was performed in each patient, and disease severity was assessed based on the apnea-hypopnea index （AHI）. These patients were classfied into four groups： non-apneic control （control, n=257） with AHI 〈5 episodes/hour; mild sleep apnea （mild, n=402） with AHI 〉5 and 〈15 episodes/hour; moderate sleep apnea （moderate, n=460） with AHI 〉15 and 〈30 episodes/hour and severe sleep apnea （severe, n=1178） with AHI 〉30 episodes/hour. Daytime blood pressure measurements were performed under standardized conditions in each patient at 10 a.m. in office on the day of referring to sleep centers for getting average value. All the patients were requested to quit medications related to blood pressure for three days before the day of assessing. Results Both daytime systolic blood pressure and diastolic blood pressure values were significantly related to AHI positively （r = 0.201 and 0.276, respectively; both P values 〈0.001） and to nadir nocturnal oxygen saturation negatively （r = -0.215 and -0.277, respectively; both P values 〈0.001）, which were the parameters of OSA severity. In two special designed mean plots, means of daytime systolic and diastolic blood pressure increased gradually with increasing AHI. Beyond AHI of 61-65, this increasing trend reached a plateau. Conclusions The results showed that OSA severity was associ

关键词： obstructive sleep apnea hypertension epidemiology blood pressure polysomnography

Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome

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Chinese Medical Journal 2012年第10期125卷 1740-1746页

作者： HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG jian WANG Guang-fa ZHANG Li-qiang ma Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong liu Hui-guo luO Yuan-ming liu jian-hong WANG Shi xiao Gao-hui lu Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan department of Respiratory Diseases Peking University People’s HospitalBelling 100044China department of Respiratory Diseases Tianjin Medical University General HospitalTianiin 300052China department of Respiratory Diseases First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China department of Respiratory Diseases West China HospitalSichuan UniversityChengduSichuan 610041China department of Respiratory Diseases Ruijin HospitalShanghai Jiao Tbng University School of MedicineShanghai 200025China department of Respiratory Diseases First Affiliated Hospita1 ofChina Medical UniversityShenyangLiaoning 110001China department of Respiratory Diseases Peking University First HospitalBeijing 100034China department of Respiratory Diseases Peking University Third HospitalBeijing 100191China department of Respiratory Diseases Henan Provincial People’s HospitalZhengzhouHenan 450003China department of Respiratory Diseases Second Affiliated Hospita1 of Shanxi Medical UniversityTaiyuanShanxi 030001China department of Respiratory Diseases First Affiliated Hospital of Fujian Medical UniversityFuzhouFuiian 350005China department of Respiratory Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologywuhanHubei 430022China department of Respiratory Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030 China Guangzhou Institute of Respiratory Disease.First Affiliated hospital of Guangzhou Medical College GuangzhouGuangdong 510120China department of Respiratory Diseases Guangxi Zhuang Autonomous Region People’s HospitalNanningGuangxi 530021China department of Respiratory Diseases Central Hospita1 of Shenyang Medical College ShenyangLiaoning 110024China department of Respiratory Diseases Beijing Gongan HospitalBeijing 100006China department of Respiratory Diseases Jiangsu Senility HospitalNanjingJiangsu 210024China department of Respiratory Diseases Afiliated Hospita1 of Ningxi

Background The nocturnal nondipping and elevated morning blood pressure （BP） in patients with obstructive sleep apnea syndrome （OSAS） have not yet been well investigated in Chinese patients. This study aimed to describe the BP profile, and to elucidate the relationships between daytime BP and nighttime BP, and between evening BP and morning BP in patients with OSAS. Methods Twenty teaching hospital sleep centers in China were organized by the Chinese Medical Association to participate in this study and 2297 patients were recruited between January 2004 and April 2006. BP assessments were made at four time points （daytime, evening, nighttime and morning） and polysomnography （PSG） was performed and subjects were classified into four groups by their apnea-hypopnea index （AHI）： control, n=213 with AHI 〈5; mild, n=420 with AHI -〉5 and 〈15; moderate, n=460 with AHI -〉15 and 〈30; and severe, n=1204 with AHI -〉30. SPSS 11.5 software package was used for statistical analysis and figure drawing. Results All the average daytime, nighttime, evening and morning BPs were positively correlated with AHI and negatively correlated with nadir nocturnal oxygen saturation. The ratios of nighttime/daytime and morning/evening average BP were positively correlated with AHI. The ratio of nighttime/daytime systolic BP became a ＂reversed BP dipping＂ pattern until the classification reached severe, while the ratio of nighttime/daytime diastolic BP became reversed at moderate. Similarly, the ratio of morning/evening diastolic BP becomes reversed even at mild. Conclusions OSAS may result in higher BP levels at all four time points. The ratios of nighttime/daytime and morning/evening BP increase with increased AHI. The increasing of diastolic BP, which is inclined to rise more quickly, is not parallel with increasing systolic BP.

关键词： obstructive sleep apnea syndrome blood pressure hypertension, dipping, polysomnography apnea-hypopnea index